http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl http://www.w3.org/TR/skos-reference/skos-owl1-dl.rdf The Brainteaser Ontology https://brainteaser.health/partners/ https://orcid.org/0000-0001-9219-6239 https://orcid.org/0000-0001-9709-6392 https://orcid.org/0000-0002-0676-682X https://orcid.org/0000-0002-5070-2049 https://orcid.org/0000-0003-0362-5893 https://orcid.org/0000-0003-4970-4554 The BRAINTEASER Ontology (BO) jointly models both Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS). BO serves multiple purposes: • to provide a unified and comprehensive conceptual view about ALS and MS, which are typically dealt with separately, allowing us to coherently integrate the data coming from the different medical partners in the project; • to seamlessly represent both retrospective data and prospective data, produced during the lifetime of BRAINTEASER; • to allow for sharing and re-using the BRAINTEASER datasets according to Open Science and FAIR principles. https://creativecommons.org/licenses/by-sa/4.0/ https://brainteaser.health/ The BRAINTEASER Ontology (BO) jointly models both Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS). Detectable speech disturbance Intelligible with repeating Normal speech process None Occurs at rest: difficulty breathing when either sitting or lying Occurs with one or more of the following: eating, bathing, dressing no change shortness of breath at rest while either sitting or lying down shortness of breath only with walking shortness of breath with minimal exertion (i.e. talking, eating, bathing or dressing) significant shortness of breath (all of the time) and considering using mechanical ventilation Needs extra pillows in order to sleep (more than two) None Some difficulty sleeping at night due to shortness of breath, does not routinely use more than two pillows Unable to sleep without mechanical assistance Unable to sleep without mechanical assistance no change occasional shortness of breath while lying on back but don't routinely use more that two (2) pillows to sleep shortness of breath while lying on back and require more than two pillows (or an equivalent) to sleep Continuous use of BiPAP during the night Intermittent use of BiPAP None continuous use of BiPAP at night continuous use of BiPAP at night and during the day (nearly 24 hours per day) intermittent use of BiPAP mechanical ventilation by intubation or tracheostomy no respiratory support no change noticeable speech difference speech has changed; asked often to repeat words or phrases speech has changed; sometimes need the use of alternative communication methods (i.e. computer, writing pad, letter board or eye chart) unable to communicate verbally Moderately excessive saliva; may have minimal drooling Normal Slight but definite excess of saliva in mouth; may have night time drooling marked amounts of excessive saliva with some daytime drooling marked excessive saliva with marked drooling requiring a constant tissue or handkerchief moderate amounts of excessive saliva with or without minimal day time drooling no change slight but definite excess of saliva with or without night time drooling Early eating problems - occasional choking Normal eating habits do not eat anything by mouth and receive all nutrition through a feeding tube (PEG) no changes (all foods and liquids) some changes in swallowing or occasional choking episodes (including coughing during swallowing) unable to eat all consistencies of food and have modified the consistency of foods eaten use a feeding tube (PEG) to supplement what is eaten by mouth No words are legible, but can still grip pen Normal Not all words are legible Slow able to hold a pen but unable to write no changes not all words are legible slower and/or sloppier but all the words are legible unable to hold a pen Can cut most foods (> 50%), although slow and clumsy; some help needed Food must be cut by someone, but can still feed slowly Normal Somewhat slow and clumsy, but no help needed food must be cut by someone else but can feed slowly without assistance needs to be fed no change sometimes need help with cutting more difficult foods somewhat slow and clumsy (or different than before) but no assistance or adaptive equipment require assistance with closures and fasteners unable to perform any of the manipulations Independent; Can complete self-care with effort or decreased efficiency Intermittent assistance or substitute methods Needs attendant for self-care Normal function do not perform self-care activities and completely dependent on caregiver no change perform self-care activities without assistance but with increased effort or decreased efficiency require daily assistance require intermittent assistance or use different methods (i.e. sit down to get dressed, fasten buttons with a fastener or your non-dominant hand) Can turn alone, or adjust sheets, but with great difficulty Normal function Somewhat slow and clumsy, but no help needed can initiate turning in bed or adjusting the bed clothes but require assistance to complete the task can turn in bed and adjust the bed clothes without assistance but it is slower or more clumsy can turn in bed or adjust the bedclothes without assistance but with great difficulty helpless in bed no change Early ambulation difficulties Non-ambulatory functional movement only Normal Walks with assistance can move legs or stand up but unable to walk from room to room cannot walk or move my legs no change require assistance to walk (i.e. cane, walker, foot brace or hand held assistance) walking has changed but do not require any assistance or devices (i.e. foot brace, cane, walker) Cannot do Mild unsteadiness or fatigue Needs assistance Normal Slow cannot climb stairs no change require assistance (i.e. using the handrail, cane or person) slower unsteady and/or more fatigued Caregiver alone Patient Patient with assistance Patient with assistance from caregiver or family member I am unable to walk about I have moderate problems in walking about I have no problems in walking about I have severe problems in walking about I have slight problems in walking about I am unable to wash or dress myself I have moderate problems washing or dressing myself I have no problems washing or dressing myself I have severe problems washing or dressing myself I have slight problems washing or dressing myself I am unable to do my usual activities I have moderate problems doing my usual activities I have no problems doing my usual activities I have severe problems doing my usual activities I have slight problems doing my usual activities I have moderate pain or discomfort I have no pain or discomfort I have severe pain or discomfort I have slight pain or discomfort I am extremely anxious or depressed I am moderately anxious or depressed I am not anxious or depressed I am severely anxious or depressed I am slightly anxious or depressed 0.0 100.0 A lot of the time From time to time, occasionally Most of the time Not at all Definitely I don't take as much care as I should I may not take quite as much care I take just as much care as ever Not at all Not very much Quite a lot Very much indeed As much as I ever did Definitely less than I used to Hardly at all Rather less than I used to Not at all Not very often Quite often Very often indeed Not often Often Sometimes Very seldom Definitely as much Hardly at all Not quite so much Only a little A little, but it doesnt worry me Not at all Very definitely and quite badly Yes, but not too badly As much as I always could Definitely not so much now Not at all Not quite so much now A great deal of the time A lot of the time From time to time, but not too often Only occasionally Most of the time Not often Sometimes Definitely Not at all Not often Usually Nearly all the time Not at all Sometimes Very often Not at all Occasionally Quite often Very often Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Never Often Rarely Sometimes Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Almost always Never Often Rarely Sometimes Excellent Fair Good Very good No, not limited at all Yes, limited a little Yes, limited a lot No, not limited at all Yes, limited a little Yes, limited a lot No, not limited at all Yes, limited a little Yes, limited a lot About the same Much better now than one year ago Much worse now than one year ago Somewhat better now than one year ago Somewhat worse now than one year ago Moderately Not at all Quite a bit Slightly Mild Moderate None Severe Very mild A little bit Moderately Not at all A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time No, not limited at all Yes, limited a little Yes, limited a lot A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time Definitely false Definitely true Mostly false Mostly true Not sure Definitely false Definitely true Mostly false Mostly true Not sure Definitely false Definitely true Mostly false Mostly true Not sure Definitely false Definitely true Mostly false Mostly true Not sure A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time No, not limited at all Yes, limited a little Yes, limited a lot A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A good bit of the time A little of the time All of the time Most of the time None of the time Some of the time A little of a problem Not a problem Somewhat of a problem Very much a problem A little of a problem Not a problem Somewhat of a problem Very much a problem A little of a problem Not a problem Somewhat of a problem Very much a problem A little of a problem Not a problem Somewhat of a problem Very much a problem No, not limited at all Yes, limited a little Yes, limited a lot Neither satisfied nor dissatisfied Somewhat dissatisfied Somewhat satisfied Very dissatisfied Very satisfied Extremely Moderately Not at all Quite a bit Slightly Extremely Moderately Not at all Quite a bit Slightly 0.0 10.0 Delighted Mixed - about equally satisfied and dissatisfied Mostly dissatisfied Mostly satisfied Pleased Terrible Unhappy No, not limited at all Yes, limited a little Yes, limited a lot No, not limited at all Yes, limited a little Yes, limited a lot No, not limited at all Yes, limited a little Yes, limited a lot No, not limited at all Yes, limited a little Yes, limited a lot No bed partner or room mate Partner in same bed Partner/room mate in other room Partner/room mate in same room but not same bed Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week Less than once a week Not during the past month Once or twice a week Three or more times a week A very big problem No problem at all Only a very slight problem Somewhat of a problem Fairly bad Fairly good Very bad Very good 0.0 10.0 0.0 10.0 Intense Moderate Professional Soft atypical alteration for MS normal traumatic typical alteration for MS 0 4 0 4 0 4 0 4 ND No Yes ND No Yes ND No Yes ND No Yes ND No Yes ND No Yes ND No Yes Definite Possible Probable ND No Yes ND No Yes ND No Yes ND No Yes high mild moderate none High Mild Moderate High Mild Moderate life risk moderate serious slight left lower lower left lower right right upper upper left upper right altered normal auditory motor somatosensory visual Difficulty seeing Dropped PEG Has a Cold Other Talked Crutches Fully ambulatory Orthosis Walker Walking stick Wheelchair clinically isolated syndrome (CIS) primary progressive MS (PP) progressive-relapsing (PR) radiologically isolated syndrome (RIS) relapsing-remitting MS (RR) secondary progressive MS (SP) in CSF in CSF & serum beyond 5years within 5 yeras Crutches Fully ambulatory Orthosis Walker Walking stick Wheelchair city rural town urban both distal proximal left right symmetric both motor neuron lower motor neuron upper motor neuron complete none partial life risk moderate serious slight female male Living with smokers Smoker Working with smokers Mild Moderate Severe ESCO:C0 Armed forces occupations include all jobs held by members of the armed forces. Members of the armed forces are those personnel who are currently serving in the armed forces, including auxiliary services, whether on a voluntary or compulsory basis, and who are not free to accept civilian employment and are subject to military discipline. Included are regular members of the army, navy, air force and other military services, as well as conscripts enrolled for military training or other service for a specified period. Occupations in this major group are classified into the following sub-major groups: 01 Commissioned Armed Forces Officers 02 Non-commissioned Armed Forces Officers 03 Armed Forces Occupations, Other Ranks Excluded from this group are: - jobs held by persons in civilian employment of government establishments concerned with defence issues; - police (other than military police); - customs inspectors and members of border or other armed civilian services. ESCO:C0 Armed forces occupations ESCO:C01 Commissioned armed forces officers provide leadership and management to organizational units in the armed forces and/or perform similar tasks to those performed in a variety of civilian occupations outside the armed forces. This group includes all members of the armed forces holding the rank of second lieutenant (or equivalent) or higher. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level. Occupations in this sub-major group are classified into the following minor group: 011 Commissioned Armed Forces Officers Excluded from this group are: - jobs held by persons in civilian employment of government establishments concerned with defence issues; - police (other than military police); - customs inspectors and members of border or other armed civilian services. ESCO:C01 Commissioned armed forces officers ESCO:C01 ESCO:C0 ESCO:C02 Non-commissioned armed forces officers enforce military discipline and supervise the activities of those employed in Sub-major Group 03: Armed Forces Occupations, Other Ranks, and/or perform similar tasks to those performed in a variety of civilian occupations outside the armed forces. This group includes members of the armed forces holding ranks such as sergeant, warrant officer and sergeant major. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Occupations in this sub-major group are classified into the following minor group: 021 Non-commissioned Armed Forces Officers Excluded from this group are: - jobs held by persons in civilian employment of government establishments concerned with defence issues; - police (other than military police); - customs inspectors and members of border or other armed civilian services. ESCO:C02 Non-commissioned armed forces officers ESCO:C02 ESCO:C0 ESCO:C03 Armed forces occupations, other ranks include all conscripted and non-conscripted members of the armed forces except commissioned and non-commissioned officers. They perform specific military tasks and/or perform similar tasks to those performed in a variety of civilian occupations outside the armed forces. Most occupations in this sub-major group require skills at the first ISCO skill level. Occupations in this sub-major group are classified into the following minor group: 031 Armed Forces Occupations, Other Ranks Excluded from this group are: - jobs held by persons in civilian employment of government establishments concerned with defence issues; - police (other than military police); - customs inspectors and members of border or other armed civilian services. ESCO:C03 Armed forces occupations, other ranks ESCO:C03 ESCO:C0 ESCO:C1 Managers plan, direct, coordinate and evaluate the overall activities of enterprises, governments and other organizations, or of organizational units within them, and formulate and review their policies, laws, rules and regulations. Competent performance in most occupations in this major group requires skills at the fourth ISCO skill level, except for Sub-major Group 14: Hospitality, Retail and Other Services Managers, for which skills at the third ISCO skill level are generally required. Tasks performed by managers usually include: formulating and advising on the policy, budgets, laws and regulations of enterprises, governments and other organizational units; establishing objectives and standards and formulating and evaluating programmes and policies and procedures for their implementation; ensuring appropriate systems and procedures are developed and implemented to provide budgetary control; authorizing material, human and financial resources to implement policies and programmes; monitoring and evaluating performance of the organization or enterprise and of its staff; selecting or approving the selection of staff; ensuring compliance with health and safety requirements; planning and directing daily operations; representing and negotiating on behalf of the government, enterprise or organizational unit managed in meetings and other forums. Occupations in this major group are classified into the following sub-major groups: 11 Chief Executives, Senior Officials and Legislators 12 Administrative and Commercial Managers 13 Production and Specialized Services Managers 14 Hospitality, Retail and Other Services Managers ESCO:C1 Managers ESCO:C11 Chief executives, senior officials and legislators formulate and review the policies, and plan, direct, coordinate and evaluate the overall activities of enterprises, governments and other organizations with the support of other managers. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level . Tasks performed by workers in this sub-major group usually include: presiding over or participating in the proceedings of legislative bodies, boards of directors and committees; formulating and advising on the policy budgets, laws and regulations of enterprises, governments and other organizations; establishing objectives for enterprises, government departments or agencies and other organizations; formulating or approving and evaluating programmes and policies and procedures for their implementation; ensuring appropriate systems and procedures are developed and implemented to provide budgetary control; authorizing material, human and financial resources to implement policies and programmes; monitoring and evaluating performance of the organization or enterprise; selecting or approving the selection of senior staff; performing ceremonial duties and representing the enterprise, government, organization or community at official occasions and in meetings, negotiations, conventions and public hearings. Occupations in this sub-major group are classified into the following minor groups: 111 Legislators and Senior Officials 112 Managing Directors and Chief Executives ESCO:C11 Chief executives, senior officials and legislators ESCO:C11 ESCO:C1 ESCO:C12 Administrative and commercial managers plan, organize, direct, control and coordinate the financial, administrative, human resource, policy, planning, research and development, advertising, public relations, and sales and marketing activities of enterprises and organizations, or of enterprises that provide such services to other enterprises and organizations. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level Tasks performed by workers in this sub-major group usually include: formulating and administering policy advice and strategic and financial planning; establishing and directing operational and administrative procedures; implementing, monitoring and evaluating strategies and policies; providing advice to senior managers; directing the development of initiatives for new products, marketing, public relations and advertising campaigns; determining and directing sales activities, product mix and customer service standards; setting prices and credit arrangements; ensuring compliance with relevant legislation, regulations and standards; controlling selection, training and performance of staff; preparing budgets and overseeing financial operations; consulting with the chief executive and with managers of other departments or sections; controlling expenditure and ensuring the efficient use of resources; representing the enterprise or organization in negotiations, and at conventions, seminars, public hearings and forums. Occupations in this sub-major group are classified into the following minor groups: 121 Business Services and Administration Managers 122 Sales, Marketing and Development Managers ESCO:C12 Administrative and commercial managers ESCO:C12 ESCO:C1 ESCO:C13 Production and specialized services managers plan, direct and coordinate the production of the goods and the provision of the specialized professional and technical services provided by an enterprise or organization, either as the manager of a department or as the general manager of an enterprise or organization that does not have a hierarchy of managers. They are responsible for manufacturing, mining, construction, logistics, information and communications technology operations for large-scale agricultural, forestry and fisheries operations, and for the provision of health, education, social welfare, banking, insurance and other professional and technical services. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level. Tasks performed by workers in this sub-major group usually include: planning details of activities in terms of output, services provided, quality, quantity, cost, timeliness and labour requirements; setting standards and objectives; controlling the operation of plant and of procedures; assuring quality of the goods produced and services provided; preparing tenders and contract bids; establishing and managing budgets, monitoring costs, and adjusting activities, procedures and resources to minimize costs; overseeing the acquisition and installation of new plant and equipment; coordinating the implementation of health and safety requirements; planning and directing daily operations; overseeing the selection, training and performance of staff; preparing, or arranging for the preparation of, reports, budgets and forecasts; representing the enterprise or organization in negotiations with other agencies, and at conventions, seminars, public hearings and forums. Occupations in this sub-major group are classified into the following minor groups: 131 Production Managers in Agriculture, Forestry and Fisheries 132 Manufacturing, Mining, Construction and Distribution Managers 133 Information and Communications Technology Services Managers 134 Professional Services Managers ESCO:C13 Production and specialised services managers ESCO:C13 ESCO:C1 ESCO:C14 Hospitality, retail and other services managers plan, organize and direct the operations of establishments which provide accommodation, hospitality, retail and other services. Competent performance in most occupations in this sub-major group requires skills at the third ISCO skill level. Tasks performed by workers in this sub-major group usually include: planning and organizing special functions, sporting, gaming and entertainment activities and the range and mix of products, stock levels and service standards; promoting and selling goods and services; observing liquor, gaming, health and other laws and regulations; developing and reviewing policies, programmes and procedures concerning customer relations and goods and services provided; promoting facilities for conferences, conventions and trade shows to potential customers; organizing the purchase and maintenance of transport vehicles, equipment and fuel, and transporting goods; controlling the selection, training and supervision of staff; ensuring compliance with occupational health and safety regulations. Occupations in this sub-major group are classified into the following minor groups: 141 Hotel and Restaurant Managers 142 Retail and Wholesale Trade Managers 143 Other Services Managers ESCO:C14 Hospitality, retail and other services managers ESCO:C14 ESCO:C1 ESCO:C2 Professionals increase the existing stock of knowledge; apply scientific or artistic concepts and theories; teach about the foregoing in a systematic manner; or engage in any combination of these activities. Competent performance in most occupations in this major group requires skills at the fourth ISCO skill level. Tasks performed by professionals usually include: conducting analysis and research, and developing concepts, theories and operational methods; advising on or applying existing knowledge related to physical sciences, mathematics, engineering and technology, life sciences, medical and health services, social sciences and humanities; teaching the theory and practice of one or more disciplines at different educational levels; teaching and educating persons with learning difficulties or special needs; providing various business, legal and social services; creating and performing works of art; providing spiritual guidance; preparing scientific papers and reports. Supervision of other workers may be included. Occupations in this major group are classified into the following sub-major groups: 21 Science and Engineering Professionals 22 Health Professionals 23 Teaching Professionals 24 Business and Administration Professionals 25 Information and Communications Technology Professionals 26 Legal, Social and Cultural Professionals ESCO:C2 Professionals ESCO:C21 Science and engineering professionals conduct research; improve or develop concepts, theories and operational methods; or apply scientific knowledge relating to fields such as physics, astronomy, meteorology, chemistry, geophysics, geology, biology, ecology, pharmacology, medicine, mathematics, statistics, architecture, engineering, design and technology. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level. Tasks performed by workers in this sub-major group usually include: conducting research, enlarging, advising on or applying scientific knowledge obtained through the study of structures and properties of physical matter and phenomena, chemical characteristics and processes of various substances, materials and products, all forms of human, animal and plant life and of mathematical and statistical concepts and methods; advising on, designing and directing construction of buildings, towns and traffic systems, or civil engineering and industrial structures, as well as machines and other equipment; advising on and applying mining methods and ensuring their optimum use; surveying land and sea and making maps; studying and advising on technological aspects of particular materials, products and processes, and on efficiency of production and work organization; preparing scientific papers and reports. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 211 Physical and Earth Science Professionals 212 Mathematicians, Actuaries and Statisticians 213 Life Science Professionals 214 Engineering Professionals (excluding Electrotechnology) 215 Electrotechnology Engineers 216 Architects, Planners, Surveyors and Designers ESCO:C21 Science and engineering professionals ESCO:C21 ESCO:C2 ESCO:C22 Health professionals conduct research,; improve or develop concepts, theories and operational methods; and apply scientific knowledge relating to medicine, nursing, dentistry, veterinary medicine, pharmacy, and promotion of health. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level. Tasks performed by workers in this sub-major group usually include: conducting research and obtaining scientific knowledge through the study of human and animal disorders and illnesses and ways of treating them; advising on or applying preventive and curative measures, or promoting health; preparing scientific papers and reports. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 221 Medical Doctors 222 Nursing and Midwifery Professionals 223 Traditional and Complementary Medicine Professionals 224 Paramedical Practitioners 225 Veterinarians 226 Other Health Professionals ESCO:C22 Health professionals ESCO:C22 ESCO:C2 ESCO:C23 Teaching professionals teach the theory and practice of one or more disciplines at different educational levels; conduct research; improve or develop concepts, theories and operational methods pertaining to their particular discipline; and prepare scholarly papers and books. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level. Tasks performed by workers in this sub-major group usually include: conducting classes, courses, or tutorials at a particular educational level for educational and vocational purposes, including private lessons; conducting adult literacy programmes; teaching and educating persons with learning difficulties or special needs; designing and modifying curricula; inspecting and advising on teaching methods and aids; participating in decisions concerning the organization of teaching and related activities at schools and universities; conducting research in particular subjects to improve or develop concepts, theories or operational methods for application in industrial and other fields; preparing scholarly papers and books. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor group: 231 University and Higher Education Teachers 232 Vocational Education Teachers 233 Secondary Education Teachers 234 Primary School and Early Childhood Teachers 235 Other Teaching Professionals ESCO:C23 Teaching professionals ESCO:C23 ESCO:C2 ESCO:C24 Business and administration professionals perform analytical, conceptual and practical tasks to provide services in financial matters, human resource development, public relations, marketing and sales in the technical, medical, information and communications technology areas; and conduct reviews of organizational structures, methods and systems as well as quantitative analyses of information affecting investment programmes. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level. Tasks performed by workers in this sub-major group usually include: collecting, analysing and interpreting information on the financial viability, cost structures and trading effectiveness of organizations; conducting audits, preparing financial statements and controlling treasury systems for organizations; developing and reviewing financial plans and strategies, executing buy and sell orders, and negotiating the purchase and sale of commodities; developing, implementing and evaluating staff recruitment, training and development programmes; researching, developing and implementing marketing and public relations campaigns; studying and developing methods and policies to improve and promote government and business operations and effectiveness; acquiring and updating knowledge of employers’ and competitors’ goods and services, and of market conditions; assessing customers’ needs and explaining and demonstrating goods and services to them. Occupations in this sub-major group are classified into the following minor group: 241 Finance Professionals 242 Administration Professionals 243 Sales, Marketing and Public Relations Professionals ESCO:C24 Business and administration professionals ESCO:C24 ESCO:C2 ESCO:C25 Information and communications technology professionals conduct research; plan, design, write, test, provide advice and improve information technology systems, hardware, software and related concepts for specific applications; develop associated documentation including principles, policies and procedures; and design, develop, control, maintain and support databases and other information systems to ensure optimal performance and data integrity and security. Tasks performed by workers in this sub-major group usually include: researching information technology use in business functions; identifying areas for improvement and researching the theoretical aspects and operational methods for the use of computers; evaluating, planning and designing hardware or software configurations for specific applications including for Internet, Intranet and multimedia systems; designing, writing, testing and maintaining computer programs; designing and developing database architecture and database management systems; developing and implementing security plans and data administration policy, and administering computer networks and related computing environments; analysing, developing, interpreting and evaluating complex system design and architecture specifications, data models and diagrams in the development, configuration and integration of computer systems. Occupations in this sub-major group are classified into the following minor groups: 251 Software and Applications Developers and Analysts 252 Database and Network Professionals ESCO:C25 Information and communications technology professionals ESCO:C25 ESCO:C2 ESCO:C26 Legal, social and cultural professionals conduct research; improve or develop concepts, theories and operational methods; or apply knowledge relating to the law, storage and retrieval of information and artefacts, psychology, social welfare, politics, economics, history, religion, languages, sociology, other social sciences, and arts and entertainment. Competent performance in most occupations in this sub-major group requires skills at the fourth ISCO skill level. Tasks performed by workers in this sub-major group usually include: conducting research on legal problems; drafting laws and regulations; advising clients on legal cases; pleading and conducting cases in a court of law; presiding over judicial proceedings in a court of law; developing and maintaining library and gallery collections of archives; conducting research, improving or developing concepts, theories and operational methods or applying knowledge relating to the field of social sciences; conceiving, creating and performing in literary and artistic works; interpreting and communicating news, ideas, impressions and facts. Occupations in this sub-major group are classified into the following minor groups: 261 Legal Professionals 262 Librarians, Archivists and Curators 263 Social and Religious Professionals 264 Authors, Journalists and Linguists 265 Creative and Performing Artists ESCO:C26 Legal, social and cultural professionals ESCO:C26 ESCO:C2 ESCO:C3 Technicians and associate professionals perform technical and related tasks connected with research and the application of scientific or artistic concepts and operational methods, and government or business regulations. Competent performance in most occupations in this major group requires skills at the third ISCO skill level. Tasks performed by technicians and associate professionals usually include: undertaking and carrying out technical work connected with research and the application of concepts and operational methods in the fields of physical sciences including engineering and technology, life sciences including the medical profession, and social sciences and humanities; initiating and carrying out various technical services related to trade, finance and administration including administration of government laws and regulations, and to social work; providing technical support for the arts and entertainment; participating in sporting activities; executing some religious tasks. Supervision of other workers may be included. Occupations in this major group are classified into the following sub-major groups: 31 Science and Engineering Associate Professionals 32 Health Associate Professionals 33 Business and Administration Associate Professionals 34 Legal, Social, Cultural and Related Associate Professionals 35 Information and Communications Technicians ESCO:C3 Technicians and associate professionals ESCO:C31 Science and engineering associate professionals perform technical tasks connected with research and operational methods in science and engineering. They supervise and control technical and operational aspects of mining, manufacturing, construction and other engineering operations, and operate technical equipment including aircraft and ships. Competent performance in most occupations in this sub-major group requires skills at the third ISCO skill level. Tasks performed by workers in this sub-major group usually include: setting up, monitoring and operating instruments and equipment, conducting and monitoring experiments and tests of systems; collecting and testing samples; recording observations and analysing data; preparing, revising and interpreting technical drawings and diagrams; coordinating, supervising, controlling and scheduling the activities of other workers; operating and monitoring switchboards, computerized control systems, and multi-function process control machinery; performing technical functions to ensure safe and efficient movement and operations in ships, aircraft and other equipment. Occupations in this sub-major group are classified into the following minor groups: 311 Physical and Engineering Science Technicians 312 Mining, Manufacturing and Construction Supervisors 313 Process Control Technicians 314 Life Science Technicians and Related Associate Professionals 315 Ship and Aircraft Controllers and Technicians ESCO:C31 Science and engineering associate professionals ESCO:C31 ESCO:C3 ESCO:C32 Health associate professionals perform technical and practical tasks to support diagnosis and treatment of illness, disease, injuries and impairments in humans and animals, and to support implementation of health care, treatment and referral plans usually established by medical, veterinary, nursing and other health professionals. Competent performance in most occupations in this sub-major group requires skills at the third ISCO skill level. Tasks performed by workers in the sub-major group usually include: testing and operating medical imaging equipment and administering radiation therapy; performing clinical tests on specimens of bodily fluids and tissues; preparing medications and other pharmaceutical compounds under the guidance of pharmacists; designing, fitting, servicing and repairing medical and dental devices and appliances; providing nursing and personal care and midwifery support services; using herbal and other therapies based on theories, beliefs and experiences originating in specific cultures. Occupations in this sub-major group are classified into the following minor groups: 321 Medical and Pharmaceutical Technicians 322 Nursing and Midwifery Associate Professionals 323 Traditional and Complementary Medicine Associate Professionals 324 Veterinary Technicians and Assistants 325 Other Health Associate Professionals ESCO:C32 Health associate professionals ESCO:C32 ESCO:C3 ESCO:C33 Business and administration associate professionals perform mostly technical tasks connected with the practical application of knowledge relating to financial accounting and transaction matters, mathematical calculations, human resource development, selling and buying financial instruments, specialized secretarial tasks, and enforcing or applying government rules. Also included are workers who provide business services such as customs clearance, conference planning, job placements, buying and selling real estate or bulk commodities, and serving as agents for performers such as athletes and artists. Competent performance in most occupations in this sub-major group requires skills at the third ISCO skill level. Tasks performed by workers in this sub-major group usually include recording and transmitting buy and sell orders for securities, stocks, bonds or other financial instruments and for foreign exchange for future or immediate delivery; submitting credit and loan applications to management with recommendations for approval or rejection; approving or rejecting applications within authorized limits ensuring that credit standards of the institution are respected; maintaining complete records of all financial transactions of an undertaking according to general bookkeeping principles, with guidance from accountants; assisting in planning and performing mathematical, statistical, actuarial, accounting and related calculations; selling and buying financial instruments. Occupations in this sub-major group are classified into the following minor groups: 331 Financial and Mathematical Associate Professionals 332 Sales and Purchasing Agents and Brokers 333 Business Services Agents 334 Administrative and Specialized Secretaries 335 Government Regulatory Associate Professionals ESCO:C33 Business and administration associate professionals ESCO:C33 ESCO:C3 ESCO:C34 Legal, social, cultural and related associate professionals perform technical tasks connected with the practical application of knowledge relating to legal services, social work, culture, food preparation, sport and religion. Competent performance in most occupations in this sub-major group requires skills at the third ISCO skill level. Tasks performed by workers in this sub-major group usually include: providing technical and practical services and support functions in legal processes and investigations, social and community assistance programmes, and religious and cultural activities; participating and adjudicating in sporting events; developing and delivering sports coaching, fitness and recreational programmes; combining creative and technical skills in a variety of artistic, cultural and culinary activities; creating dishes and menus and overseeing the preparation of meals. Occupations in this sub-major group are classified into the following minor groups: 341 Legal, Social and Religious Associate Professionals 342 Sports and Fitness Workers 343 Artistic, Cultural and Culinary Associate Professionals ESCO:C34 Legal, social, cultural and related associate professionals ESCO:C34 ESCO:C3 ESCO:C35 Information and communications technicians provide support for the day-to-day running of computer systems, communications systems and networks, and perform technical tasks related to telecommunications, broadcast image and sound as well as other types of telecommunications signals on land, sea or in aircraft. Competent performance in most occupations in this sub-major group requires skills at the third ISCO skill level. Tasks performed by workers in this sub-major group usually include: providing assistance to information and communications systems users; installing new programs and equipment; establishing, operating and maintaining network and other data communications systems; installing, monitoring and supporting Internet and Intranet websites or web server hardware or software; modifying web pages; and performing web server backup and recovery operations; controlling equipment to record sound, edit and mix image and sound recordings; controlling and maintaining transmitting and broadcast systems and satellite systems for radio and television programmes; controlling and maintaining radio communications systems, satellite services and multiplex systems on land, sea or in aircraft; providing technical assistance connected with research and development of computer systems and telecommunications equipment, or testing prototypes; designing and preparing blueprints of circuitry according to the specifications given; providing technical supervision of the manufacture, utilization, maintenance and repair of telecommunications systems. Occupations in this sub-major group are classified into the following minor groups: 351 Information and Communications Technology Operations and User Support Technicians 352 Telecommunications and Broadcasting Technicians ESCO:C35 Information and communications technicians ESCO:C35 ESCO:C3 ESCO:C4 Clerical support workers record, organize, store, compute and retrieve information, and perform a number of clerical duties in connection with money-handling operations, travel arrangements, requests for information, and appointments. Competent performance in most occupations in this major group requires skills at the second ISCO skill level. Tasks performed by clerical support workers usually include: stenography, typing, and operating word processors and other office machines; entering data into computers; carrying out secretarial duties; recording and computing numerical data; keeping records relating to stocks, production and transport; keeping records relating to passenger and freight transport; carrying out clerical duties in libraries; filing documents; carrying out duties in connection with mail services; preparing and checking material for printing; assisting persons who cannot read or write with correspondence; performing money-handling operations; dealing with travel arrangements; supplying information requested by clients and making appointments; operating a telephone switchboard. Supervision of other workers may be included. Occupations in this major group are classified into the following sub-major groups: 41 General and Keyboard Clerks 42 Customer Services Clerks 43 Numerical and Material Recording Clerks 44 Other Clerical Support Workers ESCO:C4 Clerical support workers ESCO:C41 General and keyboard clerks record, organize, store and retrieve information and perform a wide range of clerical and administrative tasks according to established procedures. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: recording, preparing, sorting, classifying and filing information; sorting, opening and sending mail; preparing reports and correspondence of a routine nature; photocopying and faxing documents; operating personal computers, word processors or typewriters to record, input and process text and data; proofreading and correcting copy; preparing invoices and checking figures. Occupations in this sub-major group are classified into the following minor groups: 411 General Office Clerks 412 Secretaries (general) 413 Keyboard Operators ESCO:C41 General and keyboard clerks ESCO:C41 ESCO:C4 ESCO:C42 Customer services clerks deal with clients in connection with money-handling operations, travel arrangements, requests for information, making appointments, operating telephone switchboards, and interviewing for surveys or to complete applications for eligibility for services. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: performing money-handling operations in banks, post offices, betting and gambling establishments, or dealing with travel arrangements; supplying information requested by clients and making appointments; operating telephone switchboards; greeting and receiving visitors; interviewing survey respondents; interviewing applicants for services. Occupations in this sub-major group are classified into the following minor groups: 421 Tellers, Money Collectors and Related Clerks 422 Client Information Workers ESCO:C42 Customer services clerks ESCO:C42 ESCO:C4 ESCO:C43 Numerical and material recording clerks obtain, compile and compute accounting, bookkeeping, statistical, financial and other numerical data, and take charge of cash transactions incidental to business matters. Some occupations classified here keep records of goods produced, purchased, stocked and dispatched, and of materials needed at specified production dates, or keep records of operational aspects and coordinate the timing of passenger and freight transport. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: helping with accounting and bookkeeping records and computations; calculating unit production costs; calculating wages and in some cases preparing wage packets and paying wages; taking charge of cash transactions incidental to the business; obtaining, compiling and computing statistical or actuarial data; performing clerical tasks relating to the financial transactions of an insurance establishment, bank or similar establishment; recording produced, stocked, ordered and dispatched goods; recording production materials received, put into stock or issued; computing quantities of the production materials required at specified dates and helping with preparation and checking of production operation schedules; keeping records of operational aspects and coordinating the timing of passenger and freight transport. Occupations in this sub-major group are classified into the following minor groups: 431 Numerical Clerks 432 Material Recording and Transport Clerks ESCO:C43 Numerical and material recording clerks ESCO:C43 ESCO:C4 ESCO:C44 Other clerical support workers sort and deliver mail, file documents, prepare information for processing, maintain personnel records, check material for consistency with original source material, assist persons who cannot read or write, and perform various other specialized clerical duties. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: recording information regarding acquisition, issue and return of library books; classifying and filing various documents and other records; maintaining personnel records; sorting, recording and delivering mail from post offices, as well as from or within an enterprise; coding; correcting proofs; performing a range of miscellaneous clerical duties; writing on behalf of persons who are unable to read or write. Occupations in this sub-major group are classified into the following minor group: 441 Other Clerical Support Workers ESCO:C44 Other clerical support workers ESCO:C44 ESCO:C4 ESCO:C5 Services and sales workers provide personal and protective services related to travel, housekeeping, catering, personal care, protection against fire and unlawful acts; or demonstrate and sell goods in wholesale or retail shops and similar establishments, as well as at stalls and on markets. Competent performance in most occupations in this major group requires skills at the second ISCO skill level. Tasks performed by services and sales workers usually include: organizing and providing services during travel; housekeeping; preparing and serving of food and beverages; caring for children; providing personal and basic health care at homes or in institutions, as well as hairdressing, beauty treatment and companionship; telling fortunes; embalming and arranging funerals; providing security services and protecting individuals and property against fire and unlawful acts; enforcing of law and order; posing as models for advertising, artistic creation and display of goods; selling goods in wholesale or retail establishments, as well as at stalls and on markets; and demonstrating goods to potential customers. Supervision of other workers may be included. Occupations in this major group are classified into the following sub-major groups: 51 Personal Services Workers 52 Sales Workers 53 Personal Care Workers 54 Protective Services Workers ESCO:C5 Service and sales workers ESCO:C51 Personal services workers provide personal services related to travel, housekeeping, catering and hospitality, hairdressing and beauty treatment, animal care grooming and training, companionship and other services of a personal nature. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: organizing and providing services in connection with travel and sightseeing; housekeeping; preparing and serving food and beverages; hairdressing and beauty treatment; telling fortunes; embalming and arranging funerals; grooming, caring for and training animals; teaching people to drive motor vehicles; providing companionship and other personal services. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 511 Travel Attendants, Conductors and Guides 512 Cooks 513 Waiters and Bartenders 514 Hairdressers, Beauticians and Related Workers 515 Building and Housekeeping Supervisors 516 Other Personal Services Workers ESCO:C51 Personal service workers ESCO:C51 ESCO:C5 ESCO:C52 Sales workers sell and demonstrate goods in wholesale or retail shops, at stalls and markets, door-to-door, via telephone or customer contact centres. They may record and accept payment for goods and services purchased, and may operate small retail outlets. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: selling goods in wholesale or retail establishments, at street or market stalls, door-to-door, via telephone or customer contact centres; demonstrating and displaying goods to potential customers; selling and serving food for immediate consumption at counters and in the street; buying or contracting a regular supply of products to be sold; stacking and displaying goods for sale and wrapping or packing goods sold; determining product mix, stock and price levels for goods to be sold; operating cash registers, optical price scanners, computers or other equipment to record and accept payment for the purchase of goods and services. Supervision of other workers may be required in some occupations classified here. Occupations in this sub-major group are classified into the following minor groups: 521 Street and Market Salespersons 522 Shop Salespersons 523 Cashiers and Ticket Clerks 524 Other Sales Workers ESCO:C52 Sales workers ESCO:C52 ESCO:C5 ESCO:C53 Personal care workers provide care, supervision and assistance for children, patients and elderly, convalescent or disabled persons in institutional and residential settings. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: assisting with mobility, washing and other personal needs; assisting children individually to learn social skills; supervising and participating in activities that enhance children’s physical, social, emotional and intellectual development; observing and reporting concerns to appropriate health or social service workers. Occupations in this sub-major group are classified into the following minor groups: 531 Child Care Workers and Teachers’ Aides 532 Personal Care Workers in Health Services ESCO:C53 Personal care workers ESCO:C53 ESCO:C5 ESCO:C54 Protective services workers protect individuals and property against fire and other hazards, maintain law and order and enforce laws and regulations. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: preventing, fighting and extinguishing fires; rescuing people from burning buildings and accident sites and those trapped in dangerous situations; maintaining law and order, enforcing laws and regulations, patrolling public areas and arresting suspected offenders; directing traffic and assuming authority in the event of accidents; watching over and maintaining order among inmates of prisons, reformatories or penitentiaries; patrolling or monitoring premises to guard property against theft and vandalism, controlling access to establishments and maintaining order and enforcing regulations at public events and within establishments. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor group: 541 Protective Services Workers ESCO:C54 Protective services workers ESCO:C54 ESCO:C5 ESCO:C6 Skilled agricultural, forestry and fishery workers grow and harvest field or tree and shrub crops; gather wild fruits and plants; breed, tend or hunt animals; produce a variety of animal husbandry products; cultivate, conserve and exploit forests; breed or catch fish; and cultivate or gather other forms of aquatic life in order to provide food, shelter and income for themselves and their households. Competent performance in most occupations in this major group requires skills at the second ISCO skill level. Tasks performed by skilled agricultural, forestry and fishery workers usually include: preparing the soil; sowing, planting, spraying, fertilizing and harvesting field crops; growing fruit and other tree and shrub crops; growing garden vegetables and horticultural products; gathering wild fruits and plants; breeding, raising, tending or hunting animals mainly to obtain meat, milk, hair, fur, skin, or sericultural, apiarian or other products; cultivating, conserving and exploiting forests; breeding or catching fish; cultivating or gathering other forms of aquatic life; storing and carrying out some basic processing of their produce; selling their products to purchasers, marketing organizations or at markets. Supervision of other workers may be included. Occupations in this major group are classified into the following sub-major groups: 61 Market-oriented Skilled Agricultural Workers 62 Market-oriented Skilled Forestry, Fishery and Hunting Workers 63 Subsistence Farmers, Fishers, Hunters and Gatherers ESCO:C6 Skilled agricultural, forestry and fishery workers ESCO:C61 Market-oriented skilled agricultural workers plan, organize and perform farming operations to grow and harvest field or tree and shrub crops; and to produce a variety of animals and animal products for sale or delivery on a regular basis to wholesale buyers, marketing organizations or at markets. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: preparing the soil; sowing, planting, spraying, fertilizing and harvesting field crops; growing fruit and other tree and shrub crops; growing garden vegetables and horticultural products; raising, breeding and tending animals mainly to obtain meat, milk, hair, fur, skin, or sericultural, apiarian or other products; storing and carrying out some processing of produce; selling their products to purchasers, marketing organizations or at markets. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 611 Market Gardeners and Crop growers 612 Animal Producers 613 Mixed Crop and Animal Producers ESCO:C61 Market-oriented skilled agricultural workers ESCO:C61 ESCO:C6 ESCO:C62 Market-oriented skilled forestry, fishery and hunting workers plan, organize and perform operations to cultivate, conserve and exploit natural and plantation forests; breed and raise fish; harvest and catch fish; and hunt and trap animals, for sale or delivery on a regular basis to wholesale buyers, marketing organizations or at markets. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: renting or investing in equipment and machinery and purchasing supplies; planning and undertaking forestry, aquaculture, fishery and hunting operations; maintaining buildings, tanks, machinery and other equipment; delivering or marketing products; supervising and training other workers. Occupations in this sub-major group are classified into the following minor groups: 621 Forestry and Related Workers 622 Fishery Workers, Hunters and Trappers ESCO:C62 Market-oriented skilled forestry, fishery and hunting workers ESCO:C62 ESCO:C6 ESCO:C63 Subsistence farmers, fishers, hunters and gatherers grow and harvest field or tree and shrub crops, vegetables and fruit; gather wild fruits, medicinal and other plants; tend or hunt animals; catch fish and gather various forms of aquatic life in order to provide food, shelter and, in some cases, a minimum of cash income for themselves and their households. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: preparing the soil; sowing, planting, tending and harvesting field crops; growing vegetables, fruit and other tree and shrub crops; gathering wild fruits, medicinal and other plants; breeding, tending and feeding animals and poultry mainly to obtain meat, eggs, milk, hair, skin or other products; hunting or trapping animals; catching fish and gathering other forms of aquatic life; fetching water and gathering firewood; storing produce for later use and carrying out some processing of produce; building and maintaining houses and other shelters; making tools, clothes and utensils for use by the household; selling or bartering some products at local markets. Occupations in this sub-major group are classified into the following minor groups: 631 Subsistence Crop Farmers 632 Subsistence Livestock Farmers 633 Subsistence Mixed Crop and Livestock Farmers 634 Subsistence Fishers, Hunters, Trappers and Gatherers ESCO:C63 Subsistence farmers, fishers, hunters and gatherers ESCO:C63 ESCO:C6 ESCO:C7 Craft and related trades workers apply specific technical and practical knowledge and skills to construct and maintain buildings; form metal; erect metal structures; set machine tools or make, fit, maintain and repair machinery, equipment or tools; carry out printing work; and produce or process foodstuffs, textiles, wooden, metal and other articles, including handicraft goods. Competent performance in most occupations in this major group requires skills at the second ISCO skill level. The work is carried out by hand and by hand-powered and other tools which are used to reduce the amount of physical effort and time required for specific tasks, as well as to improve the quality of the products. The tasks call for an understanding of all stages of the production process, the materials and tools used, and the nature and purpose of the final product. Tasks performed by craft and related trades workers usually include: constructing, maintaining and repairing buildings and other structures; casting, welding and shaping metal; installing and erecting heavy metal structures, tackle and related equipment; making machinery, tools, equipment and other metal articles; setting for operators, or setting and operating various machine tools; fitting, maintaining and repairing industrial machinery, engines, vehicles, electrical and electronic instruments and other equipment; making precision instruments, jewellery, household and other precious metal articles, pottery, glass and related products; producing handicrafts; executing printing work; producing and processing foodstuffs and various articles made of wood, textiles, leather and related materials. Supervision of other workers may be included. Self-employed craft and related trades workers, who operate their own businesses either independently or with assistance from a small number of others, may also perform a range of tasks associated with management of the business, account and record keeping and client service, although such tasks would not normally comprise the major component of the work. Occupations in this major group are classified into the following sub-major groups: 71 Building and Related Trades Workers (excluding electricians) 72 Metal, Machinery and Related Trades Workers 73 Handicraft and Printing Workers 74 Electrical and Electronics Trades Workers 75 Food Processing, Woodworking, Garment and Other Craft and Related Trades Workers ESCO:C7 Craft and related trades workers ESCO:C71 Building and related trades workers construct, maintain and repair buildings; erect and repair foundations, walls and structures of brick, stone and similar materials; shape and finish stone for building and other purposes. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. The work is carried out by hand and by hand-powered and other tools which are used to reduce the amount of physical effort and time required for specific tasks, as well as to improve the quality of the products. The tasks call for an understanding of the work organization, the materials and tools used, and the nature and purpose of the final product. Tasks performed by workers in this sub-major group usually include: constructing, maintaining and repairing buildings and other structures, using traditional and/or modern building techniques; constructing and repairing foundations, walls and structures of brick, stone and similar materials; breaking quarried stone into slabs or blocks; cutting, shaping and finishing stone for building, ornamental, monumental and other purposes; erecting reinforced concrete frameworks and structures as well as finishing and repairing cement surfaces; cutting, shaping, assembling and maintaining wooden structures and fittings; performing miscellaneous construction and building maintenance tasks. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 711 Building Frame and Related Trades Workers 712 Building Finishers and Related Trades Workers 713 Painters, Building Structure Cleaners and Related Trades Workers ESCO:C71 Building and related trades workers, excluding electricians ESCO:C71 ESCO:C7 ESCO:C72 Metal, machinery and related trades workers cast, weld, forge and, by other methods, form metal; erect, maintain and repair heavy metal structures; engage in machine-tool setting as well as in fitting, maintaining and repairing machinery including engines and vehicles; or they produce tools and various non-precious metal articles. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. The work is carried out by hand and by hand-powered and other tools which are used to reduce the amount of physical effort and time required for specific tasks, as well as to improve the quality of the products. The tasks call for an understanding of the work organization, materials and tools used, and the nature and purpose of the final product Tasks performed by workers in this sub-major group usually include: making moulds and cores for casting metal; casting, welding and shaping metal; installing, erecting, maintaining and repairing heavy metal structures, tackle and related equipment; forging and forming steel and other non-precious metals to make and repair machinery, tools, equipment and other articles; setting for operators or setting and operating various machine tools; fitting, maintaining and repairing industrial machinery, including engines and vehicles. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 721 Sheet and Structural Metal Workers, Moulders and Welders, and Related Workers 722 Blacksmiths, Toolmakers and Related Trades Workers 723 Machinery Mechanics and Repairers ESCO:C72 Metal, machinery and related trades workers ESCO:C72 ESCO:C7 ESCO:C73 Handicraft and printing workers combine artistic and manual skills to design, produce, maintain and decorate precision instruments, musical instruments, jewellery and other precious metals, pottery, porcelain and glassware, items made of wood or textile, leather or related materials, and printed products such as books, newspapers and magazines. They apply traditional and/or recently developed techniques to carve, mould, assemble, weave and decorate various articles; to compose and set type prior to printing; to set up and operate printing presses; to bind and finish printed products; and to prepare stencils and operate screen printing equipment. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. The work may be carried out by hand or involve the use of hand tools and hand-held power tools, and in some cases the set-up and operation of machinery and machine tools. The tasks call for an understanding of the work organization, materials and tools used, and the nature and purpose of the final product. Tasks performed by workers in this sub-major group usually include: making and repairing nautical, meteorological, optical and other precision instruments and equipment; making and repairing musical instruments; making jewellery and precious metalware; making pottery, porcelain ware, ceramics and glassware; painting and decorating various articles; producing handicraft articles in wood or textile, leather and related materials; performing printing or book-binding tasks. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 731 Handicraft Workers 732 Printing Trades Workers ESCO:C73 Handicraft and printing workers ESCO:C73 ESCO:C7 ESCO:C74 Electrical and electronics trades workers install, fit and maintain electrical wiring systems and machinery and other electrical apparatus, electrical transmission and supply lines and cables, and electronic and telecommunications equipment and systems. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. The work is carried out by hand and by hand-powered and other tools which are used to reduce the amount of physical effort and time required for specific tasks, as well as to improve the quality of the products. The tasks call for an understanding of the work organization, materials and tools used, and the nature and purpose of the final product. Tasks performed by workers in this sub-major group usually include: installing, maintaining, fitting and adjusting electrical and electronic wiring systems, machinery and equipment; examining blueprints, wiring diagrams and specifications to determine sequences and methods of operation; inspecting and testing electrical and electronic systems, equipment, cables and machinery to identify hazards, defects and the need for adjustment or repair; installing, maintaining and repairing electrical and telecommunications transmission lines; joining electrical, telecommunications and data cables; maintaining, troubleshooting, fitting, adjusting, testing and repairing electronic equipment such as commercial and office machines, electronic instruments and control systems, computers, and telecommunications and data transmission equipment. Occupations in this sub-major group are classified into the following minor groups: 741 Electrical Equipment Installers and Repairers 742 Electronics and Telecommunications Installers and Repairers ESCO:C74 Electrical and electronic trades workers ESCO:C74 ESCO:C7 ESCO:C75 Food processing, woodworking, garment and other craft and related trades workers treat and process agricultural and fisheries raw materials into food and other products, and produce and repair goods made of wood, textiles, fur, leather or other materials. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. The work is carried out by hand and by hand-powered and other tools which are used to reduce the amount of physical effort and time required for specific tasks, as well as to improve the quality of the products. The tasks call for an understanding of the work organization, materials and tools used, and the nature and purpose of the final product. Tasks performed by workers in this sub-major group usually include: treating and processing meat, fish, grain, fruit, vegetables and related materials into food stuffs, and tobacco into tobacco products; tasting and grading food products and beverages; treating and processing natural fibres, skins and hides; making and repairing furniture and other goods made of wood; preparing hides, skins and pelts for further use; making and repairing textiles, garments, hats, shoes and related products. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 751 Food Processing and Related Trades Workers 752 Wood Treaters, Cabinet-makers and Related Trades Workers 753 Garment and Related Trades Workers 754 Other Craft and Related Workers ESCO:C75 Food processing, wood working, garment and other craft and related trades workers ESCO:C75 ESCO:C7 ESCO:C8 Plant and machine operators and assemblers operate and monitor industrial and agricultural machinery and equipment on the spot or by remote control; drive and operate trains, motor vehicles and mobile machinery and equipment; or assemble products from component parts according to strict specifications and procedures. Competent performance in most occupations in this major group requires skills at the second ISCO skill level. The work mainly calls for experience with and an understanding of industrial and agricultural machinery and equipment, as well as an ability to cope with machine-paced operations and to adapt to technological innovations. Tasks performed by plant and machine operators and assemblers usually include: operating and monitoring mining or other industrial machinery and equipment for processing metal, minerals, glass, ceramics, wood, paper or chemicals; operating and monitoring machinery and equipment used to produce articles made of metal, minerals, chemicals, rubber, plastics, wood, paper, textiles, fur or leather, and which process foodstuffs and related products; driving and operating trains and motor vehicles; driving, operating and monitoring mobile industrial and agricultural machinery and equipment; and assembling products from component parts according to strict specifications and procedures. Supervision of other workers may be included. Occupations in this major group are classified into the following sub-major groups: 81 Stationary Plant and Machine Operators 82 Assemblers 83 Drivers and Mobile Plant Operators ESCO:C8 Plant and machine operators and assemblers ESCO:C81 Stationary plant and machine operators monitor and operate stationary industrial plant, machinery and equipment, or for which mobility is not an integral part of operation. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. The work mainly calls for experience with and an understanding of the industrial plant, machinery or equipment being operated and monitored. Ability to cope with machine-paced operations and to adapt to innovations in machinery and equipment are often required. Tasks performed by workers in this sub-major group usually include: setting up, operating and monitoring a variety of stationary plant and machinery; detecting malfunctions and taking corrective action; examining outputs for defects and conformity with specifications and adjusting machine settings accordingly; performing maintenance, repairs and cleaning; recording data and maintaining production records. Supervision of other workers may be included. Occupations in this sub-major group are classified into the following minor groups: 811 Mining and Mineral Processing Plant Operators 812 Metal Processing and Finishing Plant Operators 813 Chemical and Photographic Products Plant and Machine Operators 814 Rubber, Plastic and Paper Products Machine Operators 815 Textile, Fur and Leather Products Machine Operators 816 Food and Related Products Machine Operators 817 Wood Processing and Papermaking Plant Operators 818 Other Stationary Plant and Machine Operators ESCO:C81 Stationary plant and machine operators ESCO:C81 ESCO:C8 ESCO:C82 Assemblers assemble prefabricated parts or components to form subassemblies, products and equipment, according to procedures strictly laid down. The products worked on may be moved from one worker to the next along assembly lines. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: assembling components into various types of product and equipment, according to strictly laid down procedures; reviewing work orders, specifications, diagrams and drawings to determine materials needed and assembly instructions; recording production and operational data on specified forms; inspecting and testing completed components and assemblies, wiring installations and circuits; rejecting faulty assemblies and components. Occupations in this sub-major group are classified into the following minor group: 821 Assemblers ESCO:C82 Assemblers ESCO:C82 ESCO:C8 ESCO:C83 Drivers and mobile plant operators drive and tend trains and motor vehicles, or drive, operate and monitor industrial and agricultural machinery and equipment, or execute deck duties on board ship and other water-borne craft. Competent performance in most occupations in this sub-major group requires skills at the second ISCO skill level. Tasks performed by workers in this sub-major group usually include: driving and tending trains and motor vehicles; driving, operating and monitoring mobile industrial and agricultural machinery and equipment; carrying out deck duties on board ship and other water-borne craft. Occupations in this sub-major group are classified into the following minor groups: 831 Locomotive Engine Drivers and Related Workers 832 Car, Van and Motorcycle Drivers 833 Heavy Truck and Bus Drivers 834 Mobile Plant Operators 835 Ships’ Deck Crews and Related Workers ESCO:C83 Drivers and mobile plant operators ESCO:C83 ESCO:C8 ESCO:C9 Elementary occupations involve the performance of simple and routine tasks which may require the use of hand-held tools and considerable physical effort. Most occupations in this major group require skills at the first ISCO skill level. Tasks performed by workers in elementary occupations usually include: cleaning, restocking supplies and performing basic maintenance in apartments, houses, kitchens, hotels, offices and other buildings; washing cars and windows; helping in kitchens and performing simple tasks in food preparation; delivering messages or goods; carrying luggage and handling baggage and freight; stocking vending-machines or reading and emptying meters; collecting and sorting refuse; sweeping streets and similar places; performing various simple farming, fishing, hunting or trapping tasks; performing simple tasks connected with mining, construction and manufacturing including product-sorting; packing and unpacking produce by hand, and filling shelves; providing various street services; pedalling or hand-guiding vehicles to transport passengers and goods; driving animal-drawn vehicles or machinery. Supervision of other workers may be included. Occupations in this major group are classified into the following sub-major groups: 91 Cleaners and Helpers 92 Agricultural, Forestry and Fishery Labourers 93 Labourers in Mining, Construction, Manufacturing and Transport 94 Food Preparation Assistants 95 Street and Related Sales and Services Workers 96 Refuse Workers and Other Elementary Workers ESCO:C9 Elementary occupations ESCO:C91 Cleaners and helpers perform various tasks in private households, hotels, offices, hospitals and other establishments, as well as in aircraft, trains, coaches, trams and similar vehicles, in order to keep the interiors and fixtures clean, and launder and press garments and textiles by hand. Most occupations in this sub-major group require skills at the first ISCO skill level. Tasks performed by workers in this sub-major group usually include: sweeping or vacuum cleaning; washing and polishing floors, furniture and other objects; taking care of linen and bedmaking; helping with preparation of meals and cleaning in kitchens; washing and cleaning cars and windows; pressing or laundering garments and textiles by hand. Occupations in this sub-major group are classified into the following minor groups: 911 Domestic, Hotel and Office Cleaners and Helpers 912 Vehicle, Window, Laundry and Other Hand Cleaning Workers ESCO:C91 Cleaners and helpers ESCO:C91 ESCO:C9 ESCO:C92 Agricultural, forestry and fishery labourers perform simple and routine tasks in the production of crops and livestock, cultivation and maintenance of gardens and parks, exploitation and conservation of forests, and conduct of aquaculture and fisheries operations. Most occupations in this sub-major group require skills at the first ISCO skill level. Tasks performed by workers in this sub-major group usually include: digging, raking and shovelling using hand tools; loading, unloading and stacking supplies, produce and other materials; watering, thinning, weeding and tending crops by hand or using hand tools; planting, harvesting, picking and collecting produce by hand; feeding, watering and cleaning animals and keeping their quarters clean; monitoring livestock and reporting on their condition; preparing and operating nets, lines and other fishing tackle and deck equipment; grading, sorting, bunching and packing produce into containers; performing minor repairs on fixtures, buildings, equipment, vessels and fences. Occupations in this sub-major group are classified into the following minor group: 921 Agricultural, Forestry and Fishery Labourers ESCO:C92 Agricultural, forestry and fishery labourers ESCO:C92 ESCO:C9 ESCO:C93 Labourers in mining, construction, manufacturing and transport perform simple and routine manual tasks in mining, quarrying, civil engineering, building, manufacturing, transport and storage operations, and operate human-powered and animal-drawn vehicles and machinery. Most occupations in this sub-major group require skills at the first ISCO skill level. Task performed by workers in this sub-major group usually include: digging holes and spreading excavated materials, sand, soil and gravel using hand-held tools; sorting, loading, unloading, moving, stacking and storing materials, equipment, products, supplies, baggage and cargo by hand; cleaning machinery, equipment, tools and work sites; packing and unpacking material and products and filling containers and shelves with products by hand; operating human-powered and animal-drawn vehicles and machinery. Occupations in this sub-major group are classified into the following minor groups: 931 Mining and Construction Labourers 932 Manufacturing Labourers 933 Transport and Storage Labourers ESCO:C93 Labourers in mining, construction, manufacturing and transport ESCO:C93 ESCO:C9 ESCO:C94 Food preparation assistants prepare and cook to order a small variety of pre-cooked food or beverages, clear tables, clean kitchen areas and wash dishes. Most occupations in this sub-major group require skills at the first ISCO skill level. Tasks performed by workers in this sub-major group usually include: preparing simple or pre-prepared foods and beverages such as sandwiches, pizzas, fish and chips, salads and coffee; washing, cutting, measuring and mixing foods for cooking; operating cooking equipment such as grills, microwaves and deep-fat fryers; cleaning kitchens, food preparation areas and service areas; cleaning cooking and general utensils used in kitchens and restaurants. Occupations in this sub-major group are classified into the following minor group: 941 Food Preparation Assistants ESCO:C94 Food preparation assistants ESCO:C94 ESCO:C9 ESCO:C95 Street and related sales and services workers sell goods (excluding food) for immediate consumption, and provide a variety of services on streets and in other public places such as stations. Most occupations in this sub-major group require skills at the first ISCO skill level. Tasks performed by workers in this sub-major group usually include: buying or making various items for sale; loading and unloading items for sale and transporting them; obtaining the materials necessary to perform services; approaching people on the street to offer goods or services; cleaning and polishing shoes; cleaning and polishing car windows; running errands; assisting car drivers to find a parking place and ensuring that the car is not damaged during the driver’s absence; handing out leaflets and free newspapers; receiving immediate payment. Occupations in this sub-major group are classified into the following minor groups: 951 Street and Related Services Workers 952 Street Vendors (excluding Food) ESCO:C95 Street and related sales and service workers ESCO:C95 ESCO:C9 ESCO:C96 Refuse workers and other elementary workers collect, process and recycle garbage from buildings, yards, streets and other public places. They keep streets and other public places clean and tidy, deliver and carry messages and packages and perform odd jobs for private households or establishments. Most occupations in this sub-major group require skills at the first ISCO skill level. Tasks performed by workers in this sub-major group usually include: collecting, loading and unloading garbage; sweeping streets, parks and other public places; chopping firewood; collecting and carrying firewood, water, packages, luggage and messages; beating dust out of carpets and performing other odd-job tasks. Occupations in this sub-major group are classified into the following minor groups: 961 Refuse Workers 962 Other Elementary Workers ESCO:C96 Refuse workers and other elementary workers ESCO:C96 ESCO:C9 http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#NO2_concentration Nitrogen Dioxide concentration http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#O3_concentration Ozone concentration http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM10_concentration Particulate Matter <10 µm concentration http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM2.5_concentration Particulate Matter <2.5 µm concentration http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#SO2_concentration Sulphur Dioxide concentration ATC:A https://uts.nlm.nih.gov/uts/umls/concept/C3653992 ATC:A Alimentary Tract and Metabolism ATC:A01 https://uts.nlm.nih.gov/uts/umls/concept/C3653755 ATC:A01 Stomatological Preparations ATC:A01 ATC:A ATC:A02 https://uts.nlm.nih.gov/uts/umls/concept/C3653499 ATC:A02 Drugs for Acid Related Disorders ATC:A02 ATC:A ATC:A02AD02 https://uts.nlm.nih.gov/uts/umls/concept/C0065512 ATC:A02AD02 Malgradate ATC:A02AD02 ATC:A02 ATC:A02BC01 UMLS:C0028978 ATC:A02BC01 Omeprazole ATC:A02BC01 ATC:A02 ATC:A02BC02 https://uts.nlm.nih.gov/uts/umls/concept/C0081876 ATC:A02BC02 Pantoprazole ATC:A02BC02 ATC:A02 ATC:A02BC05 https://uts.nlm.nih.gov/uts/umls/concept/C0937846 ATC:A02BC05 Esomeprazole ATC:A02BC05 ATC:A02 ATC:A02BX06 https://uts.nlm.nih.gov/uts/umls/concept/C0033321 ATC:A02BX06 Proglumide ATC:A02BX06 ATC:A02 ATC:A03 https://uts.nlm.nih.gov/uts/umls/concept/C3653766 ATC:A03 Drugs for Functional Gastrointestinal Disorders ATC:A03 ATC:A ATC:A03FA03 https://uts.nlm.nih.gov/uts/umls/concept/C0013015 ATC:A03FA03 Domperidone ATC:A03FA03 ATC:A03 ATC:A04 https://uts.nlm.nih.gov/uts/umls/concept/C3653765 ATC:A04 Antiemetics and Antinauseants ATC:A04 ATC:A ATC:A05 https://uts.nlm.nih.gov/uts/umls/concept/C3654041 ATC:A05 Bile and Liver Therapy Drugs ATC:A05 ATC:A ATC:A05A https://uts.nlm.nih.gov/uts/umls/concept/C3654040 ATC:A05A Bile Therapy ATC:A05A ATC:A05 ATC:A05AA02 https://uts.nlm.nih.gov/uts/umls/concept/C0042105 ATC:A05AA02 Ursodeoxycholic Acid ATC:A05AA02 ATC:A05A ATC:A05B https://uts.nlm.nih.gov/uts/umls/concept/C3653559 ATC:A05B Liver Therapy, Lipotropics ATC:A05B ATC:A05 ATC:A05C https://uts.nlm.nih.gov/uts/umls/concept/C3653658 ATC:A05C Drugs for Bile Therapy and Lipotropics in Combination ATC:A05C ATC:A05 ATC:A06 https://uts.nlm.nih.gov/uts/umls/concept/C3653756 ATC:A06 Drugs for Constipation ATC:A06 ATC:A ATC:A06AD11 https://uts.nlm.nih.gov/uts/umls/concept/C0022957 ATC:A06AD11 Lactulose ATC:A06AD11 ATC:A06 ATC:A07 https://uts.nlm.nih.gov/uts/umls/concept/C3653721 ATC:A07 Antidiarrheals, Intestinal Antiinflammatory/Antiinfective Agents ATC:A07 ATC:A ATC:A07EC01 https://uts.nlm.nih.gov/uts/umls/concept/C0036078 ATC:A07EC01 Sulfasalazine ATC:A07EC02 https://uts.nlm.nih.gov/uts/umls/concept/C0127615 ATC:A07EC02 Mesalazine ATC:A07EC02 ATC:A07 ATC:A08 https://uts.nlm.nih.gov/uts/umls/concept/C3653760 ATC:A08 Antiobesity Preparations, excl. Diet Products ATC:A08 ATC:A ATC:A09 https://uts.nlm.nih.gov/uts/umls/concept/C3653759 ATC:A09 Digestives, incl. Enzymes ATC:A09 ATC:A ATC:A10 https://uts.nlm.nih.gov/uts/umls/concept/C3653344 ATC:A10 Drugs Used in Diabetes ATC:A10 ATC:A ATC:A10A https://uts.nlm.nih.gov/uts/umls/concept/C3653579 ATC:A10A Insulins and Analogues ATC:A10A ATC:A10 ATC:A10AB04 https://uts.nlm.nih.gov/uts/umls/concept/C0293359 ATC:A10AB04 Insulin Lispro ATC:A10AB04 ATC:A10A ATC:A10AE04 https://uts.nlm.nih.gov/uts/umls/concept/C0907402 ATC:A10AE04 Insulin Glargine ATC:A10AE04 ATC:A10A ATC:A10BA02 https://uts.nlm.nih.gov/uts/umls/concept/C0025598 ATC:A10BA02 Metformin ATC:A10BA02 ATC:A10 ATC:A10BB09 https://uts.nlm.nih.gov/uts/umls/concept/C0017631 ATC:A10BB09 Gliclazide ATC:A10BB09 ATC:A10 ATC:A10BB12 https://uts.nlm.nih.gov/uts/umls/concept/C0061323 ATC:A10BB12 Glimepiride ATC:A10BB12 ATC:A10 ATC:A10BH01 https://uts.nlm.nih.gov/uts/umls/concept/C1565750 ATC:A10BH01 Sitagliptin ATC:A10BH01 ATC:A10 ATC:A10BJ06 UMLS:C3885068 ATC:A10BJ06 Semaglutide ATC:A10BJ06 ATC:A10 ATC:A10BX02 UMLS:C0246689 ATC:A10BX02 Repaglinide ATC:A10BX02 ATC:A10 ATC:A11 https://uts.nlm.nih.gov/uts/umls/concept/C0042890 ATC:A11 Vitamins ATC:A11 ATC:A ATC:A11CC05 https://uts.nlm.nih.gov/uts/umls/concept/C0008318 ATC:A11CC05 Colecalciferol ATC:A11CC05 ATC:A11 ATC:A11CC06 https://uts.nlm.nih.gov/uts/umls/concept/C0006657 ATC:A11CC06 Calcifediol ATC:A11CC06 ATC:A11 ATC:A11HA05 https://uts.nlm.nih.gov/uts/umls/concept/C0005575 ATC:A11HA05 Biotin ATC:A11HA05 ATC:A11 ATC:A12 https://uts.nlm.nih.gov/uts/umls/concept/C0556112 ATC:A12 Mineral Supplements ATC:A12 ATC:A ATC:A12AX https://uts.nlm.nih.gov/uts/umls/concept/C3653309 ATC:A12AX Calcium, Combinations with Vitamin D and/or Other Drugs ATC:A12AX ATC:A12 ATC:A13 https://uts.nlm.nih.gov/uts/umls/concept/C3543842 ATC:A13 Tonics ATC:A13 ATC:A ATC:A14 https://uts.nlm.nih.gov/uts/umls/concept/C3653709 ATC:A14 Anabolic Agents for Systemic Use ATC:A14 ATC:A ATC:A15 https://uts.nlm.nih.gov/uts/umls/concept/C0376447 ATC:A15 Appetite Stimulants ATC:A15 ATC:A ATC:A16 https://uts.nlm.nih.gov/uts/umls/concept/C3542964 ATC:A16 Other Alimentary Tract and Metabolism ATC:A16 ATC:A ATC:A16AA02 https://uts.nlm.nih.gov/uts/umls/concept/C0036002 ATC:A16AA02 Ademetionine ATC:A16AA02 ATC:A16 ATC:B https://uts.nlm.nih.gov/uts/umls/concept/C3654015 ATC:B Blood and Blood Forming Organs ATC:B01 https://uts.nlm.nih.gov/uts/umls/concept/C1704311 ATC:B01 Antithrombotic Agents ATC:B01 ATC:B ATC:B01AA03 https://uts.nlm.nih.gov/uts/umls/concept/C0043031 ATC:B01AA03 Warfarin ATC:B01AA03 ATC:B01 ATC:B01AC04 https://uts.nlm.nih.gov/uts/umls/concept/C0070166 ATC:B01AC04 Clopidogrel ATC:B01AC04 ATC:B01 ATC:B01AC05 https://uts.nlm.nih.gov/uts/umls/concept/C0040207 ATC:B01AC05 Ticlopidine ATC:B01AC05 ATC:B01 ATC:B01AC22 https://uts.nlm.nih.gov/uts/umls/concept/C1620287 ATC:B01AC22 Prasugrel ATC:B01AC22 ATC:B01 ATC:B01AE07 UMLS:C1571583 ATC:B01AE07 Dabigatran Etexilate ATC:B01AE07 ATC:B01 ATC:B01AF01 https://uts.nlm.nih.gov/uts/umls/concept/C1739768 ATC:B01AF01 Rivaroxaban ATC:B01AF01 ATC:B01 ATC:B01AF02 UMLS:C1831808 ATC:B01AF02 Apixaban ATC:B01AF02 ATC:B01 ATC:B02 https://uts.nlm.nih.gov/uts/umls/concept/C0085824 ATC:B02 Antihemorrhagics ATC:B02 ATC:B ATC:B03 https://uts.nlm.nih.gov/uts/umls/concept/C3653788 ATC:B03 Antianemic Preparations ATC:B03 ATC:B ATC:B03BA01 https://uts.nlm.nih.gov/uts/umls/concept/C0042845 ATC:B03BA01 Cyanocobalamin ATC:B03BA01 ATC:B03 ATC:B05 https://uts.nlm.nih.gov/uts/umls/concept/C3653601 ATC:B05 Blood Substitutes and Perfusion Solutions ATC:B05 ATC:B ATC:B06 https://uts.nlm.nih.gov/uts/umls/concept/C3540010 ATC:B06 Other Hematological Agents ATC:B06 ATC:B ATC:C https://uts.nlm.nih.gov/uts/umls/concept/C3540036 ATC:C Cardiovascular System ATC:C01 https://uts.nlm.nih.gov/uts/umls/concept/C3654025 ATC:C01 Cardiac Therapy ATC:C01BD01 https://uts.nlm.nih.gov/uts/umls/concept/C0002598 ATC:C01BD01 Amiodarone ATC:C01BD01 ATC:C01 ATC:C02 https://uts.nlm.nih.gov/uts/umls/concept/C0003364 ATC:C02 Antihypertensives ATC:C02 ATC:C ATC:C02KX02 UMLS:C1176329 ATC:C02KX02 Ambrisentan ATC:C02KX02 ATC:C02 ATC:C03 https://uts.nlm.nih.gov/uts/umls/concept/C0012798 ATC:C03 Diuretics ATC:C03 ATC:C ATC:C03AA03 UMLS:C0020261 ATC:C03AA03 Hydrochlorothiazide ATC:C03AA03 ATC:C03 ATC:C03CA01 https://uts.nlm.nih.gov/uts/umls/concept/C0016860 ATC:C03CA01 Furosemide ATC:C03CA01 ATC:C03 ATC:C04 https://uts.nlm.nih.gov/uts/umls/concept/C0724804 ATC:C04 Peripheral Vasodilators ATC:C04 ATC:C ATC:C04AE02 https://uts.nlm.nih.gov/uts/umls/concept/C0028008 ATC:C04AE02 Nicergoline ATC:C04AE02 ATC:C04 ATC:C05 https://uts.nlm.nih.gov/uts/umls/concept/C0304533 ATC:C05 Vasoprotectives ATC:C05 ATC:C ATC:C07 https://uts.nlm.nih.gov/uts/umls/concept/C0001645 ATC:C07 Beta Blocking Agents ATC:C07 ATC:C ATC:C07AA05 https://uts.nlm.nih.gov/uts/umls/concept/C0033497 ATC:C07AA05 Propanolol ATC:C07AA05 ATC:C07 ATC:C07AB03 https://uts.nlm.nih.gov/uts/umls/concept/C0004147 ATC:C07AB03 Atenolol ATC:C07AB03 ATC:C07 ATC:C07AB07 https://uts.nlm.nih.gov/uts/umls/concept/C0053799 ATC:C07AB07 Bisoprolol ATC:C07AB07 ATC:C07 ATC:C07AB12 https://uts.nlm.nih.gov/uts/umls/concept/C0068475 ATC:C07AB12 Nebivolol ATC:C07AB12 ATC:C07 ATC:C07CB03 https://uts.nlm.nih.gov/uts/umls/concept/C3653013 ATC:C07CB03 Atenolol and Other Diuretics ATC:C07CB03 ATC:C07 ATC:C08 Calcium Channel Blockers ATC:C08 ATC:C ATC:C08CA01 https://uts.nlm.nih.gov/uts/umls/concept/C0051696 ATC:C08CA01 Amlodipine ATC:C08CA01 ATC:C08 ATC:C08CA12 https://uts.nlm.nih.gov/uts/umls/concept/C0078703 ATC:C08CA12 Barnidipine ATC:C08CA12 ATC:C08 ATC:C08CA13 https://uts.nlm.nih.gov/uts/umls/concept/C0526399 ATC:C08CA13 Lercanidipine ATC:C08CA13 ATC:C08 ATC:C08DA01 https://uts.nlm.nih.gov/uts/umls/concept/C0042523 ATC:C08DA01 Verapamil ATC:C08DA01 ATC:C08 ATC:C09 https://uts.nlm.nih.gov/uts/umls/concept/C3653735 ATC:C09 Agents Acting on the Renin-Angiotensin System ATC:C09 ATC:C ATC:C09AA https://uts.nlm.nih.gov/uts/umls/concept/C3653768 ATC:C09AA ACE Inhibitors, Plain ATC:C09AA ATC:C09 ATC:C09AA02 https://uts.nlm.nih.gov/uts/umls/concept/C0014025 ATC:C09AA02 Enalapril ATC:C09AA02 ATC:C09AA ATC:C09AA05 https://uts.nlm.nih.gov/uts/umls/concept/C0072973 ATC:C09AA05 Ramipril ATC:C09AA05 ATC:C09AA ATC:C09BB04 https://uts.nlm.nih.gov/uts/umls/concept/C2931929 ATC:C09BB04 Perindopril and Amlodipine ATC:C09BB04 ATC:C09AA ATC:C09CA01 https://uts.nlm.nih.gov/uts/umls/concept/C0126174 ATC:C09CA01 Losartan ATC:C09CA01 ATC:C09AA ATC:C09CA03 UMLS:C0216784 ATC:C09CA03 Valsartan ATC:C09CA03 ATC:C09 ATC:C09CA07 https://uts.nlm.nih.gov/uts/umls/concept/C0248719 ATC:C09CA07 Telmisartan ATC:C09CA07 ATC:C09AA ATC:C09CA08 https://uts.nlm.nih.gov/uts/umls/concept/C0386393 ATC:C09CA08 Olmesartan Medoxomil ATC:C09CA08 ATC:C09AA ATC:C09DA06 UMLS:C3653044 ATC:C09DA06 Candesartan and Diuretics ATC:C09DA06 ATC:C09 ATC:C09DB02 UMLS:C3652731 ATC:C09DB02 Olmesartan Medoxomil and Amlodipine ATC:C09DB02 ATC:C09 ATC:C10 https://uts.nlm.nih.gov/uts/umls/concept/C3653535 ATC:C10 Lipid Modifying Agents ATC:C10 ATC:C ATC:C10AA UMLS:C3539119 ATC:C10AA HMG CoA Reductase Inhibitors ATC:C10AA ATC:C10 ATC:C10AA01 https://uts.nlm.nih.gov/uts/umls/concept/C0074554 ATC:C10AA01 Simvastatin ATC:C10AA01 ATC:C10AA ATC:C10AA05 https://uts.nlm.nih.gov/uts/umls/concept/C0286651 ATC:C10AA05 Atrovastatin ATC:C10AA05 ATC:C10AA ATC:C10AA07 UMLS:C0965129 ATC:C10AA07 Rosuvastatin ATC:C10AA07 ATC:C10 ATC:C10AX09 UMLS:C1142985 ATC:C10AX09 Ezetimibe ATC:C10AX09 ATC:C10 ATC:D https://uts.nlm.nih.gov/uts/umls/concept/C0011625 ATC:D Dermatologicals ATC:D01 https://uts.nlm.nih.gov/uts/umls/concept/C3653281 ATC:D01 Antifungals for Dermatological Use ATC:D01 ATC:D ATC:D02 https://uts.nlm.nih.gov/uts/umls/concept/C3653752 ATC:D02 Emollients and Protectives ATC:D02 ATC:D ATC:D03 https://uts.nlm.nih.gov/uts/umls/concept/C3653566 ATC:D03 Preparations for Treatment of Wounds and Ulcers ATC:D03 ATC:D ATC:D04 https://uts.nlm.nih.gov/uts/umls/concept/C3653761 ATC:D04 Antipruritics, incl. Antihistamines, Anesthetics, etc. ATC:D04 ATC:D ATC:D05 https://uts.nlm.nih.gov/uts/umls/concept/C1874314 ATC:D05 Antipsoriatics ATC:D05 ATC:D ATC:D06 https://uts.nlm.nih.gov/uts/umls/concept/C3653726 ATC:D06 Antibiotics and Chemotherapeutics for Dermatological Use ATC:D06 ATC:D ATC:D07 Corticosteroids, Dermatological Preparations ATC:D07 ATC:D ATC:D07AA02 https://uts.nlm.nih.gov/uts/umls/concept/C0020268 ATC:D07AA02 Hydrocortisone ATC:D07AA02 ATC:D07 ATC:D08 https://uts.nlm.nih.gov/uts/umls/concept/C3653284 ATC:D08 Antispetic and Disinfectants ATC:D08 ATC:D ATC:D09 https://uts.nlm.nih.gov/uts/umls/concept/C0471863 ATC:D09 Medicated Dressings ATC:D09 ATC:D ATC:D10 https://uts.nlm.nih.gov/uts/umls/concept/C0358061 ATC:D10 Anti-Acne Preparations ATC:D10 ATC:D ATC:D11 https://uts.nlm.nih.gov/uts/umls/concept/C3653942 ATC:D11 Other Dermatological Preparations ATC:D11 ATC:D ATC:G https://uts.nlm.nih.gov/uts/umls/concept/C3653431 ATC:G Genito Urinary System and Sex Hormones ATC:G01 https://uts.nlm.nih.gov/uts/umls/concept/C3653587 ATC:G01 Gynecological Antiinfectives and Antiseptics ATC:G01 ATC:G ATC:G02 https://uts.nlm.nih.gov/uts/umls/concept/C3653939 ATC:G02 Other Gynecologicals ATC:G02 ATC:G ATC:G03 https://uts.nlm.nih.gov/uts/umls/concept/C3653561 ATC:G03 Sex Hormones and Modulators of the Genital System ATC:G03 ATC:G ATC:G03AA09 https://uts.nlm.nih.gov/uts/umls/concept/C1112096 ATC:G03AA09 Desogestrel and Ethinylestradiol ATC:G03AA09 ATC:G03 ATC:G03AA12 https://uts.nlm.nih.gov/uts/umls/concept/C2604206 ATC:G03AA12 Drospirenone and Ethinylestradiol ATC:G03AA12 ATC:G03 ATC:G03AB https://uts.nlm.nih.gov/uts/umls/concept/C3540748 ATC:G03AB Progestogens and Estrogens Systemic Contraceptives, Sequential Preparations ATC:G03AB ATC:G03 ATC:G03AB08 UMLS:C2936902 ATC:G03AB08 Dienogest and Estradiol ATC:G03AB08 ATC:G03 ATC:G03AC08 UMLS:C0047683 ATC:G03AC08 Etonogestrel ATC:G03AC08 ATC:G03 ATC:G03AC09 UMLS:C0057558 ATC:G03AC09 Desogestrel ATC:G03AC09 ATC:G03 ATC:G03CX01 UMLS:C0076660 ATC:G03CX01 Tibolone ATC:G03CX01 ATC:G03 ATC:G04 https://uts.nlm.nih.gov/uts/umls/concept/C3653764 ATC:G04 Urologicals ATC:G04 ATC:G ATC:G04BD04 https://uts.nlm.nih.gov/uts/umls/concept/C0069805 ATC:G04BD04 Oxybutynin ATC:G04BD04 ATC:G04 ATC:G04BD07 https://uts.nlm.nih.gov/uts/umls/concept/C0388753 ATC:G04BD07 Tolterodine ATC:G04BD07 ATC:G04 ATC:G04BD09 https://uts.nlm.nih.gov/uts/umls/concept/C0772089 ATC:G04BD09 Trospium ATC:G04BD09 ATC:G04 ATC:G04BE03 https://uts.nlm.nih.gov/uts/umls/concept/C0529793 ATC:G04BE03 Sildenafil ATC:G04BE03 ATC:G04 ATC:G04BE08 UMLS:C1176316 ATC:G04BE08 Tadalafil ATC:G04BE08 ATC:G04 ATC:G04CA01 UMLS:C0051150 ATC:G04CA01 Alfuzosin ATC:G04CA01 ATC:G04 ATC:G04CA02 https://uts.nlm.nih.gov/uts/umls/concept/C0257343 ATC:G04CA02 Tamsulosin ATC:G04CA02 ATC:G04 ATC:G04CB02 UMLS:C0754659 ATC:G04CB02 Dustasteride ATC:G04CB02 ATC:G04 ATC:H https://uts.nlm.nih.gov/uts/umls/concept/C3653821 ATC:H Systemic Hormonal Preparations, excl. Sex Hormones and Insulins ATC:H01 https://uts.nlm.nih.gov/uts/umls/concept/C3653567 ATC:H01 Pituitary and Hypothalamic Hormones and Analogues ATC:H01 ATC:H ATC:H01AA01 https://uts.nlm.nih.gov/uts/umls/concept/C0001655 ATC:H01AA01 Corticotropin ATC:H01AA01 ATC:H01 ATC:H01AA02 https://uts.nlm.nih.gov/uts/umls/concept/C0010192 ATC:H01AA02 Tetracosactide ATC:H01AA02 ATC:H01 ATC:H02 https://uts.nlm.nih.gov/uts/umls/concept/C3653708 ATC:H02 Corticosteroids for Systemic Use ATC:H02 ATC:H ATC:H02AB https://uts.nlm.nih.gov/uts/umls/concept/C3540777 ATC:H02AB Glucocorticoids, Systemic ATC:H02AB ATC:H02 ATC:H02AB01 https://uts.nlm.nih.gov/uts/umls/concept/C0005308 ATC:H02AB01 Betamethasone ATC:H02AB01 ATC:H02AB ATC:H02AB02 https://uts.nlm.nih.gov/uts/umls/concept/C0011777 ATC:H02AB02 Dexamethasone ATC:H02AB02 ATC:H02AB ATC:H02AB04 https://uts.nlm.nih.gov/uts/umls/concept/C0025815 ATC:H02AB04 Methylprednisolone ATC:H02AB04 ATC:H02AB ATC:H02AB06 https://uts.nlm.nih.gov/uts/umls/concept/C0032950 ATC:H02AB06 Prednisolone ATC:H02AB06 ATC:H02AB ATC:H02AB07 https://uts.nlm.nih.gov/uts/umls/concept/C0032952 ATC:H02AB07 Prednisone ATC:H02AB07 ATC:H02AB ATC:H02AB09 https://uts.nlm.nih.gov/uts/umls/concept/C0020268 ATC:H02AB09 Hydrocortisone ATC:H02AB09 ATC:H02AB ATC:H02AB13 https://uts.nlm.nih.gov/uts/umls/concept/C0057258 ATC:H02AB13 Deflazacort ATC:H02AB13 ATC:H02AB ATC:H03 https://uts.nlm.nih.gov/uts/umls/concept/C3540775 ATC:H03 Thyroid Therapy ATC:H03 ATC:H ATC:H03AA01 https://uts.nlm.nih.gov/uts/umls/concept/C0079691 ATC:H03AA01 Levothyroxine Sodium ATC:H03AA01 ATC:H03 ATC:H03BB02 https://uts.nlm.nih.gov/uts/umls/concept/C0025644 ATC:H03BB02 Thiamazole ATC:H03BB02 ATC:H03 ATC:H04 https://uts.nlm.nih.gov/uts/umls/concept/C0030292 ATC:H04 Pancreatic Hormones ATC:H04 ATC:H ATC:H05 https://uts.nlm.nih.gov/uts/umls/concept/C3653518 ATC:H05 Calcium Homeostasis ATC:H05 ATC:H ATC:J https://uts.nlm.nih.gov/uts/umls/concept/C3653775 ATC:J Antiinfectives for Systemic Use ATC:J01 https://uts.nlm.nih.gov/uts/umls/concept/C3653727 ATC:J01 Antibacterials for Systemic Use ATC:J01 ATC:J ATC:J01CR02 https://uts.nlm.nih.gov/uts/umls/concept/C3653015 ATC:J01CR02 Amoxicillin and Beta-Lactamase Inhibitor ATC:J01CR02 ATC:J01 ATC:J01DD04 https://uts.nlm.nih.gov/uts/umls/concept/C0007561 ATC:J01DD04 Ceftriaxone ATC:J01DD04 ATC:J01 ATC:J02 https://uts.nlm.nih.gov/uts/umls/concept/C3653762 ATC:J02 Antimycotics for Systemic Use ATC:J02 ATC:J ATC:J04 https://uts.nlm.nih.gov/uts/umls/concept/C0360390 ATC:J04 Antimycobacterials ATC:J04 ATC:J ATC:J04AB02 https://uts.nlm.nih.gov/uts/umls/concept/C0035608 ATC:J04AB02 Rifampicin ATC:J04AB02 ATC:J04 ATC:J05 https://uts.nlm.nih.gov/uts/umls/concept/C3653777 ATC:J05 Antivirals for Systemic Use ATC:J05 ATC:J ATC:J05AB01 https://uts.nlm.nih.gov/uts/umls/concept/C0001367 ATC:J05AB01 Aciclovir ATC:J05AB01 ATC:J05 ATC:J05AB11 https://uts.nlm.nih.gov/uts/umls/concept/C0249458 ATC:J05AB11 Valaciclovir ATC:J05AB11 ATC:J05 ATC:J06 https://uts.nlm.nih.gov/uts/umls/concept/C3653581 ATC:J06 Immune Sera and Immunoglobulins ATC:J06 ATC:J ATC:J06BA02 https://uts.nlm.nih.gov/uts/umls/concept/C3652960 ATC:J06BA02 Immunoglobulins, Normal Human, for Intravascular Adm. ATC:J06BA02 ATC:J06 ATC:J06BB02 https://uts.nlm.nih.gov/uts/umls/concept/C4048265 ATC:J06BB02 Tetanus Immunoglobulin ATC:J06BB02 ATC:J06 ATC:J07 https://uts.nlm.nih.gov/uts/umls/concept/C0042210 ATC:J07 Vaccines ATC:J07 ATC:J ATC:J07AF https://uts.nlm.nih.gov/uts/umls/concept/C0012551 ATC:J07AF Diphtheria Vaccines ATC:J07AF ATC:J07 ATC:J07BC01 https://uts.nlm.nih.gov/uts/umls/concept/C3652493 ATC:J07BC01 Hepatitis B, Purified Antigen ATC:J07BC01 ATC:J07 ATC:J07BF03 https://uts.nlm.nih.gov/uts/umls/concept/C3652521 ATC:J07BF03 Poliomyelitis, Trivalent, Inactivated, Whole Virus ATC:J07BF03 ATC:J07 ATC:J07BX https://uts.nlm.nih.gov/uts/umls/concept/C3653947 ATC:J07BX Other Vaccines ATC:J07BX ATC:J07 ATC:L https://uts.nlm.nih.gov/uts/umls/concept/C3653621 ATC:L Antineoplastic and Immunomodulating Agents ATC:L01 https://uts.nlm.nih.gov/uts/umls/concept/C0003392 ATC:L01 Antineoplastic Agents ATC:L01 ATC:L ATC:L01AA01 https://uts.nlm.nih.gov/uts/umls/concept/C0010583 ATC:L01AA01 Cyclophosphamide ATC:L01AA01 ATC:L01 ATC:L01BA01 https://uts.nlm.nih.gov/uts/umls/concept/C0025677 ATC:L01BA01 Methotrexate ATC:L01BA01 ATC:L01 ATC:L01BB04 https://uts.nlm.nih.gov/uts/umls/concept/C0092801 ATC:L01BB04 Cladribine ATC:L01BB04 ATC:L01 ATC:L01DB07 https://uts.nlm.nih.gov/uts/umls/concept/C0026259 ATC:L01DB07 Mitoxantrone ATC:L01DB07 ATC:L01 ATC:L01ED03 https://uts.nlm.nih.gov/uts/umls/concept/C3853921 ATC:L01ED03 Alectinib ATC:L01ED03 ATC:L01 ATC:L01FA02 UMLS:C1832027 ATC:L01FA02 Ofatumumab ATC:L01FA02 ATC:L01 ATC:L01XC02 https://uts.nlm.nih.gov/uts/umls/concept/C0393022 ATC:L01XC02 Rituximab ATC:L01XC02 ATC:L01 ATC:L01XC03 https://uts.nlm.nih.gov/uts/umls/concept/C0728747 ATC:L01XC03 Trastuzumab ATC:L01XC03 ATC:L01 ATC:L02 https://uts.nlm.nih.gov/uts/umls/concept/C3540795 ATC:L02 Endocrine Therapy ATC:L02 ATC:L ATC:L02BA01 https://uts.nlm.nih.gov/uts/umls/concept/C0039286 ATC:L02BA01 Tamoxifen ATC:L02BA01 ATC:L02 ATC:L03 https://uts.nlm.nih.gov/uts/umls/concept/C0001551 ATC:L03 Immunostimulants ATC:L03 ATC:L ATC:L03AB02 https://uts.nlm.nih.gov/uts/umls/concept/C0015980 ATC:L03AB02 Interferon Beta Natural ATC:L03AB02 ATC:L03 ATC:L03AB07 https://uts.nlm.nih.gov/uts/umls/concept/C0254119 ATC:L03AB07 Interferon Beta-1a ATC:L03AB07 ATC:L03 ATC:L03AB08 https://uts.nlm.nih.gov/uts/umls/concept/C0244713 ATC:L03AB08 Interferon Beta-1b ATC:L03AB08 ATC:L03 ATC:L03AB10 https://uts.nlm.nih.gov/uts/umls/concept/C0796545 ATC:L03AB10 Peginterferon Alfa-2b ATC:L03AB10 ATC:L03 ATC:L03AB13 https://uts.nlm.nih.gov/uts/umls/concept/C3848580 ATC:L03AB13 Peginterferon Beta-1a ATC:L03AB13 ATC:L03 ATC:L03AX03 https://uts.nlm.nih.gov/uts/umls/concept/C0004886 ATC:L03AX03 BCG Vaccine ATC:L03AX03 ATC:L03 ATC:L03AX13 https://uts.nlm.nih.gov/uts/umls/concept/C0289884 ATC:L03AX13 Glatiramer Acetate ATC:L03AX13 ATC:L03 ATC:L04 https://uts.nlm.nih.gov/uts/umls/concept/C0021081 ATC:L04 Immunosuppressants ATC:L04 ATC:L ATC:L04AA23 https://uts.nlm.nih.gov/uts/umls/concept/C1172734 ATC:L04AA23 Natalizumab ATC:L04AA23 ATC:L04 ATC:L04AA27 https://uts.nlm.nih.gov/uts/umls/concept/C1699926 ATC:L04AA27 Fingolimod ATC:L04AA27 ATC:L04 ATC:L04AA31 https://uts.nlm.nih.gov/uts/umls/concept/C1718383 ATC:L04AA31 Teriflunomide ATC:L04AA31 ATC:L04 ATC:L04AA34 https://uts.nlm.nih.gov/uts/umls/concept/C0383429 ATC:L04AA34 Alemtuzumab ATC:L04AA34 ATC:L04 ATC:L04AA36 https://uts.nlm.nih.gov/uts/umls/concept/C1882138 ATC:L04AA36 Ocrelizumab ATC:L04AA36 ATC:L04 ATC:L04AA38 UMLS:C4278675 ATC:L04AA38 Ozanimod ATC:L04AA38 ATC:L04 ATC:L04AA40 https://uts.nlm.nih.gov/uts/umls/concept/C0092801 ATC:L04AA40 Cladribine ATC:L04AA40 ATC:L04 ATC:L04AA42 https://uts.nlm.nih.gov/uts/umls/concept/C3657824 ATC:L04AA42 Siponimod ATC:L04AA42 ATC:L04 ATC:L04AC01 https://uts.nlm.nih.gov/uts/umls/concept/C0663182 ATC:L04AC01 Daclizumab ATC:L04AC01 ATC:L04 ATC:L04AC05 https://uts.nlm.nih.gov/uts/umls/concept/C1608841 ATC:L04AC05 Ustekinumab ATC:L04AC05 ATC:L04 ATC:L04AC07 https://uts.nlm.nih.gov/uts/umls/concept/C1609165 ATC:L04AC07 Tocilizumab ATC:L04AC07 ATC:L04 ATC:L04AC10 https://uts.nlm.nih.gov/uts/umls/concept/C3179547 ATC:L04AC10 Secukinumab ATC:L04AC10 ATC:L04 ATC:L04AX01 https://uts.nlm.nih.gov/uts/umls/concept/C0004482 ATC:L04AX01 Azathioprine ATC:L04AX01 ATC:L04 ATC:L04AX03 https://uts.nlm.nih.gov/uts/umls/concept/C0025677 ATC:L04AX03 Methotrexate ATC:L04AX03 ATC:L04 ATC:L04AX07 https://uts.nlm.nih.gov/uts/umls/concept/C0058218 ATC:L04AX07 Dimethyl Fumarate ATC:L04AX07 ATC:L04 ATC:M https://uts.nlm.nih.gov/uts/umls/concept/C3653821 ATC:M Musculo-Skeletal System ATC:M01 https://uts.nlm.nih.gov/uts/umls/concept/C3653623 ATC:M01 Antiinflammatory and Antirheumatic Products ATC:M01 ATC:M ATC:M01A UMLS:C3653622 ATC:M01A Antiinflammatory and Antirheumatic Products, Non-Steroids ATC:M01A ATC:M01 ATC:M01AB01 https://uts.nlm.nih.gov/uts/umls/concept/C0021246 ATC:M01AB01 Indometacin ATC:M01AB01 ATC:M01 ATC:M01AB15 https://uts.nlm.nih.gov/uts/umls/concept/C0073631 ATC:M01AB15 Ketorolac ATC:M01AB15 ATC:M01 ATC:M01AE01 https://uts.nlm.nih.gov/uts/umls/concept/C0020740 ATC:M01AE01 Ibuprofen ATC:M01AE01 ATC:M01 ATC:M01AH05 https://uts.nlm.nih.gov/uts/umls/concept/C0972314 ATC:M01AH05 Etoricoxib ATC:M01AH05 ATC:M01 ATC:M02 https://uts.nlm.nih.gov/uts/umls/concept/C3653753 ATC:M02 Topical Products for Joint and Muscular Pain ATC:M02 ATC:M ATC:M03 https://uts.nlm.nih.gov/uts/umls/concept/C0358430 ATC:M03 Muscle Relaxants ATC:M03 ATC:M ATC:M03AX01 https://uts.nlm.nih.gov/uts/umls/concept/C0006055 ATC:M03AX01 Botulinum Toxin ATC:M03AX01 ATC:M03 ATC:M03BX01 https://uts.nlm.nih.gov/uts/umls/concept/C0004609 ATC:M03BX01 Baclofen ATC:M03BX01 ATC:M03 ATC:M03BX02 https://uts.nlm.nih.gov/uts/umls/concept/C0146011 ATC:M03BX02 Tizanidine ATC:M03BX02 ATC:M03 ATC:M03CA01 https://uts.nlm.nih.gov/uts/umls/concept/C0010976 ATC:M03CA01 Dantrolene ATC:M03CA01 ATC:M03 ATC:M04 https://uts.nlm.nih.gov/uts/umls/concept/C0018100 ATC:M04 Antigout Preparations ATC:M04 ATC:M ATC:M05 https://uts.nlm.nih.gov/uts/umls/concept/C3653497 ATC:M05 Drugs for Treatment of Bone Diseases ATC:M05 ATC:M ATC:M05BX04 https://uts.nlm.nih.gov/uts/umls/concept/C1690432 ATC:M05BX04 Denosumab ATC:M05BX04 ATC:M05 ATC:M09 https://uts.nlm.nih.gov/uts/umls/concept/C3653872 ATC:M09 Other Drugs for Disorders of the Musculo-Skeletal System ATC:M09 ATC:M ATC:N https://uts.nlm.nih.gov/uts/umls/concept/C3542961 ATC:N Nervous System ATC:N01 https://uts.nlm.nih.gov/uts/umls/concept/C0002932 ATC:N01 Anesthetics ATC:N01 ATC:N ATC:N02 https://uts.nlm.nih.gov/uts/umls/concept/C0002771 ATC:N02 Analgesics ATC:N02 ATC:N ATC:N02AA59 https://uts.nlm.nih.gov/uts/umls/concept/C3653191 ATC:N02AA59 Codeine, Combinations excl. Psycholeptics ATC:N02AA59 ATC:N02 ATC:N02BA01 UMLS:C0004057 ATC:N02BA01 Acetylsalicylic Acid ATC:N02BA01 ATC:N02 ATC:N02BA51 https://uts.nlm.nih.gov/uts/umls/concept/C3653192 ATC:N02BA51 Acetylsalicylic Acid, Combinations excl. Psycholeptics ATC:N02BA51 ATC:N02 ATC:N02BE01 https://uts.nlm.nih.gov/uts/umls/concept/C0000970 ATC:N02BE01 Paracetamol ATC:N02BE01 ATC:N02 ATC:N02BG10 https://uts.nlm.nih.gov/uts/umls/concept/C0006864 ATC:N02BG10 Cannabinoids ATC:N02BG10 ATC:N02 ATC:N02CC01 UMLS:C0075632 ATC:N02CC01 Sumatriptan ATC:N02CC01 ATC:N02 ATC:N02CC03 https://uts.nlm.nih.gov/uts/umls/concept/C0528166 ATC:N02CC03 Zolmitriptan ATC:N02CC03 ATC:N02 ATC:N03 https://uts.nlm.nih.gov/uts/umls/concept/C0003299 ATC:N03 Antiepileptics ATC:N03 ATC:N ATC:N03AA02 https://uts.nlm.nih.gov/uts/umls/concept/C0031412 ATC:N03AA02 Phenobarbital ATC:N03AA02 ATC:N03 ATC:N03AA04 https://uts.nlm.nih.gov/uts/umls/concept/C0105205 ATC:N03AA04 Barbexaclone ATC:N03AA04 ATC:N03 ATC:N03AB02 https://uts.nlm.nih.gov/uts/umls/concept/C0031507 ATC:N03AB02 Phenytoin ATC:N03AB02 ATC:N03 ATC:N03AE01 https://uts.nlm.nih.gov/uts/umls/concept/C0009011 ATC:N03AE01 Clonazepam ATC:N03AE01 ATC:N03 ATC:N03AF01 https://uts.nlm.nih.gov/uts/umls/concept/C0006949 ATC:N03AF01 Carbamazepine ATC:N03AF01 ATC:N03 ATC:N03AF02 https://uts.nlm.nih.gov/uts/umls/concept/C0069751 ATC:N03AF02 Oxcarbazepine ATC:N03AF02 ATC:N03 ATC:N03AG01 https://uts.nlm.nih.gov/uts/umls/concept/C0042291 ATC:N03AG01 Valproic Acid ATC:N03AG01 ATC:N03 ATC:N03AG04 https://uts.nlm.nih.gov/uts/umls/concept/C0048044 ATC:N03AG04 Vigabatrin ATC:N03AG04 ATC:N03 ATC:N03AX09 https://uts.nlm.nih.gov/uts/umls/concept/C0064636 ATC:N03AX09 Lamotrigine ATC:N03AX09 ATC:N03 ATC:N03AX11 https://uts.nlm.nih.gov/uts/umls/concept/C0076829 ATC:N03AX11 Topiramate ATC:N03AX11 ATC:N03 ATC:N03AX12 https://uts.nlm.nih.gov/uts/umls/concept/C0060926 ATC:N03AX12 Gabapentin ATC:N03AX12 ATC:N03 ATC:N03AX14 https://uts.nlm.nih.gov/uts/umls/concept/C0377265 ATC:N03AX14 Levetiracetam ATC:N03AX14 ATC:N03 ATC:N03AX16 https://uts.nlm.nih.gov/uts/umls/concept/C0657912 ATC:N03AX16 Pregabalin ATC:N03AX16 ATC:N03 ATC:N03AX24 UMLS:C0006863 ATC:N03AX24 Cannabidiol ATC:N03AX24 ATC:N03 ATC:N04 https://uts.nlm.nih.gov/uts/umls/concept/C0003405 ATC:N04 Anti-Parkinson Drugs ATC:N04 ATC:N ATC:N04BA02 https://uts.nlm.nih.gov/uts/umls/concept/C3653004 ATC:N04BA02 Levodopa and Decarboxylase Inhibitor ATC:N04BA02 ATC:N04 ATC:N04BB01 https://uts.nlm.nih.gov/uts/umls/concept/C0002403 ATC:N04BB01 Amantadine ATC:N04BB01 ATC:N04 ATC:N04BC04 https://uts.nlm.nih.gov/uts/umls/concept/C0244821 ATC:N04BC04 Ropinirole ATC:N04BC04 ATC:N04 ATC:N04BC05 https://uts.nlm.nih.gov/uts/umls/concept/C0074710 ATC:N04BC05 Pramipexole ATC:N04BC05 ATC:N04 ATC:N04BC06 https://uts.nlm.nih.gov/uts/umls/concept/C0107994 ATC:N04BC06 Cabergoline ATC:N04BC06 ATC:N04 ATC:N05 https://uts.nlm.nih.gov/uts/umls/concept/C3653516 ATC:N05 Psycholeptics ATC:N05 ATC:N ATC:N05AF05 https://uts.nlm.nih.gov/uts/umls/concept/C0376160 ATC:N05AF05 Zuclopenthixol ATC:N05AF05 ATC:N05 ATC:N05AH03 https://uts.nlm.nih.gov/uts/umls/concept/C0171023 ATC:N05AH03 Olanzapine ATC:N05AH03 ATC:N05 ATC:N05AH04 https://uts.nlm.nih.gov/uts/umls/concept/C0123091 ATC:N05AH04 Quetiapine ATC:N05AH04 ATC:N05 ATC:N05AX12 UMLS:C0299792 ATC:N05AX12 Aripiprazole ATC:N05AX12 ATC:N05 ATC:N05AX13 https://uts.nlm.nih.gov/uts/umls/concept/C0753678 ATC:N05AX13 Paliperidone ATC:N05AX13 ATC:N05 ATC:N05B UMLS:C0040616 ATC:N05B Anxiolytics ATC:N05B ATC:N05 ATC:N05BA01 https://uts.nlm.nih.gov/uts/umls/concept/C0012010 ATC:N05BA01 Diazepam ATC:N05BA01 ATC:N05 ATC:N05BA06 UMLS:C0024002 ATC:N05BA06 Lorazepam ATC:N05BA06 ATC:N05 ATC:N05BA08 https://uts.nlm.nih.gov/uts/umls/concept/C0006213 ATC:N05BA08 Bromazepam ATC:N05BA08 ATC:N05 ATC:N05BA09 https://uts.nlm.nih.gov/uts/umls/concept/C0055891 ATC:N05BA09 Clobazam ATC:N05BA09 ATC:N05 ATC:N05BA11 https://uts.nlm.nih.gov/uts/umls/concept/C0032910 ATC:N05BA11 Prazepam ATC:N05BA11 ATC:N05 ATC:N05BA12 https://uts.nlm.nih.gov/uts/umls/concept/C0002333 ATC:N05BA12 Alprazolam ATC:N05BA12 ATC:N05 ATC:N05BA19 https://uts.nlm.nih.gov/uts/umls/concept/C0059862 ATC:N05BA19 Etizolam ATC:N05BA19 ATC:N05 ATC:N05C https://uts.nlm.nih.gov/uts/umls/concept/C0020592 ATC:N05C Hypnotics and Sedatives ATC:N05C ATC:N05 ATC:N05CD01 https://uts.nlm.nih.gov/uts/umls/concept/C0016375 ATC:N05CD01 Flurazepam ATC:N05CD01 ATC:N05C ATC:N05CD05 https://uts.nlm.nih.gov/uts/umls/concept/C0040879 ATC:N05CD05 Triazolam ATC:N05CD05 ATC:N05C ATC:N05CD09 https://uts.nlm.nih.gov/uts/umls/concept/C0054151 ATC:N05CD09 Brotizolam ATC:N05CD09 ATC:N05C ATC:N05CF02 https://uts.nlm.nih.gov/uts/umls/concept/C0078839 ATC:N05CF02 Zolpidem ATC:N05CF02 ATC:N05C ATC:N05CH01 https://uts.nlm.nih.gov/uts/umls/concept/C0025219 ATC:N05CH01 Melatonin ATC:N05CH01 ATC:N05C ATC:N06 https://uts.nlm.nih.gov/uts/umls/concept/C3653540 ATC:N06 Psychoanaleptics ATC:N06 ATC:N ATC:N06A UMLS:C0003289 ATC:N06A Antidepressants ATC:N06A ATC:N06 ATC:N06AA09 https://uts.nlm.nih.gov/uts/umls/concept/C0002600 ATC:N06AA09 Amitriptyline ATC:N06AA09 ATC:N06A ATC:N06AB03 https://uts.nlm.nih.gov/uts/umls/concept/C0016365 ATC:N06AB03 Fluoxetine ATC:N06AB03 ATC:N06A ATC:N06AB04 https://uts.nlm.nih.gov/uts/umls/concept/C0008845 ATC:N06AB04 Citalopram ATC:N06AB04 ATC:N06A ATC:N06AB05 https://uts.nlm.nih.gov/uts/umls/concept/C0070122 ATC:N06AB05 Paroxetine ATC:N06AB05 ATC:N06A ATC:N06AB06 https://uts.nlm.nih.gov/uts/umls/concept/C0074393 ATC:N06AB06 Sertraline ATC:N06AB06 ATC:N06A ATC:N06AB10 https://uts.nlm.nih.gov/uts/umls/concept/C1099456 ATC:N06AB10 Escitalopram ATC:N06AB10 ATC:N06A ATC:N06AX05 https://uts.nlm.nih.gov/uts/umls/concept/C0040805 ATC:N06AX05 Trazodone ATC:N06AX05 ATC:N06A ATC:N06AX11 https://uts.nlm.nih.gov/uts/umls/concept/C0049506 ATC:N06AX11 Mitrazapine ATC:N06AX11 ATC:N06A ATC:N06AX16 https://uts.nlm.nih.gov/uts/umls/concept/C0078569 ATC:N06AX16 Venlafaxine ATC:N06AX16 ATC:N06A ATC:N06AX18 https://uts.nlm.nih.gov/uts/umls/concept/C0168388 ATC:N06AX18 Reboxetine ATC:N06AX18 ATC:N06A ATC:N06AX21 UMLS:C0245561 ATC:N06AX21 Duloxetine ATC:N06AX21 ATC:N06A ATC:N06AX23 UMLS:C1880288 ATC:N06AX23 Desvenlafaxine ATC:N06AX23 ATC:N06 ATC:N06AX26 UMLS:C3661282 ATC:N06AX26 Vertioxetine ATC:N06AX26 ATC:N06A ATC:N06BA07 https://uts.nlm.nih.gov/uts/umls/concept/C0066677 ATC:N06BA07 Modafinil ATC:N06BA07 ATC:N06 ATC:N06BX12 https://uts.nlm.nih.gov/uts/umls/concept/C0001040 ATC:N06BX12 Acetylcarnitine ATC:N06BX12 ATC:N06 ATC:N06CA01 https://uts.nlm.nih.gov/uts/umls/concept/C3653016 ATC:N06CA01 Amitriptyline and Psycholeptics ATC:N06CA01 ATC:N06 ATC:N06DA03 https://uts.nlm.nih.gov/uts/umls/concept/C0649350 ATC:N06DA03 Rivastigmine ATC:N06DA03 ATC:N06 ATC:N07 https://uts.nlm.nih.gov/uts/umls/concept/C3653848 ATC:N07 Other Nervous System Drugs ATC:N07 ATC:N ATC:N07BB04 https://uts.nlm.nih.gov/uts/umls/concept/C0027360 ATC:N07BB04 Naltrexone ATC:N07BB04 ATC:N07 ATC:N07CA01 https://uts.nlm.nih.gov/uts/umls/concept/C0005301 ATC:N07CA01 Betahistine ATC:N07CA01 ATC:N07 ATC:N07CA02 https://uts.nlm.nih.gov/uts/umls/concept/C0008803 ATC:N07CA02 Cinnarizine ATC:N07CA02 ATC:N07 ATC:N07CA03 https://uts.nlm.nih.gov/uts/umls/concept/C0016295 ATC:N07CA03 Flunarizine ATC:N07CA03 ATC:N07 ATC:N07CA52 https://uts.nlm.nih.gov/uts/umls/concept/C3653100 ATC:N07CA52 Cinnarizine, Combinations ATC:N07CA52 ATC:N07 ATC:N07XX02 https://uts.nlm.nih.gov/uts/umls/concept/C0073379 ATC:N07XX02 Riluzole ATC:N07XX02 ATC:N07 ATC:N07XX07 https://uts.nlm.nih.gov/uts/umls/concept/C0000477 ATC:N07XX07 Fampridine ATC:N07XX07 ATC:N07 ATC:P https://uts.nlm.nih.gov/uts/umls/concept/C3653620 ATC:P Antiparastic Products, Insecticides and Repllents ATC:P01 https://uts.nlm.nih.gov/uts/umls/concept/C0003416 ATC:P01 Antiprotozoals ATC:P01 ATC:P ATC:P01BA02 https://uts.nlm.nih.gov/uts/umls/concept/C0020336 ATC:P01BA02 Hydroxychloroquine ATC:P01BA02 ATC:P01 ATC:P02 https://uts.nlm.nih.gov/uts/umls/concept/C0003158 ATC:P02 Anthelmintics ATC:P02 ATC:P ATC:P03 https://uts.nlm.nih.gov/uts/umls/concept/C3653591 ATC:P03 Ectoparasiticides, incl. Scabicides, Insecticides and Repellents ATC:P03 ATC:P ATC:R https://uts.nlm.nih.gov/uts/umls/concept/C0282686 ATC:R Respiratory System ATC:R01 https://uts.nlm.nih.gov/uts/umls/concept/C3653410 ATC:R01 Nasal Preparations ATC:R01 ATC:R ATC:R02 https://uts.nlm.nih.gov/uts/umls/concept/C3653754 ATC:R02 Throat Preparations ATC:R02 ATC:R ATC:R03 https://uts.nlm.nih.gov/uts/umls/concept/C3653498 ATC:R03 Drugs for Obstructive Airway Diseases ATC:R03 ATC:R ATC:R03AC03 UMLS:C0039542 ATC:R03AC03 Terbutaline ATC:R03AC03 ATC:R03 ATC:R03AK07 UMLS:C1276807 ATC:R03AK07 Formoterol and Budesonide ATC:R03AK07 ATC:R03 ATC:R03BA05 UMLS:C0082607 ATC:R03BA05 Fluticasone ATC:R03BA05 ATC:R03 ATC:R03BB04 UMLS:C1306772 ATC:R03BB04 Tiotropium Bromide ATC:R03BB04 ATC:R03 ATC:R03CC02 UMLS:C0001927 ATC:R03CC02 Salbutamol ATC:R03CC02 ATC:R03 ATC:R03DC03 UMLS:C0298130 ATC:R03DC03 Montelukast ATC:R03DC03 ATC:R03 ATC:R05 https://uts.nlm.nih.gov/uts/umls/concept/C1511537 ATC:R05 Cough and Cold Preparations ATC:R05 ATC:R ATC:R06 https://uts.nlm.nih.gov/uts/umls/concept/C3653763 ATC:R06 Antihistamines for Systemic Use ATC:R06 ATC:R ATC:R06AB04 https://uts.nlm.nih.gov/uts/umls/concept/C0008281 ATC:R06AB04 Chlorphenamine ATC:R06AB04 ATC:R06 ATC:R06AD03 https://uts.nlm.nih.gov/uts/umls/concept/C0039865 ATC:R06AD03 Thiethylperazine ATC:R06AD03 ATC:R06 ATC:R06AE07 https://uts.nlm.nih.gov/uts/umls/concept/C0055147 ATC:R06AE07 Cetirizine ATC:R06AE07 ATC:R06 ATC:R06AE09 UMLS:C1174893 ATC:R06AE09 Levocetirizine ATC:R06AE09 ATC:R06 ATC:R07 https://uts.nlm.nih.gov/uts/umls/concept/C3653833 ATC:R07 Other Respiratory System Products ATC:R07 ATC:R ATC:S https://uts.nlm.nih.gov/uts/umls/concept/C3654000 ATC:S Sensory Organs ATC:S01 https://uts.nlm.nih.gov/uts/umls/concept/C2013096 ATC:S01 Ophthalmologicals ATC:S01 ATC:S ATC:S01EE05 UMLS:C1451502 ATC:S01EE05 Tafluprost ATC:S01EE05 ATC:S01 ATC:S02 https://uts.nlm.nih.gov/uts/umls/concept/C3653485 ATC:S02 Otologicals ATC:S02 ATC:S ATC:S03 https://uts.nlm.nih.gov/uts/umls/concept/C3653568 ATC:S03 Ophthalmologicals and Otologicals Products ATC:S03 ATC:S ATC:V https://uts.nlm.nih.gov/uts/umls/concept/C3540763 ATC:V Various ATC:V01 https://uts.nlm.nih.gov/uts/umls/concept/C0002092 ATC:V01 Allergens ATC:V01 ATC:V ATC:V03 https://uts.nlm.nih.gov/uts/umls/concept/C3653767 ATC:V03 All Other Therapeutic Products ATC:V03 ATC:V ATC:V03AF03 https://uts.nlm.nih.gov/uts/umls/concept/C0731033 ATC:V03AF03 Calcium Folinate ATC:V03AF03 ATC:V03 ATC:V04 Diagnostic Agents ATC:V04 ATC:V ATC:V06 https://uts.nlm.nih.gov/uts/umls/concept/C3653491 ATC:V06 General Nutrients ATC:V06 ATC:V ATC:V07 https://uts.nlm.nih.gov/uts/umls/concept/C3653748 ATC:V07 All Other Non-Therapeutic Products ATC:V07 ATC:V ATC:V08 https://uts.nlm.nih.gov/uts/umls/concept/C0009924 ATC:V08 Contrast Media ATC:V08 ATC:V ATC:V09 https://uts.nlm.nih.gov/uts/umls/concept/C0360048 ATC:V09 Diagnostic Radiopharmaceuticals ATC:V09 ATC:V ATC:V10 https://uts.nlm.nih.gov/uts/umls/concept/C0358509 ATC:V10 Therapeutic Radiopharmaceuticals ATC:V10 ATC:V ATC:V20 https://uts.nlm.nih.gov/uts/umls/concept/C3653515 ATC:V20 Surgical Dressings ATC:V20 ATC:V http://purl.bioontology.org/ontology/SNOMEDCT/107769006 https://uts.nlm.nih.gov/uts/umls/concept/C0186318 http://purl.bioontology.org/ontology/SNOMEDCT/107769006 Surgical procedure involving an upper extremity. http://purl.bioontology.org/ontology/SNOMEDCT/107769006 Operative Procedure on Upper Extremity http://purl.bioontology.org/ontology/SNOMEDCT/107784002 https://uts.nlm.nih.gov/uts/umls/concept/C0187763 http://purl.bioontology.org/ontology/SNOMEDCT/107784002 Surgical procedure involiving a lower extremity. http://purl.bioontology.org/ontology/SNOMEDCT/107784002 Surgical Procedure on Lower Extremity http://purl.bioontology.org/ontology/SNOMEDCT/110469002 https://uts.nlm.nih.gov/uts/umls/concept/C0195324 http://purl.bioontology.org/ontology/SNOMEDCT/110469002 The excision of a cone of tissue, especially of the CERVIX UTERI. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/110469002 Cone Biopsy http://purl.bioontology.org/ontology/SNOMEDCT/112902005 The surgical removal of part of bladder. http://purl.bioontology.org/ontology/SNOMEDCT/112902005 Partial Cystectomy http://purl.bioontology.org/ontology/SNOMEDCT/1144987003 https://uts.nlm.nih.gov/uts/umls/concept/C5546135 http://purl.bioontology.org/ontology/SNOMEDCT/1144987003 The absence of menses in a woman who has achieved reproductive age due to disorder of pituitary gland. [Partial Defintion Source: NCI http://purl.bioontology.org/ontology/SNOMEDCT/1144987003 Amenorrhea due to Pituitary Dysfunction http://purl.bioontology.org/ontology/SNOMEDCT/1144987003 http://purl.obolibrary.org/obo/NCIT_C61443 http://purl.bioontology.org/ontology/SNOMEDCT/118445002 https://uts.nlm.nih.gov/uts/umls/concept/C1293110 http://purl.bioontology.org/ontology/SNOMEDCT/118445002 Surgical removal of bening neoplasm. http://purl.bioontology.org/ontology/SNOMEDCT/118445002 Excision of Benign Neoplasm http://purl.bioontology.org/ontology/SNOMEDCT/118445002 http://purl.bioontology.org/ontology/SNOMEDCT/370612006 http://purl.bioontology.org/ontology/SNOMEDCT/13619001 https://uts.nlm.nih.gov/uts/umls/concept/C0040145 http://purl.bioontology.org/ontology/SNOMEDCT/13619001 Surgery to remover part or all of the thyroid gland. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/13619001 Thyroid Gland Excision http://purl.bioontology.org/ontology/SNOMEDCT/14045001 https://uts.nlm.nih.gov/uts/umls/concept/C0043157 http://purl.bioontology.org/ontology/SNOMEDCT/14045001 A person having origins in any of the original peoples of Europe, the Middle East, or North Africa. (OMB) [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/14045001 Caucasian http://purl.bioontology.org/ontology/SNOMEDCT/177250006 https://uts.nlm.nih.gov/uts/umls/concept/C0198542 http://purl.bioontology.org/ontology/SNOMEDCT/177250006 Surgical removal of excess abdominal skin and fat and tightening of the ABDOMINAL WALL. Abdominoplasty may include LIPECTOMY of INTRA-ABDOMINAL FAT, tightening of the ABDOMINAL MUSCLES, and re-creation of the UMBILICUS. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/177250006 Abdominoplasty http://purl.bioontology.org/ontology/SNOMEDCT/18167009 https://uts.nlm.nih.gov/uts/umls/concept/C0337824 http://purl.bioontology.org/ontology/SNOMEDCT/18167009 Denotes a person with ancestral origins are in any of the countries of Africa. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/18167009 Black African http://purl.bioontology.org/ontology/SNOMEDCT/183005 https://uts.nlm.nih.gov/uts/umls/concept/C0271893 http://purl.bioontology.org/ontology/SNOMEDCT/183005 The autoimmune inability of the bone marrow to produce hematopoietic elements. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/183005 Autoimmune Pancytopenia http://purl.bioontology.org/ontology/SNOMEDCT/183005 http://purl.obolibrary.org/obo/NCIT_C34889 http://purl.bioontology.org/ontology/SNOMEDCT/193093009 https://uts.nlm.nih.gov/uts/umls/concept/C0376175 http://purl.bioontology.org/ontology/SNOMEDCT/193093009 A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376) [Defintion Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/193093009 Bell's Palsy http://purl.bioontology.org/ontology/SNOMEDCT/193093009 http://purl.obolibrary.org/obo/NCIT_C26769 http://purl.bioontology.org/ontology/SNOMEDCT/202708005 https://uts.nlm.nih.gov/uts/umls/concept/C0281899 http://purl.bioontology.org/ontology/SNOMEDCT/202708005 Lumbar Hernia [Definition Source: MedDRA] http://purl.bioontology.org/ontology/SNOMEDCT/202708005 Prolapsed Lumbar Intervertebral Disc http://purl.bioontology.org/ontology/SNOMEDCT/202708005 http://purl.obolibrary.org/obo/NCIT_C34685 http://purl.bioontology.org/ontology/SNOMEDCT/20805001 UMLS:C0189054 http://purl.bioontology.org/ontology/SNOMEDCT/20805001 Rhinoseptoplasty, also known as rhino septoplasty or septorhinoplasty, is a nose job procedure that makes cosmetic changes while realigning a malformed nasal septum. [Defintion Source: themodernplasticsurgery] http://purl.bioontology.org/ontology/SNOMEDCT/20805001 Rhinoseptoplasty http://purl.bioontology.org/ontology/SNOMEDCT/21371007 https://uts.nlm.nih.gov/uts/umls/concept/C0198482 http://purl.bioontology.org/ontology/SNOMEDCT/21371007 A surgical procedure located in the abdomnial region. http://purl.bioontology.org/ontology/SNOMEDCT/21371007 Operation on Abdominal Region http://purl.bioontology.org/ontology/SNOMEDCT/23056005 UMLS:C0036396 http://purl.bioontology.org/ontology/SNOMEDCT/23056005 Pain in the lower back and hip radiating in the distribution of the sciatic nerve. [HPO:probinson, PMID:17872935] (HPO) http://purl.bioontology.org/ontology/SNOMEDCT/23056005 Sciatica http://purl.bioontology.org/ontology/SNOMEDCT/23056005 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.bioontology.org/ontology/SNOMEDCT/232717009 https://uts.nlm.nih.gov/uts/umls/concept/C0010055 http://purl.bioontology.org/ontology/SNOMEDCT/232717009 Surgery performed to bypass partially or completely occluded coronary arteries, thereby increasing the blood supply of the heart. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/232717009 Coronary Artery Bypass Graft http://purl.bioontology.org/ontology/SNOMEDCT/23344004 https://uts.nlm.nih.gov/uts/umls/concept/C0401119 http://purl.bioontology.org/ontology/SNOMEDCT/23344004 Lumbar Hernia [Definition Source: SNOMEDCT] http://purl.bioontology.org/ontology/SNOMEDCT/23344004 Lumbar Hernia http://purl.bioontology.org/ontology/SNOMEDCT/23344004 http://purl.obolibrary.org/obo/NCIT_C34685 http://purl.bioontology.org/ontology/SNOMEDCT/233935004 https://uts.nlm.nih.gov/uts/umls/concept/C0524702 http://purl.bioontology.org/ontology/SNOMEDCT/233935004 Pulmonary embolism is caused by emboli, which have originated from venous thrombi, travelling to and occluding the arteries of the lung. [PMID:29770793] http://purl.bioontology.org/ontology/SNOMEDCT/233935004 Pulmonary Thromboembolism http://purl.bioontology.org/ontology/SNOMEDCT/233935004 http://purl.obolibrary.org/obo/NCIT_C28195 http://purl.bioontology.org/ontology/SNOMEDCT/235159007 The placement of a feeding tube through the abdominal wall into the stomach using an endoscope. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/235159007 Percutaneous Endoscopic Gastrostomy (PEG) http://purl.bioontology.org/ontology/SNOMEDCT/236825001 https://uts.nlm.nih.gov/uts/umls/concept/C0403848 http://purl.bioontology.org/ontology/SNOMEDCT/236825001 Drainage of abscess of Barholin's gland. http://purl.bioontology.org/ontology/SNOMEDCT/236825001 Drainage of Bartholin's Abscess http://purl.bioontology.org/ontology/SNOMEDCT/236886002 https://uts.nlm.nih.gov/uts/umls/concept/C0020699 http://purl.bioontology.org/ontology/SNOMEDCT/236886002 A surgical procedure to remove the uterine body (partial hysterectomy) or the uterine body and cervix (total hysterectomy). [Definition source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/236886002 Hysterectomy http://purl.bioontology.org/ontology/SNOMEDCT/24079001 https://uts.nlm.nih.gov/uts/umls/concept/C0011615 http://purl.bioontology.org/ontology/SNOMEDCT/24079001 A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/24079001 Atopic Dermatitis http://purl.bioontology.org/ontology/SNOMEDCT/24079001 http://purl.obolibrary.org/obo/NCIT_C3001 http://purl.bioontology.org/ontology/SNOMEDCT/250980009 The conversion of one cardiac rhythm or electrical pattern to another, almost always from an abnormal to a normal one, by pharmacologic means using medications or by electrical cardioversion using a defibrillator. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/250980009 Cardioversion http://purl.bioontology.org/ontology/SNOMEDCT/26212005 UMLS:C0003506 http://purl.bioontology.org/ontology/SNOMEDCT/26212005 Replacement of Aortic Valve http://purl.bioontology.org/ontology/SNOMEDCT/300009002 https://uts.nlm.nih.gov/uts/umls/concept/C0576748 http://purl.bioontology.org/ontology/SNOMEDCT/300009002 Surgical removal of acoustic neuroma. http://purl.bioontology.org/ontology/SNOMEDCT/300009002 Removal of Acoustic Neuroma http://purl.bioontology.org/ontology/SNOMEDCT/300025007 https://uts.nlm.nih.gov/uts/umls/concept/C0576763 http://purl.bioontology.org/ontology/SNOMEDCT/300025007 Surgical removal of basal cell carcinoma. http://purl.bioontology.org/ontology/SNOMEDCT/300025007 Excision of Basal Cell Carcinoma http://purl.bioontology.org/ontology/SNOMEDCT/302870006 UMLS:C0020557 http://purl.bioontology.org/ontology/SNOMEDCT/302870006 A condition of elevated levels of TRIGLYCERIDES in the blood. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/302870006 Hypertriglyceridaemia http://purl.bioontology.org/ontology/SNOMEDCT/302870006 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.bioontology.org/ontology/SNOMEDCT/303011007 https://uts.nlm.nih.gov/uts/umls/concept/C0027947 http://purl.bioontology.org/ontology/SNOMEDCT/303011007 A decrease in the number of NEUTROPHILS found in the blood. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/303011007 Neutropenic Disorder http://purl.bioontology.org/ontology/SNOMEDCT/303011007 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.bioontology.org/ontology/SNOMEDCT/311801003 Any approach involiving the head and neck region. http://purl.bioontology.org/ontology/SNOMEDCT/311801003 Head and Neck Approaches http://purl.bioontology.org/ontology/SNOMEDCT/315240009 https://uts.nlm.nih.gov/uts/umls/concept/C0005680 http://purl.bioontology.org/ontology/SNOMEDCT/315240009 A person having origins in the original peoples of sub-Saharan Africa or the Caribbean. http://purl.bioontology.org/ontology/SNOMEDCT/315240009 Black (ethnic group) http://purl.bioontology.org/ontology/SNOMEDCT/315280000 https://uts.nlm.nih.gov/uts/umls/concept/C1282531 http://purl.bioontology.org/ontology/SNOMEDCT/315280000 A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. (OMB) [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/315280000 Asian (ethnic group) http://purl.bioontology.org/ontology/SNOMEDCT/35926005 UMLS:C0188184 http://purl.bioontology.org/ontology/SNOMEDCT/35926005 Repair of Knee Cruciate Ligaments http://purl.bioontology.org/ontology/SNOMEDCT/370612006 https://uts.nlm.nih.gov/uts/umls/concept/C1299802 http://purl.bioontology.org/ontology/SNOMEDCT/370612006 The surgical removal of a neoplasm. http://purl.bioontology.org/ontology/SNOMEDCT/370612006 Excision of Neoplasm http://purl.bioontology.org/ontology/SNOMEDCT/37340000 https://uts.nlm.nih.gov/uts/umls/concept/C0085084 http://purl.bioontology.org/ontology/SNOMEDCT/37340000 Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/37340000 Motor Neuron Disease http://purl.bioontology.org/ontology/SNOMEDCT/37340000 http://purl.obolibrary.org/obo/NCIT_C4802 http://purl.bioontology.org/ontology/SNOMEDCT/38102005 https://uts.nlm.nih.gov/uts/umls/concept/C0008320 http://purl.bioontology.org/ontology/SNOMEDCT/38102005 Surgical removal of the gallbladder. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/38102005 Cholecystectomy http://purl.bioontology.org/ontology/SNOMEDCT/385487005 https://uts.nlm.nih.gov/uts/umls/concept/C0524832 http://purl.bioontology.org/ontology/SNOMEDCT/385487005 Any surgery performed inside the thoracic cavity. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/385487005 Surgical Procedure on Thorax http://purl.bioontology.org/ontology/SNOMEDCT/387731002 UMLS:C0022983 http://purl.bioontology.org/ontology/SNOMEDCT/387731002 A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots. [Defintion Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/387731002 Laminectomy http://purl.bioontology.org/ontology/SNOMEDCT/389145006 https://uts.nlm.nih.gov/uts/umls/concept/C0155877 http://purl.bioontology.org/ontology/SNOMEDCT/389145006 Allergic Asthma http://purl.bioontology.org/ontology/SNOMEDCT/389145006 Allergic Asthma http://purl.bioontology.org/ontology/SNOMEDCT/389145006 http://purl.obolibrary.org/obo/NCIT_C28397 http://purl.bioontology.org/ontology/SNOMEDCT/414408004 https://uts.nlm.nih.gov/uts/umls/concept/C0086409 http://purl.bioontology.org/ontology/SNOMEDCT/414408004 A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. The term, "Spanish origin" can be used in addition to "Hispanic or Latino". (OMB) [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/414408004 Hispanic http://purl.bioontology.org/ontology/SNOMEDCT/428297005 https://uts.nlm.nih.gov/uts/umls/concept/C1997755 http://purl.bioontology.org/ontology/SNOMEDCT/428297005 Surgical removal of a cyst. http://purl.bioontology.org/ontology/SNOMEDCT/428297005 Excision of Cyst http://purl.bioontology.org/ontology/SNOMEDCT/428402007 https://uts.nlm.nih.gov/uts/umls/concept/C1997868 http://purl.bioontology.org/ontology/SNOMEDCT/428402007 Lumbo-sacral spine surgery http://purl.bioontology.org/ontology/SNOMEDCT/428402007 Operative Procedure on Lumbosacral Spinal Structure http://purl.bioontology.org/ontology/SNOMEDCT/428490009 https://uts.nlm.nih.gov/uts/umls/concept/C1997463 http://purl.bioontology.org/ontology/SNOMEDCT/428490009 Surgical procedure on the cervical spine. http://purl.bioontology.org/ontology/SNOMEDCT/428490009 Surgical Procedure on Cervical Spine http://purl.bioontology.org/ontology/SNOMEDCT/428614005 https://uts.nlm.nih.gov/uts/umls/concept/C1997608 http://purl.bioontology.org/ontology/SNOMEDCT/428614005 Thoracic spine surgery. http://purl.bioontology.org/ontology/SNOMEDCT/428614005 Operative Procedure on Thoracic Spinal Structure http://purl.bioontology.org/ontology/SNOMEDCT/442338001 https://uts.nlm.nih.gov/uts/umls/concept/C0017125 http://purl.bioontology.org/ontology/SNOMEDCT/442338001 Surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/442338001 Gastryc Bypass http://purl.bioontology.org/ontology/SNOMEDCT/445968009 https://uts.nlm.nih.gov/uts/umls/concept/C2960489 http://purl.bioontology.org/ontology/SNOMEDCT/445968009 Surgical insertion of intrathecal access system for drug delivery. http://purl.bioontology.org/ontology/SNOMEDCT/445968009 Insertion of Implantable Intrathecal Access System http://purl.bioontology.org/ontology/SNOMEDCT/447139008 https://uts.nlm.nih.gov/uts/umls/concept/C0159870 http://purl.bioontology.org/ontology/SNOMEDCT/447139008 A closed fracture of the tibia. http://purl.bioontology.org/ontology/SNOMEDCT/447139008 Closed Fracture of Tibia http://purl.bioontology.org/ontology/SNOMEDCT/447139008 http://purl.obolibrary.org/obo/NCIT_C99083 http://purl.bioontology.org/ontology/SNOMEDCT/50172003 UMLS:C0186045 http://purl.bioontology.org/ontology/SNOMEDCT/50172003 Lumbar spinal fusion is surgery to join, or fuse, two or more vertebrae in the low back. The surgery is also called arthrodesis. [Defintion Source: myhealth.alberta.ca] http://purl.bioontology.org/ontology/SNOMEDCT/50172003 Lumbar Spinal Fusion http://purl.bioontology.org/ontology/SNOMEDCT/55622001 https://uts.nlm.nih.gov/uts/umls/concept/C0189343 http://purl.bioontology.org/ontology/SNOMEDCT/55622001 Surgical formation of an opening into the trachea through the neck, or the opening so created. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/55622001 Emergency Tracheostomy http://purl.bioontology.org/ontology/SNOMEDCT/609637006 https://uts.nlm.nih.gov/uts/umls/concept/C3661975 http://purl.bioontology.org/ontology/SNOMEDCT/609637006 Pelvic surgery. http://purl.bioontology.org/ontology/SNOMEDCT/609637006 Procedure on Pelvic Region of Trunk http://purl.bioontology.org/ontology/SNOMEDCT/700074001 https://uts.nlm.nih.gov/uts/umls/concept/C3839771 http://purl.bioontology.org/ontology/SNOMEDCT/700074001 Surgical removal of dermatofibroma. http://purl.bioontology.org/ontology/SNOMEDCT/700074001 Excision of dermatofibroma http://purl.bioontology.org/ontology/SNOMEDCT/73589001 https://uts.nlm.nih.gov/uts/umls/concept/C0021818 http://purl.bioontology.org/ontology/SNOMEDCT/73589001 Herniated Disc [Definition Source: MedDRA] http://purl.bioontology.org/ontology/SNOMEDCT/73589001 Intervertebral Disc Prolapse http://purl.bioontology.org/ontology/SNOMEDCT/73589001 http://purl.obolibrary.org/obo/NCIT_C34685 http://purl.bioontology.org/ontology/SNOMEDCT/74146001 https://uts.nlm.nih.gov/uts/umls/concept/C0194475 http://purl.bioontology.org/ontology/SNOMEDCT/74146001 Surgical repair of bladder http://purl.bioontology.org/ontology/SNOMEDCT/74146001 Repair of Bladder http://purl.bioontology.org/ontology/SNOMEDCT/80146002 https://uts.nlm.nih.gov/uts/umls/concept/C0003611 http://purl.bioontology.org/ontology/SNOMEDCT/80146002 Surgical removal of the vermiform appendix. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/80146002 Appendectomy http://purl.bioontology.org/ontology/SNOMEDCT/882784691000119100 https://uts.nlm.nih.gov/uts/umls/concept/C5244027 http://purl.bioontology.org/ontology/SNOMEDCT/882784691000119100 Pneumonia caused by severe acute respiratory syndrome coronavirus 2 [Definition Source: SNOMEDCT] http://purl.bioontology.org/ontology/SNOMEDCT/882784691000119100 Pneumonia Caused By SARS-CoV-2 http://purl.bioontology.org/ontology/SNOMEDCT/882784691000119100 http://purl.obolibrary.org/obo/NCIT_C3333 http://purl.bioontology.org/ontology/SNOMEDCT/89743005 UMLS:C0948163 http://purl.bioontology.org/ontology/SNOMEDCT/89743005 Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/89743005 Leukoaraiosis http://purl.bioontology.org/ontology/SNOMEDCT/89743005 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.bioontology.org/ontology/SNOMEDCT/90199006 https://uts.nlm.nih.gov/uts/umls/concept/C0040771 http://purl.bioontology.org/ontology/SNOMEDCT/90199006 Prostate tissue removal via a cystoscope. [Definition Source: NCI] http://purl.bioontology.org/ontology/SNOMEDCT/90199006 Transurethral Prostatectomy http://purl.bioontology.org/ontology/SNOMEDCT/90460009 https://uts.nlm.nih.gov/uts/umls/concept/C0027531 http://purl.bioontology.org/ontology/SNOMEDCT/90460009 General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck. [Defintion Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/90460009 Neck Trauma http://purl.bioontology.org/ontology/SNOMEDCT/90460009 http://purl.obolibrary.org/obo/NCIT_C36282 http://purl.bioontology.org/ontology/SNOMEDCT/9389005 https://uts.nlm.nih.gov/uts/umls/concept/C0019357 http://purl.bioontology.org/ontology/SNOMEDCT/9389005 A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed) [Defintion Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/9389005 Herpes Simplex Keratitis http://purl.bioontology.org/ontology/SNOMEDCT/9389005 http://purl.obolibrary.org/obo/NCIT_C155871 http://purl.bioontology.org/ontology/SNOMEDCT/9389005 http://purl.obolibrary.org/obo/NCIT_C26805 http://purl.bioontology.org/ontology/SNOMEDCT/9429009 https://uts.nlm.nih.gov/uts/umls/concept/C0017193 http://purl.bioontology.org/ontology/SNOMEDCT/9429009 Surgical procedures involving the STOMACH and sometimes the lower ESOPHAGUS to correct anatomical defects, or to treat MORBID OBESITY by reducing the size of the stomach. There are several subtypes of bariatric gastroplasty, such as vertical banded gastroplasty, silicone ring vertical gastroplasty, and horizontal banded gastroplasty. [Definition Source: MSH] http://purl.bioontology.org/ontology/SNOMEDCT/9429009 Gastroplasty http://purl.obolibrary.org/obo/NCIT_C100023 https://uts.nlm.nih.gov/uts/umls/concept/C0581375 http://purl.obolibrary.org/obo/NCIT_C100023 There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in two coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery). (ACC) [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C100023 Two Vessel Coronary Disease http://purl.obolibrary.org/obo/NCIT_C100023 http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C100104 https://uts.nlm.nih.gov/uts/umls/concept/C0037088 http://purl.obolibrary.org/obo/NCIT_C100104 Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C100104 Sign or Symptom http://purl.obolibrary.org/obo/NCIT_C100104 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C100808 UMLS:C3639750 http://purl.obolibrary.org/obo/NCIT_C100808 Any individual related biologically or legally to another individual and considered two degrees removed from the immediate family as in the case of cousins. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C100808 Third Degree Relative http://purl.obolibrary.org/obo/NCIT_C101214 https://uts.nlm.nih.gov/uts/umls/concept/C0080178 http://purl.obolibrary.org/obo/NCIT_C101214 A congenital neural tube defect in which vertebrae are not fully formed. It results in the protrusion of the spinal cord through the opening of the vertebrae. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C101214 Spina Bifida http://purl.obolibrary.org/obo/NCIT_C101214 http://purl.obolibrary.org/obo/NCIT_C27586 http://purl.obolibrary.org/obo/NCIT_C101398 https://uts.nlm.nih.gov/uts/umls/concept/C1428691 http://purl.obolibrary.org/obo/NCIT_C101398 This gene may play a role in cell death. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C101398 C9orf72 Gene http://purl.obolibrary.org/obo/NCIT_C101491 https://uts.nlm.nih.gov/uts/umls/concept/C1420393 http://purl.obolibrary.org/obo/NCIT_C101491 This gene is involved in signal transduction. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C101491 SQSTM1 Gene http://purl.obolibrary.org/obo/NCIT_C111201 UMLS:C3830065 http://purl.obolibrary.org/obo/NCIT_C111201 A male who shares with his sibling the genetic makeup inherited from both of the biological parents. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C111201 Brother http://purl.obolibrary.org/obo/NCIT_C111201 http://purl.obolibrary.org/obo/NCIT_C21481 http://purl.obolibrary.org/obo/NCIT_C111202 UMLS:C3827310 http://purl.obolibrary.org/obo/NCIT_C111202 A female who shares with her sibling the genetic makeup inherited from both of the biological parents. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C111202 Sister http://purl.obolibrary.org/obo/NCIT_C111202 http://purl.obolibrary.org/obo/NCIT_C21481 http://purl.obolibrary.org/obo/NCIT_C112175 https://uts.nlm.nih.gov/uts/umls/concept/C0002994 http://purl.obolibrary.org/obo/NCIT_C112175 Rapid swelling of the deep layers of the skin due to transient vascular leakage of serous fluid. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C112175 Angioedema http://purl.obolibrary.org/obo/NCIT_C112175 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C112183 https://uts.nlm.nih.gov/uts/umls/concept/C0005741 http://purl.obolibrary.org/obo/NCIT_C112183 Inflammation of the eyelids near the eyelashes. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C112183 Blepharitits http://purl.obolibrary.org/obo/NCIT_C112183 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C112208 https://uts.nlm.nih.gov/uts/umls/concept/C3541994 http://purl.obolibrary.org/obo/NCIT_C112208 A potentially life-threatening hypersensitivity reaction to a pharmacologic substance that is characterized by rash, lymphadenopathy, fever, hematologic abnormalities and involvement of one or more internal organs. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C112208 Drug Hypersensitivity Syndrome http://purl.obolibrary.org/obo/NCIT_C112208 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C112357 https://uts.nlm.nih.gov/uts/umls/concept/C0026394 http://purl.obolibrary.org/obo/NCIT_C112357 A species of enveloped and brick-shaped viruses in the Poxviridae family and Molluscipoxvirus genus. The genome is composed of non-segmented, linear double-stranded DNA. Molluscum contagiosum viruses are found in humans and can cause the disease Molluscum contagiosum. Molluscum contagiosum viruses are transmitted via direct person-to-person contact and contact with infected fomites. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C112357 Molluscum Contagiosum Virus http://purl.obolibrary.org/obo/NCIT_C112833 https://uts.nlm.nih.gov/uts/umls/concept/C0040262 http://purl.obolibrary.org/obo/NCIT_C112833 A skin condition characterized by hypopigmented, pink or tan, confetti-like, discrete and confluent scaly macules distributed on the chest, shoulders and upper back. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C112833 Tinea Versicolor http://purl.obolibrary.org/obo/NCIT_C112833 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C114830 UMLS:C0042870 http://purl.obolibrary.org/obo/NCIT_C114830 Abnormally low level of 25-hydroxyvitamin D in the blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C114830 Vitamin D Deficiency http://purl.obolibrary.org/obo/NCIT_C114830 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C115958 https://uts.nlm.nih.gov/uts/umls/concept/C0521618 http://purl.obolibrary.org/obo/NCIT_C115958 Narrowing of the luminal diameter of one or both ureters due to intrinsic factors. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C115958 Ureteral Stenosis http://purl.obolibrary.org/obo/NCIT_C115958 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C116369 https://uts.nlm.nih.gov/uts/umls/concept/C0003126 http://purl.obolibrary.org/obo/NCIT_C116369 Inability to smell. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C116369 Anosmia http://purl.obolibrary.org/obo/NCIT_C116369 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C116374 https://uts.nlm.nih.gov/uts/umls/concept/C2364111 http://purl.obolibrary.org/obo/NCIT_C116374 Inability to taste. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C116374 Ageusia http://purl.obolibrary.org/obo/NCIT_C116374 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C116585 https://uts.nlm.nih.gov/uts/umls/concept/C0018946 http://purl.obolibrary.org/obo/NCIT_C116585 A collection of blood between the dura mater and the brain. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C116585 Subdural Hematoma http://purl.obolibrary.org/obo/NCIT_C116585 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C116921 https://uts.nlm.nih.gov/uts/umls/concept/C0338656 http://purl.obolibrary.org/obo/NCIT_C116921 Diminished mental function. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C116921 Cognitive Impariment http://purl.obolibrary.org/obo/NCIT_C116921 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C117005 https://uts.nlm.nih.gov/uts/umls/concept/C0154723 http://purl.obolibrary.org/obo/NCIT_C117005 A migraine disorder characterized by episodes that are preceded by focal neurological symptoms. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C117005 Migraine With Aura http://purl.obolibrary.org/obo/NCIT_C117005 http://purl.obolibrary.org/obo/NCIT_C89715 http://purl.obolibrary.org/obo/NCIT_C117084 https://uts.nlm.nih.gov/uts/umls/concept/C0032768 http://purl.obolibrary.org/obo/NCIT_C117084 Pain that occurs after the disappearance of herpes zoster infection lesions. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C117084 Post-Herpetic Neuralgia http://purl.obolibrary.org/obo/NCIT_C117084 http://purl.obolibrary.org/obo/NCIT_C4876 http://purl.obolibrary.org/obo/NCIT_C118723 https://uts.nlm.nih.gov/uts/umls/concept/C0005747 http://purl.obolibrary.org/obo/NCIT_C118723 Involuntary twitching of the eyelid. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C118723 Blepharospasm http://purl.obolibrary.org/obo/NCIT_C118723 http://purl.obolibrary.org/obo/NCIT_C36282 http://purl.obolibrary.org/obo/NCIT_C119640 https://uts.nlm.nih.gov/uts/umls/concept/C1424774 http://purl.obolibrary.org/obo/NCIT_C119640 This gene plays a role in both neuroprotection and Golgi maintenance [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C119640 OPTN Gene http://purl.obolibrary.org/obo/NCIT_C122419 https://uts.nlm.nih.gov/uts/umls/concept/C0259797 http://purl.obolibrary.org/obo/NCIT_C122419 A wound received from the teeth of a dog. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C122419 Dog Bite http://purl.obolibrary.org/obo/NCIT_C122419 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C122822 UMLS:C0008350 http://purl.obolibrary.org/obo/NCIT_C122822 The presence of calculi in the gallbladder. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C122822 Cholelithiasis http://purl.obolibrary.org/obo/NCIT_C122822 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C122875 https://uts.nlm.nih.gov/uts/umls/concept/C1413935 http://purl.obolibrary.org/obo/NCIT_C122875 This gene is involved in the modulation of retrograde transport of cytoplasmic organelles and vesicles. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C122875 DCTN1 Gene http://purl.obolibrary.org/obo/NCIT_C123215 https://uts.nlm.nih.gov/uts/umls/concept/C0520575 http://purl.obolibrary.org/obo/NCIT_C123215 Sudden onset pyelonephritis. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C123215 Acute Pyelonephritis http://purl.obolibrary.org/obo/NCIT_C123215 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C123330 UMLS:C0024437 http://purl.obolibrary.org/obo/NCIT_C123330 Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C123330 Macular Degeneration http://purl.obolibrary.org/obo/NCIT_C123330 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C12401 https://uts.nlm.nih.gov/uts/umls/concept/C0015392 http://purl.obolibrary.org/obo/NCIT_C12401 The organ of sight or vision. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12401 Eye http://purl.obolibrary.org/obo/NCIT_C12419 https://uts.nlm.nih.gov/uts/umls/concept/C0018670 http://purl.obolibrary.org/obo/NCIT_C12419 The anterior and superior part of a human bearing the mouth, the brain and sensory organs. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12419 Head http://purl.obolibrary.org/obo/NCIT_C12429 https://uts.nlm.nih.gov/uts/umls/concept/C0015385 http://purl.obolibrary.org/obo/NCIT_C12429 A body region referring to an upper or lower extremity. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12429 Limb http://purl.obolibrary.org/obo/NCIT_C12431 https://uts.nlm.nih.gov/uts/umls/concept/C0005953 http://purl.obolibrary.org/obo/NCIT_C12431 The tissue occupying the spaces of bone. It consists of blood vessel sinuses and a network of hematopoietic cells which give rise to the red cells, white cells, and megakaryocytes. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12431 Bone Marrow http://purl.obolibrary.org/obo/NCIT_C12439 https://uts.nlm.nih.gov/uts/umls/concept/C0006104 http://purl.obolibrary.org/obo/NCIT_C12439 An organ composed of grey and white matter containing billions of neurons that is the center for intelligence and reasoning. It is protected by the bony cranium. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12439 Brain http://purl.obolibrary.org/obo/NCIT_C12441 https://uts.nlm.nih.gov/uts/umls/concept/C0006121 http://purl.obolibrary.org/obo/NCIT_C12441 Three sections, the midbrain, pons and medulla oblongata, that are located at the base of the brain. The brain stem regulates the central nervous system, and is vital as a conduit for motor and sensory innervations. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12441 Brain Stem http://purl.obolibrary.org/obo/NCIT_C12445 https://uts.nlm.nih.gov/uts/umls/concept/C0007765 http://purl.obolibrary.org/obo/NCIT_C12445 The portion of the brain located at the base of the skull that is responsible for balance, equilibrium and movement. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12445 Cerebellum http://purl.obolibrary.org/obo/NCIT_C12464 https://uts.nlm.nih.gov/uts/umls/concept/C0037925 http://purl.obolibrary.org/obo/NCIT_C12464 The elongated, approximately cylindrical part of the central nervous system of vertebrates that lies in the vertebral canal and from which the spinal nerves emerge. [Definition Source: NCI][attribution: On-line Medical Dictionary] http://purl.obolibrary.org/obo/NCIT_C12464 Spinal Cord http://purl.obolibrary.org/obo/NCIT_C12512 https://uts.nlm.nih.gov/uts/umls/concept/C1522407 http://purl.obolibrary.org/obo/NCIT_C12512 The part of the brain that is located superior to the tentorium cerebelli. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12512 Supratentorial Brain http://purl.obolibrary.org/obo/NCIT_C12664 https://uts.nlm.nih.gov/uts/umls/concept/C0230168 http://purl.obolibrary.org/obo/NCIT_C12664 The cavity located between the lungs and pelvis. It contains the lower esophagus, stomach, pancreas, intestines, liver, gallbladder and spleen. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12664 Abdomen http://purl.obolibrary.org/obo/NCIT_C12671 https://uts.nlm.nih.gov/uts/umls/concept/C1140618 http://purl.obolibrary.org/obo/NCIT_C12671 The region of the body that includes the arm, the forearm, and hand. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12671 Upper Extremity http://purl.obolibrary.org/obo/NCIT_C12671 http://purl.obolibrary.org/obo/NCIT_C12429 http://purl.obolibrary.org/obo/NCIT_C12742 https://uts.nlm.nih.gov/uts/umls/concept/C0023216 http://purl.obolibrary.org/obo/NCIT_C12742 The limb that is composed of the hip, thigh, leg and foot. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12742 Lower Extremity http://purl.obolibrary.org/obo/NCIT_C12742 http://purl.obolibrary.org/obo/NCIT_C12429 http://purl.obolibrary.org/obo/NCIT_C12767 https://uts.nlm.nih.gov/uts/umls/concept/C0030797 http://purl.obolibrary.org/obo/NCIT_C12767 The bony, basin-shaped structure formed by the hipbones and the base of the backbone supporting the lower limbs in humans. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12767 Pelvis http://purl.obolibrary.org/obo/NCIT_C12799 https://uts.nlm.nih.gov/uts/umls/concept/C0817096 http://purl.obolibrary.org/obo/NCIT_C12799 The division of the body lying between the neck and the abdomen. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12799 Thorax http://purl.obolibrary.org/obo/NCIT_C128405 https://uts.nlm.nih.gov/uts/umls/concept/C0276139 http://purl.obolibrary.org/obo/NCIT_C128405 Pericarditis that is caused by an infection with a viral agent. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C128405 Viral Pericarditis http://purl.obolibrary.org/obo/NCIT_C128405 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C12892 https://uts.nlm.nih.gov/uts/umls/concept/C0581619 http://purl.obolibrary.org/obo/NCIT_C12892 The portion of the spinal cord located in the cervical region. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12892 Cervical Spinal Cord http://purl.obolibrary.org/obo/NCIT_C12894 https://uts.nlm.nih.gov/uts/umls/concept/C0581620 http://purl.obolibrary.org/obo/NCIT_C12894 The portion of the spinal cord located in the thoracic region. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12894 Thoracic Spinal Cord http://purl.obolibrary.org/obo/NCIT_C129644 https://uts.nlm.nih.gov/uts/umls/concept/C0700502 http://purl.obolibrary.org/obo/NCIT_C129644 Hypothyroidism, the cause of which is not present at birth. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C129644 Acquired Hypothyroidism http://purl.obolibrary.org/obo/NCIT_C129644 http://purl.obolibrary.org/obo/NCIT_C26800 http://purl.obolibrary.org/obo/NCIT_C129933 UMLS:C0154682 http://purl.obolibrary.org/obo/NCIT_C129933 A progressive neurodegenerative disorder affecting upper motor neurons, characterized by progressive muscle weakness. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C129933 Primary Lateral Sclerosis http://purl.obolibrary.org/obo/NCIT_C129933 http://purl.bioontology.org/ontology/SNOMEDCT/37340000 http://purl.obolibrary.org/obo/NCIT_C12998 https://uts.nlm.nih.gov/uts/umls/concept/C0037949 http://purl.obolibrary.org/obo/NCIT_C12998 A series of bones, muscles, tendons, and other tissues reaching from the base of the skull to the tailbone. The vertebral column forms the axis of the skeleton and encloses as well as protects the spinal cord and the fluid surrounding the spinal cord. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C12998 Vertebral Column http://purl.obolibrary.org/obo/NCIT_C13063 https://uts.nlm.nih.gov/uts/umls/concept/C0027530 http://purl.obolibrary.org/obo/NCIT_C13063 The region that connects the head to the rest of the body. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C13063 Neck http://purl.obolibrary.org/obo/NCIT_C142296 The space between the L4 and L5 vertebrae. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C142296 L4-L5 Intervertebral Space http://purl.obolibrary.org/obo/NCIT_C148427 UMLS:C1142169 http://purl.obolibrary.org/obo/NCIT_C148427 The reemergence of acute myeloid leukemia after a period of remission. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C148427 Recurrent Acute Myeloid Leukemia http://purl.obolibrary.org/obo/NCIT_C148427 http://purl.obolibrary.org/obo/NCIT_C3171 http://purl.obolibrary.org/obo/NCIT_C1505 https://uts.nlm.nih.gov/uts/umls/concept/C0242295 http://purl.obolibrary.org/obo/NCIT_C1505 Oral preparations containing dietary ingredient(s) intended to supplement the diet. Dietary ingredients include vitamins, minerals, herbs, amino acids, extracts and metabolites. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C1505 Dietary Supplement http://purl.obolibrary.org/obo/NCIT_C1505 Dietary supplements do not have an ATC but they belong to the GMP class 4AA2F30. http://purl.obolibrary.org/obo/NCIT_C15304 A procedure that collects plasma from the peripheral blood while returning the rest to the donor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C15304 Plasmapheresis http://purl.obolibrary.org/obo/NCIT_C15304 ImmunoactiveDrugs http://purl.obolibrary.org/obo/NCIT_C15342 UMLS:C0040732 http://purl.obolibrary.org/obo/NCIT_C15342 Transference of a tissue or organ within an individual, between individuals of the same species, or between individuals of different species. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C15342 Transplantation http://purl.obolibrary.org/obo/NCIT_C15402 UMLS:C0195324 http://purl.obolibrary.org/obo/NCIT_C15402 Surgical removal of a cone-shaped portion of tissue from the uterine cervix. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C15402 Conization http://purl.obolibrary.org/obo/NCIT_C15454 https://uts.nlm.nih.gov/uts/umls/concept/C1512343 http://purl.obolibrary.org/obo/NCIT_C15454 Any surgery involving a structure in the head and neck region. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C15454 Head and Neck Surgery http://purl.obolibrary.org/obo/NCIT_C15454 http://purl.bioontology.org/ontology/SNOMEDCT/311801003 http://purl.obolibrary.org/obo/NCIT_C155871 https://uts.nlm.nih.gov/uts/umls/concept/C0019348 http://purl.obolibrary.org/obo/NCIT_C155871 An infection that is caused by herpes simplex virus. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C155871 Herpes Simplex Virus Infection http://purl.obolibrary.org/obo/NCIT_C155871 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C156767 https://uts.nlm.nih.gov/uts/umls/concept/C0007117 http://purl.obolibrary.org/obo/NCIT_C156767 A carcinoma involving the basal cells. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C156767 Basal Cell Carcinoma http://purl.obolibrary.org/obo/NCIT_C156767 http://purl.obolibrary.org/obo/NCIT_C2916 http://purl.obolibrary.org/obo/NCIT_C157942 https://uts.nlm.nih.gov/uts/umls/concept/C4324621 http://purl.obolibrary.org/obo/NCIT_C157942 The use of opioids that results in the development of a dependency that adversely affects an individual's life. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C157942 Opioid Use Disorder http://purl.obolibrary.org/obo/NCIT_C157959 https://uts.nlm.nih.gov/uts/umls/concept/C0155862 http://purl.obolibrary.org/obo/NCIT_C157959 Pneumonia that is attributed to the bacteria Streptococcus pneumonia. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C157959 Pneumococcal Pneumonia http://purl.obolibrary.org/obo/NCIT_C157959 http://purl.obolibrary.org/obo/NCIT_C3333 http://purl.obolibrary.org/obo/NCIT_C171133 https://uts.nlm.nih.gov/uts/umls/concept/C5203670 http://purl.obolibrary.org/obo/NCIT_C171133 An acute infection of the respiratory tract that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on currently available information, SARS-CoV-2 is thought to mainly spread from person to person through respiratory droplets. Typically, there is a two- to 14-day incubation period and infected persons can present with no symptoms or mild to severe fever, dry cough, fatigue, and difficulty breathing. Dysgeusia, anosmia, and gastrointestinal and flu-like symptoms have also been reported. Older adults and persons of any age who have serious underlying medical conditions may be of higher risk for severe illness, including secondary infections, respiratory failure, and multi-organ dysfunction. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C171133 COVID-19 Infection http://purl.obolibrary.org/obo/NCIT_C171133 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C171204 https://uts.nlm.nih.gov/uts/umls/concept/C0039980 http://purl.obolibrary.org/obo/NCIT_C171204 Trauma to the chest. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C171204 Thoracic Trauma http://purl.obolibrary.org/obo/NCIT_C171204 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C171457 https://uts.nlm.nih.gov/uts/umls/concept/C2349740 http://purl.obolibrary.org/obo/NCIT_C171457 A type of mechanical ventilation procedure that uses a non-invasive means, such as a face mask or nasal mask, to deliver oxygenated air into the lungs. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C171457 Non-Invasive Mechanical Ventilation (NIV) http://purl.obolibrary.org/obo/NCIT_C180747 UMLS:C3805092 http://purl.obolibrary.org/obo/NCIT_C180747 A change in the nucleotide sequence of the MTHFR gene. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C180747 MTHFR Gene Mutation http://purl.obolibrary.org/obo/NCIT_C185645 https://uts.nlm.nih.gov/uts/umls/concept/C0235378 http://purl.obolibrary.org/obo/NCIT_C185645 Toxicity that impairs or damages the liver. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C185645 Hepatic Toxicity http://purl.obolibrary.org/obo/NCIT_C185645 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C19811 https://uts.nlm.nih.gov/uts/umls/concept/C1519210 http://purl.obolibrary.org/obo/NCIT_C19811 Any relative who is two meioses away from a particular individual in a family; a relative with whom one quarter of an individual's genes is shared (i.e., grandparent, grandchild, uncle, aunt, nephew, niece, half-sibling) (from Genetics Home Reference glossary) [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C19811 Second Degree Relative http://purl.obolibrary.org/obo/NCIT_C21009 UMLS:C0206078 http://purl.obolibrary.org/obo/NCIT_C21009 Surgical excision of an intervertebral disc. Often performed for pain relief. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C21009 Discectomy http://purl.obolibrary.org/obo/NCIT_C21481 https://uts.nlm.nih.gov/uts/umls/concept/C1517194 http://purl.obolibrary.org/obo/NCIT_C21481 Any relative who is one meiosis away from a particular individual in a family; a relative with whom one half of an individual's genes is shared (i.e., parent, sibling, offspring) (from Genetics Home Reference glossary) [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C21481 First Degree Relative http://purl.obolibrary.org/obo/NCIT_C24845 https://uts.nlm.nih.gov/uts/umls/concept/C1336579 http://purl.obolibrary.org/obo/NCIT_C24845 This gene plays a role in the immune response and signal transduction. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C24845 TBK1 Gene http://purl.obolibrary.org/obo/NCIT_C25165 UMLS:C0337552 http://purl.obolibrary.org/obo/NCIT_C25165 A female human offspring. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C25165 Daughter http://purl.obolibrary.org/obo/NCIT_C25165 http://purl.obolibrary.org/obo/NCIT_C21481 http://purl.obolibrary.org/obo/NCIT_C25174 UMLS:C0015671 http://purl.obolibrary.org/obo/NCIT_C25174 A male parent. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C25174 Father http://purl.obolibrary.org/obo/NCIT_C25174 http://purl.obolibrary.org/obo/NCIT_C21481 http://purl.obolibrary.org/obo/NCIT_C25189 UMLS:C0026591 http://purl.obolibrary.org/obo/NCIT_C25189 A female parent. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C25189 Mother http://purl.obolibrary.org/obo/NCIT_C25189 http://purl.obolibrary.org/obo/NCIT_C21481 http://purl.obolibrary.org/obo/NCIT_C25205 https://uts.nlm.nih.gov/uts/umls/concept/C0037683 http://purl.obolibrary.org/obo/NCIT_C25205 A male human offspring. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C25205 Son http://purl.obolibrary.org/obo/NCIT_C25205 http://purl.obolibrary.org/obo/NCIT_C21481 http://purl.obolibrary.org/obo/NCIT_C264 Medicine to stop, prevent, or control seizures (convulsions). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C264 Anticonvulsant Agent http://purl.obolibrary.org/obo/NCIT_C264 DrugsForOtherDiseases http://purl.obolibrary.org/obo/NCIT_C26682 https://uts.nlm.nih.gov/uts/umls/concept/C0000737 http://purl.obolibrary.org/obo/NCIT_C26682 Painful sensation in the abdominal region. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26682 Abdominal Pain http://purl.obolibrary.org/obo/NCIT_C26682 http://purl.obolibrary.org/obo/NCIT_C4876 http://purl.obolibrary.org/obo/NCIT_C26704 https://uts.nlm.nih.gov/uts/umls/concept/C0004626 http://purl.obolibrary.org/obo/NCIT_C26704 Acute infection of the lung parenchyma caused by bacteria (e.g., Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila). Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26704 Bacterial Pneumonia http://purl.obolibrary.org/obo/NCIT_C26704 http://purl.obolibrary.org/obo/NCIT_C3333 http://purl.obolibrary.org/obo/NCIT_C26714 https://uts.nlm.nih.gov/uts/umls/concept/C0007570 http://purl.obolibrary.org/obo/NCIT_C26714 An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26714 Celiac Disease http://purl.obolibrary.org/obo/NCIT_C26714 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26717 https://uts.nlm.nih.gov/uts/umls/concept/C0007933 http://purl.obolibrary.org/obo/NCIT_C26717 An eyelid cyst caused by the blockage of a meibomian gland. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26717 Chalazion http://purl.obolibrary.org/obo/NCIT_C26717 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26747 https://uts.nlm.nih.gov/uts/umls/concept/C0011860 http://purl.obolibrary.org/obo/NCIT_C26747 A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26747 Type 2 Diabetes Mellitus http://purl.obolibrary.org/obo/NCIT_C26747 http://purl.obolibrary.org/obo/NCIT_C2985 http://purl.obolibrary.org/obo/NCIT_C26769 https://uts.nlm.nih.gov/uts/umls/concept/C0015469 http://purl.obolibrary.org/obo/NCIT_C26769 Partial or complete paralysis of the facial muscles of one side of a person's face. It is caused by damage to the seventh cranial nerve. It is usually temporary but it may recur. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26769 Cranial Nerve VII Palsy http://purl.obolibrary.org/obo/NCIT_C26769 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26774 https://uts.nlm.nih.gov/uts/umls/concept/C0015802 http://purl.obolibrary.org/obo/NCIT_C26774 A traumatic or pathologic injury to the femur in which the continuity of the femur is broken. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26774 Femur Fracture http://purl.obolibrary.org/obo/NCIT_C26774 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C26780 https://uts.nlm.nih.gov/uts/umls/concept/C0017152 http://purl.obolibrary.org/obo/NCIT_C26780 Inflammation of the stomach. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26780 Gastritis http://purl.obolibrary.org/obo/NCIT_C26780 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26781 UMLS:C0017168 http://purl.obolibrary.org/obo/NCIT_C26781 A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26781 Gastroesophageal Reflux Disease http://purl.obolibrary.org/obo/NCIT_C26781 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26782 https://uts.nlm.nih.gov/uts/umls/concept/C0017601 http://purl.obolibrary.org/obo/NCIT_C26782 Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26782 Glaucoma http://purl.obolibrary.org/obo/NCIT_C26782 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26800 https://uts.nlm.nih.gov/uts/umls/concept/C0020676 http://purl.obolibrary.org/obo/NCIT_C26800 Abnormally low levels of thyroid hormone. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C26800 Hypothyroidism http://purl.obolibrary.org/obo/NCIT_C26800 http://purl.obolibrary.org/obo/NCIT_C26893 http://purl.obolibrary.org/obo/NCIT_C26805 https://uts.nlm.nih.gov/uts/umls/concept/C0022568 http://purl.obolibrary.org/obo/NCIT_C26805 Inflammation of the cornea. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26805 Keratitis http://purl.obolibrary.org/obo/NCIT_C26805 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26806 https://uts.nlm.nih.gov/uts/umls/concept/C0022578 http://purl.obolibrary.org/obo/NCIT_C26806 A degenerative, structural disorder of the eye, characterized by a cone-shaped protrusion of the cornea. It may lead to visual disturbances. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26806 Keratoconus http://purl.obolibrary.org/obo/NCIT_C26806 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26815 https://uts.nlm.nih.gov/uts/umls/concept/C0023524 http://purl.obolibrary.org/obo/NCIT_C26815 A progressive demyelination within the central nervous system associated with reactivation of a latent JC virus infection. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26815 Progressive Multifocal Leukoencephalopathy http://purl.obolibrary.org/obo/NCIT_C26815 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26816 https://uts.nlm.nih.gov/uts/umls/concept/C0750394 http://purl.obolibrary.org/obo/NCIT_C26816 A laboratory test result indicating a decreased number of white blood cells in the peripheral blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26816 Leukopenia http://purl.obolibrary.org/obo/NCIT_C26816 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C26823 https://uts.nlm.nih.gov/uts/umls/concept/C0853986 http://purl.obolibrary.org/obo/NCIT_C26823 An abnormally small number of lymphocytes in the circulating blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26823 Lymphopenia http://purl.obolibrary.org/obo/NCIT_C26823 http://purl.obolibrary.org/obo/NCIT_C26816 http://purl.obolibrary.org/obo/NCIT_C26835 UMLS:C0027765 http://purl.obolibrary.org/obo/NCIT_C26835 A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26835 Nervous System Disorder http://purl.obolibrary.org/obo/NCIT_C26835 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26845 https://uts.nlm.nih.gov/uts/umls/concept/C0030567 http://purl.obolibrary.org/obo/NCIT_C26845 A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26845 Parkinson's Disease http://purl.obolibrary.org/obo/NCIT_C26845 http://purl.obolibrary.org/obo/NCIT_C79593 http://purl.obolibrary.org/obo/NCIT_C26855 UMLS:C0032026 http://purl.obolibrary.org/obo/NCIT_C26855 A mild, self-limited skin disorder that is most commonly seen in children and young adults. It is characterized by an initial large round spot on the chest, abdomen, or back, often referred to as a herald patch, that is usually followed within a week by a distinctive pattern of similar but smaller papules on the torso, arms, and legs. There may also be itching, especially when overheated. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26855 Pityriasis Rosea http://purl.obolibrary.org/obo/NCIT_C26855 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26874 https://uts.nlm.nih.gov/uts/umls/concept/C0035305 http://purl.obolibrary.org/obo/NCIT_C26874 An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26874 Retinal Detachment http://purl.obolibrary.org/obo/NCIT_C26874 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26883 https://uts.nlm.nih.gov/uts/umls/concept/C1527336 http://purl.obolibrary.org/obo/NCIT_C26883 An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26883 Sjogren Syndrome http://purl.obolibrary.org/obo/NCIT_C26883 http://purl.obolibrary.org/obo/NCIT_C2889 http://purl.obolibrary.org/obo/NCIT_C26893 https://uts.nlm.nih.gov/uts/umls/concept/C0040128 http://purl.obolibrary.org/obo/NCIT_C26893 A non-neoplastic or neoplastic disorder that affects the thyroid gland. Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, follicular adenoma, and carcinoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26893 Thyroid Gland Disorder http://purl.obolibrary.org/obo/NCIT_C26893 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26894 https://uts.nlm.nih.gov/uts/umls/concept/C0040147 http://purl.obolibrary.org/obo/NCIT_C26894 Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26894 Thyroiditis http://purl.obolibrary.org/obo/NCIT_C26894 http://purl.obolibrary.org/obo/NCIT_C26893 http://purl.obolibrary.org/obo/NCIT_C26905 UMLS:C0042018 http://purl.obolibrary.org/obo/NCIT_C26905 A concretion in the urinary tract. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26905 Urinary Stone http://purl.obolibrary.org/obo/NCIT_C26915 https://uts.nlm.nih.gov/uts/umls/concept/C0042900 http://purl.obolibrary.org/obo/NCIT_C26915 Generalized well circumscribed patches of leukoderma that are generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C26915 Vitiligo http://purl.obolibrary.org/obo/NCIT_C26915 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26921 https://uts.nlm.nih.gov/uts/umls/concept/C0085594 http://purl.obolibrary.org/obo/NCIT_C26921 Shivering secondary to a febrile process. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26921 Fever Chills http://purl.obolibrary.org/obo/NCIT_C26921 http://purl.obolibrary.org/obo/NCIT_C4876 http://purl.obolibrary.org/obo/NCIT_C26934 https://uts.nlm.nih.gov/uts/umls/concept/C0149523 http://purl.obolibrary.org/obo/NCIT_C26934 An acute infection of the bladder. It is usually caused by bacteria. Signs and symptoms include increased frequency of urination, pain or burning during urination, fever, cloudy or bloody urine, and suprapubic pain. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26934 Acute Cystitis http://purl.obolibrary.org/obo/NCIT_C26934 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26948 https://uts.nlm.nih.gov/uts/umls/concept/C0151905 http://purl.obolibrary.org/obo/NCIT_C26948 An increase in the level of alanine aminotransferase in the blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26948 Alanine Aminotransferase Increased http://purl.obolibrary.org/obo/NCIT_C26948 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C26952 https://uts.nlm.nih.gov/uts/umls/concept/C0152177 http://purl.obolibrary.org/obo/NCIT_C26952 A non-neoplastic or neoplastic disorder affecting the trigeminal nerve (fifth cranial nerve). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26952 Trigeminal Nerve Disorder http://purl.obolibrary.org/obo/NCIT_C26952 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C26989 https://uts.nlm.nih.gov/uts/umls/concept/C0159877 http://purl.obolibrary.org/obo/NCIT_C26989 Traumatic or pathological injury to the ankle joint in which the continuity of an ankle bone is broken. Symptoms include pain, swelling, and difficulty moving the affected leg and foot. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C26989 Ankle Fracture http://purl.obolibrary.org/obo/NCIT_C26989 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C27006 https://uts.nlm.nih.gov/uts/umls/concept/C0206061 http://purl.obolibrary.org/obo/NCIT_C27006 Inflammation of interstitial lung tissue, usually associated with infection. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27006 Interstitial Pneumonia http://purl.obolibrary.org/obo/NCIT_C27006 http://purl.obolibrary.org/obo/NCIT_C3333 http://purl.obolibrary.org/obo/NCIT_C27020 UMLS:C0236100 http://purl.obolibrary.org/obo/NCIT_C27020 A non-neoplastic or neoplastic disorder that affects the female genital system. Representative examples of non-neoplastic disorders include infection, endometriosis, and adenomyosis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27020 Female Reproductive System Disorder http://purl.obolibrary.org/obo/NCIT_C27020 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C27043 https://uts.nlm.nih.gov/uts/umls/concept/C0264490 http://purl.obolibrary.org/obo/NCIT_C27043 Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27043 Acute Respiratory Failure http://purl.obolibrary.org/obo/NCIT_C27043 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C27168 https://uts.nlm.nih.gov/uts/umls/concept/C0520679 http://purl.obolibrary.org/obo/NCIT_C27168 A disorder characterized by recurrent episodic disruptions of breathing during sleep. It is caused by the intermittent relaxation of pharyngeal muscles leading to the narrowing or complete blockage of the upper airway. This results in compensatory arousal from sleep to breathe again. An anatomically narrow airway from body habitus or enlarged pharyngeal structures may also predispose to obstruction. Clinical presentation usually includes snoring, daytime sleepiness, difficulty concentrating and fatigue. Clinical course may progress to chronic hypoxemia with cardiovascular and cerebrovascular sequelae. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27168 Obstructive Sleep Apnea Syndrome http://purl.obolibrary.org/obo/NCIT_C27168 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C27191 https://uts.nlm.nih.gov/uts/umls/concept/C0677607 http://purl.obolibrary.org/obo/NCIT_C27191 An autoimmune disorder caused by the production of autoantibodies against thyroid tissue. There is progressive destruction of the thyroid follicles leading to hypothyroidism. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27191 Hashimoto Thyroiditis http://purl.obolibrary.org/obo/NCIT_C27191 http://purl.obolibrary.org/obo/NCIT_C26894 http://purl.obolibrary.org/obo/NCIT_C27204 UMLS:C0035435 http://purl.obolibrary.org/obo/NCIT_C27204 Inflammatory and degenerative diseases of connective tissue structures, such as arthritis. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27204 Rheumatologic Disorder http://purl.obolibrary.org/obo/NCIT_C27204 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C27219 UMLS:C0877203 http://purl.obolibrary.org/obo/NCIT_C27219 A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27219 Viral Respiratory Tract Infection http://purl.obolibrary.org/obo/NCIT_C27219 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C27586 https://uts.nlm.nih.gov/uts/umls/concept/C1335000 http://purl.obolibrary.org/obo/NCIT_C27586 Any disorder other than abnormal tissue growth resulting from uncontrolled cell proliferation affecting the nervous system. http://purl.obolibrary.org/obo/NCIT_C27586 Non-Neoplastic Central Nervous System Disorder http://purl.obolibrary.org/obo/NCIT_C27586 http://purl.obolibrary.org/obo/NCIT_C26835 http://purl.obolibrary.org/obo/NCIT_C27586 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C27996 UMLS:C0027051 http://purl.obolibrary.org/obo/NCIT_C27996 Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C27996 Myocardial Infarction http://purl.obolibrary.org/obo/NCIT_C27996 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C28195 https://uts.nlm.nih.gov/uts/umls/concept/C0040038 http://purl.obolibrary.org/obo/NCIT_C28195 Occlusion of the lumen of a vessel by a thrombus that has migrated from a distal site via the blood stream. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C28195 Thromboembolism http://purl.obolibrary.org/obo/NCIT_C28195 http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C28286 UMLS:C0917801 http://purl.obolibrary.org/obo/NCIT_C28286 A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C28286 Insomnia http://purl.obolibrary.org/obo/NCIT_C28286 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C28381 https://uts.nlm.nih.gov/uts/umls/concept/C1409894 http://purl.obolibrary.org/obo/NCIT_C28381 A circular band of muscle that functions to regulate the size of an orifice in the body. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C28381 Sphincter http://purl.obolibrary.org/obo/NCIT_C28397 https://uts.nlm.nih.gov/uts/umls/concept/C0004096 http://purl.obolibrary.org/obo/NCIT_C28397 A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C28397 Asthma http://purl.obolibrary.org/obo/NCIT_C28397 http://purl.obolibrary.org/obo/NCIT_C98541 http://purl.obolibrary.org/obo/NCIT_C2851 UMLS:C0001175 http://purl.obolibrary.org/obo/NCIT_C2851 A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2851 Acquired Immunodeficiency Syndrome (AIDS) http://purl.obolibrary.org/obo/NCIT_C2851 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2852 https://uts.nlm.nih.gov/uts/umls/concept/C0001418 http://purl.obolibrary.org/obo/NCIT_C2852 A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2852 Adenocarcinoma http://purl.obolibrary.org/obo/NCIT_C2852 http://purl.obolibrary.org/obo/NCIT_C2916 http://purl.obolibrary.org/obo/NCIT_C28539 https://uts.nlm.nih.gov/uts/umls/concept/C1367578 http://purl.obolibrary.org/obo/NCIT_C28539 This gene plays a role in the transcriptional activation of androgen responsive genes. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C28539 AR Gene http://purl.obolibrary.org/obo/NCIT_C2866 https://uts.nlm.nih.gov/uts/umls/concept/C0002395 http://purl.obolibrary.org/obo/NCIT_C2866 A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2866 Alzheimer's Disease http://purl.obolibrary.org/obo/NCIT_C2866 http://purl.obolibrary.org/obo/NCIT_C4786 http://purl.obolibrary.org/obo/NCIT_C2869 https://uts.nlm.nih.gov/uts/umls/concept/C0002871 http://purl.obolibrary.org/obo/NCIT_C2869 A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2869 Anemia http://purl.obolibrary.org/obo/NCIT_C2869 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2875 Loss of appetite. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2875 https://uts.nlm.nih.gov/uts/umls/concept/C1971624 http://purl.obolibrary.org/obo/NCIT_C2875 Anorexia http://purl.obolibrary.org/obo/NCIT_C2875 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2878 https://uts.nlm.nih.gov/uts/umls/concept/C0003469 http://purl.obolibrary.org/obo/NCIT_C2878 A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2878 Anxiety Disorder http://purl.obolibrary.org/obo/NCIT_C2878 http://purl.obolibrary.org/obo/NCIT_C2893 http://purl.obolibrary.org/obo/NCIT_C2881 https://uts.nlm.nih.gov/uts/umls/concept/C0003811 http://purl.obolibrary.org/obo/NCIT_C2881 Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2881 Arrhythmia http://purl.obolibrary.org/obo/NCIT_C2881 http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C2883 https://uts.nlm.nih.gov/uts/umls/concept/C0003864 http://purl.obolibrary.org/obo/NCIT_C2883 An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2883 Arthritis http://purl.obolibrary.org/obo/NCIT_C2883 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2884 https://uts.nlm.nih.gov/uts/umls/concept/C0003873 http://purl.obolibrary.org/obo/NCIT_C2884 A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2884 Rheumatoid Arthritis http://purl.obolibrary.org/obo/NCIT_C2884 http://purl.obolibrary.org/obo/NCIT_C2883 http://purl.obolibrary.org/obo/NCIT_C2884 http://purl.obolibrary.org/obo/NCIT_C2889 http://purl.obolibrary.org/obo/NCIT_C2889 https://uts.nlm.nih.gov/uts/umls/concept/C0004364 http://purl.obolibrary.org/obo/NCIT_C2889 A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2889 Autoimmune Disease http://purl.obolibrary.org/obo/NCIT_C2889 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2893 https://uts.nlm.nih.gov/uts/umls/concept/C0004936 http://purl.obolibrary.org/obo/NCIT_C2893 A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2893 Psychiatric Disorder http://purl.obolibrary.org/obo/NCIT_C2893 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2897 UMLS:C1704272 http://purl.obolibrary.org/obo/NCIT_C2897 A non-cancerous nodular enlargement of the prostate gland. It is characterized by the presence of epithelial cell nodules, and stromal nodules containing fibrous and smooth muscle elements. It is the most common urologic disorder in men, causing blockage of urine flow. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2897 Benign Prostatic Hyperplasia http://purl.obolibrary.org/obo/NCIT_C2897 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2914 https://uts.nlm.nih.gov/uts/umls/concept/C0006852 http://purl.obolibrary.org/obo/NCIT_C2914 Infection of the vulva and vagina with a fungus of the genus CANDIDA. It is a disease associated with HIV infection. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2914 Vulvovaginal Candidiasis http://purl.obolibrary.org/obo/NCIT_C2914 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2916 https://uts.nlm.nih.gov/uts/umls/concept/C0007097 http://purl.obolibrary.org/obo/NCIT_C2916 A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2916 Carcinoma http://purl.obolibrary.org/obo/NCIT_C2916 http://purl.obolibrary.org/obo/NCIT_C9305 http://purl.obolibrary.org/obo/NCIT_C2920 https://uts.nlm.nih.gov/uts/umls/concept/C0007114 http://purl.obolibrary.org/obo/NCIT_C2920 A primary or metastatic malignant neoplasm involving the skin. Primary malignant skin neoplasms most often are carcinomas (either basal cell or squamous cell carcinomas) or melanomas. Metastatic malignant neoplasms to the skin include carcinomas and lymphomas. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2920 Malignant Skin Neoplasm http://purl.obolibrary.org/obo/NCIT_C2920 http://purl.obolibrary.org/obo/NCIT_C9305 http://purl.obolibrary.org/obo/NCIT_C2921 https://uts.nlm.nih.gov/uts/umls/concept/C0007117 http://purl.obolibrary.org/obo/NCIT_C2921 The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2921 Skin Basal Cell Carcinoma http://purl.obolibrary.org/obo/NCIT_C2921 http://purl.obolibrary.org/obo/NCIT_C156767 http://purl.obolibrary.org/obo/NCIT_C2922 https://uts.nlm.nih.gov/uts/umls/concept/C0007118 http://purl.obolibrary.org/obo/NCIT_C2922 A basal cell carcinoma which displays squamous differentiation. The neoplastic cells have more abundant cytoplasm with more marked keratinization than typical basal cell carcinomas. It usually has a more aggressive clinical course compared to typical basal cell carcinoma, and it may produce regional or widespread metastases. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2922 Skin Basosquamous Cell Carcinoma http://purl.obolibrary.org/obo/NCIT_C2922 http://purl.obolibrary.org/obo/NCIT_C2921 http://purl.obolibrary.org/obo/NCIT_C2931 https://uts.nlm.nih.gov/uts/umls/concept/C0007222 http://purl.obolibrary.org/obo/NCIT_C2931 A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2931 Cardiovascular Disorder http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2955 UMLS:C0009402 http://purl.obolibrary.org/obo/NCIT_C2955 A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2955 Colorectal Carcinoma http://purl.obolibrary.org/obo/NCIT_C2955 http://purl.obolibrary.org/obo/NCIT_C3262 http://purl.obolibrary.org/obo/NCIT_C2978 https://uts.nlm.nih.gov/uts/umls/concept/C0010709 http://purl.obolibrary.org/obo/NCIT_C2978 A sac-like closed membranous structure that may be empty or contain fluid or amorphous material. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2978 Cyst http://purl.obolibrary.org/obo/NCIT_C2978 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C2982 https://uts.nlm.nih.gov/uts/umls/concept/C0011570 http://purl.obolibrary.org/obo/NCIT_C2982 A melancholy feeling of sadness and despair. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2982 Depression http://purl.obolibrary.org/obo/NCIT_C2982 http://purl.obolibrary.org/obo/NCIT_C92200 http://purl.obolibrary.org/obo/NCIT_C2985 https://uts.nlm.nih.gov/uts/umls/concept/C0011849 http://purl.obolibrary.org/obo/NCIT_C2985 A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2985 Diabetes Mellitus http://purl.obolibrary.org/obo/NCIT_C2985 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2986 https://uts.nlm.nih.gov/uts/umls/concept/C0011854 http://purl.obolibrary.org/obo/NCIT_C2986 A chronic condition characterized by minimal or absent production of insulin by the pancreas. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C2986 Type 1 Diabtes Mellitus http://purl.obolibrary.org/obo/NCIT_C2986 http://purl.obolibrary.org/obo/NCIT_C2889 http://purl.obolibrary.org/obo/NCIT_C2986 http://purl.obolibrary.org/obo/NCIT_C2985 http://purl.obolibrary.org/obo/NCIT_C29888 https://uts.nlm.nih.gov/uts/umls/concept/C0026780 http://purl.obolibrary.org/obo/NCIT_C29888 A contagious viral infection caused by the mumps virus. Symptoms include swollen and tender parotid glands, fever, muscle aches and fatigue. Due to vaccination programs, mumps has become a rare disease. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C29888 Mumps http://purl.obolibrary.org/obo/NCIT_C29888 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C2991 https://uts.nlm.nih.gov/uts/umls/concept/C0012634 http://purl.obolibrary.org/obo/NCIT_C2991 Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C2991 Disease or Disorder http://purl.obolibrary.org/obo/NCIT_C3001 https://uts.nlm.nih.gov/uts/umls/concept/C0013595 http://purl.obolibrary.org/obo/NCIT_C3001 A form of dermatitis characterized by red, itchy, scaly, or crusty patches that can be chronic or intermittent. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C3001 Eczema http://purl.obolibrary.org/obo/NCIT_C3001 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3014 https://uts.nlm.nih.gov/uts/umls/concept/C0014175 http://purl.obolibrary.org/obo/NCIT_C3014 The growth of functional endometrial tissue in anatomic sites outside the uterine body. It most often occurs in the pelvic organs. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3014 Endometriosis http://purl.obolibrary.org/obo/NCIT_C3014 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3020 https://uts.nlm.nih.gov/uts/umls/concept/C0014544 http://purl.obolibrary.org/obo/NCIT_C3020 A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3020 Seizure Disorder http://purl.obolibrary.org/obo/NCIT_C3020 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3021 https://uts.nlm.nih.gov/uts/umls/concept/C0014548 http://purl.obolibrary.org/obo/NCIT_C3021 A chronic condition characterised by recurrent generalised seizures. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3021 Generalized Epilepsy http://purl.obolibrary.org/obo/NCIT_C3021 http://purl.obolibrary.org/obo/NCIT_C3020 http://purl.obolibrary.org/obo/NCIT_C3041 https://uts.nlm.nih.gov/uts/umls/concept/C0016045 http://purl.obolibrary.org/obo/NCIT_C3041 A non-metastasizing neoplasm arising from the fibrous tissue. It is characterized by the presence of spindle-shaped fibroblasts. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3041 Fibroma http://purl.obolibrary.org/obo/NCIT_C3041 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3079 UMLS:C0018799 http://purl.obolibrary.org/obo/NCIT_C3079 A non-neoplastic or neoplastic disorder that affects the heart and/or the pericardium. Representative examples include endocarditis, pericarditis, atrial myxoma, cardiac myeloid sarcoma, and pericardial malignant mesothelioma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3079 Heart Disorder http://purl.obolibrary.org/obo/NCIT_C3079 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3086 https://uts.nlm.nih.gov/uts/umls/concept/C0018920 http://purl.obolibrary.org/obo/NCIT_C3086 A hemangioma characterized by the presence of cavernous vascular spaces. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3086 Cavernous Hemangioma http://purl.obolibrary.org/obo/NCIT_C3086 http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C3095 https://uts.nlm.nih.gov/uts/umls/concept/C0019158 http://purl.obolibrary.org/obo/NCIT_C3095 Inflammation of the liver; usually from a viral infection, but sometimes from toxic agents. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3095 Hepatitis http://purl.obolibrary.org/obo/NCIT_C3095 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3096 https://uts.nlm.nih.gov/uts/umls/concept/C0019159 http://purl.obolibrary.org/obo/NCIT_C3096 Acute inflammation of the liver caused by the hepatitis A virus. It is highly contagious and usually contracted through close contact with an infected individual or their feces, contaminated food or water. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3096 Hepatitis A Infection http://purl.obolibrary.org/obo/NCIT_C3096 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3098 UMLS:C0019196 http://purl.obolibrary.org/obo/NCIT_C3098 A viral infection caused by the hepatitis C virus. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3098 Hepatitis C Infection http://purl.obolibrary.org/obo/NCIT_C3098 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3107 https://uts.nlm.nih.gov/uts/umls/concept/C0019621 http://purl.obolibrary.org/obo/NCIT_C3107 A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (WHO, 2001) [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3107 Langerhans Cell Histiocytosis http://purl.obolibrary.org/obo/NCIT_C3107 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3114 https://uts.nlm.nih.gov/uts/umls/concept/C0020517 http://purl.obolibrary.org/obo/NCIT_C3114 An immune response that occurs following exposure to an innocuous antigen, but that does not require the presence of preformed antibodies to the antigen. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3114 Hypersensitivity http://purl.obolibrary.org/obo/NCIT_C3114 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3117 https://uts.nlm.nih.gov/uts/umls/concept/C0020538 http://purl.obolibrary.org/obo/NCIT_C3117 Blood pressure that is abnormally high. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3117 Hypertension http://purl.obolibrary.org/obo/NCIT_C3117 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C3122 https://uts.nlm.nih.gov/uts/umls/concept/C0020546 http://purl.obolibrary.org/obo/NCIT_C3122 A severe, acute increase in blood pressure that may result in stroke or myocardial ischemia. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3122 Hypertensive Crisis http://purl.obolibrary.org/obo/NCIT_C3122 http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C3123 https://uts.nlm.nih.gov/uts/umls/concept/C0020550 http://purl.obolibrary.org/obo/NCIT_C3123 Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3123 Hyperthyroidism http://purl.obolibrary.org/obo/NCIT_C3123 http://purl.obolibrary.org/obo/NCIT_C26893 http://purl.obolibrary.org/obo/NCIT_C3124 UMLS:C0020564 http://purl.obolibrary.org/obo/NCIT_C3124 Abnormal enlargement of a body part or organ. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3124 Hypertrophy http://purl.obolibrary.org/obo/NCIT_C3124 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3134 https://uts.nlm.nih.gov/uts/umls/concept/C0014511 http://purl.obolibrary.org/obo/NCIT_C3134 The most common type of cutaneous cyst. It results from the proliferation of epidermal cells in a circumscribed space within the dermis. It is usually asymptomatic and presents as a firm, round nodule. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3134 Epidermal Inclusion Cyst http://purl.obolibrary.org/obo/NCIT_C3134 http://purl.obolibrary.org/obo/NCIT_C2978 http://purl.obolibrary.org/obo/NCIT_C3171 UMLS:C0023467 http://purl.obolibrary.org/obo/NCIT_C3171 A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3171 Acute Myeloid Leukemia http://purl.obolibrary.org/obo/NCIT_C3171 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3199 UMLS:C0024117 http://purl.obolibrary.org/obo/NCIT_C3199 A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3199 Chronic Obstructive Pulmonary Disease http://purl.obolibrary.org/obo/NCIT_C3199 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3211 UMLS:C0024305 http://purl.obolibrary.org/obo/NCIT_C3211 Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3211 Non-Hodgkin Lymphoma http://purl.obolibrary.org/obo/NCIT_C3211 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3243 https://uts.nlm.nih.gov/uts/umls/concept/C0026769 http://purl.obolibrary.org/obo/NCIT_C3243 A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3243 Multiple Sclerosis http://purl.obolibrary.org/obo/NCIT_C3243 http://purl.obolibrary.org/obo/NCIT_C27586 http://purl.obolibrary.org/obo/NCIT_C3243 http://purl.obolibrary.org/obo/NCIT_C99383 http://purl.obolibrary.org/obo/NCIT_C3245 https://uts.nlm.nih.gov/uts/umls/concept/C0026946 http://purl.obolibrary.org/obo/NCIT_C3245 An infection caused by a fungus. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3245 Fungal Infection http://purl.obolibrary.org/obo/NCIT_C3245 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3262 https://uts.nlm.nih.gov/uts/umls/concept/C0375111 http://purl.obolibrary.org/obo/NCIT_C3262 A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3262 Neoplasm http://purl.obolibrary.org/obo/NCIT_C3262 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3283 https://uts.nlm.nih.gov/uts/umls/concept/C0028754 http://purl.obolibrary.org/obo/NCIT_C3283 Having a high amount of body fat (body mass index [BMI] of 30 or more). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3283 Obesity http://purl.obolibrary.org/obo/NCIT_C3283 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C3298 https://uts.nlm.nih.gov/uts/umls/concept/C0029456 http://purl.obolibrary.org/obo/NCIT_C3298 A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3298 Osteoporosis http://purl.obolibrary.org/obo/NCIT_C3298 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3329 https://uts.nlm.nih.gov/uts/umls/concept/C0032000 http://purl.obolibrary.org/obo/NCIT_C3329 A well-differentiated neuroendocrine neoplasm that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. It has a low frequency of metastatic spread. When metastatic, the term metastatic pituitary neuroendocrine tumor is endorsed instead of pituitary carcinoma. (WHO) [Definition Source: NCI] It has exact synonim: Pituitary Gland Adenoma. http://purl.obolibrary.org/obo/NCIT_C3329 Pituitary Neuroendocrine Tumor http://purl.obolibrary.org/obo/NCIT_C3329 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3331 https://uts.nlm.nih.gov/uts/umls/concept/C0032227 http://purl.obolibrary.org/obo/NCIT_C3331 Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3331 Pleural Effusion http://purl.obolibrary.org/obo/NCIT_C3331 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C3333 https://uts.nlm.nih.gov/uts/umls/concept/C0032285 http://purl.obolibrary.org/obo/NCIT_C3333 An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, due to infections (viruses, fungi, mycoplasma, or bacteria), treatment (e.g. radiation), or exposure (inhalation) to chemicals. Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3333 Pneumonia http://purl.obolibrary.org/obo/NCIT_C3333 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3346 https://uts.nlm.nih.gov/uts/umls/concept/C0033860 http://purl.obolibrary.org/obo/NCIT_C3346 An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C3346 Psoriasis http://purl.obolibrary.org/obo/NCIT_C3346 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3364 UMLS:C0036690 http://purl.obolibrary.org/obo/NCIT_C3364 The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3364 Septicemia http://purl.obolibrary.org/obo/NCIT_C3364 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3367 https://uts.nlm.nih.gov/uts/umls/concept/C1285578 http://purl.obolibrary.org/obo/NCIT_C3367 Clinical, laboratory or molecular evidence, or absence of evidence of disease. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3367 Finding http://purl.obolibrary.org/obo/NCIT_C3390 https://uts.nlm.nih.gov/uts/umls/concept/C0038454 http://purl.obolibrary.org/obo/NCIT_C3390 A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3390 Stroke http://purl.obolibrary.org/obo/NCIT_C3390 http://purl.obolibrary.org/obo/NCIT_C27586 http://purl.obolibrary.org/obo/NCIT_C3408 https://uts.nlm.nih.gov/uts/umls/concept/C0392386 http://purl.obolibrary.org/obo/NCIT_C3408 A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3408 Thrombocytopenia http://purl.obolibrary.org/obo/NCIT_C3408 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C3418 https://uts.nlm.nih.gov/uts/umls/concept/C0040558 http://purl.obolibrary.org/obo/NCIT_C3418 A parasitic disease contracted by the ingestion or fetal transmission of toxoplasma gondii. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3418 Toxoplasmosis http://purl.obolibrary.org/obo/NCIT_C3418 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3432 UMLS:C0042109 http://purl.obolibrary.org/obo/NCIT_C3432 A transient, itchy skin eruption characterized by wheals with pale interiors and red margins. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3432 Urticaria http://purl.obolibrary.org/obo/NCIT_C3432 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3434 https://uts.nlm.nih.gov/uts/umls/concept/C0042133 http://purl.obolibrary.org/obo/NCIT_C3434 A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3434 Uterine Corpus Leiomyoma http://purl.obolibrary.org/obo/NCIT_C3434 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34360 https://uts.nlm.nih.gov/uts/umls/concept/C0001627 http://purl.obolibrary.org/obo/NCIT_C34360 A genetic disorder characterized by defects in the synthesis of cortisol and/or aldosterone, resulting in hyperplasia of the adrenal cortical cells. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34360 Congenital Adrenal Hyperplasia http://purl.obolibrary.org/obo/NCIT_C34360 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34373 https://uts.nlm.nih.gov/uts/umls/concept/C0002736 http://purl.obolibrary.org/obo/NCIT_C34373 A neurodegenerative disorder characterized by progressive degeneration of the motor neurons of the central nervous system. It results in weakness and atrophy of the muscles which leads to an inability to initiate and control voluntary movements. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34373 Amyotrophic Lateral Sclerosis http://purl.obolibrary.org/obo/NCIT_C34373 http://purl.bioontology.org/ontology/SNOMEDCT/37340000 http://purl.obolibrary.org/obo/NCIT_C34373 http://purl.obolibrary.org/obo/NCIT_C4802 http://purl.obolibrary.org/obo/NCIT_C34379 https://uts.nlm.nih.gov/uts/umls/concept/C0002881 http://purl.obolibrary.org/obo/NCIT_C34379 A congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34379 Hereditary Hemolytic Anemia http://purl.obolibrary.org/obo/NCIT_C34379 http://purl.obolibrary.org/obo/NCIT_C2869 http://purl.obolibrary.org/obo/NCIT_C34423 https://uts.nlm.nih.gov/uts/umls/concept/C0005586 http://purl.obolibrary.org/obo/NCIT_C34423 A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34423 Bipolar Disorder http://purl.obolibrary.org/obo/NCIT_C34423 http://purl.obolibrary.org/obo/NCIT_C92200 http://purl.obolibrary.org/obo/NCIT_C34486 https://uts.nlm.nih.gov/uts/umls/concept/C0434579 http://purl.obolibrary.org/obo/NCIT_C34486 A closed dislocation of the shoulder [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34486 Closed Dislocation of Shoulder http://purl.obolibrary.org/obo/NCIT_C34486 http://purl.obolibrary.org/obo/NCIT_C35020 http://purl.obolibrary.org/obo/NCIT_C34499 https://uts.nlm.nih.gov/uts/umls/concept/C0009438 http://purl.obolibrary.org/obo/NCIT_C34499 The presence of one or more stones in the common bile duct. They are composed either of cholesterol or, less commonly, calcium salts and bilirubin. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34499 Common Bile Duct Stone http://purl.obolibrary.org/obo/NCIT_C3457 UMLS:C0079731 http://purl.obolibrary.org/obo/NCIT_C3457 The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3457 B-Cell Non-Hodgkin Lymphoma http://purl.obolibrary.org/obo/NCIT_C3457 http://purl.obolibrary.org/obo/NCIT_C3211 http://purl.obolibrary.org/obo/NCIT_C34607 https://uts.nlm.nih.gov/uts/umls/concept/C0015702 http://purl.obolibrary.org/obo/NCIT_C34607 A condition associated with glucose-6-phosphate dehydrogenase deficiency, which is characterized by hemolysis. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34607 Favism http://purl.obolibrary.org/obo/NCIT_C34607 http://purl.obolibrary.org/obo/NCIT_C2869 http://purl.obolibrary.org/obo/NCIT_C34632 https://uts.nlm.nih.gov/uts/umls/concept/C0017160 http://purl.obolibrary.org/obo/NCIT_C34632 An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34632 Gastroenteritits http://purl.obolibrary.org/obo/NCIT_C34632 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34660 https://uts.nlm.nih.gov/uts/umls/concept/C0018674 http://purl.obolibrary.org/obo/NCIT_C34660 A traumatic injury to the head. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34660 Head Trauma http://purl.obolibrary.org/obo/NCIT_C34660 http://purl.obolibrary.org/obo/NCIT_C36282 http://purl.obolibrary.org/obo/NCIT_C34661 https://uts.nlm.nih.gov/uts/umls/concept/C0018681 http://purl.obolibrary.org/obo/NCIT_C34661 Pain in various parts of the head, not confined to the area of distribution of any nerve. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34661 Headache http://purl.obolibrary.org/obo/NCIT_C34661 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C34685 https://uts.nlm.nih.gov/uts/umls/concept/C0019270 http://purl.obolibrary.org/obo/NCIT_C34685 The protrusion of part of an organ or fibroadipose tissue through an abnormal opening. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34685 Hernia http://purl.obolibrary.org/obo/NCIT_C34685 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3469 https://uts.nlm.nih.gov/uts/umls/concept/C0013312 http://purl.obolibrary.org/obo/NCIT_C3469 A superficial fibromatosis arising from the soft tissue of the palm. It is characterized by the presence of spindle-shaped fibroblasts, and an infiltrative growth pattern. It predominantly affects adult males. [Definition Source: NCI] It has exact synonim: Dupuytren Contracture; Palmar Fibromatosis; Dupuytren's Contracture. http://purl.obolibrary.org/obo/NCIT_C3469 Palmar Fibromatosis http://purl.obolibrary.org/obo/NCIT_C3469 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34690 https://uts.nlm.nih.gov/uts/umls/concept/C0019294 http://purl.obolibrary.org/obo/NCIT_C34690 The protrusion of a sac-like structure containing fibroadipose tissue through an abnormal opening in the inguinal region. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34690 Inguinal Hernia http://purl.obolibrary.org/obo/NCIT_C34690 http://purl.obolibrary.org/obo/NCIT_C34685 http://purl.obolibrary.org/obo/NCIT_C34695 https://uts.nlm.nih.gov/uts/umls/concept/C0019345 http://purl.obolibrary.org/obo/NCIT_C34695 A lesion caused by type 1 or type 2 herpes simplex virus, involving the oralfacial region. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34695 Cold Sore http://purl.obolibrary.org/obo/NCIT_C34695 http://purl.obolibrary.org/obo/NCIT_C155871 http://purl.obolibrary.org/obo/NCIT_C34726 https://uts.nlm.nih.gov/uts/umls/concept/C0021345 http://purl.obolibrary.org/obo/NCIT_C34726 A clinical syndrome of fever, sore throat, fatigue, and lymphadenopathy caused by infection with the Epstein-Barr virus. Subsequent physical findings may include hepatomegaly, palatal petechiae, jaundice, uvular edema, and splenomegaly. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34726 Infectious Mononucleosis http://purl.obolibrary.org/obo/NCIT_C34726 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34733 https://uts.nlm.nih.gov/uts/umls/concept/C0021847 http://purl.obolibrary.org/obo/NCIT_C34733 Ileus of the intestine in which there is no mechanical obstruction. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34733 Intestinal Pseudo-Obstruction http://purl.obolibrary.org/obo/NCIT_C34733 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34736 https://uts.nlm.nih.gov/uts/umls/concept/C0022073 http://purl.obolibrary.org/obo/NCIT_C34736 Inflammation of the iris and the ciliary body. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34736 Iridocyclitis http://purl.obolibrary.org/obo/NCIT_C34736 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34753 UMLS:C0022744 http://purl.obolibrary.org/obo/NCIT_C34753 Trauma to the knee. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34753 Knee Injury http://purl.obolibrary.org/obo/NCIT_C34753 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C3478 https://uts.nlm.nih.gov/uts/umls/concept/C0085580 http://purl.obolibrary.org/obo/NCIT_C3478 Hypertension that presents without an identifiable cause. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3478 Essential Hypertension http://purl.obolibrary.org/obo/NCIT_C3478 http://purl.obolibrary.org/obo/NCIT_C3117 http://purl.obolibrary.org/obo/NCIT_C34786 https://uts.nlm.nih.gov/uts/umls/concept/C0023976 http://purl.obolibrary.org/obo/NCIT_C34786 A ventricular arrhythmia characterized by a long QT interval, and accompanied by syncopal episodes sometimes leading to sudden death due to paroxysmal ventricular arrhythmia. This arrhythmia is associated with a prolongation of repolarization following depolarization of the cardiac ventricles. The prolongation of the Q-T interval combined with torsades de pointes manifests as several different forms; some may be acquired or congenital; some may lead to serious arrhythmia and sudden cardiac death. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34786 Long QT Syndrome http://purl.obolibrary.org/obo/NCIT_C34786 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34876 UMLS:C0029410 http://purl.obolibrary.org/obo/NCIT_C34876 Osteoarthritis of the hip joint. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34876 Hip Osteoarthritis http://purl.obolibrary.org/obo/NCIT_C34876 http://purl.obolibrary.org/obo/NCIT_C2883 http://purl.obolibrary.org/obo/NCIT_C34889 https://uts.nlm.nih.gov/uts/umls/concept/C0030312 http://purl.obolibrary.org/obo/NCIT_C34889 A finding of low numbers of red and white blood cells and platelets in the peripheral blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34889 Pancytopenia http://purl.obolibrary.org/obo/NCIT_C34889 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C34890 UMLS:C0030319 http://purl.obolibrary.org/obo/NCIT_C34890 An anxiety disorder characterized by multiple unexpected panic attacks with persistent concern of recurring attacks. Panic disorder may or may not be accompanied by agoraphobia. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34890 Panic Disorder http://purl.obolibrary.org/obo/NCIT_C34890 http://purl.obolibrary.org/obo/NCIT_C2878 http://purl.obolibrary.org/obo/NCIT_C34911 https://uts.nlm.nih.gov/uts/umls/concept/C0030824 http://purl.obolibrary.org/obo/NCIT_C34911 An allergy to Penicillin. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34911 Penicillin Allergy http://purl.obolibrary.org/obo/NCIT_C34911 http://purl.obolibrary.org/obo/NCIT_C112208 http://purl.obolibrary.org/obo/NCIT_C34922 https://uts.nlm.nih.gov/uts/umls/concept/C0031212 http://purl.obolibrary.org/obo/NCIT_C34922 A diverse category of psychiatric disorders characterized by behavior that deviates markedly from the expectations of the individual's culture; this pattern of deviation is pervasive and inflexible and is stable over time. The behavioral pattern negatively interferes with relationships and work. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34922 Personality Disorder http://purl.obolibrary.org/obo/NCIT_C34922 http://purl.obolibrary.org/obo/NCIT_C2893 http://purl.obolibrary.org/obo/NCIT_C34932 https://uts.nlm.nih.gov/uts/umls/concept/C1761609 http://purl.obolibrary.org/obo/NCIT_C34932 Inflammation of the lungs due to the inhalation of solid or liquid material. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34932 Aspiration Pneumonitis http://purl.obolibrary.org/obo/NCIT_C34932 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34935 https://uts.nlm.nih.gov/uts/umls/concept/C0032650 http://purl.obolibrary.org/obo/NCIT_C34935 Swelling and protrusion of the gastrocnemius-semimembranosus bursa due to an accumulation of synovial fluid. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34935 Baker Cyst http://purl.obolibrary.org/obo/NCIT_C34935 http://purl.obolibrary.org/obo/NCIT_C2978 http://purl.obolibrary.org/obo/NCIT_C34995 https://uts.nlm.nih.gov/uts/umls/concept/C0036202 http://purl.obolibrary.org/obo/NCIT_C34995 An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin. Cardiac involvement is also possible. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34995 Sarcoidosis http://purl.obolibrary.org/obo/NCIT_C34995 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C34997 https://uts.nlm.nih.gov/uts/umls/concept/C0036205 http://purl.obolibrary.org/obo/NCIT_C34997 Sarcoidosis affecting the lung parenchyma. It is characterized by the presence of non-necrotizing granulomas in the lung tissues. It is manifested with dyspnea, cough, fever, night sweats, fatigue, and weight loss. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C34997 Pulmonary Sarcoidosis http://purl.obolibrary.org/obo/NCIT_C34997 http://purl.obolibrary.org/obo/NCIT_C34995 http://purl.obolibrary.org/obo/NCIT_C34997 http://purl.obolibrary.org/obo/NCIT_C98541 http://purl.obolibrary.org/obo/NCIT_C35020 https://uts.nlm.nih.gov/uts/umls/concept/C0037005 http://purl.obolibrary.org/obo/NCIT_C35020 A dislocation of the shoulder joint. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35020 Shoulder Dislocation http://purl.obolibrary.org/obo/NCIT_C35020 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C35024 https://uts.nlm.nih.gov/uts/umls/concept/C0037199 http://purl.obolibrary.org/obo/NCIT_C35024 An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35024 Sinusitis http://purl.obolibrary.org/obo/NCIT_C35024 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C35038 https://uts.nlm.nih.gov/uts/umls/concept/C0038160 http://purl.obolibrary.org/obo/NCIT_C35038 Infection by Staphylococcus. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35038 Staphylococcal Infection http://purl.obolibrary.org/obo/NCIT_C35038 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C35053 https://uts.nlm.nih.gov/uts/umls/concept/C0039070 http://purl.obolibrary.org/obo/NCIT_C35053 A spontaneous loss of consciousness caused by insufficient blood supply to the brain. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35053 Syncope http://purl.obolibrary.org/obo/NCIT_C35053 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C35069 https://uts.nlm.nih.gov/uts/umls/concept/C0039730 http://purl.obolibrary.org/obo/NCIT_C35069 An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35069 Thalassemia http://purl.obolibrary.org/obo/NCIT_C35069 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C3510 https://uts.nlm.nih.gov/uts/umls/concept/C0151779 http://purl.obolibrary.org/obo/NCIT_C3510 A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3510 Cutaneous Melanoma http://purl.obolibrary.org/obo/NCIT_C3510 http://purl.obolibrary.org/obo/NCIT_C2920 http://purl.obolibrary.org/obo/NCIT_C35131 https://uts.nlm.nih.gov/uts/umls/concept/C0042998 http://purl.obolibrary.org/obo/NCIT_C35131 An inflammatory pathologic process that affects the vulva and the vagina. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35131 Vulvovaginitis http://purl.obolibrary.org/obo/NCIT_C35131 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C35204 https://uts.nlm.nih.gov/uts/umls/concept/C0155626 http://purl.obolibrary.org/obo/NCIT_C35204 Necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35204 Acute Myocardial Infarction http://purl.obolibrary.org/obo/NCIT_C35204 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C35350 https://uts.nlm.nih.gov/uts/umls/concept/C0435750 http://purl.obolibrary.org/obo/NCIT_C35350 A traumatic break in one of the bones in the rib cage that does not involve a break in the adjacent skin. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35350 Closed Fracture of Rib http://purl.obolibrary.org/obo/NCIT_C35350 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C35475 https://uts.nlm.nih.gov/uts/umls/concept/C0518988 http://purl.obolibrary.org/obo/NCIT_C35475 An infectious process that affects a tooth. It is characterized by localized periapical or periodontal collection of pus. It presents with pain and swelling of the gums and/or cheek. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35475 Tooth Abscess http://purl.obolibrary.org/obo/NCIT_C35475 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C35548 https://uts.nlm.nih.gov/uts/umls/concept/C1136085 http://purl.obolibrary.org/obo/NCIT_C35548 An abnormal laboratory test result indicating the presence of monoclonal immunoglobulins in the blood or urine. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C35548 Monoclonal Gammopathy http://purl.obolibrary.org/obo/NCIT_C35548 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C36282 https://uts.nlm.nih.gov/uts/umls/concept/C0575141 http://purl.obolibrary.org/obo/NCIT_C36282 Symptoms, physical examination results, and/or laboratory test results related to the head and neck. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C36282 Head and Neck Finding http://purl.obolibrary.org/obo/NCIT_C36282 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C3671 https://uts.nlm.nih.gov/uts/umls/concept/C3263723 http://purl.obolibrary.org/obo/NCIT_C3671 Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3671 Injury http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C37920 https://uts.nlm.nih.gov/uts/umls/concept/C0428977 http://purl.obolibrary.org/obo/NCIT_C37920 An abnormally slow heart rate. Thresholds for different age, gender, and patient populations exist. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C37920 Bradycardia http://purl.obolibrary.org/obo/NCIT_C37920 http://purl.obolibrary.org/obo/NCIT_C2881 http://purl.obolibrary.org/obo/NCIT_C37967 https://uts.nlm.nih.gov/uts/umls/concept/C1522133 http://purl.obolibrary.org/obo/NCIT_C37967 A laboratory test result indicating an increased amount of cholesterol in the blood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C37967 Hypercholesterolemia http://purl.obolibrary.org/obo/NCIT_C37967 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C38012 https://uts.nlm.nih.gov/uts/umls/concept/C0033687 http://purl.obolibrary.org/obo/NCIT_C38012 The presence of abnormal amounts of protein in the urine. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C38012 Proteinuria http://purl.obolibrary.org/obo/NCIT_C38012 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C38057 https://uts.nlm.nih.gov/uts/umls/concept/C0042571 http://purl.obolibrary.org/obo/NCIT_C38057 A feeling of movement, a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo). Vertigo is medically distinct from dizziness, lightheadedness, and unsteadiness. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C38057 Vertigo http://purl.obolibrary.org/obo/NCIT_C38057 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C3852 UMLS:C0236075 http://purl.obolibrary.org/obo/NCIT_C3852 Any of the mental or physical manifestations that accompany perimenopause and menopause. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3852 Menopausal Symptom http://purl.obolibrary.org/obo/NCIT_C3852 http://purl.obolibrary.org/obo/NCIT_C4876 http://purl.obolibrary.org/obo/NCIT_C3884 https://uts.nlm.nih.gov/uts/umls/concept/C0241060 http://purl.obolibrary.org/obo/NCIT_C3884 A cystic lesion located in the skin. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C3884 Skin Cyst http://purl.obolibrary.org/obo/NCIT_C3884 http://purl.obolibrary.org/obo/NCIT_C2978 http://purl.obolibrary.org/obo/NCIT_C4017 UMLS:C1527349 http://purl.obolibrary.org/obo/NCIT_C4017 A breast carcinoma arising from the ducts. While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast. Ductal carcinomas account for about two thirds of all breast cancers. Two types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) and invasive breast carcinoma of no special type. The latter often spreads to the axillary lymph nodes and other anatomic sites. The two forms of ductal carcinoma often coexist. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4017 Breast Ductal Carcinoma http://purl.obolibrary.org/obo/NCIT_C4017 http://purl.obolibrary.org/obo/NCIT_C4872 http://purl.obolibrary.org/obo/NCIT_C40197 https://uts.nlm.nih.gov/uts/umls/concept/C1512433 http://purl.obolibrary.org/obo/NCIT_C40197 A precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C40197 High Grade Cervical Squamous Intraepithelial Neoplasia http://purl.obolibrary.org/obo/NCIT_C40197 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C4345 https://uts.nlm.nih.gov/uts/umls/concept/C1292778 http://purl.obolibrary.org/obo/NCIT_C4345 A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008) [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4345 Myeloproliferative Neoplasm http://purl.obolibrary.org/obo/NCIT_C4345 http://purl.obolibrary.org/obo/NCIT_C3262 http://purl.obolibrary.org/obo/NCIT_C4349 https://uts.nlm.nih.gov/uts/umls/concept/C0338106 http://purl.obolibrary.org/obo/NCIT_C4349 An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4349 Colon Adenocarcinoma http://purl.obolibrary.org/obo/NCIT_C4349 http://purl.obolibrary.org/obo/NCIT_C2852 http://purl.obolibrary.org/obo/NCIT_C4786 https://uts.nlm.nih.gov/uts/umls/concept/C0497327 http://purl.obolibrary.org/obo/NCIT_C4786 Loss of intellectual abilities interfering with an individual's social and occupational functions. Causes include Alzheimer's disease, brain injuries, brain tumors, and vascular disorders. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4786 Dementia http://purl.obolibrary.org/obo/NCIT_C4786 http://purl.obolibrary.org/obo/NCIT_C4802 http://purl.obolibrary.org/obo/NCIT_C4802 https://uts.nlm.nih.gov/uts/umls/concept/C0270715 http://purl.obolibrary.org/obo/NCIT_C4802 A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4802 Central Nervous System Degenerative Disorder http://purl.obolibrary.org/obo/NCIT_C4802 http://purl.obolibrary.org/obo/NCIT_C27586 http://purl.obolibrary.org/obo/NCIT_C4847 UMLS:C1302363 http://purl.obolibrary.org/obo/NCIT_C4847 A morphologic finding indicating the presence of dysplastic glandular epithelial cells in the colonic mucosa. There is no evidence of invasion. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4847 Colon Dysplasia http://purl.obolibrary.org/obo/NCIT_C4847 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C4872 https://uts.nlm.nih.gov/uts/umls/concept/C0678222 http://purl.obolibrary.org/obo/NCIT_C4872 A carcinoma arising from the breast, most commonly the terminal ductal-lobular unit. It is the most common malignant tumor in females. Risk factors include country of birth, family history, menstrual and reproductive history, fibrocystic disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic route, and by the blood vessel route. The most common site of lymph node involvement is the axilla. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4872 Breast Carcinoma http://purl.obolibrary.org/obo/NCIT_C4872 http://purl.obolibrary.org/obo/NCIT_C2916 http://purl.obolibrary.org/obo/NCIT_C4876 https://uts.nlm.nih.gov/uts/umls/concept/C1457887 http://purl.obolibrary.org/obo/NCIT_C4876 Subjective evidence of disease perceived by the patient. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4876 Symptom http://purl.obolibrary.org/obo/NCIT_C4876 http://purl.obolibrary.org/obo/NCIT_C100104 http://purl.obolibrary.org/obo/NCIT_C48824 https://uts.nlm.nih.gov/uts/umls/concept/C0024094 http://purl.obolibrary.org/obo/NCIT_C48824 The part of the spine in the lower back that consists of the lumbar region and the sacrum. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C48824 Lumbosacral Region http://purl.obolibrary.org/obo/NCIT_C4914 https://uts.nlm.nih.gov/uts/umls/concept/C0699893 http://purl.obolibrary.org/obo/NCIT_C4914 A carcinoma that arises from the skin. Representative examples are basal cell carcinoma and squamous cell carcinoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C4914 Skin Carcinoma http://purl.obolibrary.org/obo/NCIT_C4914 http://purl.obolibrary.org/obo/NCIT_C2916 http://purl.obolibrary.org/obo/NCIT_C4914 http://purl.obolibrary.org/obo/NCIT_C2920 http://purl.obolibrary.org/obo/NCIT_C49343 https://uts.nlm.nih.gov/uts/umls/concept/C0149871 http://purl.obolibrary.org/obo/NCIT_C49343 A blood clot in a deep vein, predominantly in the lower extremity, but may include the pelvis or upper extremity. [Definition Source: NCI][attribution: NICHD] http://purl.obolibrary.org/obo/NCIT_C49343 Deep Vein Thrombosis http://purl.obolibrary.org/obo/NCIT_C49343 http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C50466 https://uts.nlm.nih.gov/uts/umls/concept/C0004238 http://purl.obolibrary.org/obo/NCIT_C50466 A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC) [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50466 Atrial Fibrillation http://purl.obolibrary.org/obo/NCIT_C50466 http://purl.obolibrary.org/obo/NCIT_C2881 http://purl.obolibrary.org/obo/NCIT_C50530 https://uts.nlm.nih.gov/uts/umls/concept/C0011880 http://purl.obolibrary.org/obo/NCIT_C50530 The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50530 Diabetic Ketoacidosis http://purl.obolibrary.org/obo/NCIT_C50530 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C50577 https://uts.nlm.nih.gov/uts/umls/concept/C0018801 http://purl.obolibrary.org/obo/NCIT_C50577 Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50577 Heart Failure http://purl.obolibrary.org/obo/NCIT_C50577 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C50579 UMLS:C0018944 http://purl.obolibrary.org/obo/NCIT_C50579 A localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50579 Hematoma http://purl.obolibrary.org/obo/NCIT_C50579 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C50643 https://uts.nlm.nih.gov/uts/umls/concept/C0270697 http://purl.obolibrary.org/obo/NCIT_C50643 Headache in erect position, after lumbar puncture; due to lowering of intracranial pressure by leakage of cerebrospinal fluid through the needle tract. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50643 Lumbar Puncture Headache http://purl.obolibrary.org/obo/NCIT_C50643 http://purl.obolibrary.org/obo/NCIT_C34661 http://purl.obolibrary.org/obo/NCIT_C50667 https://uts.nlm.nih.gov/uts/umls/concept/C1709158 http://purl.obolibrary.org/obo/NCIT_C50667 An abnormality that affects hearing within the first month after birth. It may or may not result in hearing loss. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50667 Neonatal Hearing Impairment http://purl.obolibrary.org/obo/NCIT_C50667 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C50713 https://uts.nlm.nih.gov/uts/umls/concept/C0034065 http://purl.obolibrary.org/obo/NCIT_C50713 The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50713 Pulmonary Embolism http://purl.obolibrary.org/obo/NCIT_C50713 http://purl.obolibrary.org/obo/NCIT_C2931 http://purl.obolibrary.org/obo/NCIT_C50781 https://uts.nlm.nih.gov/uts/umls/concept/C0007787 http://purl.obolibrary.org/obo/NCIT_C50781 A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C50781 Transient Ischemic Attack http://purl.obolibrary.org/obo/NCIT_C50781 http://purl.obolibrary.org/obo/NCIT_C27586 http://purl.obolibrary.org/obo/NCIT_C51224 https://uts.nlm.nih.gov/uts/umls/concept/C0004239 http://purl.obolibrary.org/obo/NCIT_C51224 A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth-like pattern between the QRS complexes. (CDISC) [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C51224 Atrial Flutter http://purl.obolibrary.org/obo/NCIT_C51224 http://purl.obolibrary.org/obo/NCIT_C2881 http://purl.obolibrary.org/obo/NCIT_C51447 UMLS:C0035229 http://purl.obolibrary.org/obo/NCIT_C51447 Impairment of gas exchange within the lungs secondary to a disease process, neoplasm, or trauma, possibly resulting in hypoxia, hypercarbia, or both, but not requiring intubation or mechanical ventilation. Patients are normally managed with pharmaceutical therapy, supplemental oxygen, or both. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C51447 Pulmonary Insufficiency http://purl.obolibrary.org/obo/NCIT_C51447 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C51605 UMLS:C0041271 http://purl.obolibrary.org/obo/NCIT_C51605 Surgery to remove part or all of the fallopian tube(s). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C51605 Salpingectomy http://purl.obolibrary.org/obo/NCIT_C51750 UMLS:C0161872 http://purl.obolibrary.org/obo/NCIT_C51750 Total or partial excision of the turbinates. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C51750 Turbinectomy http://purl.obolibrary.org/obo/NCIT_C53458 https://uts.nlm.nih.gov/uts/umls/concept/C0311392 http://purl.obolibrary.org/obo/NCIT_C53458 Objective evidence of disease perceptible to the examining healthcare provider. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C53458 Sign http://purl.obolibrary.org/obo/NCIT_C53458 http://purl.obolibrary.org/obo/NCIT_C100104 http://purl.obolibrary.org/obo/NCIT_C54578 https://uts.nlm.nih.gov/uts/umls/concept/C1420306 http://purl.obolibrary.org/obo/NCIT_C54578 This gene plays a role in the detoxification of superoxide radicals in the cytosol. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C54578 SOD1 Gene http://purl.obolibrary.org/obo/NCIT_C55098 https://uts.nlm.nih.gov/uts/umls/concept/C1557189 http://purl.obolibrary.org/obo/NCIT_C55098 An enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart is damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. Also called alanine aminotransferase (ALT). [Definition Source: RxList] Common Terminology Criteria for Adverse Events (CTCAE) [Definition Source: U.s. Department of Health and Human Services] http://purl.obolibrary.org/obo/NCIT_C55098 Serum Glutamic Pyruvic Transaminase, CTCAE http://purl.obolibrary.org/obo/NCIT_C55098 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C60785 https://uts.nlm.nih.gov/uts/umls/concept/C0149889 http://purl.obolibrary.org/obo/NCIT_C60785 A pathologic tract that connects an opening in the anal canal to the perianal skin. In the vast majority of cases there is a history of perianal abscess. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C60785 Anorectal Fistula http://purl.obolibrary.org/obo/NCIT_C60785 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C60989 https://uts.nlm.nih.gov/uts/umls/concept/C0026896 http://purl.obolibrary.org/obo/NCIT_C60989 A chronic autoimmune neuromuscular disorder characterized by skeletal muscle weakness. It is caused by the blockage of the acetylcholine receptors at the neuromuscular junction. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C60989 Myasthenia Gravis http://purl.obolibrary.org/obo/NCIT_C60989 http://purl.obolibrary.org/obo/NCIT_C99383 http://purl.obolibrary.org/obo/NCIT_C61277 https://uts.nlm.nih.gov/uts/umls/concept/C0003872 http://purl.obolibrary.org/obo/NCIT_C61277 Joint inflammation associated with psoriasis. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C61277 Psoriatic Arthritis http://purl.obolibrary.org/obo/NCIT_C61277 http://purl.obolibrary.org/obo/NCIT_C2883 http://purl.obolibrary.org/obo/NCIT_C61443 https://uts.nlm.nih.gov/uts/umls/concept/C0002453 http://purl.obolibrary.org/obo/NCIT_C61443 The absence of menses in a woman who has achieved reproductive age. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C61443 Amenorrhea http://purl.obolibrary.org/obo/NCIT_C61443 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C61595 https://uts.nlm.nih.gov/uts/umls/concept/C0023791 http://purl.obolibrary.org/obo/NCIT_C61595 A naturally occurring micronutrient, synthesized in small amounts by plants and animals (including humans), with antioxidant and potential chemopreventive activities. Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C61595 Alpha-Lipoic Acid http://purl.obolibrary.org/obo/NCIT_C61595 http://purl.obolibrary.org/obo/NCIT_C1505 http://purl.obolibrary.org/obo/NCIT_C6727 https://uts.nlm.nih.gov/uts/umls/concept/C0162678 http://purl.obolibrary.org/obo/NCIT_C6727 An autosomal dominant hereditary neoplastic syndrome. Two distinct clinicopathological entities are recognized: neurofibromatosis type 1 and neurofibromatosis type 2. Neurofibromatosis type 1 is associated with the presence of cafe-au-lait cutaneous lesions, multiple neurofibromas, malignant peripheral nerve sheath tumors, optic nerve gliomas, and bone lesions. Neurofibromatosis type 2 is associated with the presence of schwannomas, meningiomas, and gliomas. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C6727 Neurofibromatosis http://purl.obolibrary.org/obo/NCIT_C6727 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C69313 https://uts.nlm.nih.gov/uts/umls/concept/C0728985 http://purl.obolibrary.org/obo/NCIT_C69313 The set of vertebrae immediately caudal to the skull. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C69313 Cervical Spine http://purl.obolibrary.org/obo/NCIT_C69314 https://uts.nlm.nih.gov/uts/umls/concept/C3887615 http://purl.obolibrary.org/obo/NCIT_C69314 Those vertebrae between the ribs and the pelvis, L1-L5 in man. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C69314 Lumbar Spine http://purl.obolibrary.org/obo/NCIT_C69315 https://uts.nlm.nih.gov/uts/umls/concept/C0581269 http://purl.obolibrary.org/obo/NCIT_C69315 The vertebrae of the thoracic spine, numbered one through twelve in man. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C69315 Thoracic Spine http://purl.obolibrary.org/obo/NCIT_C70428 https://uts.nlm.nih.gov/uts/umls/concept/C0036749 http://purl.obolibrary.org/obo/NCIT_C70428 Inflammation of a serous membrane. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C70428 Serositis http://purl.obolibrary.org/obo/NCIT_C70428 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C71079 https://uts.nlm.nih.gov/uts/umls/concept/C0019360 http://purl.obolibrary.org/obo/NCIT_C71079 A common dermal and neurologic disorder caused by reactivation of the varicella-zoster virus that has remained dormant within dorsal root ganglia, often for decades, after the patient's initial exposure to the virus in the form of varicella (chickenpox). It is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C71079 Herpes Zoster http://purl.obolibrary.org/obo/NCIT_C71079 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C71398 https://uts.nlm.nih.gov/uts/umls/concept/C0337573 http://purl.obolibrary.org/obo/NCIT_C71398 A male grandchild. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C71398 Grandson http://purl.obolibrary.org/obo/NCIT_C71398 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C71399 UMLS:C0337561 http://purl.obolibrary.org/obo/NCIT_C71399 A female grandchild. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C71399 Granddaughter http://purl.obolibrary.org/obo/NCIT_C71399 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C71408 https://uts.nlm.nih.gov/uts/umls/concept/C0337578 http://purl.obolibrary.org/obo/NCIT_C71408 A daughter of your brother or sister. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C71408 Niece http://purl.obolibrary.org/obo/NCIT_C71408 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C71409 https://uts.nlm.nih.gov/uts/umls/concept/C0337579 http://purl.obolibrary.org/obo/NCIT_C71409 A son of your brother or sister. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C71409 Nephew http://purl.obolibrary.org/obo/NCIT_C71409 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C71410 UMLS:C0337580 http://purl.obolibrary.org/obo/NCIT_C71410 A child of your aunt or uncle or their descendents. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C71410 Cousin http://purl.obolibrary.org/obo/NCIT_C71411 https://uts.nlm.nih.gov/uts/umls/concept/C0337583 http://purl.obolibrary.org/obo/NCIT_C71411 A child of your aunt or uncle. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C71411 First Cousin http://purl.obolibrary.org/obo/NCIT_C71411 http://purl.obolibrary.org/obo/NCIT_C100808 http://purl.obolibrary.org/obo/NCIT_C7405 https://uts.nlm.nih.gov/uts/umls/concept/C0017154 http://purl.obolibrary.org/obo/NCIT_C7405 Atrophic gastritis that is persistent and long-standing. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C7405 Chronic Atropic Gastritis http://purl.obolibrary.org/obo/NCIT_C7405 http://purl.obolibrary.org/obo/NCIT_C26780 http://purl.obolibrary.org/obo/NCIT_C7510 https://uts.nlm.nih.gov/uts/umls/concept/C0007115 http://purl.obolibrary.org/obo/NCIT_C7510 A primary or metastatic malignant neoplasm affecting the thyroid gland. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C7510 Malignant Thyroid Gland Neoplasm http://purl.obolibrary.org/obo/NCIT_C7510 http://purl.obolibrary.org/obo/NCIT_C26893 http://purl.obolibrary.org/obo/NCIT_C7570 https://uts.nlm.nih.gov/uts/umls/concept/C0027962 http://purl.obolibrary.org/obo/NCIT_C7570 A neoplasm composed of melanocytes that usually appears as a dark spot on the skin. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C7570 Melanocytic Nevus http://purl.obolibrary.org/obo/NCIT_C7570 http://purl.obolibrary.org/obo/NCIT_C3262 http://purl.obolibrary.org/obo/NCIT_C78302 https://uts.nlm.nih.gov/uts/umls/concept/C0392171 http://purl.obolibrary.org/obo/NCIT_C78302 Complaints describing a pattern similar to influenza, which may include one or more of the following symptoms: fever, chills, muscle or body aches, cough, sore throat, rhinitis, or fatigue. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C78302 Flu-Like Symptoms http://purl.obolibrary.org/obo/NCIT_C78302 http://purl.obolibrary.org/obo/NCIT_C4876 http://purl.obolibrary.org/obo/NCIT_C78576 UMLS:C0033975 http://purl.obolibrary.org/obo/NCIT_C78576 A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C78576 Psychosis http://purl.obolibrary.org/obo/NCIT_C78576 http://purl.obolibrary.org/obo/NCIT_C2893 http://purl.obolibrary.org/obo/NCIT_C78593 https://uts.nlm.nih.gov/uts/umls/concept/C0152169 http://purl.obolibrary.org/obo/NCIT_C78593 Paroxysmal and severe flank pain radiating to the inguinal area. It is caused by the passage of a kidney stone through the ureter. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C78593 Renal Colic http://purl.obolibrary.org/obo/NCIT_C78593 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C79532 https://uts.nlm.nih.gov/uts/umls/concept/C2607914 http://purl.obolibrary.org/obo/NCIT_C79532 Inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea, and itching. It may lead to fatigue, drowsiness, and malaise thus causing impairment of the quality of life. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C79532 Allergic Rhinitis http://purl.obolibrary.org/obo/NCIT_C79532 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C79593 https://uts.nlm.nih.gov/uts/umls/concept/C0015371 http://purl.obolibrary.org/obo/NCIT_C79593 A movement disorder caused by defects in the basal ganglia. The clinical manifestations include changes in the muscle tone, dyskinesia, and akinesia. Causes include vascular disorders, degenerative disorders, and antipsychotic drugs. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C79593 Extrapyramidal Disorder http://purl.obolibrary.org/obo/NCIT_C79593 http://purl.obolibrary.org/obo/NCIT_C4802 http://purl.obolibrary.org/obo/NCIT_C80020 https://uts.nlm.nih.gov/uts/umls/concept/C1420588 http://purl.obolibrary.org/obo/NCIT_C80020 This gene is involved in transcription and mRNA splicing. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C80020 TARDBP Gene http://purl.obolibrary.org/obo/NCIT_C80310 https://uts.nlm.nih.gov/uts/umls/concept/C2698259 http://purl.obolibrary.org/obo/NCIT_C80310 A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C80310 Monoclonal B_Cell Lymphocytosis http://purl.obolibrary.org/obo/NCIT_C80310 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C80385 https://uts.nlm.nih.gov/uts/umls/concept/C0242339 http://purl.obolibrary.org/obo/NCIT_C80385 A lipoprotein metabolism disorder characterized by decreased levels of high-density lipoproteins, or elevated levels of plasma cholesterol, low-density lipoproteins and/or triglycerides. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C80385 Dyslipidemia http://purl.obolibrary.org/obo/NCIT_C80385 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C8366 UMLS:C0878500 http://purl.obolibrary.org/obo/NCIT_C8366 A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as low grade (mild dysplasia) or high grade (moderate or severe dysplasia). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C8366 Intraepithelial Neoplasia http://purl.obolibrary.org/obo/NCIT_C8366 http://purl.obolibrary.org/obo/NCIT_C3262 http://purl.obolibrary.org/obo/NCIT_C84484 https://uts.nlm.nih.gov/uts/umls/concept/C0162316 http://purl.obolibrary.org/obo/NCIT_C84484 Anemia caused by low iron intake, inefficient iron absorption in the gastrointestinal tract, or chronic blood loss. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84484 Iron-Deficiency Anemia http://purl.obolibrary.org/obo/NCIT_C84484 http://purl.obolibrary.org/obo/NCIT_C2869 http://purl.obolibrary.org/obo/NCIT_C84505 UMLS:C0039685 http://purl.obolibrary.org/obo/NCIT_C84505 A congenital heart disorder characterized by the presence of the following four abnormalities: ventricular septal defect, pulmonary stenosis, overriding aorta, and right ventricular hypertrophy. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84505 Tetralogy of Fallot http://purl.obolibrary.org/obo/NCIT_C84505 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C84601 https://uts.nlm.nih.gov/uts/umls/concept/C0242644 http://purl.obolibrary.org/obo/NCIT_C84601 A disorder caused by a spinal injury leading to an incomplete spinal lesion. Patients develop paralysis, ataxia and loss of sensation. Causes include spinal cord tumors, spinal traumas, ischemia, and inflammatory processes affecting the spine. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84601 Brown-Sequard Syndrome http://purl.obolibrary.org/obo/NCIT_C84601 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C84705 https://uts.nlm.nih.gov/uts/umls/concept/C0015523 http://purl.obolibrary.org/obo/NCIT_C84705 A rare inherited bleeding disorder caused by deficiency of coagulation factor XI. It may be asymptomatic or manifest with bleeding. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84705 Hereditary Factor XI Deficiency http://purl.obolibrary.org/obo/NCIT_C84705 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C84719 https://uts.nlm.nih.gov/uts/umls/concept/C0338451 http://purl.obolibrary.org/obo/NCIT_C84719 A syndrome caused by progressive degeneration of the frontal or temporal lobes of the brain. It is manifested with personality changes and deterioration of the language skills. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84719 Frontotemporal Dementia http://purl.obolibrary.org/obo/NCIT_C84719 http://purl.obolibrary.org/obo/NCIT_C4786 http://purl.obolibrary.org/obo/NCIT_C84770 UMLS:C0598608 http://purl.obolibrary.org/obo/NCIT_C84770 A serious metabolic condition caused by mutations in the MTHFR gene, medications, or nutritional deficiency. It results in increased levels of homocysteine in the blood. Patients with this condition are at an increased risk for recurrent blood clots formation and cardiovascular accidents. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84770 Hyperhomocysteinemia http://purl.obolibrary.org/obo/NCIT_C84770 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C84776 https://uts.nlm.nih.gov/uts/umls/concept/C0020757 http://purl.obolibrary.org/obo/NCIT_C84776 A group of inherited or acquired skin disorders characterized by a dry, thickened, and scaly skin. The skin changes range from mild to severe. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84776 Ichthyosis http://purl.obolibrary.org/obo/NCIT_C84776 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C8486 https://uts.nlm.nih.gov/uts/umls/concept/C0677721 http://purl.obolibrary.org/obo/NCIT_C8486 Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C8486 Ann Arbor Stage IV Mantle Cell Lymphoma http://purl.obolibrary.org/obo/NCIT_C8486 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C84950 https://uts.nlm.nih.gov/uts/umls/concept/C0029134 http://purl.obolibrary.org/obo/NCIT_C84950 A disorder characterized by inflammation of the optic nerve. Causes include autoimmune disorders, infections, toxins, drugs, and multiple sclerosis. It may manifest with acute loss of vision and pain. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C84950 Optic Neuritis http://purl.obolibrary.org/obo/NCIT_C84950 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C85024 https://uts.nlm.nih.gov/uts/umls/concept/C0282513 http://purl.obolibrary.org/obo/NCIT_C85024 A rare neurologic progressive disorder characterized by impairment of the language and speech abilities. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C85024 Primary Progressive Aphasia http://purl.obolibrary.org/obo/NCIT_C85024 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C85026 UMLS:C0030442 http://purl.obolibrary.org/obo/NCIT_C85026 A progressive motor neuron disorder affecting the muscles which are innervated by cranial nerves of the lower brain stem. Signs and symptoms include difficulties in chewing and swallowing, dysarthria, and weakness of the facial muscles and tongue. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C85026 Progressive Bulbar Palsy http://purl.obolibrary.org/obo/NCIT_C85026 http://purl.bioontology.org/ontology/SNOMEDCT/37340000 http://purl.obolibrary.org/obo/NCIT_C85027 UMLS:C0917981 http://purl.obolibrary.org/obo/NCIT_C85027 A rare, milder form of amyotrophic lateral sclerosis. It is characterized by a slowly progressive clinical course. Signs and symptoms include muscle weakness, atrophy, and fasciculation. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C85027 Progressive Muscular Atrophy http://purl.obolibrary.org/obo/NCIT_C85027 http://purl.obolibrary.org/obo/NCIT_C34373 http://purl.obolibrary.org/obo/NCIT_C8509 https://uts.nlm.nih.gov/uts/umls/concept/C0677930 http://purl.obolibrary.org/obo/NCIT_C8509 A tumor at the original site of origin. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C8509 Primary Neoplasm http://purl.obolibrary.org/obo/NCIT_C8509 http://purl.obolibrary.org/obo/NCIT_C3262 http://purl.obolibrary.org/obo/NCIT_C85233 https://uts.nlm.nih.gov/uts/umls/concept/C1839259 http://purl.obolibrary.org/obo/NCIT_C85233 A rare, slowly progressive degenerative disorder affecting males. It is caused by mutations in the androgen receptor (AR) gene. It is characterized by bulbar and limb muscle weakness and atrophy, and gynecomastia. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C85233 Spinal and Bulbar Muscular Atrophy, X-linked 1 http://purl.obolibrary.org/obo/NCIT_C85233 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C8668 https://uts.nlm.nih.gov/uts/umls/concept/C0854831 http://purl.obolibrary.org/obo/NCIT_C8668 Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C8668 Ann Arbor Stage IV T-Cell Non-Hodgkin Lymphoma http://purl.obolibrary.org/obo/NCIT_C8668 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C87069 https://uts.nlm.nih.gov/uts/umls/concept/C0008925 http://purl.obolibrary.org/obo/NCIT_C87069 A congenital abnormality consisting of a fissure in the midline of the hard and/or soft palate; it is the result of the failure of the two sides of the palate to fuse during embryonic development. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C87069 Cleft Palate http://purl.obolibrary.org/obo/NCIT_C87069 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C87497 https://uts.nlm.nih.gov/uts/umls/concept/C0016053 http://purl.obolibrary.org/obo/NCIT_C87497 A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C87497 Fibromyalgia http://purl.obolibrary.org/obo/NCIT_C87497 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C89715 https://uts.nlm.nih.gov/uts/umls/concept/C0149931 http://purl.obolibrary.org/obo/NCIT_C89715 A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C89715 Migraine http://purl.obolibrary.org/obo/NCIT_C89715 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C9039 UMLS:C0302592 http://purl.obolibrary.org/obo/NCIT_C9039 A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are squamous cell carcinoma and adenocarcinoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C9039 Cervical Carcinoma http://purl.obolibrary.org/obo/NCIT_C9039 http://purl.obolibrary.org/obo/NCIT_C27020 http://purl.obolibrary.org/obo/NCIT_C9039 http://purl.obolibrary.org/obo/NCIT_C2916 http://purl.obolibrary.org/obo/NCIT_C9175 https://uts.nlm.nih.gov/uts/umls/concept/C0021843 http://purl.obolibrary.org/obo/NCIT_C9175 Blockage of the normal flow of the intestinal contents within the bowel. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C9175 Bowel Obstruction http://purl.obolibrary.org/obo/NCIT_C9175 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C91852 https://uts.nlm.nih.gov/uts/umls/concept/C1414860 http://purl.obolibrary.org/obo/NCIT_C91852 This gene is involved in gene expression, genomic integrity and RNA processing. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C91852 FUS Gene http://purl.obolibrary.org/obo/NCIT_C92200 https://uts.nlm.nih.gov/uts/umls/concept/C0525045 http://purl.obolibrary.org/obo/NCIT_C92200 A category of psychiatric disorders which have as their most predominant feature a disturbance in mood. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C92200 Mood Disorder http://purl.obolibrary.org/obo/NCIT_C92200 http://purl.obolibrary.org/obo/NCIT_C2893 http://purl.obolibrary.org/obo/NCIT_C9242 https://uts.nlm.nih.gov/uts/umls/concept/C0007102 http://purl.obolibrary.org/obo/NCIT_C9242 A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C9242 Malignant Colon Neoplasm http://purl.obolibrary.org/obo/NCIT_C9242 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C92560 https://uts.nlm.nih.gov/uts/umls/concept/C4317146 http://purl.obolibrary.org/obo/NCIT_C92560 The backward flow of stomach acid contents into the esophagus (the tube that connects the mouth to the stomach). [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C92560 Gastroesophageal Reflux http://purl.obolibrary.org/obo/NCIT_C92560 http://purl.obolibrary.org/obo/NCIT_C3367 http://purl.obolibrary.org/obo/NCIT_C93040 https://uts.nlm.nih.gov/uts/umls/concept/C0001973 http://purl.obolibrary.org/obo/NCIT_C93040 Physical and psychological dependence on alcohol. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C93040 Alcohol Dependance http://purl.obolibrary.org/obo/NCIT_C93040 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C9305 https://uts.nlm.nih.gov/uts/umls/concept/C0006826 http://purl.obolibrary.org/obo/NCIT_C9305 A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C9305 Malignant Neoplasm http://purl.obolibrary.org/obo/NCIT_C9305 http://purl.obolibrary.org/obo/NCIT_C3262 http://purl.obolibrary.org/obo/NCIT_C9384 UMLS:C1378703 http://purl.obolibrary.org/obo/NCIT_C9384 A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C9384 Kidney Carcinoma http://purl.obolibrary.org/obo/NCIT_C9384 http://purl.obolibrary.org/obo/NCIT_C2916 http://purl.obolibrary.org/obo/NCIT_C94575 https://uts.nlm.nih.gov/uts/umls/concept/C0036285 http://purl.obolibrary.org/obo/NCIT_C94575 A streptococcal infection, mainly occurring among children, that is characterized by a red skin rash, sore throat, and fever. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C94575 Scarlet Fever http://purl.obolibrary.org/obo/NCIT_C94575 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C94676 UMLS:C2986622 http://purl.obolibrary.org/obo/NCIT_C94676 A neoplastic process in the cervix characterized by morphologic features of both moderate and severe intraepithelial neoplasia. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C94676 Cervical Intraepithelial Neoplasia Grade 2/3 http://purl.obolibrary.org/obo/NCIT_C94676 http://purl.obolibrary.org/obo/NCIT_C27020 http://purl.obolibrary.org/obo/NCIT_C96569 https://uts.nlm.nih.gov/uts/umls/concept/C3272868 http://purl.obolibrary.org/obo/NCIT_C96569 A female relative who is a sibling of either of the biological parents, and who share a common ancestor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96569 Aunt http://purl.obolibrary.org/obo/NCIT_C96569 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C96573 https://uts.nlm.nih.gov/uts/umls/concept/C0337477 http://purl.obolibrary.org/obo/NCIT_C96573 A male relative who is the biological father of either the biological mother or the biological father. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96573 Grandfather http://purl.obolibrary.org/obo/NCIT_C96573 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C96574 https://uts.nlm.nih.gov/uts/umls/concept/C0337476 http://purl.obolibrary.org/obo/NCIT_C96574 A female relative who is the biological mother of either the biological mother or the biological father. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96574 Grandmother http://purl.obolibrary.org/obo/NCIT_C96574 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C96575 https://uts.nlm.nih.gov/uts/umls/concept/C3272872 http://purl.obolibrary.org/obo/NCIT_C96575 A female relative who is a sibling of the biological mother, and who both share a common ancestor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96575 Maternal Aunt http://purl.obolibrary.org/obo/NCIT_C96575 http://purl.obolibrary.org/obo/NCIT_C96569 http://purl.obolibrary.org/obo/NCIT_C96579 UMLS:C3272876 http://purl.obolibrary.org/obo/NCIT_C96579 A male relative who is a sibling of the biological mother, and who both share a common ancestor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96579 Maternal Uncle http://purl.obolibrary.org/obo/NCIT_C96579 http://purl.obolibrary.org/obo/NCIT_C96587 http://purl.obolibrary.org/obo/NCIT_C96581 https://uts.nlm.nih.gov/uts/umls/concept/C3272877 http://purl.obolibrary.org/obo/NCIT_C96581 A female relative who is a sibling of the biological father, and who both share a common ancestor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96581 Paternal Aunt http://purl.obolibrary.org/obo/NCIT_C96581 http://purl.obolibrary.org/obo/NCIT_C96569 http://purl.obolibrary.org/obo/NCIT_C96585 UMLS:C3272881 http://purl.obolibrary.org/obo/NCIT_C96585 A male relative who is a sibling of the biological father, and who both share a common ancestor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96585 Paternal Uncle http://purl.obolibrary.org/obo/NCIT_C96585 http://purl.obolibrary.org/obo/NCIT_C96587 http://purl.obolibrary.org/obo/NCIT_C96587 UMLS:C3272882 http://purl.obolibrary.org/obo/NCIT_C96587 A male relative who is a sibling of either of the biological parents, and who share a common ancestor. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C96587 Uncle http://purl.obolibrary.org/obo/NCIT_C96587 http://purl.obolibrary.org/obo/NCIT_C19811 http://purl.obolibrary.org/obo/NCIT_C97132 https://uts.nlm.nih.gov/uts/umls/concept/C0008049 http://purl.obolibrary.org/obo/NCIT_C97132 A contagious childhood disorder caused by the varicella zoster virus. It is transmitted via respiratory secretions and contact with chickenpox blister contents. It presents with a vesicular skin rash, usually associated with fever, headache, and myalgias. The pruritic fluid-filled vesicles occur 10-21 days after exposure and last for 3-4 days. An additional 3-4 days of malaise follows before the affected individual feels better. An individual is contagious 1-2 days prior to the appearance of the blisters until all blisters are crusted over. Generally, healthy individuals recover without complications. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C97132 Chicken Pox http://purl.obolibrary.org/obo/NCIT_C97132 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C97142 https://uts.nlm.nih.gov/uts/umls/concept/C0001361 http://purl.obolibrary.org/obo/NCIT_C97142 An acute inflammation of the tonsils caused by viruses or bacteria. Signs and symptoms include fever, enlargement of the tonsils, difficulty swallowing, and enlargement of the regional lymph nodes. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C97142 Acute Tonsillitis http://purl.obolibrary.org/obo/NCIT_C97142 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C98541 https://uts.nlm.nih.gov/uts/umls/concept/C0746102 http://purl.obolibrary.org/obo/NCIT_C98541 A persistent non-neoplastic disorder of the lungs. Representative examples include: chronic obstructive pulmonary disease, chronic bronchitis, emphysema, pulmonary fibrosis, pneumoconiosis, asbestosis, atelectasis, radiation induced pneumonitis, and radiation fibrosis. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C98541 Chronic Lung Disorder http://purl.obolibrary.org/obo/NCIT_C98541 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C98967 https://uts.nlm.nih.gov/uts/umls/concept/C0022738 http://purl.obolibrary.org/obo/NCIT_C98967 A rare congenital syndrome characterized by the fusion of the vertebrae in the cervical spine. Patients present with a short neck and restricted mobility of the upper spine. Other signs and symptoms include scoliosis, spina bifida, cleft palate, and rib malformations. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C98967 Klippel-Feil Syndrome http://purl.obolibrary.org/obo/NCIT_C98967 http://purl.obolibrary.org/obo/NCIT_C2991 http://purl.obolibrary.org/obo/NCIT_C99039 https://uts.nlm.nih.gov/uts/umls/concept/C0034628 http://purl.obolibrary.org/obo/NCIT_C99039 Traumatic or pathological injury to the radius bone in which the continuity of the bone is broken. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C99039 Radius Fracture http://purl.obolibrary.org/obo/NCIT_C99039 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C99083 https://uts.nlm.nih.gov/uts/umls/concept/C0040185 http://purl.obolibrary.org/obo/NCIT_C99083 Traumatic or pathological injury to the tibia in which the continuity of the bone is broken. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C99083 Tibia Fracture http://purl.obolibrary.org/obo/NCIT_C99083 http://purl.obolibrary.org/obo/NCIT_C3671 http://purl.obolibrary.org/obo/NCIT_C99383 https://uts.nlm.nih.gov/uts/umls/concept/C0751871 http://purl.obolibrary.org/obo/NCIT_C99383 A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis. [Definition Source: NCI] http://purl.obolibrary.org/obo/NCIT_C99383 Autoimmune Nervous System Disorder http://purl.obolibrary.org/obo/NCIT_C99383 http://purl.obolibrary.org/obo/NCIT_C2889 http://purl.obolibrary.org/obo/OAE_0000005 An adverse event that occurs after a drug administration. [Definition Source: OAE] http://purl.obolibrary.org/obo/OAE_0000005 Adverse Drug Event http://purl.obolibrary.org/obo/OAE_0000220 https://uts.nlm.nih.gov/uts/umls/concept/C0852908 http://purl.obolibrary.org/obo/OAE_0000220 An errored drug administration where a patient is administered with an ineffective drug. [Definition Source: OAE] http://purl.obolibrary.org/obo/OAE_0000220 Administration of Ineffective Drug http://purl.obolibrary.org/obo/OAE_0000220 http://purl.obolibrary.org/obo/OAE_0000005 http://purl.obolibrary.org/obo/OAE_0000890 https://uts.nlm.nih.gov/uts/umls/concept/C0013182 http://purl.obolibrary.org/obo/OAE_0000890 A hypersensitivity AE that has an outcome of allergic reactions to certain drugs. [Definition Source: OAE] http://purl.obolibrary.org/obo/OAE_0000890 Drug Hypersensitivity AE http://purl.obolibrary.org/obo/OAE_0000890 http://purl.obolibrary.org/obo/OAE_0000005 http://purl.obolibrary.org/obo/OAE_0000891 https://uts.nlm.nih.gov/uts/umls/concept/C0277585 http://purl.obolibrary.org/obo/OAE_0000891 A drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug. [Definition Source: OAE] http://purl.obolibrary.org/obo/OAE_0000891 Drug Intolerance AE http://purl.obolibrary.org/obo/OAE_0000891 http://purl.obolibrary.org/obo/OAE_0000005 http://www.w3.org/2000/10/swap/pim/contact#Person A human being. [Definition Source: NCI] http://www.w3.org/2000/10/swap/pim/contact#Person Person https://imm.medicina.ulisboa.pt/ Institute of Molecular Medicine Joao Lobo Antunes https://imm.medicina.ulisboa.pt/ Instituto de medicina molecular Joao Lobo Antunes https://orcid.org/0000-0001-9219-6239 Nicola Ferro https://orcid.org/0000-0001-9219-6239 Nicola Ferro https://orcid.org/0000-0001-9709-6392 Giorgio Maria Di Nunzio https://orcid.org/0000-0001-9709-6392 Giorgio Maria Di Nunzio https://orcid.org/0000-0002-0676-682X Laura Menotti https://orcid.org/0000-0002-0676-682X Laura Menotti https://orcid.org/0000-0002-5070-2049 Guglielmo Faggioli https://orcid.org/0000-0002-5070-2049 Guglielmo Faggioli https://orcid.org/0000-0003-0362-5893 Stefano Marchesin https://orcid.org/0000-0003-0362-5893 Stefano Marchesin https://orcid.org/0000-0003-4970-4554 Gianmaria Silvello https://orcid.org/0000-0003-4970-4554 Gianmaria Silvello ALSBrainteaserComorbidities Comorbidities checked for ALS patient in the BRAINTEASER study. ALSBrainteaserComorbidities ALS Brainteaser Comorbidities ALSFRS The Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) is an instrument for evaluating the functional status of patients with Amyotrophic Lateral Sclerosis. It can be used to monitor functional change in a patient over time. [Definition Source: Georgetown University Hospital - Medstar Health] ALSFRS Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) ALSFRSR_Q1 UMLS:C4298336 ALSFRSR_Q1 Q1: Speech ALSFRSR_Q1 ALSFRSR_Q1 ALSFRSR_Q10 UMLS:C4298328 ALSFRSR_Q10 Q10: Dyspnea ALSFRSR_Q10 ALSFRSR_Q10 ALSFRSR_Q10alt Do you experience shortness of breath or have difficulty breathing? ALSFRSR_Q10alt ALSFRSR_Q10alt ALSFRSR_Q11 UMLS:C4298327 ALSFRSR_Q11 Q11: Orthopnea ALSFRSR_Q11 ALSFRSR_Q11 ALSFRSR_Q11alt Do you experience shortness of breath or have difficulty breathing while lying down on your back? ALSFRSR_Q11alt ALSFRSR_Q11alt ALSFRSR_Q12 UMLS:C4298326 ALSFRSR_Q12 Q12: Respiratory Insufficiency ALSFRSR_Q12 ALSFRSR_Q12 ALSFRSR_Q12alt Do you require respiratory (breathing) support? ALSFRSR_Q12alt ALSFRSR_Q12alt ALSFRSR_Q1alt Have you noticed any changes in your speech? ALSFRSR_Q1alt ALSFRSR_Q1alt ALSFRSR_Q2 UMLS:C4298335 ALSFRSR_Q2 Q2: Salivation ALSFRSR_Q2 ALSFRSR_Q2 ALSFRSR_Q2alt Have you noticed any changes (increases) in the amount of saliva in your mouth (regardless of any medication use)? ALSFRSR_Q2alt ALSFRSR_Q2alt ALSFRSR_Q3 UMLS:C4298334 ALSFRSR_Q3 Q3: Swallowing ALSFRSR_Q3 ALSFRSR_Q3 ALSFRSR_Q3alt Have there been any changes in your ability to swallow? ALSFRSR_Q3alt ALSFRSR_Q3alt ALSFRSR_Q4 UMLS:C4298333 ALSFRSR_Q4 Q4:Handwriting ALSFRSR_Q4 ALSFRSR_Q4 ALSFRSR_Q4alt Has your handwriting changed? Please choose the best answer that describes your handwriting with your dominant (usual) hand without a cuff or brace. ALSFRSR_Q4alt ALSFRSR_Q4alt ALSFRSR_Q5 Q5: Cutting Food and Handling Utensils (with or without gastrostomy). ALSFRSR_Q5 ALSFRSR_Q5 ALSFRSR_Q5A UMLS:C4285407 ALSFRSR_Q5A Q5A: Cutting Food and Handling Utensils (without gastrostomy) ALSFRSR_Q5A ALSFRSR_Q5A ALSFRSR_Q5Aalt Cutting food and handling utensils ALSFRSR_Q5Aalt ALSFRSR_Q5Aalt ALSFRSR_Q5B UMLS:C4298332 ALSFRSR_Q5B Q5B: Cutting Food and Handling Utensils (with gastrostomy) ALSFRSR_Q5B ALSFRSR_Q5B ALSFRSR_Q5Balt Using a feeding tube (PEG) ALSFRSR_Q5Balt ALSFRSR_Q5Balt ALSFRSR_Q6 UMLS:C4298331 ALSFRSR_Q6 Q6: Dressing and Hygiene ALSFRSR_Q6 ALSFRSR_Q6 ALSFRSR_Q6alt Has your ability to dress and perform self-care activities (i.e. bathing, teeth brushing, shaving, combing your hair, other hygienic activities) changed? ALSFRSR_Q6alt ALSFRSR_Q6alt ALSFRSR_Q7 UMLS:C4285576 ALSFRSR_Q7 Q7: Truning in Bed and Adjusting Bed Clothes ALSFRSR_Q7 ALSFRSR_Q7 ALSFRSR_Q7alt Has your ability to turn in bed and adjust the bed clothes (i.e. cover yourself with the sheet or blanket) changed? ALSFRSR_Q7alt ALSFRSR_Q7alt ALSFRSR_Q8 UMLS:C4298330 ALSFRSR_Q8 Q8: Walking ALSFRSR_Q8 ALSFRSR_Q8 ALSFRSR_Q8alt Has your ability to walk changed? ALSFRSR_Q8alt ALSFRSR_Q8alt ALSFRSR_Q9 UMLS:C4298329 ALSFRSR_Q9 Q9: Climbing Stairs ALSFRSR_Q9 ALSFRSR_Q9 ALSFRSR_Q9alt Has your ability to climb stairs changed? ALSFRSR_Q9alt ALSFRSR_Q9alt ALSFRS_R_WHO_COMPLETED Please indicate who completed this survey ALSFRS_R_WHO_COMPLETED ALSFRS_R_WHO_COMPLETED APConcentrationTime It defines the relationship between air pollution conentration individuals and their time of recording. APConcentrationTime APConcentrationTime Activity https://uts.nlm.nih.gov/uts/umls/concept/C0441655 Activity An active process; excludes processes and mechanisms which fulfill biological functions. [Definition Source: NCI] Activity http://purl.obolibrary.org/obo/NCIT_C43431 Activity Activity Activity In our data we refer to it as "Behaviour". Administration https://uts.nlm.nih.gov/uts/umls/concept/C1533734 Administration The act of the dispensing, applying, or tendering of something to another, such as administration of a medicine. [Definition Source: NCI] Administration http://purl.obolibrary.org/obo/NCIT_C25409 Administration Administration AdverseDrugReaction https://uts.nlm.nih.gov/uts/umls/concept/C0041755 AdverseDrugReaction Any detrimental or unintended response associated with the use of a medication in humans. [Definition Source: NCI] AdverseDrugReaction http://purl.obolibrary.org/obo/NCIT_C142385 AdverseDrugReaction Adverse Drug Reaction AnatomicalSite https://uts.nlm.nih.gov/uts/umls/concept/C1515974 AnatomicalSite Named locations of or within the body. [Definition Source: NCI] AnatomicalSite http://purl.obolibrary.org/obo/NCIT_C13717 AnatomicalSite Anatomic Site AppQuestionnaire UMLS:C0034394 AppQuestionnaire A predetermined set of questions. [Definition Source: NCI] AppQuestionnaire http://purl.obolibrary.org/obo/NCIT_C17048 AppQuestionnaire Questionnaire filled using a mobile application AtmosphericPressure UMLS:C0004180 AtmosphericPressure The pressure at any point in an atmosphere due solely to the weight of the atmospheric gases bove the point concerned. [Definition Source: MSH] AtmosphericPressure Atmospheric Pressure AvgRelHumidity Daily Average Relative Humidity AvgSeaLvlPressure Daily Average Sea Level Pressure AwajiClinicalEvaluation Diagnostic assessment of ALS following the Awaji reccomendations (doi.org/10.1016/j.clinph.2007.09.143). AwajiClinicalEvaluation Awaji Clinical Evaluation BVMTR The BVMT-R measures Visuospatial Memory for Patients with Head Trauma, LD, Psychiatric Disorder, and Mixed Diagnoses. [Source: https://www.parinc.com/Products/Pkey/30#:~:text=A%20Measure%20of%20Visuospatial%20Memory,to%20document%20changes%20over%20time.] BVMTR Brief Visuospatial Memory Test-Revised BeatToBeatData Beat-To-Beat Data registered by a wearable device. BeatToBeatData Beat-To-Beat Data BeforeOnset Any event that happened to a patient before the onset. BeforeOnset Before Onset BehavioralImpairment Diminished psychological function. BehavioralImpairment Behavioral Impairment BehavioralImpairment http://purl.obolibrary.org/obo/NCIT_C3367 C6H6_concentration Benzene concentration CO_concentration The determination of the amount of carbon monoxide present in a sample. [Definition Source: NCI] CO_concentration Carbon Monoxide concentration CSFAnalysis https://uts.nlm.nih.gov/uts/umls/concept/C2026522 CSFAnalysis A laboratory analysis of a sample of cerebrospinal fluid. [Definition Source: NCI] CSFAnalysis http://purl.obolibrary.org/obo/NCIT_C173272 CSFAnalysis CSF Analysis CVLTII UMLS:C3899729 CVLTII The second version of California Verbal Learning Test, a neuropsychological test developed to make a comprehensive and detailed assessment of verbal learning and memory in individuals ranging in age from 16 to 89 years. [Definition Source: NCI] CVLTII http://purl.obolibrary.org/obo/NCIT_C120257 CVLTII California Verbal Learning Test - Second Edition ClinicalEvaluation https://uts.nlm.nih.gov/uts/umls/concept/C1261322 ClinicalEvaluation An assessment of an individual's physical, mental, or emotional condition; information can be gathered from multiple sources, including physical exam, personal interview and observation, medical history, laboratory and imaging tests. [Definition Source: NCI] ClinicalEvaluation http://purl.obolibrary.org/obo/NCIT_C124351 ClinicalEvaluation Clinical Evaluation ClinicalTrial https://uts.nlm.nih.gov/uts/umls/concept/C0008976 ClinicalTrial A research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. [Definition Source: NCI] ClinicalTrial http://purl.obolibrary.org/obo/NCIT_C71104 ClinicalTrial Clinical Trial ClinicalTrialParticipation https://uts.nlm.nih.gov/uts/umls/concept/C4041024 ClinicalTrialParticipation The participation in a clinical trial ClinicalTrialParticipation http://purl.bioontology.org/ontology/SNOMEDCT/709491003 ClinicalTrialParticipation Clinical Trial Participation ClinicsAndHospitals https://uts.nlm.nih.gov/uts/umls/concept/C0587906 ClinicsAndHospitals Institutions with an organized medical staff for the medical care, treatment, and cure of the sick and wounded, for the study of disease, and for the training of physicians, nurses, and allied health personnel. [Definition Source: NCI] ClinicsAndHospitals http://purl.obolibrary.org/obo/NCIT_C19326 ClinicsAndHospitals Clinics and Hospitals CognitiveAssessment UMLS:C0870300 CognitiveAssessment The examination of the cognitive capacities or deficits of an individual through the application of tests that probe that individual's ability to perform various mental activities such as perception, learning, and reasoning. [Definition Source: NCI] CognitiveAssessment http://purl.obolibrary.org/obo/NCIT_C62736 CognitiveAssessment Cognitive Assessment Comorbidity https://uts.nlm.nih.gov/uts/umls/concept/C0009488 Comorbidity The coexistence of two or more disease processes. [Definition Source: NCI] Comorbidity http://purl.obolibrary.org/obo/NCIT_C16457 Comorbidity Comorbidity Condition https://uts.nlm.nih.gov/uts/umls/concept/C0348080 Condition A state of being, such as a state of health. [Definition Source: NCI] Condition http://purl.obolibrary.org/obo/NCIT_C25457 Condition Condition CortisoneTherapyForRelapse Therapy based on cortisone used for treating relapses. CortisoneTherapyForRelapse Cortisone Therapy for Relapse DYMUS A questionnaire to assess dysphagia in MS patients [DOI: 10.1016/j.jns.2007.12.021] DYMUS Dysphagia In Multiple Sclerosis DYMUS_Q1 Do you have difficulties swallowing solid food (such as meat, bread, and the like)? DYMUS_Q1 DYMUS_Q1 DYMUS_Q10 Do you have weight loss? DYMUS_Q10 DYMUS_Q10 DYMUS_Q2 Do you have difficulties swallowing liquids (such as water, milk, and the like)? DYMUS_Q2 DYMUS_Q2 DYMUS_Q3 Do you have a globus sensation in your throat during swallowing? DYMUS_Q3 DYMUS_Q3 DYMUS_Q4 Do you have food sticking in your throat? DYMUS_Q4 DYMUS_Q4 DYMUS_Q5 Do you cough or do you have a choking sensation after ingesting solid foods? DYMUS_Q5 DYMUS_Q5 DYMUS_Q6 Do you cough or do you have a choking sensation after ingesting liquids? DYMUS_Q6 DYMUS_Q6 DYMUS_Q7 Do you need to swallow several times before completely swallowing solid food? DYMUS_Q7 DYMUS_Q7 DYMUS_Q8 Do you need to cut food in small pieces before swallowing? DYMUS_Q8 DYMUS_Q8 DYMUS_Q9 Do you need to take many sips before completely swallowing liquid? DYMUS_Q9 DYMUS_Q9 Diagnosis https://uts.nlm.nih.gov/uts/umls/concept/C0011900 Diagnosis The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation. [Definition Source: NCI] Diagnosis http://purl.obolibrary.org/obo/NCIT_C15220 Diagnosis Diagnosis DiagnosticImaging https://uts.nlm.nih.gov/uts/umls/concept/C0011923 DiagnosticImaging Any method that uses a visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. [Definition Source: NCI] DiagnosticImaging http://purl.obolibrary.org/obo/NCIT_C16502 DiagnosticImaging Diagnostic Imaging DiagnosticProcedure https://uts.nlm.nih.gov/uts/umls/concept/C0430022 DiagnosticProcedure Any procedure or test to diagnose a disease or disorder. [Definition Source: NCI] DiagnosticProcedure http://purl.obolibrary.org/obo/NCIT_C18020 DiagnosticProcedure Diagnostic Procedure DiseaseDisorderOrFinding https://uts.nlm.nih.gov/uts/umls/concept/C1511989 DiseaseDisorderOrFinding A condition that is relevant to human neoplasms and non-neoplastic disorders. This includes observations, test results, history and other concepts relevant to the characterization of human pathologic conditions. [Definition Source: NCI] DiseaseDisorderOrFinding http://purl.obolibrary.org/obo/NCIT_C7057 DiseaseDisorderOrFinding Disease, Disorder or Finding DrugsForMSSymptomaticTherapy Symptomatic therapy for Multiple Sclerosis (MS). DrugsForMSSymptomaticTherapy Drugs for MS Symptomatic Therapy DrugsForMSTherapySideEffects Therapy for managing side effects of MS therapy. DrugsForMSTherapySideEffects Drugs for MS Therapy Side Effects DrugsForOtherDiseases Any drugs used to treat other diseases. DrugsForOtherDiseases Drugs for Other Diseases ECAS The ECAS is a brief multidomain assessment originally designed for people with Amyotrophic Lateral Sclerosis (ALS/Motor Neurone Disease) but is also useful in other neurodegenerative disorders. [Source: https://ecas.psy.ed.ac.uk/] ECAS Edinburgh Cognitive and Behavioural ALS Screen EDSS https://uts.nlm.nih.gov/uts/umls/concept/C0451246 EDSS A system for quantifying disability in multiple sclerosis (MS). Based on a standard neurological examination, the Expanded Disability Status Scale quantifies disability in seven Functional Systems (plus "Other") and assigns a Functional System Score in each. Results are ranked as steps from 0 to 10, with steps 1 through 4.5 describing MS patients who are fully ambulatory and steps 5 through 9.5 describing increasing impairment to ambulation. Step 10 refers to death due to MS. [Definition Source: NCI] EDSS http://purl.obolibrary.org/obo/NCIT_C98302 EDSS Expanded Disability Status Scale (EDSS) EQ5D5L UMLS:C3640517 EQ5D5L A standardized rating scale which is used as a measure of health outcome. This instrument is a descriptive system consisting of 5 dimensions: mobility, self-care, usual activity, pain/discomfort, and anxiety/depression. Each dimension has 5 levels ranging from no problem to extreme problem or incapable, which are assessed by the patient. [Definition Source: NCI] EQ5D5L http://purl.obolibrary.org/obo/NCIT_C102117 EQ5D5L European Quality of Life Five Dimension Five Level Scale Questionnaire EQ5D5L_Q1 Mobility EQ5D5L_Q1 EQ5D5L_Q1 EQ5D5L_Q2 Self-care EQ5D5L_Q2 EQ5D5L_Q2 EQ5D5L_Q3 Usual activities EQ5D5L_Q3 EQ5D5L_Q3 EQ5D5L_Q4 Pain/Discomfort EQ5D5L_Q4 EQ5D5L_Q4 EQ5D5L_Q5 Anxiety/Depression EQ5D5L_Q5 EQ5D5L_Q5 EQ5D5L_Q6 Health today EQ5D5L_Q6 EQ5D5L_Q6 EndTherapyReason The motivation for the interruption of the therapeutic treatment. EndTherapyReason End Therapy Reason Event https://uts.nlm.nih.gov/uts/umls/concept/C0441471 Event Something that happens at a given place and time. [Definition Source: NCI] Event http://purl.obolibrary.org/obo/NCIT_C25499 Event Event EvokedPotentials https://uts.nlm.nih.gov/uts/umls/concept/C0015214 EvokedPotentials Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. [Definition Source: MSH] EvokedPotentials http://purl.bioontology.org/ontology/SNOMEDCT/386205007 EvokedPotentials Evoked Potentials Gene https://uts.nlm.nih.gov/uts/umls/concept/C0017337 Gene A functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function. [Definition Source: NCI] Gene http://purl.obolibrary.org/obo/NCIT_C16612 Gene Gene GeneticTesting https://uts.nlm.nih.gov/uts/umls/concept/C0679560 GeneticTesting The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder. [Definition Source: NCI] GeneticTesting http://purl.obolibrary.org/obo/NCIT_C15709 GeneticTesting Genetic Testing GlobalRadiation Global Radiation GoldCoastCriteria Diagnostic assessment of ALS following the Gold Coast criteria (doi.org/10.1136/practneurol-2021-003256 ). GoldCoastCriteria Gold Coast Diagnosis Criteria Group https://uts.nlm.nih.gov/uts/umls/concept/C1257890 Group A group of individuals united by a common factor (e.g., geographic location, ethnicity, disease, age, gender) [Definition Source: NCI] Group http://purl.bioontology.org/ontology/SNOMEDCT/389109008 Group Group (social concept) HADS UMLS:C3539657 HADS A standardized survey developed and copyrighted by A. S. Zigmond and R. P. Snaith in 1983, 1992, 1994 and published in the Acta Psychiatrica Scandinavica journal (A.S. Zigmond and R.P. Snaith. The Hospital Anxiety and Depression Scale. Acta psychiart. scand. 1983, 67:361-370) which is used to detect depression and anxiety in individuals in a hospital or medical outpatient clinic. This instrument is a self-administered questionnaire consisting of 14 items that assess how the individual has felt over the past week. Each item as 4 response options that are associated with a score of 0 to 3. [Definition Source: NCI] HADS http://purl.obolibrary.org/obo/NCIT_C103520 HADS Hospital Anxiety and Depression Scale HADS_ALS Hospital Anxiety and Depression Scale questionnaire administered to ALS patients. HADS_ALS Hospital Anxiety and Depression Scale for ALS patients HADS_Q1 UMLS:C3641379 HADS_Q1 I feel tense or 'wound up' HADS_Q1 HADS_Q1 HADS_Q10 UMLS:C3641388 HADS_Q10 I have lost interest in my appearance HADS_Q10 HADS_Q10 HADS_Q11 UMLS:C3641389 HADS_Q11 I feel restless as I have to be on the move HADS_Q11 HADS_Q11 HADS_Q12 UMLS:C3641390 HADS_Q12 I look forward with enjoyment to things HADS_Q12 HADS_Q12 HADS_Q13 UMLS:C3641391 HADS_Q13 I get sudden feelings of panic HADS_Q13 HADS_Q13 HADS_Q14 UMLS:C3641392 HADS_Q14 I can enjoy a good book or radio or TV program HADS_Q14 HADS_Q14 HADS_Q2 UMLS:C3641380 HADS_Q2 I still enjoy the things I used to enjoy HADS_Q2 HADS_Q2 HADS_Q3 UMLS:C3641381 HADS_Q3 I get a sort of frightened feeling as if something awful is about to happen HADS_Q3 HADS_Q3 HADS_Q4 UMLS:C3641382 HADS_Q4 I can laugh and see the funny side of things HADS_Q4 HADS_Q4 HADS_Q5 UMLS:C3641383 HADS_Q5 Worrying thoughts go through my mind HADS_Q5 HADS_Q5 HADS_Q6 UMLS:C3641384 HADS_Q6 I feel cheerful HADS_Q6 HADS_Q6 HADS_Q7 UMLS:C3641385 HADS_Q7 I can sit at ease and feel relaxed HADS_Q7 HADS_Q7 HADS_Q8 UMLS:C3641386 HADS_Q8 I feel as if I am slowed down HADS_Q8 HADS_Q8 HADS_Q9 UMLS:C3641387 HADS_Q9 I get a sort of frightened feeling like 'butterflies' in the stomach HADS_Q9 HADS_Q9 HandDexterity Test performed to assess the ability of a person to use the fingers, hands and arms to perform a task. [Definition Source: physio-pedia.com] HandDexterity Hand Dexterity HeartRateMeasurement UMLS:C0018810 HeartRateMeasurement The number of heartbeats per unit of time, usually expressed as beats per minute. [Definition Source: NCI] HeartRateMeasurement http://purl.obolibrary.org/obo/NCIT_C49677 HeartRateMeasurement Heart Rate Measurement HematologyTest https://uts.nlm.nih.gov/uts/umls/concept/C0200627 HematologyTest A laboratory test to measure hematopoietic components and investigate hematologic disorders in a blood sample. [Definition Source: NCI] HematologyTest http://purl.obolibrary.org/obo/NCIT_C49286 HematologyTest Hematology Test Humidity UMLS:C0020167 Humidity A measure of the water vapor content of air. [Definition Source: NCI] Humidity http://purl.obolibrary.org/obo/NCIT_C88206 Humidity Humidity IgGIndexCSF The IgG index is the ratio of the quotients for IgG and albumin (IgGcsf/IgGs)/(Albcsf/Albs). It is a quantitative analysis of the relationship between CSF IgG and serum IgG, divided by the same relationship for albumin. [Definition Source: Simonsen, Cecilia Smith et al. “The diagnostic value of IgG index versus oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis.” Multiple sclerosis journal - experimental, translational and clinical vol. 6,1 2055217319901291. 22 Jan. 2020] IgGIndexCSF IgGIndexCSF ImmunoactiveDrugs Therapy employed to slow the progression of the disease. ImmunoactiveDrugs Immunoactive Drugs Impairment https://uts.nlm.nih.gov/uts/umls/concept/C0221099 Impairment Loss or abnormality of psychological, physiological, or anatomic structure or function. [Definition Source: NCI] Impairment http://purl.obolibrary.org/obo/NCIT_C21055 Impairment Impairment InterventionOrProcedure https://uts.nlm.nih.gov/uts/umls/concept/C0184661 InterventionOrProcedure An activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmental acts that can have preventive, therapeutic, or palliative effects. [Definition Source: NCI] InterventionOrProcedure http://purl.obolibrary.org/obo/NCIT_C25218 InterventionOrProcedure Intervention or Procedure J07BX03 https://uts.nlm.nih.gov/uts/umls/concept/C5400806 J07BX03 Covid-19 Vaccines J07BX03 ATC:J07BX KingsClinicalStaging The King’s staging system consists of five disease stages, with Stage 5 being death. Stages 1–3 are based upon the number of El Escorial central nervous system (CNS) regions involved in the disease, measured by weakness, wasting, spasticity, dysphagia, or dysarthria. Stage 4 is nutritional failure, defined by the requirement for gastrostomy, or respiratory failure, defined by the requirement for noninvasive ventilation (NIV), and based upon the National Institute for Clinical Excellence MND Guidelines (Supplemental Material). [Definition Source: Balendra, Rubika et al. “A standard operating procedure for King's ALS clinical staging.” Amyotrophic lateral sclerosis & frontotemporal degeneration vol. 20,3-4 (2019): 159-164.] KingsClinicalStaging King's Clinical Staging Method Kinship The relationship between members of the same family. [Cambridge Dictionary] Kinship https://dictionary.cambridge.org/dictionary/english/kinship Kinship Kinship Kinship This class is always instantiated as a blank node KinshipType The type of the relationship between members of the same family. KinshipType KinshipType KinshipType For the purpose of our ontology, we only consider biological kinship. We omit the word "biological" from the invidual's labels, for example "father" refers to "biological father". LaboratoryTestResult https://uts.nlm.nih.gov/uts/umls/concept/C0587081 LaboratoryTestResult The outcome of a laboratory test. [Definition Source: NCI] LaboratoryTestResult http://purl.obolibrary.org/obo/NCIT_C36292 LaboratoryTestResult Laboratory Test Result Last5YearsEvent Events occurred in the last 5 years (from the first visit). Last5YearsEvent Last 5 Years Event Lifestyle https://uts.nlm.nih.gov/uts/umls/concept/C0023676 Lifestyle A manner of living that reflects the person's values and attitudes. [Definition Source: NCI] Lifestyle http://purl.obolibrary.org/obo/NCIT_C16795 Lifestyle Lifestyle MFIS UMLS:C3810705 MFIS A standardized rating scale developed by Fisk et al in 1994, which assesses how fatigue may affect a person and the impact of fatigue on quality of life. The questionnaire contains 21 questions which are scored ranging from 0 (never) to 4 (almost always). [Definition Source: NCI] MFIS http://purl.obolibrary.org/obo/NCIT_C113877 MFIS Modified Fatigue Impact Scale MFIS_Q1 UMLS:C3829104 MFIS_Q1 I have been less alert MFIS_Q1 MFIS_Q1 MFIS_Q10 UMLS:C3827236 MFIS_Q10 I have trouble maintaining physical effort for long periods MFIS_Q10 MFIS_Q10 MFIS_Q11 UMLS:C3829103 MFIS_Q11 I have had difficulty making decisions MFIS_Q11 MFIS_Q11 MFIS_Q12 UMLS:C3829096 MFIS_Q12 I have been less motivated to do anything that requires thinking MFIS_Q12 MFIS_Q12 MFIS_Q13 UMLS:C3829093 MFIS_Q13 My muscles have felt weak MFIS_Q13 MFIS_Q13 MFIS_Q14 UMLS:C3829108 MFIS_Q14 I have been physically uncomfortable MFIS_Q14 MFIS_Q14 MFIS_Q15 UMLS:C3829099 MFIS_Q15 I have had trouble finishing tasks that require thinking MFIS_Q15 MFIS_Q15 MFIS_Q16 UMLS:C3829107 MFIS_Q16 I have had difficulty organizing my thoughts when doing things at home or at work MFIS_Q16 MFIS_Q16 MFIS_Q17 UMLS:C3829098 MFIS_Q17 I have been less able to complete tasks that require physical effort MFIS_Q17 MFIS_Q17 MFIS_Q18 UMLS:C3829092 MFIS_Q18 My thinking has been slowed down MFIS_Q18 MFIS_Q18 MFIS_Q19 UMLS:C3829100 MFIS_Q19 I have had trouble concentrating MFIS_Q19 MFIS_Q19 MFIS_Q2 UMLS:C3829102 MFIS_Q2 I have had difficulty paying attention for long periods of time MFIS_Q2 MFIS_Q2 MFIS_Q20 UMLS:C3829101 MFIS_Q20 I have limited my physical activities MFIS_Q20 MFIS_Q20 MFIS_Q21 UMLS:C3829091 MFIS_Q21 I have needed to rest more often or for longer periods MFIS_Q21 MFIS_Q21 MFIS_Q3 UMLS:C3829088 MFIS_Q3 I have been unable to think clearly MFIS_Q3 MFIS_Q3 MFIS_Q4 UMLS:C3829106 MFIS_Q4 I have been clumsy and uncoordinated MFIS_Q4 MFIS_Q4 MFIS_Q5 UMLS:C3829105 MFIS_Q5 I have been forgetful MFIS_Q5 MFIS_Q5 MFIS_Q6 UMLS:C3829090 MFIS_Q6 I have had to pace myself in my physical activities MFIS_Q6 MFIS_Q6 MFIS_Q7 UMLS:C3829097 MFIS_Q7 I have been less motivated to do anything that requires physical effort MFIS_Q7 MFIS_Q7 MFIS_Q8 UMLS:C3829095 MFIS_Q8 I have been less motivated to participate in social activities MFIS_Q8 MFIS_Q8 MFIS_Q9 UMLS:C3829094 MFIS_Q9 I have been limited in my ability to do things away from home MFIS_Q9 MFIS_Q9 MRI https://uts.nlm.nih.gov/uts/umls/concept/C0024485 MRI Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders. [Definition Source: NCI] MRI http://purl.obolibrary.org/obo/NCIT_C16809 MRI Magnetic Resonance Imaging (MRI) MSInPaediatricAge An indicator of whether the patient contracted Multiple Sclerosis (MS) in paediatric age. MSInPaediatricAge MSInPaediatricAge MSQOL54 UMLS:C3826975 MSQOL54 A standardized rating scale developed by Vickrey et al in 1995 and 1997, which combines items that are generic and disease-specific to assess quality of life and the level of physical, emotional, and cognitive functions in patients with multiple sclerosis. The questionnaire contains 54 questions and generates 12 subscales: physical function, role limitations due to physical problems, role limitations due to emotional problems, pain, emotional well-being, energy, health perceptions, social function, cognitive function, health distress, sexual function and overall quality of life. [Definition Source: NCI] MSQOL54 http://purl.obolibrary.org/obo/NCIT_C113878 MSQOL54 MSQOL54 Multiple Sclerosis Quality of Life (MSQOL)-54 Instrument MSQOL54_Q1 UMLS:C3828889 MSQOL54_Q1 In general, would you say your health is: MSQOL54_Q1 MSQOL54_Q1 MSQOL54_Q10 UMLS:C3828905 MSQOL54_Q10 Does your health limit you in walking several blocks? If so, how much? MSQOL54_Q10 MSQOL54_Q10 MSQOL54_Q11 UMLS:C3828906 MSQOL54_Q11 Does your health limit you in walking one block? If so, how much? MSQOL54_Q11 MSQOL54_Q11 MSQOL54_Q12 UMLS:C3828914 MSQOL54_Q12 Does your health limit you in bathing and dressing yourself? If so, how much? MSQOL54_Q12 MSQOL54_Q12 MSQOL54_Q13 UMLS:C3828897 MSQOL54_Q13 During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Cut down on the amount of time you could spend on work or other activities MSQOL54_Q13 MSQOL54_Q13 MSQOL54_Q14 UMLS:C3828898 MSQOL54_Q14 During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Accomplished less than you would like MSQOL54_Q14 MSQOL54_Q14 MSQOL54_Q15 UMLS:C3828895 MSQOL54_Q15 During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Were limited in the kind of work or other activities MSQOL54_Q15 MSQOL54_Q15 MSQOL54_Q16 UMLS:C3828895 MSQOL54_Q16 During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Had difficulty performing the work or other activities (for example, it took extra effor) MSQOL54_Q16 MSQOL54_Q16 MSQOL54_Q17 UMLS:C3828931 MSQOL54_Q17 During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of any emotional problems (such as feeling depressed or anxious). Cut down on the amount of time you could spend on work or other activities MSQOL54_Q17 MSQOL54_Q17 MSQOL54_Q18 UMLS:C3828932 MSQOL54_Q18 During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of any emotional problems (such as feeling depressed or anxious). Accomplished less than you would like MSQOL54_Q18 MSQOL54_Q18 MSQOL54_Q19 UMLS:C3828930 MSQOL54_Q19 During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of any emotional problems (such as feeling depressed or anxious). Didn’t do work or other activities as carefully as usual MSQOL54_Q19 MSQOL54_Q19 MSQOL54_Q2 UMLS:C3828904 MSQOL54_Q2 Compared to one year ago, how would you rate your health in general now? MSQOL54_Q2 MSQOL54_Q2 MSQOL54_Q20 UMLS:C3828928 MSQOL54_Q20 During the past 4 weeks, to what extent has your physical health or emotional problems interfered with your normal social activities with family, friends, neighbors, or groups? MSQOL54_Q20 MSQOL54_Q20 MSQOL54_Q21 UMLS:C3828938 MSQOL54_Q21 How much bodily pain have you had during the past 4 weeks? MSQOL54_Q21 MSQOL54_Q21 MSQOL54_Q22 UMLS:C3828899 MSQOL54_Q22 During the past 4 weeks, how much did pain interfere with your normal work (including both work outside the home and housework)? MSQOL54_Q22 MSQOL54_Q22 MSQOL54_Q23 UMLS:C3828927 MSQOL54_Q23 How much of the time during the past 4 weeks did you feel full of pep? MSQOL54_Q23 MSQOL54_Q23 MSQOL54_Q24 UMLS:C3828939 MSQOL54_Q24 How much of the time during the past 4 weeks have you been a very nervous person? MSQOL54_Q24 MSQOL54_Q24 MSQOL54_Q25 UMLS:C3828920 MSQOL54_Q25 How much of the time during the past 4 weeks have you felt so down in the dumps that nothing could cheer you up? MSQOL54_Q25 MSQOL54_Q25 MSQOL54_Q26 UMLS:C3828922 MSQOL54_Q26 How much of the time during the past 4 weeks have you felt calm and peaceful? MSQOL54_Q26 MSQOL54_Q26 MSQOL54_Q27 UMLS:C3828917 MSQOL54_Q27 How much of the time during the past 4 weeks did you have a lot of energy? MSQOL54_Q27 MSQOL54_Q27 MSQOL54_Q28 UMLS:C3828921 MSQOL54_Q28 How much of the time during the past 4 weeks have you felt downhearted and blue? MSQOL54_Q28 MSQOL54_Q28 MSQOL54_Q29 UMLS:C3828923 MSQOL54_Q29 How much of the time during the past 4 weeks did you feel worn out? MSQOL54_Q29 MSQOL54_Q29 MSQOL54_Q3 UMLS:C3828908 MSQOL54_Q3 Does your health limit you in vigorous activities, such as running, lifting heavy objects, participating in strenuous sports? If so, how much? MSQOL54_Q3 MSQOL54_Q3 MSQOL54_Q30 UMLS:C3828940 MSQOL54_Q30 How much of the time during the past 4 weeks have you been a happy person? MSQOL54_Q30 MSQOL54_Q30 MSQOL54_Q31 UMLS:C3828925 MSQOL54_Q31 How much of the time during the past 4 weeks did you feel tired? MSQOL54_Q31 MSQOL54_Q31 MSQOL54_Q32 UMLS:C3828926 MSQOL54_Q32 How much of the time during the past 4 weeks did you feel rested on waking in the morning? MSQOL54_Q32 MSQOL54_Q32 MSQOL54_Q33 UMLS:C3828892 MSQOL54_Q33 During the past 4 weeks, how much of the time has your physical health or emotional problems interfered with your social activities (like visiting with friends, relatives, etc.)? MSQOL54_Q33 MSQOL54_Q33 MSQOL54_Q34 UMLS:C3828918 MSQOL54_Q34 I seem to get sick a little easier than other people MSQOL54_Q34 MSQOL54_Q34 MSQOL54_Q35 UMLS:C3828941 MSQOL54_Q35 I am as healthy as anybody I know MSQOL54_Q35 MSQOL54_Q35 MSQOL54_Q36 UMLS:C3828929 MSQOL54_Q36 I expect my health to get worse MSQOL54_Q36 MSQOL54_Q36 MSQOL54_Q37 UMLS:C3828915 MSQOL54_Q37 My health is excellent MSQOL54_Q37 MSQOL54_Q37 MSQOL54_Q38 UMLS:C3828933 MSQOL54_Q38 How much of the time during the past 4 weeks were you discouraged by your health problems? MSQOL54_Q38 MSQOL54_Q38 MSQOL54_Q39 UMLS:C3828919 MSQOL54_Q39 How much of the time during the past 4 weeks were you frustrated about your health? MSQOL54_Q39 MSQOL54_Q39 MSQOL54_Q4 UMLS:C3828909 MSQOL54_Q4 Does your health limit you in moderate activities, such as moving a table, pushing a vacuum cleaner, bowling, or playing golf? MSQOL54_Q4 MSQOL54_Q4 MSQOL54_Q40 UMLS:C3828916 MSQOL54_Q40 How much of the time during the past 4 weeks was your health a worry in your life? MSQOL54_Q40 MSQOL54_Q40 MSQOL54_Q41 UMLS:C3828924 MSQOL54_Q41 How much of the time during the past 4 weeks did you feel weighed down by your health problems? MSQOL54_Q41 MSQOL54_Q41 MSQOL54_Q42 UMLS:C3828935 MSQOL54_Q42 How much of the time during the past 4 weeks have you had difficulty concentrating and thinking? MSQOL54_Q42 MSQOL54_Q42 MSQOL54_Q43 UMLS:C3828891 MSQOL54_Q43 How much of the time during the past 4 weeks did you have trouble keeping your attention on an activity for long? MSQOL54_Q43 MSQOL54_Q43 MSQOL54_Q44 UMLS:C3828890 MSQOL54_Q44 How much of the time during the past 4 weeks have you had trouble with your memory? MSQOL54_Q44 MSQOL54_Q44 MSQOL54_Q45 UMLS:C3828901 MSQOL54_Q45 How much of the time during the past 4 weeks have others, such as family members or friends, noticed that you have trouble with your memory or problems with your concentration? MSQOL54_Q45 MSQOL54_Q45 MSQOL54_Q46 UMLS:C3828902 MSQOL54_Q46 How much of a problem was the lack of sexual interest for you during the past 4 weeks? MSQOL54_Q46 MSQOL54_Q46 MSQOL54_Q47 UMLS:C3827368 MSQOL54_Q47 How much of a problem was the difficulty getting or keeping an erection for you during the past 4 weeks? MSQOL54_Q47 MSQOL54_Q47 MSQOL54_Q48 UMLS:C3828934 MSQOL54_Q48 How much of a problem was the difficulty having orgasm for you during the past 4 weeks? MSQOL54_Q48 MSQOL54_Q48 MSQOL54_Q49 UMLS:C3828942 MSQOL54_Q49 How much of a problem was the for ability to satisfy sexual partner you during the past 4 weeks? MSQOL54_Q49 MSQOL54_Q49 MSQOL54_Q5 UMLS:C3828910 MSQOL54_Q5 Does your health limit you in lifting or carrying groceries? If so, how much? MSQOL54_Q5 MSQOL54_Q5 MSQOL54_Q50 UMLS:C3827367 MSQOL54_Q50 Overall, how satisfied were you with your sexual function during the past 4 weeks? MSQOL54_Q50 MSQOL54_Q50 MSQOL54_Q51 UMLS:C3828937 MSQOL54_Q51 During the past 4 weeks, to what extent have problems with your bowel or bladder function interfered with your normal social activities with family, friends, neighbors, or groups? MSQOL54_Q51 MSQOL54_Q51 MSQOL54_Q52 UMLS:C3828900 MSQOL54_Q52 During the past 4 weeks, how much did pain interfere with your enjoyment of life? MSQOL54_Q52 MSQOL54_Q52 MSQOL54_Q53 UMLS:C3828893 MSQOL54_Q53 Overall, how would you rate your own quality-of-life? MSQOL54_Q53 MSQOL54_Q53 MSQOL54_Q54 UMLS:C3828936 MSQOL54_Q54 Which best describes how you feel about your life as a whole? MSQOL54_Q54 MSQOL54_Q54 MSQOL54_Q6 UMLS:C3828911 MSQOL54_Q6 Does your health limit you in climbing several flights of stair? If so, how much? MSQOL54_Q6 MSQOL54_Q6 MSQOL54_Q7 UMLS:C3828912 MSQOL54_Q7 Does your health limit you in climbing one flights of stair? If so, how much? MSQOL54_Q7 MSQOL54_Q7 MSQOL54_Q8 UMLS:C3828913 MSQOL54_Q8 Does your health limit you in bending, kneeling, or stooping? If so, how much? MSQOL54_Q8 MSQOL54_Q8 MSQOL54_Q9 UMLS:C3828907 MSQOL54_Q9 Does your health limit you in walking more than a mile? If so, how much? MSQOL54_Q9 MSQOL54_Q9 MaxTemp Daily Maximum Temperature MeanGlobRadiation Daily Mean Global Radiation MeanTemp Daily Mean Temperature MeanWindSpeed Daily Mean Wind Speed MenstrualCycle UMLS:C0025329 MenstrualCycle The Menstrual Cycle involves regularly recurring hormonal changes and physiologic endometrial changes during the reproductive period in human females, and some primates, and culminates in partial sloughing of the endometrium (menstruation) in the absence of fertilization. For most women, one cycle takes 28 days. [Definition Source: NCI] MenstrualCycle http://purl.obolibrary.org/obo/NCIT_C16838 MenstrualCycle Menstrual Cycle MiToSFunctionalStaging The Milano–Torino (MiToS) Staging system comprises six stages, based on functional impairment as assessed by the revised ALS Functional Rating Scale (ALSFRS-R). [Definition Source: Balendra, Rubika et al. “A standard operating procedure for King's ALS clinical staging.” Amyotrophic lateral sclerosis & frontotemporal degeneration vol. 20,3-4 (2019): 159-164.] MiToSFunctionalStaging Milano-Torino Functional Staging System (MiToS) MinTemp Daily Minimum Temperature MoreThan5YearsEvent Events occured more than 5 years ago, counting from the first visit. MoreThan5YearsEvent More Than 5 Years Event MuscleToneALS Muscle tone assessment performed to ALS patients. MuscleToneALS Muscle Tone ALS MuscleToneAssessment UMLS:C4707572 MuscleToneAssessment Muscle Tone measured by the modified Ashworth scale. The modified Ashworth scale is a muscle tone assessment scale used to assess the resistance experienced during passive range of motion, which does not require any instrumentation and is quick to perform. [Source: ncbi.nlm.nih.gov/books/NBK554572/] MuscleToneAssessment Muscle Tone Assessment MuscleToneMS Muscle tone assessment performed to MS patients. MuscleToneMS Muscle Tone MS N07XX09 ATC:L04AX07 N07XX09 BG-12 N07XX09 ATC:N07 Occupation The principal activity that a person does to earn money. [Definition Source: NCI] Occupation http://data.europa.eu/esco/isco Occupation Occupation OligoclonalBands https://uts.nlm.nih.gov/uts/umls/concept/C4048246 OligoclonalBands The presence of more than one immunoglobulin band in the serum, urine, or cerebrospinal fluid. It usually results from infectious or immunologic disorders. [Definition Source: NCI] OligoclonalBands http://purl.obolibrary.org/obo/NCIT_C113809 OligoclonalBands Oligoclonal Bands Onset https://uts.nlm.nih.gov/uts/umls/concept/C0332162 Onset The start, beginning, or early stages. [Definition Source: NCI] Onset http://purl.obolibrary.org/obo/NCIT_C25279 Onset Onset PET https://uts.nlm.nih.gov/uts/umls/concept/C0032743 PET A technique for measuring the gamma radiation produced by collisions of electrons and positrons (anti-electrons) within living tissue. In positron emission tomography (PET), a subject is given a dose of a positron-emitting radionuclide attached to a metabolically active substance (for example, 2-fluoro-2-deoxy-D-glucose (FDG), which is similar to a naturally occurring sugar, glucose, with the addition of a radioactive fluorine atom). When living tissue containing the positron emitter is bombarded by electrons, gamma radiation produced by collisions of electrons and positrons is detected by a scanner, revealing in fine detail the tissue location of the metabolically-active substance administered. [Definition Source: NCI] PET http://purl.obolibrary.org/obo/NCIT_C17007 PET Positron Emission Tomography (PET) PFTs UMLS:C0024119 PFTs A broad range of tests that are performed to assess how well lungs inhale and exhale air and how efficiently they transfer oxygen into the blood. [Definition Source: NCI] PFTs http://purl.obolibrary.org/obo/NCIT_C38081 PFTs Pulmonary function testing PFTs_FEV1_L UMLS:C0849974 PFTs_FEV1_L A test of lung function, the FEV1 is the volume exhaled during the first second of a forced expiratory maneuver started from the level of total lung capacity. It is the most frequently used index for assessing bronchoconstriction or bronchodilatation. [Definition Source: NCI] PFTs_FEV1_L PFTs_FEV1_L PFTs_FEV1_P UMLS:C0849974 PFTs_FEV1_P A test of lung function, the FEV1 is the volume exhaled during the first second of a forced expiratory maneuver started from the level of total lung capacity. It is the most frequently used index for assessing bronchoconstriction or bronchodilatation. [Definition Source: NCI] PFTs_FEV1_P PFTs_FEV1_P PFTs_FEV6_L UMLS:C1708092 PFTs_FEV6_L A test of lung function, the FEV6 is the volume exhaled during six seconds of a forced expiratory maneuver started from the level of total lung capacity. [Definition Source: NCI] PFTs_FEV6_L PFTs_FEV6_L PFTs_FEV6_P UMLS:C1708092 PFTs_FEV6_P A test of lung function, the FEV6 is the volume exhaled during six seconds of a forced expiratory maneuver started from the level of total lung capacity. [Definition Source: NCI] PFTs_FEV6_P PFTs_FEV6_P PM1_concentration Particulate Matter <1 µm concentration PSQI UMLS:C3697468 PSQI A self-rated questionnaire which assesses sleep quality and disturbances over a one month time interval. [Definition Source: NCI] PSQI http://purl.obolibrary.org/obo/NCIT_C103849 PSQI Pittsburgh Sleep Quality Index PSQI_Q1 During the past month, what time have you usually gone to bed at night? PSQI_Q1 PSQI_Q1 PSQI_Q10 Do you have a bed partner or room mate? PSQI_Q10 PSQI_Q10 PSQI_Q11A Loud snoring PSQI_Q11A PSQI_Q11A PSQI_Q11B Long pauses between breaths while asleep PSQI_Q11B PSQI_Q11B PSQI_Q11C Legs twitching or jerking while you sleep PSQI_Q11C PSQI_Q11C PSQI_Q11D Episodes of disorientation or confusion during sleep PSQI_Q11D PSQI_Q11D PSQI_Q11E Other restlessness while you sleep, please describe PSQI_Q11E PSQI_Q11E PSQI_Q2 During the past month, how long (in minutes) has it usually taken you to fall asleep each night? PSQI_Q2 PSQI_Q2 PSQI_Q3 During the past month, what time have you usually gotten up in the morning? PSQI_Q3 PSQI_Q3 PSQI_Q4 During the past month, how many hours of actual sleep did you get at night? (This may be different than the number of hours you spent in bed.) PSQI_Q4 PSQI_Q4 PSQI_Q5A Cannot get to sleep within 30 minutes PSQI_Q5A PSQI_Q5A PSQI_Q5B Wake up in the middle of the night or early morning PSQI_Q5B PSQI_Q5B PSQI_Q5C Have to get up to use the bathroom PSQI_Q5C PSQI_Q5C PSQI_Q5D Cannot breathe comfortably PSQI_Q5D PSQI_Q5D PSQI_Q5E Cough or snore loudly PSQI_Q5E PSQI_Q5E PSQI_Q5F Feel too cold PSQI_Q5F PSQI_Q5F PSQI_Q5G Feel too hot PSQI_Q5G PSQI_Q5G PSQI_Q5H Have bad dreams PSQI_Q5H PSQI_Q5H PSQI_Q5I Have pain PSQI_Q5I PSQI_Q5I PSQI_Q5J_1 Other reason(s), please describe: PSQI_Q5J_1 PSQI_Q5J_1 PSQI_Q5J_2 how often have you had trouble sleeping because of this? PSQI_Q5J_2 PSQI_Q5J_2 PSQI_Q6 During the past month, how often have you taken medicine to help you sleep (prescribed or “over the counter”)? PSQI_Q6 PSQI_Q6 PSQI_Q7 During the past month, how often have you had trouble staying awake while driving, eating meals, or engaging in social activity? PSQI_Q7 PSQI_Q7 PSQI_Q8 During the past month, how much of a problem has it been for you to keep up enough enthusiasm to get things done? PSQI_Q8 PSQI_Q8 PSQI_Q9 During the past month, how would you rate your sleep quality overall? PSQI_Q9 PSQI_Q9 Patient https://uts.nlm.nih.gov/uts/umls/concept/C0030705 Patient A person who receives medical attention, care, or treatment, or who is registered with medical professional or institution with the purpose to receive medical care when necessary. [Definition Source: NCI] Patient http://purl.obolibrary.org/obo/NCIT_C16960 Patient Patient PharmacologicSubstance https://uts.nlm.nih.gov/uts/umls/concept/C1254351 PharmacologicSubstance Any natural, endogenously-derived, synthetic or semi-synthetic compound with pharmacologic activity. A pharmacologic substance has one or more specific mechanism of action(s) through which it exerts one or more effect(s) on the human or animal body. They can be used to potentially prevent, diagnose, treat or relieve symptoms of a disease. Formulation specific agents and some combination agents are also classified as pharmacologic substances. [Definition Source: NCI] PharmacologicSubstance http://purl.obolibrary.org/obo/NCIT_C1909 PharmacologicSubstance Pharmacologic Substance PhysicalActivity https://uts.nlm.nih.gov/uts/umls/concept/C0026606 PhysicalActivity Any form of exercise or movement. Physical activity may include planned activity such as walking, running, basketball, or other sports. Physical activity may also include other daily activities such as household chores, yard work, walking the dog, etc. [Definition Source: NCI][attribution: from NIDDK Glossary; http://www.niddk.nih.gov/health/nutrit/pubs/glossary/glossaryintro.htm] PhysicalActivity http://purl.obolibrary.org/obo/NCIT_C17708 PhysicalActivity Physical Activity PhysicalActivityData UMLS:C0026606 PhysicalActivityData Any form of exercise or movement. Physical activity may include planned activity such as walking, running, basketball, or other sports. Physical activity may also include other daily activities such as household chores, yard work, walking the dog, etc. [Definition Source: NCI] PhysicalActivityData http://purl.obolibrary.org/obo/NCIT_C17708 PhysicalActivityData Physical Activity Data Place A particular part or region of space; a physical locality, a locale; a spot, a location. [Definition Source: Oxford English Dictionary] Place Place Precipitation Precipitation PrecipitationSum Daily Precipitation Sum Pregnancy https://uts.nlm.nih.gov/uts/umls/concept/C0032961 Pregnancy The state or condition of having a developing embryo or fetus in the body (uterus), after union of an ovum and spermatozoon, during the period from conception to birth. [Definition Source: NCI] Pregnancy http://purl.obolibrary.org/obo/NCIT_C25742 Pregnancy Pregnancy ProtocolEvent https://uts.nlm.nih.gov/uts/umls/concept/C2698908 ProtocolEvent Other important events that occur during a trial but are not driven by protocol requirements. [Definition Source: NCI] ProtocolEvent http://purl.obolibrary.org/obo/NCIT_C74589 ProtocolEvent Protocol Event PulmonaryFunctionTest https://uts.nlm.nih.gov/uts/umls/concept/C0024119 PulmonaryFunctionTest A broad range of tests that are performed to assess how well lungs inhale and exhale air and how efficiently they transfer oxygen into the blood. [Definition Source: NCI] PulmonaryFunctionTest http://purl.obolibrary.org/obo/NCIT_C38081 PulmonaryFunctionTest Pulmonary Function Test Questionnaire https://uts.nlm.nih.gov/uts/umls/concept/C0034394 Questionnaire A predetermined set of questions. [Definition Source: NCI] Questionnaire http://purl.obolibrary.org/obo/NCIT_C17048 Questionnaire Questionnaire Relapse https://uts.nlm.nih.gov/uts/umls/concept/C0277556 Relapse The return of a disease after a period of remission. [Definition Source: NCI] Relapse http://purl.obolibrary.org/obo/NCIT_C38155 Relapse Relapse Residence https://uts.nlm.nih.gov/uts/umls/concept/C0237096 Residence Any address at which a person dwells more than temporarily. [Definition Source: NCI] Residence http://purl.obolibrary.org/obo/NCIT_C25273 Residence Residence RespiratoryData Respiratory Data registered by a wearable device. RespiratoryData Respiratory Data SDMT UMLS:C3891405 SDMT A standardized rating scale developed by Aaron Smith in 1982, which is used to identify individuals with neurological impairment, as well as to assess divided attention, visual scanning and motor speed. This functional test measures the time to pair abstract symbols with specific numbers with a 90 second time limit. Scoring of this test is based on the total number of correctly coded items from 0-110 in 90 seconds. [Definition Source: NCI] SDMT http://purl.obolibrary.org/obo/NCIT_C115793 SDMT Symbol Digit Modalities Functional Test SLEEP_ALS UMLS:C5420463 SLEEP_ALS A question about an individual's sleeping. [Definition Source: NCI] SLEEP_ALS http://purl.obolibrary.org/obo/NCIT_C173925 SLEEP_ALS Sleep Quality SLEEP_ALS_Q1 UMLS:C4054285 SLEEP_ALS_Q1 During the last 7 days, how would you rate your sleep quality overall? Choose a number from 1 to 10 that best describes your sleep quality SLEEP_ALS_Q1 SLEEP_ALS_Q1 SPO2Data SPO2 Data registered by a wearable device. SPO2Data SPO2 Data SelfALSFRSR ALSFRS-R assessed by the patient using the mobile questionnaires. SelfALSFRSR Self assessed ALSFRS-R questionnaire SleepData UMLS:C0037313 SleepData A natural and periodic state of rest during which consciousness of the world is suspended. [Definition Source: NCI] SleepData http://purl.obolibrary.org/obo/NCIT_C73425 SleepData Sleep Data Smoking https://uts.nlm.nih.gov/uts/umls/concept/C0037369 Smoking The act of puffing and/or inhaling the combustion products of a substance so as to be tasted and absorbed into the bloodstream. [Definition Source: NCI] Smoking http://purl.obolibrary.org/obo/NCIT_C154329 Smoking Smoking StressLevel UMLS:C0038435 StressLevel The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities. [Definition Source: NCI] StressLevel http://purl.obolibrary.org/obo/NCIT_C35041 StressLevel Stress Level SurgicalProcedure https://uts.nlm.nih.gov/uts/umls/concept/C0543467 SurgicalProcedure A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery. [Definition Source: NCI] SurgicalProcedure http://purl.obolibrary.org/obo/NCIT_C15329 SurgicalProcedure Surgical Procedure SurgicalType It defines some type of surgical procedures a patient could undergo. SurgicalType Surgical Procedure Type Symptom UMLS:C1457887 Symptom Subjective evidence of disease perceived by the patient. [Definition Source: NCI] Symptom http://purl.obolibrary.org/obo/NCIT_C4876 Symptom Symptom Temperature The temperature of the surroundings. [Definition Source: NCI] Temperature http://purl.obolibrary.org/obo/NCIT_C90380 Temperature Temperature TherapeuticProcedure https://uts.nlm.nih.gov/uts/umls/concept/C0087111 TherapeuticProcedure An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process. [Definition Source: NCI] TherapeuticProcedure http://purl.obolibrary.org/obo/NCIT_C49236 TherapeuticProcedure Therapeutic Procedure TherapeuticProcedureType It defines some type of therapeutic procedures that could be administered to a patient. TherapeuticProcedureType Therapeutic Procedure Type TherapeuticTreatment The therapeutic treatment that has been administered to a patient. TherapeuticTreatment Therapeutic Treatment Trauma https://uts.nlm.nih.gov/uts/umls/concept/C3263723 Trauma Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity. [Definition Source: NCI] Trauma http://purl.obolibrary.org/obo/NCIT_C3671 Trauma Trauma UseCaseComorbidities Comorbidities checked in a specific use-case, e.g. ALS patients in a specific study. UseCaseComorbidities Use-Case Comorbidities VAS UMLS:C3536884 VAS A psychometric response scale to assess subjective characteristics or symptoms, which relies upon a continuum of possible result values in between two fixed end-points. [Definition Source: NCI] VAS http://purl.obolibrary.org/obo/NCIT_C121547 VAS Visual Analogue Scale VASQ1 UMLS:C0042815 VASQ1 Choose a number from 0 to 10 that best describes your pain VASQ1 VAS_Q1 VAS_ALS Visual Analogue Scale questionnaire administered to ALS patients. VAS_ALS Visual Analogue Scale for ALS patients VOC_concentration Volatile Organic Compound concentration VisualAcuity UMLS:C0042812 VisualAcuity Sharpness of vision, the ability to discern fine detail. [Definition Source: NCI] VisualAcuity http://purl.obolibrary.org/obo/NCIT_C87149 VisualAcuity Visual Acuity WEIGHT UMLS:C0005910 WEIGHT The weight of a subject. [Definition Source: NCI] WEIGHT http://purl.obolibrary.org/obo/NCIT_C81328 WEIGHT Weight WEIGHT_Q1 Please, enter your weight WEIGHT_Q1 WEIGHT_Q1 WalkTest Test performed to assess the walking abilities of patients. WalkTest Walk Test WalkTestALS Walk test performed to ALS patients. WalkTestALS Walk Test ALS WalkTestMS Walk test performed to MS patients. WalkTestMS Walk Test MS WearableDataMeasurement Measurements collected by wearables. WearableDataMeasurement Wearable Data Measurement WeatherData The different weather information registered by sensing devices. WeatherData Weather Data WindSpeed Wind Speed abdominalSurgery Whether a patient had an abdominal surgery. abdominalSurgery abdominalSurgery activeKilocalories Active kilocalories registered by the wearable device. [uom: kcal] activeKilocalories activeKilocalories activeTime Active time registered by the wearable device. [uom: seconds] activeTime activeTime activityDistance Activity distance registered by the wearable device. [uom: meters] activityDistance activityDistance activityEndYear The year in which an activity ended. activityEndYear activityEndYear activityIntensity The level of intensity with which the physical activity is carried out. activityIntensity activityIntensity activityStartYear The year in which the activity started. activityStartYear activityStartYear activitySteps Activity steps registered by the wearable device. activitySteps activitySteps activityStepsGoal Activity steps goal registered by the wearable device. activityStepsGoal activityStepsGoal activityStressDuration Activity stress duration registered by the wearable device. [uom: seconds] activityStressDuration activityStressDuration activityType The type of physical activity carried out. activityType activityType administration It defines the relationship between a therapeutic treatment and the specific administration details. administration administration administrationFrequency The frequency of administration of the pharmacological substance. administrationFrequency administrationFrequency administrationRoute https://uts.nlm.nih.gov/uts/umls/concept/C0013153 administrationRoute Designation of the part of the body through which or into which, or the way in which, the medicinal product is intended to be introduced. In some cases a medicinal product can be intended for more than one route and/or method of administration. [Definition Source: NCI][attribution: ICH] administrationRoute administrationRoute administrationUoM The Unit of Measure (UoM) of the adminstration dose. administrationUoM administrationUoM adminstrationDose A definite quantity of a medicine or drug given or prescribed to be given at one time. [Definition Source: Oxford English Dictionary] adminstrationDose administrationDose adverseReaction It defines the relationship between The end therapy reason and the adverse reaction occurred. adverseReaction adverseReaction ageBaseline The MS patient's age at baseline. Expressed in years. ageBaseline ageBaseline ageDiagnosis Age of the patient at the diagnosis. ageDiagnosis ageDiagnosis ageOnset Age of the patient at the onset. ageOnset ageOnset albuminCSF A quantitative measurement of albumin present in a sample of CSF. Unit of measure : [mg/l]. albuminCSF albuminCSF alcoholUse Whether a patient drinks alcohol. alcoholUse alcoholUse alive Whether the patient is still alive. alive alive alsfrs1 Item 1 for ALSFRS: Speech. alsfrs1 alsfrs1 alsfrs10 Item 10 for Revised ALSFRS: Dyspnea. alsfrs10 alsfrs10 alsfrs11 Item 11 for Revised ALSFRS: Orthopnea. alsfrs11 alsfrs11 alsfrs12 Item 12 for Revised ALSFRS: Respiratory Insufficiency. alsfrs12 alsfrs12 alsfrs2 Item 2 for ALSFRS: Salivation. alsfrs2 alsfrs2 alsfrs3 Item 3 for ALSFRS: Swallowing. alsfrs3 alsfrs3 alsfrs4 Item 4 for ALSFRS: Handwriting. alsfrs4 alsfrs4 alsfrs5 Item 5 for ALSFRS: Cutting food and handling utensilis. alsfrs5 alsfrs5 alsfrs6 Item 6 for ALSFRS: Dressing and hygiene. alsfrs6 alsfrs6 alsfrs7 Item 7 for ALSFRS: Turning in bed and adjusting blankets. alsfrs7 alsfrs7 alsfrs8 Item 8 for ALSFRS: Walking. alsfrs8 alsfrs8 alsfrs9 Item 9 for ALSFRS: Climbing Stairs. alsfrs9 alsfrs9 alsfrsOriginal10 Original item 10 for ALSFRS: Breathing. alsfrsOriginal10 alsfrsOriginal10 alterationCSF Whether the CSF specimen is normal or presents alterations. alterationCSF alterationCSF ambulationEDSS Expanded Disability Status Score (EDSS) score for ambulation. ambulationEDSS ambulationEDSS ambulationEDSSAssistance Whether the patient used assistance to perform the ambulation test. ambulationEDSSAssistance ambulationEDSSAssistance ambulationEDSSObservedTime Observed time to walk 500m (in minutes) ambulationEDSSObservedTime ambulationEDSSObservedTime ambulationEDSSPatientDistance Distance reported by patient (in meters) without stopping ambulationEDSSPatientDistance ambulationEDSSPatientDistance ambulationEDSSPatientTime Time reported by patient (in minutes) without stopping ambulationEDSSPatientTime ambulationEDSSPatientTime anatomicalLocation It defines the location of a trauma, onset, surgical procedure or diagnostic imaging. anatomicalLocation anatomicalLocation ankleFootOrthosis Whether the patient has ankle/foot orthosis. ankleFootOrthosis ankleFootOrthosis ashworthLeftArm Muscle tone assessment of the left arm. ashworthLeftArm ashworthLeftArm ashworthLeftLeg Muscle tone assessment of the left leg. ashworthLeftLeg ashworthLeftLeg ashworthRightArm Muscle tone assessment of the right arm. ashworthRightArm ashworthRightArm ashworthRightLeg Muscle tone assessment of the right leg. ashworthRightLeg ashworthRightLeg autoimmuneDisease Whether a patient ever had an autoimmune disease. autoimmuneDisease autoimmuneDisease averageHeartRate Average heart rate registered by the wearable device. [uom: bpm] averageHeartRate averageHeartRate averageMeasurement Average of valid measurements in that week; if there are no valid measurements in that week, it is denoted as NA. averageMeasurement averageMeasurement averageStressLevel Average stress level registered by the wearable device. averageStressLevel averageStressLevel awajiClinicalLMNBulbar Whether the patient presents clinical Lower Motor Neuron (LMN) signs in the Bulbar region. awajiClinicalLMNBulbar awajiClinicalLMNBulbar awajiClinicalLMNCervical Whether the patient presents clinical Lower Motor Neuron (LMN) signs in the Cervical region. awajiClinicalLMNCervical awajiClinicalLMNCervical awajiClinicalLMNLumboSacral Whether the patient presents clinical Lower Motor Neuron (LMN) signs in the Lumbo-Sacral region. awajiClinicalLMNLumboSacral awajiClinicalLMNLumboSacral awajiClinicalLMNThoracic Whether the patient presents clinical Lower Motor Neuron (LMN) signs in the Thoracic region. awajiClinicalLMNThoracic awajiClinicalLMNThoracic awajiClinicalUMNBulbar Whether the patient presents clinical Upper Motor Neuron (UMN) signs in the Bulbar region. awajiClinicalUMNBulbar awajiClinicalUMNBulbar awajiClinicalUMNCervical Whether the patient presents clinical Upper Motor Neuron (UMN) signs in the Cervical region. awajiClinicalUMNCervical awajiClinicalUMNCervical awajiClinicalUMNLumboSacral Whether the patient presents clinical Upper Motor Neuron (UMN) signs in the Lumbo-Sacral region. awajiClinicalUMNLumboSacral awajiClinicalUMNLumboSacral awajiDiagnosisCriteria ALS diagnosis according to the Awaji criteria. awajiDiagnosisCriteria awajiDiagnosisCriteria awajiEMGLMNBulbar Whether the patient presents Lower Motor Neuron (LMN) signs in the Bulbar region, using needle electromyography (EMG). awajiEMGLMNBulbar awajiEMGLMNBulbar awajiEMGLMNCervical Whether the patient presents Lower Motor Neuron (LMN) signs in the Cervical region, using needle electromyography (EMG). awajiEMGLMNCervical awajiEMGLMNCervical awajiEMGLMNLumboSacral Whether the patient presents Lower Motor Neuron (LMN) signs in the Lumbo-Sacral region, using needle electromyography (EMG). awajiEMGLMNLumboSacral awajiEMGLMNLumboSacral awajiEMGLMNThoracic Whether the patient presents Lower Motor Neuron (LMN) signs in the Thoracic region, using needle electromyography (EMG). awajiEMGLMNThoracic awajiEMGLMNThoracic awakeDuration Awake duration registered by the wearable device. [uom: seconds] awakeDuration awakeDuration axialOnset Whether the patient experienced axial onset. The Axial Skeleton is the part of the skeleton that includes the skull and spinal column and sternum and ribs. [Definition Source: NCI] axialOnset axialOnset basalKilocalories Total basal calories registered by the wearable device. [uom: kcal] basalKilocalories basalKilocalories baselineHeartRate The baseline heart rate (at stimulus onset). baselineHeartRate baselineHeartRate beatToBeatAI Area Index, defined as the cumulative area of the sectors corresponding to the points that are located above Line of Identity (LI) divided by the cumulative area of sectors corresponding to all points in the Poincaré plot except those that are located on LI. beatToBeatAI beatToBeatAI beatToBeatC2a The contributions of heart rate acceleration in long-term Heart Rate Variability (HRV) (Piskorski, 2011). beatToBeatC2a beatToBeatC2a beatToBeatC2d The contributions of heart rate deceleration in long-term HRV (Piskorski, 2011). beatToBeatC2d beatToBeatC2d beatToBeatCSI The Cardiac Sympathetic Index (Toichi, 1997), calculated by dividing the longitudinal variability of the Poincaré plot by its transverse variability. beatToBeatCSI beatToBeatCSI beatToBeatCSIModified The modified CSI (Jeppesen, 2014) obtained by dividing the square of the longitudinal variability by its transverse variability. beatToBeatCSIModified beatToBeatCSIModified beatToBeatCVI The Cardiac Sympathetic Index (Toichi, 1997), equal to the logarithm of the product of longitudinal variability of the Poincaré plot by its transverse variability. beatToBeatCVI beatToBeatCVI beatToBeatCVSD The root mean square of the sum of successive differences (RMSSD) divided by the mean of the RR intervals (MeanNN). beatToBeatCVSD beatToBeatCVSD beatToBeatCa The total contributions of heart rate accelerations to HRV. beatToBeatCa beatToBeatCa beatToBeatCd The total contributions of heart rate accelerations to HRV. beatToBeatCd beatToBeatCd beatToBeatGI Guzik’s Index, defined as the distance of points above line of identity (LI) to LI divided by the distance of all points in Poincaré plot to LI except those that are located on LI. beatToBeatGI beatToBeatGI beatToBeatHTI The HRV triangular index, measuring the total number of RR intervals divided by the height of the RR intervals histogram. beatToBeatHTI beatToBeatHTI beatToBeatHcvNN The median absolute deviation of the RR intervals (MadNN) divided by the median of the absolute differences of their successive differences (MedianNN). beatToBeatHcvNN beatToBeatHcvNN beatToBeatIALS Inverse of the average length of the acceleration/deceleration segments. beatToBeatIALS beatToBeatIALS beatToBeatIqrNN The interquartile range (IQR) of the RR intervals. beatToBeatIqrNN beatToBeatIqrNN beatToBeatMadNN The median absolute deviation of the RR intervals. beatToBeatMadNN beatToBeatMadNN beatToBeatMeanNN The mean of the RR intervals. beatToBeatMeanNN beatToBeatMeanNN beatToBeatMedianNN The median of the absolute values of the successive differences between RR intervals. beatToBeatMedianNN beatToBeatMedianNN beatToBeatPAS Percentage of NN intervals in alternation segments beatToBeatPAS beatToBeatPAS beatToBeatPI Porta’s Index, defined as the number of points below LI divided by the total number of points in Poincaré plot except those that are located on LI. beatToBeatPI beatToBeatPI beatToBeatPIP Percentage of inflection points of the RR intervals series. beatToBeatPIP beatToBeatPIP beatToBeatPNN20 The proportion of RR intervals greater than 20ms, out of the total number of RR intervals. beatToBeatPNN20 beatToBeatPNN20 beatToBeatPNN50 The proportion of RR intervals greater than 50ms, out of the total number of RR intervals. beatToBeatPNN50 beatToBeatPNN50 beatToBeatPSS Percentage of short segments beatToBeatPSS beatToBeatPSS beatToBeatRmssd The square root of the mean of the sum of successive differences between adjacent RR intervals. beatToBeatRmssd beatToBeatRmssd beatToBeatSD1 SD1 is a measure of the spread of RR intervals on the Poincaré plot perpendicular to the line of identity. It is an index of short-term RR interval fluctuations, i.e., beat-to-beat variability. It is equivalent (although on another scale) to RMSSD, and therefore it is redundant to report correlations with both (Ciccone, 2017). beatToBeatSD1 beatToBeatSD1 beatToBeatSD1SD2 The ratio between short- and long-term fluctuations of the RR intervals (SD1 divided by SD2). beatToBeatSD1SD2 beatToBeatSD1SD2 beatToBeatSD1a Short-term variance of contributions of accelerations (shortenings of RR intervals) (Piskorski, 2011). beatToBeatSD1a beatToBeatSD1a beatToBeatSD1d Short-term variance of contributions of decelerations (prolongations of RR intervals) (Piskorski, 2011). beatToBeatSD1d beatToBeatSD1d beatToBeatSD2 Measure of the spread of RR intervals on the Poincaré plot along the line of identity. It is an index of long-term RR interval fluctuations. beatToBeatSD2 beatToBeatSD2 beatToBeatSDANN1 The standard deviation of average RR intervals extracted from 1-minute segments of time series data. beatToBeatSDANN1 beatToBeatSDANN1 beatToBeatSDANN2 The standard deviation of average RR intervals extracted from 2-minutes segments of time series data. beatToBeatSDANN2 beatToBeatSDANN2 beatToBeatSDANN5 The standard deviation of average RR intervals extracted from 5-minutes segments of time series data. beatToBeatSDANN5 beatToBeatSDANN5 beatToBeatSDNN The standard deviation of the RR intervals. beatToBeatSDNN beatToBeatSDNN beatToBeatSDNNI The mean of the standard deviations of RR intervals extracted from 2-minutes segments of time series data. beatToBeatSDNNI beatToBeatSDNNI beatToBeatSDNNI1 The mean of the standard deviations of RR intervals extracted from 1-minute segments of time series data. beatToBeatSDNNI1 beatToBeatSDNNI1 beatToBeatSDNNI5 The mean of the standard deviations of RR intervals extracted from 5-minutes segments of time series data. beatToBeatSDNNI5 beatToBeatSDNNI5 beatToBeatSDNNa Total variance of contributions of accelerations (shortenings of RR intervals) (Piskorski, 2011). beatToBeatSDNNa beatToBeatSDNNa beatToBeatSDNNd Total variance of contributions of decelerations (prolongations of RR intervals) (Piskorski, 2011). beatToBeatSDNNd beatToBeatSDNNd beatToBeatSDSD The standard deviation of the successive differences between RR intervals. beatToBeatSDSD beatToBeatSDSD beatToBeatSI Slope Index, defined as the phase angle of points above LI divided by the phase angle of all points in Poincaré plot except those that are located on LI. beatToBeatSI beatToBeatSI before20Years Whether a patient smoked before the age of 20. before20Years before20Years birthYear https://uts.nlm.nih.gov/uts/umls/concept/C2826771 birthYear The year in which a person was born. [Definition Source: NCI] birthYear birthYear birthplace It defines the relationship between a person and his or her birthplace. birthplace birthplace bmrKilocalories BMR kilocalories registered by the wearable device. [uom: kcal] bmrKilocalories bmrKilocalories bmvtrTotal Brief Visuospatial Memory Test-Revised Total Score. bmvtrTotal bmvtrTotal bodyMassIndex Weight in kilograms divided by the square of the height in metres, used esp. as an indicator of obesity or general nutritional status; also called Quetelet index; abbreviated BMI. [Definition Source: Oxford English Dictionary] bodyMassIndex bodyMassIndex bowelAndBladderEDSS Expanded Disability Status Score (EDSS) score for bowel and bladder functions. bowelAndBladderEDSS bowelAndBladderEDSS bowelAndBladderRelapse Whether the relapse involved bowel and bladder functions. bowelAndBladderRelapse bowelAndBladderRelapse brainAtrophyMRI The level of brain atrophy (cerebral atrophy) found in the brain of the patient shown by the MRI. brainAtrophyMRI brainAtrophyMRI brainsetmRelapse Whether the relapse involved the brainstem functions. brainsetmRelapse brainstemRelapse brainstemEDSS Expanded Disability Status Score (EDSS) score for brainstem functions. brainstemEDSS brainstemEDSS bulbarOnset Whether the patient experienced bulbar onset, which means he or she first notice speech or swallowing problems. [Definition Source: National Institute of Neurological Disorders and Stroke] bulbarOnset bulbarOnset bulbarSubscore Bulbar ALSFRS subscore. Sum of items: 1, 2 and 3. bulbarSubscore bulbarSubscore burdenT1Lesions The burden of T2 lesions showed in the MRI. burdenT1Lesions burdenT1Lesions burdenT2Lesions The burden of T1 lesions showed in the MRI. burdenT2Lesions burdenT2Lesions bvmtrTrial1 Brief Visuospatial Memory Test-Revised Immediate Recall Trial 1 Score. bvmtrTrial1 bvmtrTrial1 bvmtrTrial2 Brief Visuospatial Memory Test-Revised Immediate Recall Trial 2 Score. bvmtrTrial2 bvmtrTrial2 bvmtrTrial3 Brief Visuospatial Memory Test-Revised Immediate Recall Trial 3 Score. bvmtrTrial3 bvmtrTrial3 cardiacDisease Whether a patient ever had a cardiac disease. cardiacDisease cardiacDisease cerebellarEDSS Expanded Disability Status Score (EDSS) score for cerebellar functions. cerebellarEDSS cerebellarEDSS cerebellarRelapse Whether the relapse involved the celebellar functions. cerebellarRelapse cerebellarRelapse cerebralEDSS Expanded Disability Status Score (EDSS) score for cerebral functions. cerebralEDSS cerebralEDSS cervicalSpineSurgery Whether a patient had a cervical spine surgery. cervicalSpineSurgery cervicalSpineSurgery cervicalTrauma Whether a patient had a cervical trauma. cervicalTrauma cervicalTrauma clinicalTrialDescription The description of a clinical trial. clinicalTrialDescription clinicalTrialDescription clinicallyEvaluatedEDSS Expanded Disability Status Score (EDSS) evaluated by the physician. clinicallyEvaluatedEDSS clinicallyEvaluatedEDSS coexistingPregnancy It defines the relationship between a relapse and a co-occurring pregnancy. coexistingPregnancy coexistingPregnancy cognitivePhenotype Cognitive phenotype is defined as the broad set of measurable parameters associated with cognition, including not only behavioral symptoms and specific neurocognitive probes, but also physiological and structural indices which we can use to characterize cognitive function at the neural systems. [Source: doi.org/10.1007/978-1-4614-3846-5_4] cognitivePhenotype cognitivePhenotype cognitiveRelapse Whether the relapse involved the mental functions. cognitiveRelapse cognitiveRelapse comorbiditySeverity The severity of a comorbidity. comorbiditySeverity comorbiditySeverity comorbidityTreatment The treatment used for the comorbidity. comorbidityTreatment comorbidityTreatment componentName The name of the hematopoietic component tested in the laboratory test result. componentName componentName concentrationMeasurement Raw air pollution concentration measured by the Sensing Device. concentrationMeasurement concentrationMeasurement conditionEnd The calendar date of the end of the registered conditon. conditionEnd conditionEnd conditionStart The calendar date of the start of the registered conditon. conditionStart conditionStart conductedInClinic It defines the relationship between a clinical trial and a clinic or hospital. In particular, a clinical trial is conducted in a clinic or hospital. conductedInClinic conductedInClinic confirmedPregnancy It defines the relationship between the end therapy reason and a pregnancy, meaning the therapeutic treatment was interrupted due to a confirmed pregnancy. confirmedPregnancy confirmedPregnancy consists It defines the relationship between an event and an intervetion or procedure. In particular, an event could consist in an intervention or procedure. consists consists contiguousLesionsMRI Whether the MRI detected the presence of extended contiguous lesions equal to or greater than three vertical segments. contiguousLesionsMRI contiguousLesionsMRI coveredPlace It defines the relationship between the sensing device for environmental data and the covered place. coveredPlace coveredPlace cvltIITotalCorrect California Verbal Learning Test Total Corrected Score. cvltIITotalCorrect cvltIITotalCorrect cvltIITotalInterferences California Verbal Learning Test Total Interferences Score. cvltIITotalInterferences cvltIITotalInterferences cvltIITotalPerseverations California Verbal Learning Test Total Perseverations Score. cvltIITotalPerseverations cvltIITotalPerseverations cvltIITrial1Correct California Verbal Learning Test Trial 1 Corrected Score. cvltIITrial1Correct cvltIITrial1Correct cvltIITrial1Interferences California Verbal Learning Test Trial 1 Interferences Score. cvltIITrial1Interferences cvltIITrial1Interferences cvltIITrial1Perseverations California Verbal Learning Test Trial 1 Perseverations Score. cvltIITrial1Perseverations cvltIITrial1Perseverations cvltIITrial2Correct California Verbal Learning Test Trial 2 Corrected Score. cvltIITrial2Correct cvltIITrial2Correct cvltIITrial2Interferences California Verbal Learning Test Trial 2 Interferences Score. cvltIITrial2Interferences cvltIITrial2Interferences cvltIITrial2Perseverations California Verbal Learning Test Trial 2 Perseverations Score. cvltIITrial2Perseverations cvltIITrial2Perseverations cvltIITrial3Correct California Verbal Learning Test Trial 3 Corrected Score. cvltIITrial3Correct cvltIITrial3Correct cvltIITrial3Interferences California Verbal Learning Test Trial 3 Interferences Score. cvltIITrial3Interferences cvltIITrial3Interferences cvltIITrial3Perseverations California Verbal Learning Test Trial 3 Perseverations Score. cvltIITrial3Perseverations cvltIITrial3Perseverations cvltIITrial4Correct California Verbal Learning Test Trial 4 Corrected Score. cvltIITrial4Correct cvltIITrial4Correct cvltIITrial4Interferences California Verbal Learning Test Trial 4 Interferences Score. cvltIITrial4Interferences cvltIITrial4Interferences cvltIITrial4Perseverations California Verbal Learning Test Trial 4 Perseverations Score. cvltIITrial4Perseverations cvltIITrial4Perseverations cvltIITrial5Correct California Verbal Learning Test Trial 5 Corrected Score. cvltIITrial5Correct cvltIITrial5Correct cvltIITrial5Interferences California Verbal Learning Test Trial 5 Interferences Score. cvltIITrial5Interferences cvltIITrial5Interferences cvltIITrial5Perseverations California Verbal Learning Test Trial 5 Perseverations Score. cvltIITrial5Perseverations cvltIITrial5Perseverations dailyCigarettes The number of cigarettes smoked in one day on average. dailyCigarettes dailyCigarettes deathCause https://uts.nlm.nih.gov/uts/umls/concept/C0007465 deathCause The circumstance or condition that results in the death of a living being. [Definition Source: NCI] deathCause deathCause deathDate https://uts.nlm.nih.gov/uts/umls/concept/C1148348 deathDate The calendar date of subject's death. [Definition Source: NCI] deathDate deathDate deepSleepDuration Deep sleep duration registered by the wearable device. [uom: seconds] deepSleepDuration deepSleepDuration determinedBy It defines the relationship between a comorbidity and the disease that determines it. determinedBy determinedBy dextricity https://uts.nlm.nih.gov/uts/umls/concept/C0449722 dextricity The preferred hand of use for controlled and efficient performance of motor tasks. [Definition Source: NCI] dextricity dextricity diabetes Whether a patient ever had diabetes. diabetes diabetes diagnosticCriteria https://uts.nlm.nih.gov/uts/umls/concept/C0679228 diagnosticCriteria A standard from which a judgment concerning a medical diagnosis can be established. [Definition Source: NCI] diagnosticCriteria diagnosticCriteria diagnosticCriteriaLabel Criteria for the diagnosis. Possible values are: {Diagnosed MS, Neuromyelitis optica, NA} diagnosticCriteriaLabel diagnosticCriteriaLabel diagnosticDelay The Difference (in days) between the date of diagnosis and the date of onset. (diagnosis_date-onset_date) diagnosticDelay diagnosticDelay diet https://uts.nlm.nih.gov/uts/umls/concept/C0012155 diet Regular course of eating and drinking adopted by a person or animal. [Definition Source: MSH] diet diet dominantHandTrial1 Hand Dextrcity on dominant hand (Trial 1). dominantHandTrial1 dominantHandTrial1 dominantHandTrial2 Hand Dextrcity on dominant hand (Trial 2). dominantHandTrial2 dominantHandTrial2 dominantHandTrialDone Whether the hand dextricity was performed on the dominant hand. dominantHandTrialDone dominantHandTrialDone dyslipidemia Whether a patient ever had dyslipidemia. dyslipidemia dyslipidemia ecasALSnonSpecificScore Edinburgh Cognitive and Behavioural ALS Screen ALS non-specific Score. ecasALSnonSpecificScore ecasALSnonSpecificScore ecasALSspecificScore Edinburgh Cognitive and Behavioural ALS Screen ALS-specific Score. ecasALSspecificScore ecasALSspecificScore ecasCarerInterviewScore Edinburgh Cognitive and Behavioural ALS Screen Carer Interview Score. ecasCarerInterviewScore ecasCarerInterviewScore ecasExecutiveAlternation Edinburgh Cognitive and Behavioural ALS Screen Executive Alteration score. ecasExecutiveAlternation ecasExecutiveAlternation ecasExecutiveFluencyS Edinburgh Cognitive and Behavioural ALS Screen Executive Fluency of Letter S Score. ecasExecutiveFluencyS ecasExecutiveFluencyS ecasExecutiveFluencyT Edinburgh Cognitive and Behavioural ALS Screen Executive Fluency of Letter T Score. ecasExecutiveFluencyT ecasExecutiveFluencyT ecasExecutiveScore Edinburgh Cognitive and Behavioural ALS Screen Executive Score. ecasExecutiveScore ecasExecutiveScore ecasExecutiveSentenceCompletion Edinburgh Cognitive and Behavioural ALS Screen Executive Sentence Completion Score. ecasExecutiveSentenceCompletion ecasExecutiveSentenceCompletion ecasHasCarerInterview Whether during the ECAS test a carer interview was performed. ecasHasCarerInterview ecasHasCarerInterview ecasLanguageComprehension Edinburgh Cognitive and Behavioural ALS Screen Language Comprehension Score. ecasLanguageComprehension ecasLanguageComprehension ecasLanguageNaming Edinburgh Cognitive and Behavioural ALS Screen Language Naming Score. ecasLanguageNaming ecasLanguageNaming ecasLanguageScore Edinburgh Cognitive and Behavioural ALS Screen Language Score. ecasLanguageScore ecasLanguageScore ecasLanguageSpelling Edinburgh Cognitive and Behavioural ALS Screen Language Spelling score. ecasLanguageSpelling ecasLanguageSpelling ecasMemoryDelayedRecall Edinburgh Cognitive and Behavioural ALS Screen Memory Delayed Recall Score. ecasMemoryDelayedRecall ecasMemoryDelayedRecall ecasMemoryDelayedRecognition Edinburgh Cognitive and Behavioural ALS Screen Memory Delayed Recognition Score. ecasMemoryDelayedRecognition ecasMemoryDelayedRecognition ecasMemoryImmediateRecall Edinburgh Cognitive and Behavioural ALS Screen Memory Immediate Recall Score. ecasMemoryImmediateRecall ecasMemoryImmediateRecall ecasMemoryScore Edinburgh Cognitive and Behavioural ALS Screen Memory Score. ecasMemoryScore ecasMemoryScore ecasPsychosisScreenScore Edinburgh Cognitive and Behavioural ALS Screen Psychosis Screen Score. ecasPsychosisScreenScore ecasPsychosisScreenScore ecasReverseDigitSpan Edinburgh Cognitive and Behavioural ALS Screen Reverse Digit Span Score. ecasReverseDigitSpan ecasReverseDigitSpan ecasSocialCognition Edinburgh Cognitive and Behavioural ALS Screen Social Cognition Score. ecasSocialCognition ecasSocialCognition ecasSymptomsApathyOrInertia Whether the patient presents apathy or inertia symptoms. ecasSymptomsApathyOrInertia ecasSymptomsApathyOrInertia ecasSymptomsChangePrevBehaviour Whether the patient presents symptoms change from previous behaviour. ecasSymptomsChangePrevBehaviour ecasSymptomsChangePrevBehaviour ecasSymptomsDisinhibition Whether the patient presents disinhibition symptoms. ecasSymptomsDisinhibition ecasSymptomsDisinhibition ecasSymptomsHyperorality Whether the patient presents hyperorality symptoms. ecasSymptomsHyperorality ecasSymptomsHyperorality ecasSymptomsLossSympathyOrEmpathy Whether the patient presents loss sympathy or empathy symptoms. ecasSymptomsLossSympathyOrEmpathy ecasSymptomsLossSympathyOrEmpathy ecasSymptomsPerseverativeSterotyped Whether the patient presents perseverative stereotyped symptoms. ecasSymptomsPerseverativeSterotyped ecasSymptomsPerseverativeSterotyped ecasTotalScore Edinburgh Cognitive and Behavioural ALS Screen Total Score. ecasTotalScore ecasTotalScore ecasVerbalFluencyScore Edinburgh Cognitive and Behavioural ALS Screen Verbal Fluency score. ecasVerbalFluencyScore ecasVerbalFluencyScore ecasVisuospatialCubeCounting Edinburgh Cognitive and Behavioural ALS Screen Visuospatial Cube Counting Score. ecasVisuospatialCubeCounting ecasVisuospatialCubeCounting ecasVisuospatialDotCounting Edinburgh Cognitive and Behavioural ALS Screen Visuospatial Dot Counting Score. ecasVisuospatialDotCounting ecasVisuospatialDotCounting ecasVisuospatialNumberLocation Edinburgh Cognitive and Behavioural ALS Screen Visuospatial Number Location Score. ecasVisuospatialNumberLocation ecasVisuospatialNumberLocation ecasVisuospatialScore Edinburgh Cognitive and Behavioural ALS Screen Visuospatial Score. ecasVisuospatialScore ecasVisuospatialScore ecunerv Ecunerv is recommended to help maintain normal functions of the nervous system under abnormal conditions such as neuropathy (due to mechanical, metabolic, toxic, ischemic, optical, alcoholic, diabetic or post-herpetic causes), canalicular syndrome, radiculopathy. B-vitamins (B1, B6 and B12) work in synergy with magnesium and help maintain normal functions of the nervous system. Vitamin E helps protect cells from oxidative stress. [Definition Source: https://www.ecupharma.it/en/ecunerv - visited on November 28th, 2022] ecunerv Ecunerv ecunerv http://purl.obolibrary.org/obo/NCIT_C1505 ecunerv Dietary supplements do not have an ATC but they belong to the GMP class 4AA2F30. educationLevel https://uts.nlm.nih.gov/uts/umls/concept/C0013658 educationLevel An indication of the years of schooling completed in graded public, private, or parochial schools, and in colleges, universities, or professional schools. [Definition Source: NCI] educationLevel educationLevel endReason The reason for the interruption of the subject's participation in a clinical trial. endReason endReason endTherapyReason The reason for the interruption of the therapeutic treatment. endTherapyReason endTherapyReason enrolledIn It defines the relationship between a person and a clinical trial participation. In particular, a person can be enrolled in a clinical trial participation. enrolledIn enrolledIn eventEnd The calendar date of the end of the event. eventEnd eventEnd eventStart The calendar date of the start of the event. eventStart eventStart everSmoked Whether a patient has ever smoked or not. everSmoked everSmoked evokedPotentialsLocation The body location of the evoked potential test. evokedPotentialsLocation evokedPotentialsLocation evokedPotentialsLocation Locations "upper left/upper right/lower left/lower right" can only be used for Evoked Potentials of type 'somatosensory' or 'motor'. evokedPotentialsResponse The evoked potential function test result. evokedPotentialsResponse evokedPotentialsResponse evokedPotentialsType Whether the test was a Visual Evoked Potential (VEP), Auditory Evoked Potential (AEP), Somatosensory Evoked Potential (SSEP) or Motor Evoked Potential (MEP). evokedPotentialsType evokedPotentialsType factorsAffectedHandTrial The factors that affected the hand dextricity test. factorsAffectedHandTrial factorsAffectedHandTrial familiarHistoryALS Whether someone in the patient's faimily suffered from ALS. This property only applies to ALS patients. familiarHistoryALS familiarHistoryALS filledAppQuestionnaire Links each app questionnaire to the event in which it was filled. filledAppQuestionnaire filledAppQuestionnaire floorsClimbed Floors climbed registered by the wearable device. floorsClimbed floorsClimbed floorsClimbedGoal Floors climbed goal registered by the wearable device. floorsClimbedGoal floorsClimbedGoal gadoliniumLesionsT1MRI Whether the MRI detected some gadolinium-enhanced lesions in T1. gadoliniumLesionsT1MRI gadoliniumLesionsT1MRI gadoliniumLesionsT1MRINumber The number of gadolinium-enhanced lesions in T1. gadoliniumLesionsT1MRINumber gadoliniumLesionsT1MRINumber generalizedOnset Whether the patient experienced generalized onset, that are widespread symptoms. generalizedOnset generalizedOnset genomeSequencing https://uts.nlm.nih.gov/uts/umls/concept/C3640076 genomeSequencing A procedure that can determine the DNA sequence for nearly the entire genome of an individual. [Definition Source: NCI] genomeSequencing genomeSequencing glucoseCSF A quantitative measurement of blood sugar present in a sample of CSF. Unit of measure : [mg/l]. glucoseCSF glucoseCSF goldCoastExcludingOthers Whether other disease processes has been excluded. [Source: doi.org/10.1016/j.clinph.2020.04.005 ] goldCoastExcludingOthers goldCoastExcludingOthers goldCoastProgressiveMotorImpairment Whether the patient presents progressive motor impairment documented by history or repeated clinical assessment, preceded by normal motor function. [Source: doi.org/10.1016/j.clinph.2020.04.005 ] goldCoastProgressiveMotorImpairment goldCoastProgressiveMotorImpairment goldCoastUMNandLMN Whether the patient presents UMN and LMN signs in at least one body region. [Source: doi.org/10.1016/j.clinph.2020.04.005 ] goldCoastUMNandLMN goldCoastUMNandLMN granulocytesCSF The percentage of granulocytes present in a sample of CSF. Unit of measure : [%]. granulocytesCSF granulocytesCSF hadMajorTrauma Whether a patient had a major trauma before the disease onset. hadMajorTrauma hadMajorTrauma hadSurgicalIntervention Whether the patient had a surgical intervention before the disease onset. hadSurgicalIntervention hadSurgicalIntervention hasDisease It defines the relationship between a person and a disease which he or she suffers from. hasDisease hasDisease hasEthnicity It defines the patient's ethnicity. For instance, we say that: :Peter :hasEthnicity _:b . _:b a Group (social concept); a skos:Concept. hasEthnicity hasEthnicity hasKinship It defines the relation between a patient and a kinship. For instance, we say that: :Peter :hasKinship _:b . _:b a Kinship; :hasKinshipType http://aunt. http://aunt a KinshipType; a skos:Concept. hasKinship hasKinship hasKinship This property is functional because we refer only to biological kinship thus a person can only have one biological kinship with a specific person. hasKinshipType It defines the relation between a Kinship and a KinshipType. For instance, we say that: :Peter :hasKinship _:b . _:b a Kinship; :hasKinshipType http://aunt. http://aunt a KinshipType; a skos:Concept. hasKinshipType hasKinshipType hasMenstrualCycle Whether the patient has the menstrual cycle. hasMenstrualCycle hasMenstrualCycle hasMutation Whether the gene tested positive or negative for mutations during genetic testing. hasMutation hasMutation hasOccupation It defines the relationship between a patient and his or her occupation. hasOccupation hasOccupation hasRegisteredActivity It defines the relationsihip between an event and an activity. In particular, during an event a specific type of activity can be registered. hasRegisteredActivity hasRegisteredActivity hasRegisteredCondition It defines the relationsihip between an event and a comorbidity. In particular, during an event a preexisting condition can be registered. hasRegisteredCondition hasRegisteredCondition headNeckSurgery Whether a patient had a surgery in the head and neck area. headNeckSurgery headNeckSurgery headTrauma Whether a patient had an head trauma. headTrauma headTrauma height https://uts.nlm.nih.gov/uts/umls/concept/C0489786 height Distance or measurement from the base upwards; altitude; stature (of the human body). [Source: Oxford English Dictionary] height height highStressDuration High stress duration registered by the wearable device. [uom: seconds] highStressDuration highStressDuration homeWalkingStatus The ambulatory status of the patient within the house. (e.g., whether they walk on their own or they need assistive devices) homeWalkingStatus homeWalkingStatus hypertension Whether a patient ever had hypertension. hypertension hypertension immunoglobulinGCSF A quantitative measurement of Immunoglobulin G (IgG) present in a sample of CSF. Unit of measure : [mg/l]. immunoglobulinGCSF immunoglobulinGCSF inClinicalTrial It defines the relationship between a clinical trial participation and a clinical trial. In particular, a clinical trial participation refers to a clinical trial. inClinicalTrial inClinicalTrial inKinshipWith The relationship of kinship between a patient with another Person (who might also be a Patient) inKinshipWith inKinshipWith intensityDurationGoal Intensity duration goal registered by the wearable device. [uom: seconds] intensityDurationGoal intensityDurationGoal isAboutDisease It defines the relationship between a clinical trial and the disease studied in it. isAboutDisease isAboutDisease isMenstrualCycleRegular Whether the patient has a regular menstrual cycle. isMenstrualCycleRegular isMenstrualCycleRegular kingsValue The patient's disease stage according to the King's Staging System. kingsValue kingsValue lesionsT1MRI Whether the MRI detected some lesions in T1. lesionsT1MRI lesionsT1MRI lesionsT2MRI Whether the MRI detected some lesions in T2. lesionsT2MRI lesionsT2MRI leukocytesCountCSF A quantitative measurement of leukocytes present in a sample of CSF. Unit of measure : [/mm3]. leukocytesCountCSF leukocytesCountCSF lightSleepDuration Light sleep duration registered by the wearable device. [uom: seconds] lightSleepDuration lightSleepDuration limbsOnset Whether the patient experienced limb onset, which menas symptoms began in the arms or legs. [Definition Source: National Institute of Neurological Disorders and Stroke] limbsOnset limbsOnset linearTrendHeartRate The parameter corresponding to the linear trend of heart rate. linearTrendHeartRate linearTrendHeartRate lowStressDuration Low stress duration registered by the wearable device. [uom: seconds] lowStressDuration lowStressDuration lowerLimbSurgery Whether a patient had a lower limb surgery. lowerLimbSurgery lowerLimbSurgery lumboSacralSpineSurgery Whether a patient had a lumbo sacral spine surgery. lumboSacralSpineSurgery lumboSacralSpineSurgery lumboSacralTrauma Whether a patient had a lumbo sacral trauma. lumboSacralTrauma lumboSacralTrauma lymphocytesCSF The percentage of lymphocytes present in a sample of CSF. Unit of measure : [%]. lymphocytesCSF lymphocytesCSF maritalStatus https://uts.nlm.nih.gov/uts/umls/concept/C0024819 maritalStatus A demographic parameter indicating a person's current conjugal status. [Definition Source: NCI] maritalStatus maritalStatus maxHeartRate Max heart rate registered by the wearable device. [uom: bpm] maxHeartRate maxHeartRate maxStressLevel Max stress level registered by the wearable device. maxStressLevel maxStressLevel maxTimeHeartRate The time at which maximum heart rate occurs. maxTimeHeartRate maxTimeHeartRate measuredLevel The level of the hematopoietic component measured in the laboratory test result. measuredLevel measuredLevel measuredLevel This data property is populated only for numeric-valued test results. measurementCalibrated Air pollution concentration value with seasonal components and noise removed. measurementCalibrated measurementCalibrated mediumStressDuration Medium stress duration registered by the wearable device. [uom: seconds] mediumStressDuration mediumStressDuration menopauseStatus https://uts.nlm.nih.gov/uts/umls/concept/C3829127 menopauseStatus An indicator as to whether the female subject is in menopause. [Defintion source: NCI] menopauseStatus menopauseStatus menstrualCycle Links a patient to the information about her menstrual cycle. menstrualCycle menstrualCycle metersWalkedFirstMin How many meters the patient walked in the first minute. metersWalkedFirstMin metersWalkedFirstMin metersWalkedTwoMins How many meters the patient walked in two minutes. metersWalkedTwoMins metersWalkedTwoMins minHeartRate Min heart rate registered by the wearable device. [uom: bpm] minHeartRate minHeartRate minTimeHeartRate The time at which minimum heart rate occurs. minTimeHeartRate minTimeHeartRate mitosValue The patient's disease stage according to the MiToS staging system. mitosValue mitosValue moderateIntensityDuration Moderate intensity duration registered by the wearable device. [uom: seconds] moderateIntensityDuration moderateIntensityDuration moreThan10PercentWeightloss Whether a patient lost more than 10% of his or her body weight. moreThan10PercentWeightloss moreThan10PercentWeightloss motorSubscore Motor ALSFRS subscore. Sum of items: 4, 5, 6, 7, 8 and 9. motorSubscore motorSubscore multipleSclerosisType The Multiple Sclerosis (MS) disease course identified in the patient. multipleSclerosisType multipleSclerosisType multipleSclerosisType This data property is used only for MS patients. mutationType The type of mutation observed in the gene during genetic testing. mutationType mutationType neckTrauma Whether a patient had a neck trauma. neckTrauma neckTrauma newOrEnlargedLesionsT2MRI Whether the MRI detected new or enlarged gadolinium-enhanced lesions in T2 since the last MRI. newOrEnlargedLesionsT2MRI newOrEnlargedLesionsT2MRI newOrEnlargedLesionsT2MRINumber The number of new or enlarged gadolinium-enhanced lesions in T2 since the last MRI. newOrEnlargedLesionsT2MRINumber newOrEnlargedLesionsT2MRINumber nonDominantHandTrial1 Hand Dextrcity on non-dominant hand (Trial 1). nonDominantHandTrial1 nonDominantHandTrial1 nonDominantHandTrial2 Hand Dextrcity on non-dominant hand (Trial 2). nonDominantHandTrial2 nonDominantHandTrial2 nonDominantHandTrialDone Whether the hand dextricity was performed on the dominant hand. nonDominantHandTrialDone nonDominantHandTrialDone normalLevel Whether the measured level is within the normal range for the tested hematopoietic component. normalLevel normalLevel notes An open box for adding notes about the patient. notes notes numberSpinalCordLesions The number of spinal cord lesions showed in the MRI. numberSpinalCordLesions numberSpinalCordLesions observedResult It defines the relationship between an hematology test and the observed laboratory results. observedResult observedResult oligoclonalBandsNumber The number of oligoclonal bands present in the specimen. oligoclonalBandsNumber oligoclonalBandsNumber oligoclonalBandsPresence Whether the tested specimen presents oligoclonal bands. oligoclonalBandsPresence oligoclonalBandsPresence oligoclonalBandsType Whether the oligoclonal bands were found in CSF or in CSF & serum. oligoclonalBandsType oligoclonalBandsType onGene It defnies the relationship between a genetic testing and a gene. In particular, a genetic testing looks for some genetic mutations on a gene. onGene onGene onsetElapsedTime The time elapsed since the occurrence of an event that happened before the onset. onsetElapsedTime onsetElapsedTime originalALSFRS Amyotrophic Lateral Sclerosis Functional Rating Scale. Sum of items: 1,2,3,4,5,6,7,8,9 and old10. originalALSFRS originalALSFRS otherFactorsAffectedHandTrial Other factors that affected the hand dextricity test. otherFactorsAffectedHandTrial otherFactorsAffectedHandTrial otherOnset Other symptoms experienced by the patient during onset. otherOnset otherOnset otherRelapse Other functional systems involved in the relapse. otherRelapse otherRelapse outsideWalkingStatus The ambulatory status of the patient when walking outside. (e.g., whether they walk on their own or they need assistive devices) outsideWalkingStatus outsideWalkingStatus ownsSensingDevice Links each person to the sensing device they are carrying. ownsSensingDevice ownsSensingDevice packYear Quantificator of lifetime tobacco exposure defined as: (number of cigarettes smoked per day) X (number of years smoked)/20. packYear packYear participationEnd The calendar date of the end of subject's partiicpation in a clinical trial. participationEnd participationEnd participationStart The calendar date of the start of subject's partiicpation in a clinical trial. participationStart participationStart pathologicalJCCSF Whether the JC virus detected in the CSF specimen is pathological. pathologicalJCCSF pathologicalJCCSF pathologicalJCCSF This data property can only be populated in "visuJCTestedCSF" has value True. pelvicSurgery Whether a patient had a pelivc surgery. pelvicSurgery pelvicSurgery performedTreatment It defines the relationship between the therapeutic procedure and the perfomed therapeutic treatments. performedTreatment performedTreatment pharmacologicSubstance It defines the relationship between a therapeutic treatment and the employed pharmacologic subastance. pharmacologicSubstance pharmacologicSubstance phenotype UMLS:C4086242 phenotype The observable properties present during a disease. [Definition Source: NCI] phenotype http://purl.obolibrary.org/obo/NCIT_C125204 phenotype phenotype placeArea The type of populated area that better describe the place. placeArea placeArea placeLocation It defines the relationship between a patient's residence and its location. placeLocation placeLocation positivityResult Whether the laboratory test result was positive or not. positivityResult positivityResult positivityResult This data property is only populated for positive/negative laboratory test result. predominantLimbsImpairment Whether the patient predominantly presents distal limbs impairment or proximal limbs impairment. predominantLimbsImpairment predominantLimbsImpairment predominantLimbsImpairment This data property is used only for ALS patients. predominantLimbsSide The side of the body that predominantly presents limb impariment. predominantLimbsSide predominantLimbsSide predominantLimbsSide This data property is used only for ALS patients. predominantMotorNeuron Whether the patient presents a predominance of lower motor neuron, upper motor neuron or both. predominantMotorNeuron predominantMotorNeuron predominantMotorNeuron This data property is used only for ALS patients. pregnancy It defines the relationship between an event and a pregnancy that can be registrered during the event. pregnancy pregnancy pregnancyComplications Any kind of complication related to the pregnancy. pregnancyComplications pregnancyComplications pregnancyEnd The calendar date in which the pregnancy ended. pregnancyEnd pregnancyEnd pregnancyEndEvent The event that ended the pregnancy. pregnancyEndEvent pregnancyEndEvent pregnancyStart The calendar date in which the pregnancy started. pregnancyStart pregnancyStart primaryNeoplasm Whether a patient ever had a primary neoplasm. primaryNeoplasm primaryNeoplasm privacyPreservingDate Privacy preserving date computed according to an algorithm used to extract public instances. privacyPreservingDate privacyPreservingDate privacyPreservingDeathDate Privacy preserving death date computed according to an algorithm used to extract public instances. privacyPreservingDeathDate privacyPreservingDeathDate procedureEnd The calendar date of the end of an intervention or procedure. procedureEnd procedureEnd procedureStart The calendar start of an intervention or procedure. procedureStart procedureStart proteinsCSF A quantitative measurement of proteins present in a sample of CSF [ mg/l]. proteinsCSF proteinsCSF pulmonaryAOPAbs Occlusion pressure at 100 ms (P0.1) is defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit. [Definition Source: Beloncle, F., Piquilloud, L., Olivier, PY. et al. Accuracy of P0.1 measurements performed by ICU ventilators: a bench study. Ann. Intensive Care 9, 104 (2019)] pulmonaryAOPAbs pulmonaryAOPAbs pulmonaryFEV6 Forced expiratory volume (FEV) is the amount of air expired in six seconds of the FVC test. [Definition Source: John Hopkins Medicine] pulmonaryFEV6 pulmonaryFEV6 pulmonaryFVCLyingDown Forced Vital Capacity (FVC) when patient is lied down. pulmonaryFVCLyingDown pulmonaryFVCLyingDown pulmonaryFVCLyingDownPercentage Percentage of FVC lying down. pulmonaryFVCLyingDownPercentage pulmonaryFVCLyingDownPercentage pulmonaryFVCRel The percentage of Forced vital capacity (FVC) is the amount of air exhaled forcefully and quickly after inhaling as much as you can. [Defintion Source: John Hopkins Medicine] pulmonaryFVCRel pulmonaryFVCRel pulmonaryFVCSitting Forced Vital Capacity (FVC) when patient is sitted. pulmonaryFVCSitting pulmonaryFVCSitting pulmonaryFVCSittingPercentage Percentage of FVC sitting pulmonaryFVCSittingPercentage pulmonaryFVCSittingPercentage pulmonaryMEP Maximum Expiratory Pressure (MEP) is the greatest amount of pressure that can be generated by exhaling against a mouthpiece, which is a measure of the strength of respiratory muscles. [Definition Source: NCI] (uom: CMH2O) pulmonaryMEP pulmonaryMEP pulmonaryMEPAbs Maximum Expiratory Pressure (MEP) is the highest pressure that can be developed during a forceful expiratory effort against an occluded airway. It is usually measured at maximal inspiration and reported as a positive number in either cm H2O or mmHg. [Definition Source: The University of Texas Medical Branch] pulmonaryMEPAbs pulmonaryMEPAbs pulmonaryMEPpercentage Percentage of MEP. pulmonaryMEPpercentage pulmonaryMEPpercentage pulmonaryMIP Maximum Inspiratory Pressure (MIP) is the greatest amount of pressure that can be generated during inhalation against a fully occluded airway, which is used to measure the strength of respiratory muscles. [Definition Source: NCI] pulmonaryMIP pulmonaryMIP pulmonaryMIPAbs Maximum Inspiratory Pressure (MIP) is the lowest pressure developed during a forceful inspiration against an occluded airway. It is usually measured at maximal expiration and recorded as a negative number in either cm H2O or mmHg. [Definition Source: The University of Texas Medical Branch] pulmonaryMIPAbs pulmonaryMIPAbs pulmonaryMIPpercentage Percentage of MIP. pulmonaryMIPpercentage pulmonaryMIPpercentage pulmonaryNIP Maximal Negative Inspiratory Pressure (NIP) measures the strength of the diaphragm and other muscles of inspiration and reflects the ability to maintain normal lung expansion and avoid atelectasis. [Definition Source: doi.org/10.1016/B978-032304841-5.50067-4 ] pulmonaryNIP pulmonaryNIP pulmonaryPCF Peak Cough Flow (PCF) is the maximum rate of air flow expelled through the mouth, endotracheal, or tracheostomy tube during a cough. [Definition Source: NCI] pulmonaryPCF pulmonaryPCF pulmonaryPCO2 The partial pressure of carbon dioxide (PCO2) is the concentration of carbon dioxide in the blood. This is a sensitive indication of the efficiency or level of ventilation of the lungs. [Definition Source: Collins Dictionary of Medicine] pulmonaryPCO2 pulmonaryPCO2 pulmonaryPO2 The partial pressure of oxigen (PO2) is the concentration of oxygen in the blood. This commonly measured parameter is an important indicator of the efficiency with which oxygen is transferred from atmosphere to blood. [Definition Source: Collins Dictionary of Medicine] pulmonaryPO2 pulmonaryPO2 pulmonaryVCAbs Vital capacity (VC) is the total volume of air that can be exhaled after inhaling as much as you can. [Definition Source: John Hopkins Medicine] pulmonaryVCAbs pulmonaryVCAbs pyramidalEDSS Expanded Disability Status Score (EDSS) score for pyramidal functions. pyramidalEDSS pyramidalEDSS pyramidalRelapse Whether the relapse involved the pyramidal functions. pyramidalRelapse pyramidalRelapse quadraticTrendHeartRate The parameter corresponding to the curvature of heart rate. quadraticTrendHeartRate quadraticTrendHeartRate questionnaireSubmitted When the questionnaire was submitted. questionnaireSubmitted questionnaireSubmitted quotientAlbuminCSF CSF/serum albumin ratio is performed to understand the blood–CSF barrier disruption. [Defintion Source: Luque, Francisco A, and Stephen L Jaffe. “Cerebrospinal fluid analysis in multiple sclerosis.” International review of neurobiology vol. 79 (2007)] quotientAlbuminCSF quotientAlbuminCSF r2HeartRate The quality of the quadratic model. r2HeartRate r2HeartRate reasonIrregularCycle Why the patient has an irregular menstrual cycle. reasonIrregularCycle reasonIrregularCycle reasonNoMenstrualCycle Why the patient has no menstrual cycle. (e.g., menopause) reasonNoMenstrualCycle reasonNoMenstrualCycle reasonWalkTestNotCompleted The reason the walk test was not completed. reasonWalkTestNotCompleted reasonWalkTestNotCompleted relapse It defines the relationship between an event and a relapse that can be registered during the event. relapse relapse relapseClinicalTherapy Whether the relapse required treatment in an ambulatory care clinic. relapseClinicalTherapy relapseClinicalTherapy relapseCortisoneTherapy Whether the relapse required a cortisone therapy. relapseCortisoneTherapy relapseCortisoneTherapy relapseDuration The number of days the relapse lasted. relapseDuration relapseDuration relapseEnd The calendar date of the end of the relapse. relapseEnd relapseEnd relapseHospitalAdmission Whether the relapse required an hospital admission. relapseHospitalAdmission relapseHospitalAdmission relapseImpactOnADL Whether the relapse afftecd the Activity of Daily Living (ADL). relapseImpactOnADL relapseImpactOnADL relapseRecovery How much the patient recovered from the relapse. relapseRecovery relapseRecovery relapseSequela Whether the patient presented symptoms continuing in time, maybe less severe. relapseSequela relapseSequela relapseSeverity The severity of the relapse. relapseSeverity relapseSeverity relapseStart The calendar date of the start of the relapse. relapseStart relapseStart relativeEndDate Privacy preserving end date computed according to an algorithm used to extract public instances. relativeEndDate relativeEndDate relativeStartDate Privacy preserving start date computed according to an algorithm used to extract public instances. relativeStartDate relativeStartDate remSleep REM sleep duration registered by the wearable device. [uom: seconds] remSleep remSleep repirationSampEn The sample entropy repirationSampEn repirationSampEn requiredMRI It defines the relationship between a relapse and a MRI that has been required. requiredMRI requiredMRI residence It defines the relationship between a person and his or her residence. residence residence residenceEnd The calendar end date of the patient's residence in a specific geographical location. residenceEnd residenceEnd residenceStart The calendar start date of the patient's residence in a specific geographical location. residenceStart residenceStart respirationAlpha1DimMean Multifractal DFA. DimMean is the mean of singularity dimensions. respirationAlpha1DimMean respirationAlpha1DimMean respirationAlpha1DimRange Multifractal DFA. DimRange is the range of singularity dimensions, corresponding to the height of the singularity spectrum. respirationAlpha1DimRange respirationAlpha1DimRange respirationAlpha1ExpMean Multifractal DFA of short-term fluctuations. ExpMean is the mean of singularity exponents. respirationAlpha1ExpMean respirationAlpha1ExpMean respirationAlpha1ExpRange Multifractal DFA of short-term fluctuations. ExpRange is the range of singularity exponents, corresponding to the width of the singularity spectrum. respirationAlpha1ExpRange respirationAlpha1ExpRange respirationAlpha2DimMean Multifractal DFA. Dimmean is the mean of singularity dimensions. respirationAlpha2DimMean respirationAlpha2DimMean respirationAlpha2DimRange Multifractal DFA. DimRange is the range of singularity dimensions, corresponding to the height of the singularity spectrum. respirationAlpha2DimRange respirationAlpha2DimRange respirationAlpha2ExpMean Multifractal DFA of long-term fluctuations. ExpMean is the mean of singularity exponents. respirationAlpha2ExpMean respirationAlpha2ExpMean respirationAlpha2ExpRange Multifractal DFA of long-term fluctuations. ExpRange is the range of singularity exponents, corresponding to the width of the singularity spectrum. respirationAlpha2ExpRange respirationAlpha2ExpRange respirationApEn The approximate entropy respirationApEn respirationApEn respirationDFAalpha1 The “short-term” fluctuation value generated from Detrended Fluctuation Analysis i.e. the root mean square deviation from the fitted trend of the breath-to-breath intervals. Will only be computed if there are more than 160 breath cycles in the respiratory rate. respirationDFAalpha1 respirationDFAalpha1 respirationDFAalpha2 The long-term fluctuation value. Will only be computed if there are more than 640 breath cycles in the respiratory rate. respirationDFAalpha2 respirationDFAalpha2 respirationRMSSD The root mean square of successive differences of the breath-to-breath intervals. respirationRMSSD respirationRMSSD respirationSD1 A measure of the spread of breath-to-breath intervals on the Poincaré plot perpendicular to the line of identity. It is an index of short-term variability. respirationSD1 respirationSD1 respirationSD2 SD2 is a measure of the spread of breath-to-breath intervals on the Poincaré plot along the line of identity. It is an index of long-term variability. respirationSD2 respirationSD2 respirationSD2SD1 The ratio between short- and long-term fluctuations of the breath-to-breath intervals (SD2 divided by SD1). respirationSD2SD1 respirationSD2SD1 respirationSDBB The standard deviation of the breath-to-breath intervals. respirationSDBB respirationSDBB respirationSDSD The standard deviation of the successive differences between adjacent respirationSDSD respirationSDSD respiratorySubscore Respiratory ALSFRS subscore. Sum of items: 10, 11 and 12. respiratorySubscore respiratorySubscore restStressDuration Rest stress duration registered by the wearable device. [uom: seconds] restStressDuration restStressDuration restingHeartRate Resting heart rate registered by the wearable device. [uom: bpm] restingHeartRate restingHeartRate retiredAtDiagnosis An indicator of whether the patient was retired at the time of diagnosis. retiredAtDiagnosis retiredAtDiagnosis revisedALSFRS https://uts.nlm.nih.gov/uts/umls/concept/C4296567 revisedALSFRS Revised Amyotrophic Lateral Sclerosis Functional Rating Scale. Sum of items 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12. revisedALSFRS http://purl.bioontology.org/ontology/SNOMEDCT/718646004 revisedALSFRS revisedALSFRS sdmtCorrect Symbol Digital Modalities Test corrected. sdmtCorrect sdmtCorrect sdmtIncorrect Symbol Digital Modalities Test raw score. sdmtIncorrect sdmtIncorrect sensoryEDSS Expanded Disability Status Score (EDSS) score for sensory functions. sensoryEDSS sensoryEDSS sensoryRelapse Whether the relapse involved sensory functions. sensoryRelapse sensoryRelapse sex https://uts.nlm.nih.gov/uts/umls/concept/C1522384 sex The assemblage of physical properties or qualities by which male is distinguished from female; the physical difference between male and female; the distinguishing peculiarity of male or female. [Definition Source: NCI] sex sex sexuality https://uts.nlm.nih.gov/uts/umls/concept/C0036915 sexuality The feeling an individual has about their own sexual preferences and how those views are acted upon. [Definition Source: NCI] sexuality sexuality slope The slope of the ALSFRS-R score between time-of-onset and Time 0 computed as: (48-ALSFRSR(Time0))/(Time0-TimeOnset) slope slope smokersNumber The number of smokers the patient lives or works with. smokersNumber smokersNumber smokingExpositionType Type of smoking exposition. smokingExpositionType smokingExpositionType spinalCordLesions Whether the MRI showed spinal cord lesions. spinalCordLesions spinalCordLesions spo2AOD100 Cumulative area of desaturations under the 100% SpO2 level as baseline and normalized by the total recording time spo2AOD100 spo2AOD100 spo2AODMax The area under the oxygen desaturation event curve, using the maximum SpO2 value as baseline and normalized by the total recording time spo2AODMax spo2AODMax spo2AV Average of the pulse oximetry. spo2AV spo2AV spo2CA Integral SpO2 below the 90% SpO2 level normalized by the total recording time spo2CA spo2CA spo2CT Percentage of the time spent below the 90% oxygen saturation level. spo2CT spo2CT spo2DI Delta Index. spo2DI spo2DI spo2M Percentage of the pulse oximetry 90% below median oxygen saturation. spo2M spo2M spo2MED Median of the pulse oximetry. spo2MED spo2MED spo2Min Minimum value of the pulse oximetry. spo2Min spo2Min spo2ODI The average number of desaturation events per hour (int). spo2ODI spo2ODI spo2P Percentile (90th) spo2P spo2P spo2POD Percentage of oxygen desaturation events spo2POD spo2POD spo2RG SpO2 range (difference between the max and min value). spo2RG spo2RG spo2SD Standard deviation of the pulse oximetry. spo2SD spo2SD spo2ZC Number of zero-crossing points. spo2ZC spo2ZC stdHeartRate The standard deviation of the heart rate after stimulus onset. stdHeartRate stdHeartRate steps12am6am Total steps within the considered segment of data and between 12 AM and 6 AM daily steps12am6am steps12am6am steps12pm6pm Total steps within the considered segment of data and between 12 PM and 6 PM steps12pm6pm steps12pm6pm steps6am12pm Total steps within the considered segment of data and between 6 AM and 12 PM steps6am12pm steps6am12pm stressDuration Stress duration registered by the wearable device. [uom: seconds] stressDuration stressDuration stressQualifier Stress qualifier registered by the wearable device. stressQualifier stressQualifier stroke Whether a patient ever had a stroke. stroke stroke sunExposure https://uts.nlm.nih.gov/uts/umls/concept/C1456711 sunExposure The exposure to incident light from the sun. [Definition Source: NCI] sunExposure sunExposure surgicalType It defines the realtionship between the surgical procedure and the specific type of surgical procedure. surgicalType surgicalType symptomClinicalName The clinical name of the symptom. symptomClinicalName symptomClinicalName symptomEnd When the symptom ended. symptomEnd symptomEnd symptomGrade The severity of the symptom. symptomGrade symptomGrade symptomStart When the symptom started. symptomStart symptomStart symptomType Defines the symptom's category. symptomType symptomType symptomValue The numerical value associated with the symptom, e.g., the temperature fever. symptomValue symptomValue tested It defines the relationship betwen a patient and a genetic testing. In particular, a patient can be tested for genetic mutations. tested tested testedForOligoclonalBands It defines the relationship between a CSF Analysis and a test for the presence of oligoclonal bands. testedForOligoclonalBands testedForOligoclonalBands therapyType It defines the relationship between the therapeutic treatment and the type of therapeutic procedure that has been administered. therapyType therapyType thoracicSpineSurgery Whether a patient had a thoracic spine surgery. thoracicSpineSurgery thoracicSpineSurgery thoracicSurgery Whether a patient had a thoracic surgery. thoracicSurgery thoracicSurgery thoracicTrauma Whether a patient had a thoracic trauma. thoracicTrauma thoracicTrauma thyroidDisorder Whether a patient ever had a thyroid disorder. thyroidDisorder thyroidDisorder totalCalories Sum of active and basal calories totalCalories totalCalories totalLesionsT2MRI The total number of lesions in T2 detected with the MRI. totalLesionsT2MRI totalLesionsT2MRI totalSleepDuration Total sleep duration registered by the wearable device. [uom: seconds] totalSleepDuration totalSleepDuration trauma It defines the relationship between an event and a trauma that can be registered during the event. trauma trauma traumaDate The calendar date in which the trauma occurred. traumaDate traumaDate traumaDescription A description of the trauma traumaDescription traumaDescription undergo It defines the relationship between patient and event. In particular, a patient can undergo some events. undergo undergo unitOfMeasure The unit of measure of reference of the laboratory test result. unitOfMeasure unitOfMeasure unmeasurableSleepDuration Unmeasurable sleep duration registered by the wearable device. [uom: seconds] unmeasurableSleepDuration unmeasurableSleepDuration upperLimbSurgery Whether a patient had an upper limb surgery. upperLimbSurgery upperLimbSurgery validMeasurements For each recorded variable, number of valid measurements in that week, ranging from 0 to 7. validMeasurements validMeasurements vigorousIntensityDuration Vigorous intensity duration registered by the wearable device. [uom: seconds] vigorousIntensityDuration vigorousIntensityDuration virusJCTestedCSF Whether the presence of JC virus was tested in the CSF specimen. virusJCTestedCSF virusJCTestedCSF visualAcuityLeft Visual Acuity Test on the left eye. visualAcuityLeft visualAcuityLeft visualAcuityRight Visual Acuity Test on the right eye. visualAcuityRight visualAcuityRight visualEDSS Expanded Disability Status Score (EDSS) score for visual (optic) functions. visualEDSS visualEDSS visualEvokedPotentialAmplitude The amplitude for the Visual Evoked Potential (VEP) wave. [Source: Wikipedia - consulted on November 25th, 2022] Unit of Measure: [uV]. visualEvokedPotentialAmplitude visualEvokedPotentialAmplitude visualEvokedPotentialAmplitude This data property can only be used for Evoked Potential of type 'visual'. visualEvokedPotentialLatency The average peak latency for the Visual Evoked Potential (VEP) wave at approximately 100 ms following stimulus onset. [Source: Wikipedia - consulted on November 25th, 2022] Unit of Measure: [microsec]. visualEvokedPotentialLatency visualEvokedPotentialLatency visualEvokedPotentialLatency This data property can only be used for Evoked Potential of type 'visual'. visualRelapse Whether the relapse involved visual functions. visualRelapse visualRelapse walkAssistiveDevice Whether the patient uses an assistive device for walking. walkAssistiveDevice walkAssistiveDevice walkAssistiveDeviceUsed The type of assistive device used for walking. walkAssistiveDeviceUsed walkAssistiveDeviceUsed walkTestNotCompleted Whether the walk test was completed. walkTestNotCompleted walkTestNotCompleted walkingTime10Meters Time to walk 10 meters. walkingTime10Meters walkingTime10Meters walkingTime25Steps Time to take 25 steps. walkingTime25Steps walkingTime25Steps wdmDuration The duration of the measurement. wdmDuration wearableDataMeasurementDuration wdmStartTime The timestamp in which the measurement started. wdmStartTime wearableDataMeasurementStartTime weeklyFrequency The number of hours per week physical activity takes place. weeklyFrequency weeklyFrequency weight https://uts.nlm.nih.gov/uts/umls/concept/C0005910 weight Measurement of quantity by means of weighing; quantity (in the abstract) as determined in this way. [Definition Source: Oxford English Dictionary] weight weight whoThresholdExceeded Number of days spent over the respective World Health Organization (WHO) threshold in that week (computed as following); if there are no valid measurements in that week, it is denoted as NA. * For Carbon Monoxide (CO): if CO ≤ 4 mg/m3 then the value is 0; otherwise, it is 1 * For Nitrogen Dioxide (NO 2 ): if NO 2 ≤ 25 µg/m3 then the value is 0; otherwise, it is 1 * For Ozone (O3): if O 3 ≤ 100 µg/m3 then the value is 0; otherwise, it is 1 * For Particulate Matter with a diameter of 2.5 micrometers or smaller (PM 2.5): if PM 2.5 ≤ 15 µg/m 3 then the value is 0; otherwise, it is 1 * For Particulate Matter with a diameter of 10 micrometers or smaller (PM 10 ): if PM 10 ≤ 45 µg/m3 , then the value is 0; otherwise, it is 1 * For Sulfur Dioxide (SO 2 ); if SO 2 ≤ 40 µg/m3 , then the value is 0; otherwise, it is 1 whoThresholdExceeded whoThresholdExceeded zipCode A group of letters or numbers, or both, added to a postal address to facilitate the sorting and delivery of mail. Later also: the area designated by such a code. [Definition Source: Oxford English Dictionary] zipCode zipCode zipHashed The zip code hashed for privacy reasons. zipHashed zipHashed https://www.comunidad.madrid/hospital/gregoriomaranon/ Hospital General Universitario Gregorio Marañón https://www.mondino.it/ Mondino Foundation https://www.unipd.it/ University of Padua https://www.unipd.it/ Università degli Studi di Padova https://www.unito.it/ University of Turin https://www.unito.it/ Università degli Studi di Torino