This webpage describes the design and development of the BrainTeaser Ontology (BTO) whose purpose is to jointly model both Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS).
The BTO serves multiple purposes:
The BTO is innovative since it relies on very few seed concepts - Patient, Clinical Trial, Disease, Event - which allow us to jointly model ALS and MS and to grasp the time dimension entailed by the progression of such diseases.
Indeed, the core idea is that a Patient participates in a Clinical Trial, suffers from some Diseases, and undergoes Events. These Events are different in nature and cover a wide range of cases, e.g. Onset, Pregnancy, Symptom, Trauma, Diagnostic Procedure (like evoked potentials or ALS-FRS questionnaires) Therapeutic Procedure (like Mechanical Ventilation for ALS or Disease-Modifying Therapy for MS), Relapse, and more. Overall, this event-based approach allows us to model ALS and MS in an unified way, sharing concepts among these two diseases, and to track what happens during their progression. Details of the design and functioning of the BTO are provided in the next sections of this deliverable.
The BTO plays an important role in the overall BRAINTEASER architecture, shown in Figure 1. Indeed, it informs the implementation of the BRAINTEASER Semantic Data Cloud since the data contained here will be represented according to the BTO, i.e., they will be an instance of the BTO.
In Figure 1 it is possible to see that all the data will be anonymized prior to being represented in the BTO. This holds true for both the retrospective data, i.e., the data already held by clinical partners on the right of the figure, and the prospective data, i.e., the new data that will be collected during the project lifetime on the left.
The data held in the BRAINTEASER Semantic Data Cloud, exported in a suitable format, will then be used to train the AI models needed to predict the progression of both ALS and MS.
Finally, a subset of the data in the BRAINTEASER Semantic Data Cloud will be exported to the European Open Science Cloud (EOSC) and they will be also shared and exploited for the Open Evaluation Challenges.
Figure 2 shows an overall picture of the whole data flow associated with the BTO and the BRAINTEASER Semantic Data Cloud, also in relation to Open Evaluation Challenges and the EOSC.
In summary, the BTO ontology will model the following data sources:
The BTO will also allow to link these data with other resources available in the Linked Open Data Cloud.
The term ontology has its origin in philosophy, where it refers to the study of existence. Similarly, in Computer Science an ontology is an explicit specification of a conceptualization [8]. Since their conception, ontologies have been largely employed to share a common understanding of the structure of information among people and software agents [9, 10]. On top of that, ontologies allow computers to have access to structured collections of information and rules that can be used to conduct automated reasoning. For these reasons, ontologies are considered the third basic component of the Semantic Web [9, 11]. Depending on the generality of the instances included within ontologies, we can distinguish between foundation and domain ontologies. The former model com- mon concepts that can be used in a wide variety of domains. A notable example is the Friend-Of-A-Friend (FOAF) ontology, which describes people’s personal information as well as their social relationships [11]. In general, foundation ontologies are thought to be imported and reused in domain-specific applications, where the original components are refined and extended to better represent the modeled reality [10]. The latter model a specific domain, thus representing the particular meaning of terms as they apply to that specialization. Indeed, the same word can assume different meanings in different fields. To illustrate this, let’s take the word “polyp” as an example. In the medical domain, a polyp is an abnormal growth of tissue projecting from a mucous membrane. On the other hand, in zoology, a polyp represents one of the two forms found in the Phylum Cnidaria. Given the objectives of this work, below we focus on describing domain ontologies.
External Referencing Whenever we model clinical information, it is preferable to use external ontologies to provide correspondence between largely used medical terminology. Due to its widely diffused adoption and exhaustiveness, our primary taxonomy of choice is NCIT [30], but we also employed other well-known resources when no information is available in NCIT, e.g. SNOMED-CT or ATC. In general, this is common practice when developing ontologies [44]. In fact, by reusing entities and properties already defined in other ontologies, we are not only able to enforce collaboration and data consistency among databases but to guarantee the authori- tativeness of the semantic meaning of these resources. External referencing has been managed with annotation properties and using the URI of the term in the original taxonomy. In general, we used external URIs when we defined named individuals that refer to abstract concepts. On the contrary, when we inserted a new class in BTO we used the Brainteaser namespace and connected references using annotation properties.
Namespaces BTO URIs are divided into two namespaces: the schema namespace https://w3id.org/brainteaser/ontology/schema/ and the resource namespace https://w3id.org/brainteaser/ontology/resource/. All URIs corresponding to classes, data properties, and object properties belong to the former namespace. At the same time, in the latter, we include all URIs referring to real-world instances of the entities described in BTO at an ontological level. Notice that, in this sense, the resource namespace is empty until the practitioner starts populating it with real-world data. The only instances included in the schema namespace are the named individuals corresponding to Simple Knowledge Organization System (SKOS) con- cepts (as defined in Subsection 3.4). Our choice of including these elements in the schema namespace stems from the fact that, akin to relational modeling controlled dictionaries, these entities do not depend on the data underneath but can be seen as a predefined thesaurus of concepts and are a fundamental part of the environment that we model.
Classes Definition and Annotation Properties All components of the BTO have additional information in the form of annotation properties. We defined a list of essential metadata to add when we introduced a new class. Firstly, all classes must have a label denoting the name and a comment, which provides a brief explana- tion together with its source. If the class had an equivalent in NCIT, we inherited the name and definition. In this case, we also added another annotation property called “rdfs:isDefinedBy with the Internationalized Resource Identifier (IRI) corre- sponding to the NCIT term of reference. Most biomedical vocabularies are mapped in the UMLS with a unique identifier called Concept Unique Identifier (CUI) [40]. For each class that had a UMLS reference, we added the annotation property “dcterms:conformsTo” with the URL of the corresponding concept.
Naming Conventions Regarding object and data properties, we applied a similar approach and defined the needed annotations and naming conventions to provide uniformity throughout BTO. In particular, all components must have a label and a comment. About object properties, we used explanatory labels where we included the property range. In this case, the comment explains the relationship between the two classes involved. Concerning data properties, the label usually includes the name of the domain class so that its meaning is intuitive. We also added a comment with the attribute description and, when available, the definition source. In conclusion, we defined all data properties to achieve consistency when specifying datatypes. For example, all string properties have datatype “rdf:PlainLiteral”. We also used the “note” annotation property in all BTO components for additional remarks or business logic rules.
Class | Reference Taxonomy |
---|---|
Kinship Type | National Cancer Institute Thesaurus (NCIT) |
Occupation | Occupations pillar of the ESCO Classification (ESCO) |
Group (social concept) | SNOMED Clinical Terms (SNOMED-CT) |
Gene | National Cancer Institute Thesaurus (NCIT) |
Disease, Disorder or Findings | National Cancer Institute Thesaurus (NCIT) |
Surgical Procedure Type | SNOMED Clinical Terms (SNOMED-CT) |
Therapeutic Procedure Type | National Cancer Institute Thesaurus (NCIT) |
Anatomic Site | National Cancer Institute Thesaurus (NCIT) |
Pharmacological Substance | Anatomical Therapeutic Chemical (ATC) Classification |
Advesre Drug Reaction | Ontology of Adverse Events (OAE) |
Environmental Data
Besides genetic predisposition, lifestyle and environmental factors are shown to affect the risk of MS. Once we acknowledge such correlation, some of these environmental and lifestyle factors can be modified with prevention measures, especially for people at greater risk [45]. On the other hand, identifying environmental factors linked to ALS has proven to be challenging and it still lacks large cohorts. In both cases, understanding the interaction between genetic and environmental factors can be a great resource for integrating precision medicine into ALS or MS care [46]. That is why connecting environmental data to each patient in BTO is a fundamental requirement. These environmental data include pollution information for a given location, recorded by a weather station. To store this piece of information, in BTO the practitioner can record each patient’s birth and residence places using the class “Place”. To model environmental data, we imported Global City Indicator Environment Ontology[38], also known as Pollution ontology, an ontology designed to represent ontologically environmental data registered by weather stations. In par- ticular, we connected a weather station, modeled with the class “Sensing Device” from the above-mentioned ontology, to a location, modeled with the class “Place”, with the object property “:coveredPlace”, to model the fact that a station registers environmental data for a given location. We report how we integrated air pollutants in Figure 4. The concentration of each air pollutant of interest is modeled as a subclass of “Air Pollution Concentration”. Notice that we are interested in storing information about Particulate Matter (PM) 10, PM 2.5, Ozone (O3), Nitrogen Dioxide (NO2), Sulphur Dioxide (SO2), and Carbon Monoxide (CO) thus we created a class in our namespace for pollutants not represented in the imported ontology, such as CO. Air pollution concentrations are produced by sensing de- vices, thus we connected the classes “Air Pollution Concentration” and “Sensing Device” with the property “ssn:isProducedBy”. The concentration value of each air pollutant is stored using the data property “numerical value”, while the date of the measure is referred to with the object property ":APConcentrationTIme" that links “Air Pollution Concentration” class to class “time:Instant”. All classes, object properties, and data properties mentioned above are imported from the “Global City Indicator Environment Ontology”[38].
Disease, Disorder or Finding Taxonomy
The class “Disease, Disorder or Finding” includes diseases, like carcinoma or chickenpox infection, but also injuries, symptoms, and findings. This allows modeling and storing in a KB any sort of clinical event that occurred to a patient, even if it is not directly linked to ALS or MS. We modeled this class following the SKOS data model, using NCIT as reference taxonomy, with a few additions from SNOMED-CT thesaurus. As illustrated in Figure 5, we modeled past traumas with the class “Trauma”. However, some injuries have also been made available in the “Disease, Disorder or Finding” taxonomy. As a general rule, we use the taxonomy whenever the trauma is specific (e.g., “Open Dislocation of the Shoulder”). On the other hand, if the clinician knows only that a patient suffered from generic trauma to the shoulder, we instantiate an individual of type “Trauma” and connect it to its Anatomic Site (e.g., “shoulder”) with the property “:anatomicalLocation”. Notice that, thanks to SKOS characteristics, specific traumas (e.g., “open dislocation of the shoulder”) are in relation “:hasBroaderTransitive” with the general concept “injury”. We follow a similar line of thought to deal with symptoms. In this case, we use the taxonomy to model cases where the practitioner needs to store information about general symptoms (e.g., headache, fever). A particular group of symptoms that required deeper modeling granularity is the one that constitutes the onset of the disease (either ALS or MS). Given the high relevance that such symptoms have on the course of the disease, they have not been modeled using the symptoms taxonomy but as data properties of the class “Onset”.
IRI: https://w3id.org/brainteaser/ontology/schema/Activity
IRI: https://w3id.org/brainteaser/ontology/schema/Administration
IRI: https://w3id.org/brainteaser/ontology/schema/AdverseDrugReaction
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#Air_pollution
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#Air_pollution_concentration
IRI: https://w3id.org/brainteaser/ontology/schema/ALSFRS
IRI: https://w3id.org/brainteaser/ontology/schema/AnatomicalSite
IRI: https://w3id.org/brainteaser/ontology/schema/BeforeOnset
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#CH4
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#CH4_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#CO2
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#CO2_concentration
IRI: https://w3id.org/brainteaser/ontology/schema/ClinicalEvaluation
IRI: https://w3id.org/brainteaser/ontology/schema/ClinicalTrial
IRI: https://w3id.org/brainteaser/ontology/schema/ClinicalTrialParticipation
IRI: https://w3id.org/brainteaser/ontology/schema/ClinicsAndHospitals
IRI: https://w3id.org/brainteaser/ontology/schema/CO_concentration
IRI: http://www.w3.org/2004/02/skos/core#Collection
IRI: https://w3id.org/brainteaser/ontology/schema/Comorbidity
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Compount_unit
IRI: http://www.w3.org/2004/02/skos/core#Concept
IRI: http://www.w3.org/2004/02/skos/core#ConceptScheme
Thesauri, classification schemes, subject heading lists, taxonomies, 'folksonomies', and other types of controlled vocabulary are all examples of concept schemes. Concept schemes are also embedded in glossaries and terminologies.
IRI: https://w3id.org/brainteaser/ontology/schema/Condition
IRI: https://w3id.org/brainteaser/ontology/schema/CSFAnalysis
IRI: http://www.wurvoc.org/vocabularies/om-1.8/cubic_metre
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#decibel
IRI: https://w3id.org/brainteaser/ontology/schema/Diagnosis
IRI: https://w3id.org/brainteaser/ontology/schema/DiagnosticImaging
IRI: https://w3id.org/brainteaser/ontology/schema/DiagnosticProcedure
IRI: https://w3id.org/brainteaser/ontology/schema/DiseaseDisorderOrFinding
IRI: https://w3id.org/brainteaser/ontology/schema/EndTherapyReason
IRI: https://w3id.org/brainteaser/ontology/schema/Event
IRI: https://w3id.org/brainteaser/ontology/schema/EvokedPotentials
IRI: https://w3id.org/brainteaser/ontology/schema/EDSS
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#GHGs
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#GHGs_concentration
IRI: https://w3id.org/brainteaser/ontology/schema/Gene
IRI: https://w3id.org/brainteaser/ontology/schema/GeneticTesting
IRI: https://w3id.org/brainteaser/ontology/schema/Group
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#HFCs
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#HFCs_concentration
IRI: https://w3id.org/brainteaser/ontology/schema/HematologyTest
IRI: https://w3id.org/brainteaser/ontology/schema/Impairment
IRI: http://www.w3.org/2006/time#Instant
IRI: http://www.w3.org/2006/time#Interval
IRI: https://w3id.org/brainteaser/ontology/schema/InterventionOrProcedure
IRI: https://w3id.org/brainteaser/ontology/schema/KingsClinicalStaging
IRI: https://w3id.org/brainteaser/ontology/schema/Kinship
IRI: https://w3id.org/brainteaser/ontology/schema/KinshipType
IRI: https://w3id.org/brainteaser/ontology/schema/LaboratoryTestResult
IRI: https://w3id.org/brainteaser/ontology/schema/Lifestyle
IRI: https://w3id.org/brainteaser/ontology/schema/MRI
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Mass
IRI: http://www.wurvoc.org/vocabularies/om-1.8/microgram
IRI: http://ontology.eil.utoronto.ca/GCI/Foundation/GCI-Foundation.owl#microgram_per_cubic_metre
IRI: https://w3id.org/brainteaser/ontology/schema/MiToSFunctionalStaging
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#NO2
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#NO2_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#N2O
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#N2O_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#Noise_pollution
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#Noise_pollution_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#O3
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#O3_concentration
IRI: https://w3id.org/brainteaser/ontology/schema/Occupation
IRI: https://w3id.org/brainteaser/ontology/schema/OligoclonalBands
IRI: https://w3id.org/brainteaser/ontology/schema/Onset
IRI: http://www.w3.org/2004/02/skos/core#OrderedCollection
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PFCs
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PFCs_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM10
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM10_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM10_Mass
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM10_Volume
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM2.5
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM2.5_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM2.5_Mass
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#PM2.5_Volume
IRI: https://w3id.org/brainteaser/ontology/schema/Patient
IRI: http://www.w3.org/2000/10/swap/pim/contact#Person
IRI: https://w3id.org/brainteaser/ontology/schema/PharmacologicSubstance
IRI: https://w3id.org/brainteaser/ontology/schema/PhysicalActivity
IRI: https://w3id.org/brainteaser/ontology/schema/Place
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#Pollution
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#Pollution_average
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#Pollution_concentration
IRI: https://w3id.org/brainteaser/ontology/schema/PET
IRI: https://w3id.org/brainteaser/ontology/schema/Pregnancy
IRI: https://w3id.org/brainteaser/ontology/schema/ProtocolEvent
IRI: https://w3id.org/brainteaser/ontology/schema/PulmonaryFunctionTest
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Quantity
IRI: https://w3id.org/brainteaser/ontology/schema/Questionnaire
IRI: https://w3id.org/brainteaser/ontology/schema/Relapse
IRI: https://w3id.org/brainteaser/ontology/schema/Residence
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#SF6
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#SF6_concentration
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#SO2
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#SO2_concentration
IRI: http://purl.oclc.org/NET/ssnx/ssn#SensingDevice
IRI: http://purl.oclc.org/NET/ssnx/ssn#Sensor
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Singular_unit
IRI: https://w3id.org/brainteaser/ontology/schema/Smoking
IRI: https://w3id.org/brainteaser/ontology/schema/SurgicalProcedure
IRI: https://w3id.org/brainteaser/ontology/schema/SurgicalType
IRI: https://w3id.org/brainteaser/ontology/schema/TherapeuticProcedure
IRI: https://w3id.org/brainteaser/ontology/schema/TherapeuticProcedureType
IRI: https://w3id.org/brainteaser/ontology/schema/TherapeuticTreatment
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#tonne
IRI: https://w3id.org/brainteaser/ontology/schema/Trauma
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Unit_division
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Unit_multiple_or_submultiple
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Unit_of_measure
IRI: http://www.wurvoc.org/vocabularies/om-1.8/Volume
IRI: https://w3id.org/brainteaser/ontology/schema/administration
IRI: https://w3id.org/brainteaser/ontology/schema/adverseReaction
IRI: https://w3id.org/brainteaser/ontology/schema/anatomicalLocation
IRI: https://w3id.org/brainteaser/ontology/schema/APConcentrationTime
IRI: https://w3id.org/brainteaser/ontology/schema/birthplace
IRI: https://w3id.org/brainteaser/ontology/schema/coexistingPregnancy
IRI: https://w3id.org/brainteaser/ontology/schema/conductedInClinic
IRI: https://w3id.org/brainteaser/ontology/schema/confirmedPregnancy
IRI: https://w3id.org/brainteaser/ontology/schema/consists
IRI: https://w3id.org/brainteaser/ontology/schema/coveredPlace
IRI: https://w3id.org/brainteaser/ontology/schema/determinedBy
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/enrolledIn
IRI: http://www.w3.org/2004/02/skos/core#broader
IRI: http://www.w3.org/2004/02/skos/core#broadMatch
IRI: http://www.w3.org/2004/02/skos/core#broaderTransitive
has characteristics: transitive
IRI: http://www.w3.org/2004/02/skos/core#closeMatch
has characteristics: symmetric
IRI: http://www.w3.org/2004/02/skos/core#exactMatch
has characteristics: symmetric, transitive
IRI: http://www.w3.org/2004/02/skos/core#member
IRI: http://www.w3.org/2004/02/skos/core#memberList
has characteristics: functional
IRI: http://www.w3.org/2004/02/skos/core#narrower
IRI: http://www.w3.org/2004/02/skos/core#narrowMatch
IRI: http://www.w3.org/2004/02/skos/core#narrowerTransitive
has characteristics: transitive
IRI: http://www.w3.org/2004/02/skos/core#hasTopConcept
IRI: https://w3id.org/brainteaser/ontology/schema/hasDisease
IRI: https://w3id.org/brainteaser/ontology/schema/hasEthnicity
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/hasKinship
IRI: https://w3id.org/brainteaser/ontology/schema/hasKinshipType
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/hasOccupation
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/hasRegisteredActivity
IRI: https://w3id.org/brainteaser/ontology/schema/hasRegisteredCondition
IRI: http://www.w3.org/2006/time#inDateTime
IRI: https://w3id.org/brainteaser/ontology/schema/inClinicalTrial
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/inKinshipWith
IRI: http://www.w3.org/2004/02/skos/core#mappingRelation
IRI: http://www.w3.org/2004/02/skos/core#inScheme
IRI: http://www.w3.org/2004/02/skos/core#semanticRelation
IRI: http://purl.oclc.org/NET/ssnx/ssn#isProducedBy
IRI: http://www.w3.org/2004/02/skos/core#topConceptOf
IRI: https://w3id.org/brainteaser/ontology/schema/isAboutDisease
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#measures
IRI: https://w3id.org/brainteaser/ontology/schema/observedResult
IRI: https://w3id.org/brainteaser/ontology/schema/onGene
IRI: https://w3id.org/brainteaser/ontology/schema/performedTreatment
IRI: https://w3id.org/brainteaser/ontology/schema/pharmacologicSubstance
IRI: http://www.wurvoc.org/vocabularies/om-1.8/phenomenon
IRI: https://w3id.org/brainteaser/ontology/schema/placeLocation
IRI: https://w3id.org/brainteaser/ontology/schema/pregnancy
IRI: https://w3id.org/brainteaser/ontology/schema/relapse
IRI: https://w3id.org/brainteaser/ontology/schema/requiredMRI
IRI: https://w3id.org/brainteaser/ontology/schema/residence
IRI: https://w3id.org/brainteaser/ontology/schema/surgicalType
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/tested
IRI: https://w3id.org/brainteaser/ontology/schema/testedForOligoclonalBands
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/therapyType
IRI: https://w3id.org/brainteaser/ontology/schema/trauma
IRI: https://w3id.org/brainteaser/ontology/schema/undergo
IRI: http://www.wurvoc.org/vocabularies/om-1.8/unit_of_measure
IRI: http://www.wurvoc.org/vocabularies/om-1.8/value
IRI: https://w3id.org/brainteaser/ontology/schema/activityStartYear
IRI: https://w3id.org/brainteaser/ontology/schema/activityEndYear
IRI: https://w3id.org/brainteaser/ontology/schema/activityType
IRI: https://w3id.org/brainteaser/ontology/schema/adminstrationDose
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/administrationFrequency
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/administrationRoute
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/administrationUoM
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/ageOnset
IRI: https://w3id.org/brainteaser/ontology/schema/albuminCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alcoholUse
IRI: https://w3id.org/brainteaser/ontology/schema/alive
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs1
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs10
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs11
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs12
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs2
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs3
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs4
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs5
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs6
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs7
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs8
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrs9
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alsfrsOriginal10
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/alterationCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/ambulationEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/axialOnset
IRI: https://w3id.org/brainteaser/ontology/schema/before20Years
IRI: https://w3id.org/brainteaser/ontology/schema/birthYear
IRI: https://w3id.org/brainteaser/ontology/schema/bodyMassIndex
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/bowelAndBladderEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/bowelAndBladderRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/brainAtrophyMRI
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/brainstemEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/brainsetmRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/bulbarOnset
IRI: https://w3id.org/brainteaser/ontology/schema/bulbarSubscore
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/cerebellarEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/cerebellarRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/cerebralEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/clinicallyEvaluatedEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/clinicalTrialDescription
IRI: https://w3id.org/brainteaser/ontology/schema/cognitiveRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/comorbiditySeverity
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/comorbidityTreatment
IRI: https://w3id.org/brainteaser/ontology/schema/componentName
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/concentrationMeasurement
IRI: https://w3id.org/brainteaser/ontology/schema/conditionEnd
IRI: https://w3id.org/brainteaser/ontology/schema/conditionStart
IRI: https://w3id.org/brainteaser/ontology/schema/contiguousLesionsMRI
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/dailyCigarettes
IRI: https://w3id.org/brainteaser/ontology/schema/deathCause
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/deathDate
IRI: https://w3id.org/brainteaser/ontology/schema/dextricity
IRI: https://w3id.org/brainteaser/ontology/schema/diagnosticCriteria
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/diet
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/educationLevel
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/endReason
IRI: https://w3id.org/brainteaser/ontology/schema/endTherapyReason
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/eventEnd
IRI: https://w3id.org/brainteaser/ontology/schema/eventStart
IRI: https://w3id.org/brainteaser/ontology/schema/evokedPotentialsLocation
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/evokedPotentialsResponse
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/evokedPotentialsType
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/gadoliniumLesionsT1MRI
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/gadoliniumLesionsT1MRINumber
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/generalizedOnset
IRI: https://w3id.org/brainteaser/ontology/schema/genomeSequencing
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/glucoseCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/granulocytesCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/hasMutation
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/height
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/IgGIndexCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/immunoglobulinGCSF
has characteristics: functional
IRI: http://www.w3.org/2006/time#inXSDDateTime
IRI: https://w3id.org/brainteaser/ontology/schema/intensity
IRI: https://w3id.org/brainteaser/ontology/schema/kingsValue
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/lesionsT1MRI
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/leukocytesCountCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/limbsOnset
IRI: https://w3id.org/brainteaser/ontology/schema/lymphocytesCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/maritalStatus
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/measuredLevel
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/measurementCalibrated
IRI: https://w3id.org/brainteaser/ontology/schema/menopauseStatus
IRI: https://w3id.org/brainteaser/ontology/schema/mitosValue
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/moreThan10PercentWeightloss
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/motorSubscore
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/MSInPaediatricAge
IRI: https://w3id.org/brainteaser/ontology/schema/multipleSclerosisType
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/mutationType
IRI: https://w3id.org/brainteaser/ontology/schema/newOrEnlargedLesionsT2MRI
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/newOrEnlargedLesionsT2MRINumber
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/normalLevel
has characteristics: functional
IRI: http://www.w3.org/2004/02/skos/core#notation
IRI: https://w3id.org/brainteaser/ontology/schema/notes
IRI: http://www.wurvoc.org/vocabularies/om-1.8/numerical_value
IRI: https://w3id.org/brainteaser/ontology/schema/oligoclonalBandsNumber
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/oligoclonalBandsPresence
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/oligoclonalBandsType
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/onsetElapsedTime
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/originalALSFRS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/otherOnset
IRI: https://w3id.org/brainteaser/ontology/schema/otherRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/packYear
IRI: https://w3id.org/brainteaser/ontology/schema/participationEnd
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/participationStart
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pathologicalJCCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/placeArea
IRI: https://w3id.org/brainteaser/ontology/schema/positivityResult
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/predominantLimbsImpairment
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/predominantLimbsSide
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/predominantMotorNeuron
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pregnancyComplications
IRI: https://w3id.org/brainteaser/ontology/schema/pregnancyEnd
IRI: https://w3id.org/brainteaser/ontology/schema/pregnancyEndEvent
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pregnancyStart
IRI: https://w3id.org/brainteaser/ontology/schema/procedureEnd
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/procedureStart
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/proteinsCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryAOPAbs
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryFEV6
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryFVCRel
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryMEPAbs
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryMIPAbs
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryPCO2
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryPO2
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pulmonaryVCAbs
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pyramidalEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/pyramidalRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/quotientAlbuminCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/relapseClinicalTherapy
IRI: https://w3id.org/brainteaser/ontology/schema/relapseCortisoneTherapy
IRI: https://w3id.org/brainteaser/ontology/schema/relapseDuration
IRI: https://w3id.org/brainteaser/ontology/schema/relapseEnd
IRI: https://w3id.org/brainteaser/ontology/schema/relapseHospitalAdmission
IRI: https://w3id.org/brainteaser/ontology/schema/relapseImpactOnADL
IRI: https://w3id.org/brainteaser/ontology/schema/relapseRecovery
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/relapseSequela
IRI: https://w3id.org/brainteaser/ontology/schema/relapseSeverity
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/relapseStart
IRI: https://w3id.org/brainteaser/ontology/schema/residenceEnd
IRI: https://w3id.org/brainteaser/ontology/schema/residenceStart
IRI: https://w3id.org/brainteaser/ontology/schema/respiratorySubscore
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/retiredAtDiagnosis
IRI: https://w3id.org/brainteaser/ontology/schema/revisedALSFRS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/sensoryEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/sensoryRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/sex
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/sexuality
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/sunExposure
IRI: https://w3id.org/brainteaser/ontology/schema/totalLesionsT2MRI
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/traumaDate
IRI: https://w3id.org/brainteaser/ontology/schema/traumaDescription
IRI: https://w3id.org/brainteaser/ontology/schema/unitOfMeasure
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/virusJCTestedCSF
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/visualEDSS
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/visualEvokedPotentialAmplitude
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/visualEvokedPotentialLatency
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/visualRelapse
IRI: https://w3id.org/brainteaser/ontology/schema/weeklyFrequency
IRI: https://w3id.org/brainteaser/ontology/schema/weight
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/zipCode
has characteristics: functional
IRI: https://w3id.org/brainteaser/ontology/schema/zipHashed
has characteristics: functional
IRI: http://www.w3.org/2004/02/skos/core#altLabel
Acronyms, abbreviations, spelling variants, and irregular plural/singular forms may be included among the alternative labels for a concept. Mis-spelled terms are normally included as hidden labels (see skos:hiddenLabel).
IRI: http://www.wurvoc.org/vocabularies/om-1.8/alternative_label
IRI: http://www.wurvoc.org/vocabularies/om-1.8/alternative_symbol
IRI: http://www.w3.org/2004/02/skos/core#changeNote
IRI: http://www.w3.org/2000/01/rdf-schema#comment
IRI: http://purl.org/dc/terms/conformsTo
IRI: http://purl.org/dc/terms/contributor
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#creator
IRI: http://purl.org/dc/terms/creator
IRI: http://www.w3.org/2004/02/skos/core#definition
IRI: http://purl.org/dc/terms/description
IRI: http://www.w3.org/2004/02/skos/core#editorialNote
IRI: http://www.w3.org/2004/02/skos/core#example
IRI: http://www.w3.org/2004/02/skos/core#historyNote
IRI: http://www.w3.org/2000/01/rdf-schema#label
IRI: http://creativecommons.org/ns#license
IRI: http://purl.org/dc/terms/license
IRI: http://xmlns.com/foaf/0.1/name
IRI: http://www.w3.org/2004/02/skos/core#note
IRI: http://www.w3.org/2004/02/skos/core#prefLabel
IRI: http://purl.org/vocab/vann/preferredNamespacePrefix
IRI: http://purl.org/vocab/vann/preferredNamespaceUri
IRI: http://purl.org/dc/terms/publisher
IRI: http://purl.org/dc/elements/1.1/rights
IRI: http://www.w3.org/2004/02/skos/core#scopeNote
IRI: http://purl.org/dc/elements/1.1/source
IRI: http://www.wurvoc.org/vocabularies/om-1.8/symbol
IRI: http://ontology.eil.utoronto.ca/GCI/Environment/Pollution.owl#title
IRI: http://purl.org/dc/elements/1.1/title
IRI: http://www.wurvoc.org/vocabularies/om-1.8/unofficial_label
IRI: http://purl.obolibrary.org/obo/NCIT_C12664
IRI: http://purl.obolibrary.org/obo/NCIT_C26682
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/177250006
IRI: http://purl.bioontology.org/ontology/UATC/C09AA
IRI: http://purl.bioontology.org/ontology/UATC/N06BX12
IRI: http://purl.bioontology.org/ontology/UATC/N02BA51
IRI: http://purl.bioontology.org/ontology/UATC/J05AB01
IRI: http://purl.obolibrary.org/obo/NCIT_C129644
IRI: http://purl.obolibrary.org/obo/NCIT_C26934
IRI: http://purl.obolibrary.org/obo/NCIT_C35204
IRI: http://purl.obolibrary.org/obo/NCIT_C123215
IRI: http://purl.obolibrary.org/obo/NCIT_C27043
IRI: http://purl.obolibrary.org/obo/NCIT_C97142
IRI: http://purl.bioontology.org/ontology/UATC/A16AA02
IRI: http://purl.obolibrary.org/obo/NCIT_C2852
IRI: http://purl.obolibrary.org/obo/OAE_0000220
IRI: http://data.europa.eu/esco/isco/C12
IRI: http://purl.obolibrary.org/obo/OAE_0000005
IRI: http://purl.bioontology.org/ontology/UATC/C09
IRI: http://purl.obolibrary.org/obo/NCIT_C116374
IRI: http://data.europa.eu/esco/isco/C92
IRI: http://purl.obolibrary.org/obo/NCIT_C26948
IRI: http://purl.obolibrary.org/obo/NCIT_C93040
IRI: http://purl.bioontology.org/ontology/UATC/L01ED03
IRI: http://purl.bioontology.org/ontology/UATC/L04AA34
IRI: http://purl.bioontology.org/ontology/UATC/A
IRI: http://purl.bioontology.org/ontology/UATC/V07
IRI: http://purl.bioontology.org/ontology/UATC/V03
IRI: http://purl.bioontology.org/ontology/UATC/V01
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/389145006
IRI: http://purl.obolibrary.org/obo/NCIT_C79532
IRI: http://purl.obolibrary.org/obo/NCIT_C61595
IRI: http://purl.bioontology.org/ontology/UATC/N05BA12
IRI: http://purl.obolibrary.org/obo/NCIT_C2866
IRI: http://purl.bioontology.org/ontology/UATC/N04BB01
IRI: http://purl.obolibrary.org/obo/NCIT_C61443
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/1144987003
IRI: http://purl.bioontology.org/ontology/UATC/C01BD01
IRI: http://purl.bioontology.org/ontology/UATC/N06AA09
IRI: http://purl.bioontology.org/ontology/UATC/N06CA01
IRI: http://purl.bioontology.org/ontology/UATC/C08CA01
IRI: http://www.wurvoc.org/vocabularies/om-1.8/amount_of_substance_of_a_system_that_contains_as_many_elementary_entities_as_there_are_atoms_in_0.012_kilogram_of_carbon_12
IRI: http://purl.bioontology.org/ontology/UATC/J01CR02
IRI: http://purl.obolibrary.org/obo/NCIT_C34373
IRI: http://purl.bioontology.org/ontology/UATC/A14
IRI: http://purl.bioontology.org/ontology/UATC/N02
IRI: http://purl.obolibrary.org/obo/NCIT_C2869
IRI: http://purl.bioontology.org/ontology/UATC/N01
IRI: http://purl.obolibrary.org/obo/NCIT_C112175
IRI: http://purl.obolibrary.org/obo/NCIT_C26989
IRI: http://purl.obolibrary.org/obo/NCIT_C8486
IRI: http://purl.obolibrary.org/obo/NCIT_C8668
IRI: http://purl.obolibrary.org/obo/NCIT_C60785
IRI: http://purl.obolibrary.org/obo/NCIT_C2875
IRI: http://purl.obolibrary.org/obo/NCIT_C116369
IRI: http://purl.bioontology.org/ontology/UATC/P02
IRI: http://purl.bioontology.org/ontology/UATC/D10
IRI: http://purl.bioontology.org/ontology/UATC/N04
IRI: http://purl.bioontology.org/ontology/UATC/B03
IRI: http://purl.bioontology.org/ontology/UATC/J01
IRI: http://purl.bioontology.org/ontology/UATC/D06
IRI: http://purl.obolibrary.org/obo/NCIT_C264
IRI: http://purl.bioontology.org/ontology/UATC/A07
IRI: http://purl.bioontology.org/ontology/UATC/A04
IRI: http://purl.bioontology.org/ontology/UATC/N03
IRI: http://purl.bioontology.org/ontology/UATC/D01
IRI: http://purl.bioontology.org/ontology/UATC/M04
IRI: http://purl.bioontology.org/ontology/UATC/B02
IRI: http://purl.bioontology.org/ontology/UATC/R06
IRI: http://purl.bioontology.org/ontology/UATC/C02
IRI: http://purl.bioontology.org/ontology/UATC/J
IRI: http://purl.bioontology.org/ontology/UATC/M01
IRI: http://purl.bioontology.org/ontology/UATC/J04
IRI: http://purl.bioontology.org/ontology/UATC/J02
IRI: http://purl.bioontology.org/ontology/UATC/L01
IRI: http://purl.bioontology.org/ontology/UATC/L
IRI: http://purl.bioontology.org/ontology/UATC/A08
IRI: http://purl.bioontology.org/ontology/UATC/P
IRI: http://purl.bioontology.org/ontology/UATC/P01
IRI: http://purl.bioontology.org/ontology/UATC/D04
IRI: http://purl.bioontology.org/ontology/UATC/D05
IRI: http://purl.bioontology.org/ontology/UATC/D08
IRI: http://purl.bioontology.org/ontology/UATC/B01
IRI: http://purl.bioontology.org/ontology/UATC/J05
IRI: http://purl.obolibrary.org/obo/NCIT_C2878
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/80146002
IRI: http://purl.bioontology.org/ontology/UATC/A15
IRI: http://purl.obolibrary.org/obo/NCIT_C28539
IRI: http://data.europa.eu/esco/isco/C0
IRI: http://data.europa.eu/esco/isco/C03
IRI: http://purl.obolibrary.org/obo/NCIT_C2881
IRI: http://purl.obolibrary.org/obo/NCIT_C2883
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/315280000
IRI: http://purl.obolibrary.org/obo/NCIT_C34932
IRI: http://data.europa.eu/esco/isco/C82
IRI: http://purl.obolibrary.org/obo/NCIT_C28397
IRI: http://purl.bioontology.org/ontology/UATC/C07AB03
IRI: http://purl.bioontology.org/ontology/UATC/C07CB03
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/24079001
IRI: http://purl.obolibrary.org/obo/NCIT_C50466
IRI: http://purl.obolibrary.org/obo/NCIT_C51224
IRI: http://purl.bioontology.org/ontology/UATC/C10AA05
IRI: http://purl.obolibrary.org/obo/NCIT_C96569
IRI: http://purl.obolibrary.org/obo/NCIT_C2889
IRI: http://purl.obolibrary.org/obo/NCIT_C99383
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/183005
IRI: http://purl.bioontology.org/ontology/UATC/L04AX01
IRI: http://purl.bioontology.org/ontology/UATC/M03BX01
IRI: http://purl.obolibrary.org/obo/NCIT_C26704
IRI: http://purl.obolibrary.org/obo/NCIT_C34935
IRI: http://purl.bioontology.org/ontology/UATC/N03AA04
IRI: http://purl.bioontology.org/ontology/UATC/C08CA12
IRI: http://purl.obolibrary.org/obo/NCIT_C156767
IRI: http://purl.bioontology.org/ontology/UATC/L03AX03
IRI: https://w3id.org/brainteaser/ontology/schema/BehavioralImpairment
IRI: http://purl.bioontology.org/ontology/SNOMEDCT/193093009
IRI: http://purl.bioontology.org/ontology/UATC/C07
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The authors would like to thank Silvio Peroni for developing LODE, a Live OWL Documentation Environment, which is used for representing the Cross Referencing Section of this document and Daniel Garijo for developing Widoco, the program used to create the template used in this documentation.